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Volumn 3, Issue 1, 2014, Pages

Considerations on the role of environmental toxins in idiopathic Parkinson's disease pathophysiology

Author keywords

Braak's staging and pathology progression; Environmental toxins; Gene environment interactions; Idiopathic Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; BETA HEXACHLOROCYCLOHEXANE; ENVIRONMENTAL TOXIN; ORGANOCHLORINE PESTICIDE; OXIDOPAMINE; PARAQUAT; REACTIVE OXYGEN METABOLITE; ROTENONE; TOXIN; UNCLASSIFIED DRUG;

EID: 84900019823     PISSN: None     EISSN: 20479158     Source Type: Journal    
DOI: 10.1186/2047-9158-3-10     Document Type: Review
Times cited : (40)

References (158)
  • 1
    • 0032948286 scopus 로고    scopus 로고
    • Epidemiologic approaches to the study of Parkinson's disease etiology
    • 10.1097/00001648-199905000-00023, 10230846
    • Checkoway H, Nelson LM. Epidemiologic approaches to the study of Parkinson's disease etiology. Epidemiology 1999, 10:327-336. 10.1097/00001648-199905000-00023, 10230846.
    • (1999) Epidemiology , vol.10 , pp. 327-336
    • Checkoway, H.1    Nelson, L.M.2
  • 2
    • 0037246310 scopus 로고    scopus 로고
    • Systematic review of incidence studies of Parkinson's disease
    • 10.1002/mds.10305, 12518297
    • Twelves D, Perkins KS, Counsell C. Systematic review of incidence studies of Parkinson's disease. Mov Disord 2003, 18:19-31. 10.1002/mds.10305, 12518297.
    • (2003) Mov Disord , vol.18 , pp. 19-31
    • Twelves, D.1    Perkins, K.S.2    Counsell, C.3
  • 4
    • 0031727163 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease
    • 10.1034/j.1399-0004.1998.5440401.x, 9831335
    • Gasser T. Genetics of Parkinson's disease. Clin Genet 1998, 54:259-265. 10.1034/j.1399-0004.1998.5440401.x, 9831335.
    • (1998) Clin Genet , vol.54 , pp. 259-265
    • Gasser, T.1
  • 5
    • 78649284891 scopus 로고    scopus 로고
    • The genetics of Parkinson disease
    • 10.1177/0891988710383572, 3044594, 20938043
    • Bekris LM, Mata IF, Zabetian CP. The genetics of Parkinson disease. J Geriatr Psychiatry Neurol 2010, 23:228-242. 10.1177/0891988710383572, 3044594, 20938043.
    • (2010) J Geriatr Psychiatry Neurol , vol.23 , pp. 228-242
    • Bekris, L.M.1    Mata, I.F.2    Zabetian, C.P.3
  • 6
    • 0031469711 scopus 로고    scopus 로고
    • The epidemiology of Parkinson's disease
    • Ben-Shlomo Y. The epidemiology of Parkinson's disease. Baillieres Clin Neurol 1997, 6:55-68.
    • (1997) Baillieres Clin Neurol , vol.6 , pp. 55-68
    • Ben-Shlomo, Y.1
  • 7
    • 0032617868 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease
    • Tanner CM, Ben-Shlomo Y. Epidemiology of Parkinson's disease. Adv Neurol 1999, 80:153-159.
    • (1999) Adv Neurol , vol.80 , pp. 153-159
    • Tanner, C.M.1    Ben-Shlomo, Y.2
  • 8
    • 0030123881 scopus 로고    scopus 로고
    • Rising prevalence of neurodegenerative diseases worldwide
    • 10.2169/internalmedicine.35.238, 8739772
    • Kondo K. Rising prevalence of neurodegenerative diseases worldwide. Intern Med 1996, 35:238. 10.2169/internalmedicine.35.238, 8739772.
    • (1996) Intern Med , vol.35 , pp. 238
    • Kondo, K.1
  • 10
    • 84867230531 scopus 로고    scopus 로고
    • Pesticide exposure and Parkinson's disease: epidemiological evidence of association
    • 10.1016/j.neuro.2012.05.011, 22627180
    • Freire C, Koifman S. Pesticide exposure and Parkinson's disease: epidemiological evidence of association. Neurotoxicology 2012, 33:947-971. 10.1016/j.neuro.2012.05.011, 22627180.
    • (2012) Neurotoxicology , vol.33 , pp. 947-971
    • Freire, C.1    Koifman, S.2
  • 11
    • 0031843721 scopus 로고    scopus 로고
    • The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living
    • 10.1212/WNL.50.5.1346, 9595985
    • Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Richardson RJ. The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology 1998, 50:1346-1350. 10.1212/WNL.50.5.1346, 9595985.
    • (1998) Neurology , vol.50 , pp. 1346-1350
    • Gorell, J.M.1    Johnson, C.C.2    Rybicki, B.A.3    Peterson, E.L.4    Richardson, R.J.5
  • 12
    • 0025764814 scopus 로고
    • Treatment of Parkinson's disease in 'Ayurveda' (ancient Indian system of medicine): discussion paper
    • 1293381, 1886119
    • Gourie-Devi M, Ramu MG, Venkataram BS. Treatment of Parkinson's disease in 'Ayurveda' (ancient Indian system of medicine): discussion paper. J R Soc Med 1991, 84:491-492. 1293381, 1886119.
    • (1991) J R Soc Med , vol.84 , pp. 491-492
    • Gourie-Devi, M.1    Ramu, M.G.2    Venkataram, B.S.3
  • 13
    • 33646401358 scopus 로고    scopus 로고
    • Early descriptions of Parkinson disease in ancient China
    • 10.1001/archneur.63.5.782, 16682554
    • Zhang ZX, Dong ZH, Roman GC. Early descriptions of Parkinson disease in ancient China. Arch Neurol 2006, 63:782-784. 10.1001/archneur.63.5.782, 16682554.
    • (2006) Arch Neurol , vol.63 , pp. 782-784
    • Zhang, Z.X.1    Dong, Z.H.2    Roman, G.C.3
  • 14
    • 0021089452 scopus 로고
    • Aetiology of Parkinson's disease
    • Calne DB, Langston JW. Aetiology of Parkinson's disease. Lancet 1983, 2:1457-1459.
    • (1983) Lancet , vol.2 , pp. 1457-1459
    • Calne, D.B.1    Langston, J.W.2
  • 15
    • 33745919520 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease
    • 10.1016/S1474-4422(06)70471-9, 16713924
    • de Lau LM, Breteler MM. Epidemiology of Parkinson's disease. Lancet Neurol 2006, 5:525-535. 10.1016/S1474-4422(06)70471-9, 16713924.
    • (2006) Lancet Neurol , vol.5 , pp. 525-535
    • de Lau, L.M.1    Breteler, M.M.2
  • 16
    • 84867578930 scopus 로고    scopus 로고
    • Mitochondria, oxidative stress and neurodegeneration
    • 10.1016/j.jns.2012.05.030, 22669122
    • Federico A, Cardaioli E, Da Pozzo P, Formichi P, Gallus GN, Radi E. Mitochondria, oxidative stress and neurodegeneration. J Neurol Sci 2012, 322:254-262. 10.1016/j.jns.2012.05.030, 22669122.
    • (2012) J Neurol Sci , vol.322 , pp. 254-262
    • Federico, A.1    Cardaioli, E.2    Da Pozzo, P.3    Formichi, P.4    Gallus, G.N.5    Radi, E.6
  • 18
    • 84900036913 scopus 로고    scopus 로고
    • Esperanza de vida en España a lo largo del siglo XX
    • Goerlich Gisbert FJAPP. Esperanza de vida en España a lo largo del siglo XX. BBVA 2006, 1:5-43.
    • (2006) BBVA , vol.1 , pp. 5-43
    • Goerlich Gisbert, F.J.A.P.P.1
  • 20
    • 84871416768 scopus 로고    scopus 로고
    • Role of biopesticides in crop protection: present status and future prospects
    • Ranga Rao GV RO, Rameshwar Rao V, Reddy YVR. Role of biopesticides in crop protection: present status and future prospects. Indian J Plant Prot 2007, 35:1-9.
    • (2007) Indian J Plant Prot , vol.35 , pp. 1-9
    • Ranga Rao GV, R.O.1    Rameshwar Rao, V.2    Reddy, Y.V.R.3
  • 22
    • 0030878320 scopus 로고    scopus 로고
    • Environmental risk factors and Parkinson's disease: a case-control study in Taiwan
    • 10.1212/WNL.48.6.1583, 9191770
    • Liou HH, Tsai MC, Chen CJ, Jeng JS, Chang YC, Chen SY, Chen RC. Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology 1997, 48:1583-1588. 10.1212/WNL.48.6.1583, 9191770.
    • (1997) Neurology , vol.48 , pp. 1583-1588
    • Liou, H.H.1    Tsai, M.C.2    Chen, C.J.3    Jeng, J.S.4    Chang, Y.C.5    Chen, S.Y.6    Chen, R.C.7
  • 23
    • 0034947602 scopus 로고    scopus 로고
    • Environmental risk factors and Parkinson's disease: a metaanalysis
    • 10.1006/enrs.2001.4264, 11437458
    • Priyadarshi A, Khuder SA, Schaub EA, Priyadarshi SS. Environmental risk factors and Parkinson's disease: a metaanalysis. Environ Res 2001, 86:122-127. 10.1006/enrs.2001.4264, 11437458.
    • (2001) Environ Res , vol.86 , pp. 122-127
    • Priyadarshi, A.1    Khuder, S.A.2    Schaub, E.A.3    Priyadarshi, S.S.4
  • 24
    • 0036091142 scopus 로고    scopus 로고
    • Occupational and environmental risk factors for Parkinson's disease
    • 10.1016/S1353-8020(01)00054-2, 15177059
    • Lai BC, Marion SA, Teschke K, Tsui JK. Occupational and environmental risk factors for Parkinson's disease. Parkinsonism Relat Disord 2002, 8:297-309. 10.1016/S1353-8020(01)00054-2, 15177059.
    • (2002) Parkinsonism Relat Disord , vol.8 , pp. 297-309
    • Lai, B.C.1    Marion, S.A.2    Teschke, K.3    Tsui, J.K.4
  • 25
    • 0022976146 scopus 로고
    • Early onset Parkinson's disease in Saskatchewan-environmental considerations for etiology
    • Rajput AH, Uitti RJ, Stern W, Laverty W. Early onset Parkinson's disease in Saskatchewan-environmental considerations for etiology. Can J Neurol Sci 1986, 13:312-316.
    • (1986) Can J Neurol Sci , vol.13 , pp. 312-316
    • Rajput, A.H.1    Uitti, R.J.2    Stern, W.3    Laverty, W.4
  • 26
    • 0035885824 scopus 로고    scopus 로고
    • Risk factors of Parkinson's disease in Indian patients
    • 10.1016/S0022-510X(01)00578-0, 11574106
    • Behari M, Srivastava AK, Das RR, Pandey RM. Risk factors of Parkinson's disease in Indian patients. J Neurol Sci 2001, 190:49-55. 10.1016/S0022-510X(01)00578-0, 11574106.
    • (2001) J Neurol Sci , vol.190 , pp. 49-55
    • Behari, M.1    Srivastava, A.K.2    Das, R.R.3    Pandey, R.M.4
  • 27
    • 0030012558 scopus 로고    scopus 로고
    • Possible environmental, occupational, and other etiologic factors for Parkinson's disease: a case-control study in Germany
    • 10.1212/WNL.46.5.1275, 8628466
    • Seidler A, Hellenbrand W, Robra BP, Vieregge P, Nischan P, Joerg J, Oertel WH, Ulm G, Schneider E. Possible environmental, occupational, and other etiologic factors for Parkinson's disease: a case-control study in Germany. Neurology 1996, 46:1275-1284. 10.1212/WNL.46.5.1275, 8628466.
    • (1996) Neurology , vol.46 , pp. 1275-1284
    • Seidler, A.1    Hellenbrand, W.2    Robra, B.P.3    Vieregge, P.4    Nischan, P.5    Joerg, J.6    Oertel, W.H.7    Ulm, G.8    Schneider, E.9
  • 28
    • 0026711037 scopus 로고
    • Parkinson's disease and exposure to agricultural work and pesticide chemicals
    • 10.1212/WNL.42.7.1328, 1620342
    • Semchuk KM, Love EJ, Lee RG. Parkinson's disease and exposure to agricultural work and pesticide chemicals. Neurology 1992, 42:1328-1335. 10.1212/WNL.42.7.1328, 1620342.
    • (1992) Neurology , vol.42 , pp. 1328-1335
    • Semchuk, K.M.1    Love, E.J.2    Lee, R.G.3
  • 29
    • 0028339708 scopus 로고
    • Parkinson's disease and brain levels of organochlorine pesticides
    • 10.1002/ana.410360119, 7517654
    • Fleming L, Mann JB, Bean J, Briggle T, Sanchez-Ramos JR. Parkinson's disease and brain levels of organochlorine pesticides. Ann Neurol 1994, 36:100-103. 10.1002/ana.410360119, 7517654.
    • (1994) Ann Neurol , vol.36 , pp. 100-103
    • Fleming, L.1    Mann, J.B.2    Bean, J.3    Briggle, T.4    Sanchez-Ramos, J.R.5
  • 35
    • 0036804507 scopus 로고    scopus 로고
    • The cycad neurotoxic amino acid, beta-N-methylamino-L-alanine (BMAA), elevates intracellular calcium levels in dissociated rat brain cells
    • 10.1016/S0378-8741(02)00170-8, 12241991
    • Brownson DM, Mabry TJ, Leslie SW. The cycad neurotoxic amino acid, beta-N-methylamino-L-alanine (BMAA), elevates intracellular calcium levels in dissociated rat brain cells. J Ethnopharmacol 2002, 82:159-167. 10.1016/S0378-8741(02)00170-8, 12241991.
    • (2002) J Ethnopharmacol , vol.82 , pp. 159-167
    • Brownson, D.M.1    Mabry, T.J.2    Leslie, S.W.3
  • 36
    • 0029113005 scopus 로고
    • Directly toxic effects of plant chemicals which may occur in human and animal foods
    • discussion 242, 10.1002/nt.2620030411, 7582621
    • Seawright AA. Directly toxic effects of plant chemicals which may occur in human and animal foods. Nat Toxins 1995, 3:227-232. discussion 242, 10.1002/nt.2620030411, 7582621.
    • (1995) Nat Toxins , vol.3 , pp. 227-232
    • Seawright, A.A.1
  • 37
    • 74549175646 scopus 로고    scopus 로고
    • Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases
    • Bradley WG, Mash DC. Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases. Amyotroph Lateral Scler 2009, 10(Suppl 2):7-20.
    • (2009) Amyotroph Lateral Scler , vol.10 , Issue.SUPPL. 2 , pp. 7-20
    • Bradley, W.G.1    Mash, D.C.2
  • 38
    • 77049174895 scopus 로고
    • Epidemiologic investigations of amyotrophic lateral sclerosis. I. Preliminary report on geographic distribution and special reference to the Mariana Islands, including clinical and pathologic observations
    • 10.1212/WNL.4.6.438, 13165883
    • Kurland LT, Mulder DW. Epidemiologic investigations of amyotrophic lateral sclerosis. I. Preliminary report on geographic distribution and special reference to the Mariana Islands, including clinical and pathologic observations. Neurology 1954, 4:438-448. 10.1212/WNL.4.6.438, 13165883.
    • (1954) Neurology , vol.4 , pp. 438-448
    • Kurland, L.T.1    Mulder, D.W.2
  • 39
    • 0037438648 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years
    • 10.1093/aje/kwf175, 12522022
    • Plato CC, Garruto RM, Galasko D, Craig UK, Plato M, Gamst A, Torres JM, Wiederholt W. Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years. Am J Epidemiol 2003, 157:149-157. 10.1093/aje/kwf175, 12522022.
    • (2003) Am J Epidemiol , vol.157 , pp. 149-157
    • Plato, C.C.1    Garruto, R.M.2    Galasko, D.3    Craig, U.K.4    Plato, M.5    Gamst, A.6    Torres, J.M.7    Wiederholt, W.8
  • 40
    • 0032929781 scopus 로고    scopus 로고
    • Parkinson's syndrome after closed head injury: a single case report
    • 10.1136/jnnp.66.3.380, 1736270, 10084539
    • Doder M, Jahanshahi M, Turjanski N, Moseley IF, Lees AJ. Parkinson's syndrome after closed head injury: a single case report. J Neurol Neurosurg Psychiatry 1999, 66:380-385. 10.1136/jnnp.66.3.380, 1736270, 10084539.
    • (1999) J Neurol Neurosurg Psychiatry , vol.66 , pp. 380-385
    • Doder, M.1    Jahanshahi, M.2    Turjanski, N.3    Moseley, I.F.4    Lees, A.J.5
  • 41
    • 0021883296 scopus 로고
    • Posttraumatic parkinsonism
    • 10.1016/0090-3019(85)90035-7, 4023906
    • Nayernouri T. Posttraumatic parkinsonism. Surg Neurol 1985, 24:263-264. 10.1016/0090-3019(85)90035-7, 4023906.
    • (1985) Surg Neurol , vol.24 , pp. 263-264
    • Nayernouri, T.1
  • 43
    • 84883554833 scopus 로고    scopus 로고
    • Head injury and risk of Parkinson disease: a systematic review and meta-analysis
    • 10.1002/mds.25458, 23609436
    • Jafari S, Etminan M, Aminzadeh F, Samii A. Head injury and risk of Parkinson disease: a systematic review and meta-analysis. Mov Disord 2013, 28:1222-1229. 10.1002/mds.25458, 23609436.
    • (2013) Mov Disord , vol.28 , pp. 1222-1229
    • Jafari, S.1    Etminan, M.2    Aminzadeh, F.3    Samii, A.4
  • 44
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    • 10.1124/jpet.102.035048, 12490568
    • Liu B, Hong JS. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 2003, 304:1-7. 10.1124/jpet.102.035048, 12490568.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1-7
    • Liu, B.1    Hong, J.S.2
  • 45
    • 0033729657 scopus 로고    scopus 로고
    • FDG- and Dopa-PET in postencephalitic parkinsonism
    • 10.1007/s007020070018, 11145004
    • Ghaemi M, Rudolf J, Schmulling S, Bamborschke S, Heiss WD. FDG- and Dopa-PET in postencephalitic parkinsonism. J Neural Transm 2000, 107:1289-1295. 10.1007/s007020070018, 11145004.
    • (2000) J Neural Transm , vol.107 , pp. 1289-1295
    • Ghaemi, M.1    Rudolf, J.2    Schmulling, S.3    Bamborschke, S.4    Heiss, W.D.5
  • 47
    • 0021697468 scopus 로고
    • The Graeme Robertson memorial lecture, 1983. The long-term prognosis of Parkinson's disease
    • Selby G. The Graeme Robertson memorial lecture, 1983. The long-term prognosis of Parkinson's disease. Clin Exp Neurol 1984, 20:1-25.
    • (1984) Clin Exp Neurol , vol.20 , pp. 1-25
    • Selby, G.1
  • 48
    • 0023002764 scopus 로고
    • Cigarette smoking and Parkinson's disease
    • 10.1212/WNL.36.11.1490, 3531917
    • Baron JA. Cigarette smoking and Parkinson's disease. Neurology 1986, 36:1490-1496. 10.1212/WNL.36.11.1490, 3531917.
    • (1986) Neurology , vol.36 , pp. 1490-1496
    • Baron, J.A.1
  • 49
    • 0034950069 scopus 로고    scopus 로고
    • Prospective study of caffeine consumption and risk of Parkinson's disease in men and women
    • 10.1002/ana.1052, 11456310
    • Ascherio A, Zhang SM, Hernan MA, Kawachi I, Colditz GA, Speizer FE, Willett WC. Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Ann Neurol 2001, 50:56-63. 10.1002/ana.1052, 11456310.
    • (2001) Ann Neurol , vol.50 , pp. 56-63
    • Ascherio, A.1    Zhang, S.M.2    Hernan, M.A.3    Kawachi, I.4    Colditz, G.A.5    Speizer, F.E.6    Willett, W.C.7
  • 51
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • 10.1097/00005072-199603000-00001, 8786384
    • Forno LS. Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 1996, 55:259-272. 10.1097/00005072-199603000-00001, 8786384.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 53
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • 10.1016/S0197-4580(02)00065-9, 12498954
    • Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003, 24:197-211. 10.1016/S0197-4580(02)00065-9, 12498954.
    • (2003) Neurobiol Aging , vol.24 , pp. 197-211
    • Braak, H.1    Del Tredici, K.2    Rub, U.3    de Vos, R.A.4    Jansen Steur, E.N.5    Braak, E.6
  • 54
    • 5444255434 scopus 로고    scopus 로고
    • Stages in the development of Parkinson's disease-related pathology
    • 10.1007/s00441-004-0956-9, 15338272
    • Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res 2004, 318:121-134. 10.1007/s00441-004-0956-9, 15338272.
    • (2004) Cell Tissue Res , vol.318 , pp. 121-134
    • Braak, H.1    Ghebremedhin, E.2    Rub, U.3    Bratzke, H.4    Del Tredici, K.5
  • 55
    • 0030662269 scopus 로고    scopus 로고
    • Neuropathology of autonomic nervous system in Parkinson's disease
    • Wakabayashi K, Takahashi H. Neuropathology of autonomic nervous system in Parkinson's disease. Eur Neurol 1997, 38(Suppl 2):2-7.
    • (1997) Eur Neurol , vol.38 , Issue.SUPPL. 2 , pp. 2-7
    • Wakabayashi, K.1    Takahashi, H.2
  • 56
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • 10.1016/j.neulet.2005.11.012, 16330147
    • Braak H, de Vos RA, Bohl J, Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 2006, 396:67-72. 10.1016/j.neulet.2005.11.012, 16330147.
    • (2006) Neurosci Lett , vol.396 , pp. 67-72
    • Braak, H.1    de Vos, R.A.2    Bohl, J.3    Del Tredici, K.4
  • 57
    • 77953022918 scopus 로고    scopus 로고
    • Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease
    • 10.1007/s00401-010-0665-2, 20229352
    • Del Tredici K, Hawkes CH, Ghebremedhin E, Braak H. Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease. Acta Neuropathol 2010, 119:703-713. 10.1007/s00401-010-0665-2, 20229352.
    • (2010) Acta Neuropathol , vol.119 , pp. 703-713
    • Del Tredici, K.1    Hawkes, C.H.2    Ghebremedhin, E.3    Braak, H.4
  • 59
    • 0035353726 scopus 로고    scopus 로고
    • Comorbidity of the nonmotor symptoms of Parkinson's disease
    • 10.1002/mds.1099, 11391746
    • Shulman LM, Taback RL, Bean J, Weiner WJ. Comorbidity of the nonmotor symptoms of Parkinson's disease. Mov Disord 2001, 16:507-510. 10.1002/mds.1099, 11391746.
    • (2001) Mov Disord , vol.16 , pp. 507-510
    • Shulman, L.M.1    Taback, R.L.2    Bean, J.3    Weiner, W.J.4
  • 60
    • 49649114596 scopus 로고    scopus 로고
    • Quantitation of non-motor symptoms in Parkinson's disease
    • Chaudhuri KR, Martinez-Martin P. Quantitation of non-motor symptoms in Parkinson's disease. Eur J Neurol 2008, 15(Suppl 2):2-7.
    • (2008) Eur J Neurol , vol.15 , Issue.SUPPL. 2 , pp. 2-7
    • Chaudhuri, K.R.1    Martinez-Martin, P.2
  • 61
    • 34249051016 scopus 로고    scopus 로고
    • Olfactory loss may be a first sign of idiopathic Parkinson's disease
    • 10.1002/mds.21413, 17357143
    • Haehner A, Hummel T, Hummel C, Sommer U, Junghanns S, Reichmann H. Olfactory loss may be a first sign of idiopathic Parkinson's disease. Mov Disord 2007, 22:839-842. 10.1002/mds.21413, 17357143.
    • (2007) Mov Disord , vol.22 , pp. 839-842
    • Haehner, A.1    Hummel, T.2    Hummel, C.3    Sommer, U.4    Junghanns, S.5    Reichmann, H.6
  • 62
    • 4043078792 scopus 로고    scopus 로고
    • Detection of presymptomatic Parkinson's disease: combining smell tests, transcranial sonography, and SPECT
    • 10.1002/mds.20141, 15390014
    • Sommer U, Hummel T, Cormann K, Mueller A, Frasnelli J, Kropp J, Reichmann H. Detection of presymptomatic Parkinson's disease: combining smell tests, transcranial sonography, and SPECT. Mov Disord 2004, 19:1196-1202. 10.1002/mds.20141, 15390014.
    • (2004) Mov Disord , vol.19 , pp. 1196-1202
    • Sommer, U.1    Hummel, T.2    Cormann, K.3    Mueller, A.4    Frasnelli, J.5    Kropp, J.6    Reichmann, H.7
  • 63
    • 77950601138 scopus 로고    scopus 로고
    • Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease
    • 10.1136/jnnp.2009.183715, 19965851
    • Ponsen MM, Stoffers D, Wolters E, Booij J, Berendse HW. Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinson's disease. J Neurol Neurosurg Psychiatry 2010, 81:396-399. 10.1136/jnnp.2009.183715, 19965851.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 396-399
    • Ponsen, M.M.1    Stoffers, D.2    Wolters, E.3    Booij, J.4    Berendse, H.W.5
  • 64
    • 11244260421 scopus 로고    scopus 로고
    • Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT
    • Stiasny-Kolster K, Doerr Y, Moller JC, Hoffken H, Behr TM, Oertel WH, Mayer G. Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT. Brain: a j neurol 2005, 128:126-137.
    • (2005) Brain: a j neurol , vol.128 , pp. 126-137
    • Stiasny-Kolster, K.1    Doerr, Y.2    Moller, J.C.3    Hoffken, H.4    Behr, T.M.5    Oertel, W.H.6    Mayer, G.7
  • 66
    • 0028060492 scopus 로고
    • Increased risk of Parkinson's disease in parents and siblings of patients
    • 10.1002/ana.410360417, 7605419
    • Payami H, Larsen K, Bernard S, Nutt J. Increased risk of Parkinson's disease in parents and siblings of patients. Ann Neurol 1994, 36:659-661. 10.1002/ana.410360417, 7605419.
    • (1994) Ann Neurol , vol.36 , pp. 659-661
    • Payami, H.1    Larsen, K.2    Bernard, S.3    Nutt, J.4
  • 68
    • 0029005009 scopus 로고
    • Increased risk of Parkinson's disease in relatives of patients
    • Vieregge P, Heberlein I. Increased risk of Parkinson's disease in relatives of patients. Ann Neurol 1995, 37:685.
    • (1995) Ann Neurol , vol.37 , pp. 685
    • Vieregge, P.1    Heberlein, I.2
  • 70
    • 0030056696 scopus 로고    scopus 로고
    • Risk of Parkinson's disease among first-degree relatives: A community-based study
    • 10.1212/WNL.47.1.155, 8710070
    • Marder K, Tang MX, Mejia H, Alfaro B, Cote L, Louis E, Groves J, Mayeux R. Risk of Parkinson's disease among first-degree relatives: A community-based study. Neurology 1996, 47:155-160. 10.1212/WNL.47.1.155, 8710070.
    • (1996) Neurology , vol.47 , pp. 155-160
    • Marder, K.1    Tang, M.X.2    Mejia, H.3    Alfaro, B.4    Cote, L.5    Louis, E.6    Groves, J.7    Mayeux, R.8
  • 75
    • 0031753976 scopus 로고    scopus 로고
    • Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease
    • 10.1007/s004390050845, 9856485
    • Leroy E, Anastasopoulos D, Konitsiotis S, Lavedan C, Polymeropoulos MH. Deletions in the Parkin gene and genetic heterogeneity in a Greek family with early onset Parkinson's disease. Hum Genet 1998, 103:424-427. 10.1007/s004390050845, 9856485.
    • (1998) Hum Genet , vol.103 , pp. 424-427
    • Leroy, E.1    Anastasopoulos, D.2    Konitsiotis, S.3    Lavedan, C.4    Polymeropoulos, M.H.5
  • 84
    • 20744435383 scopus 로고    scopus 로고
    • Molecular pathophysiology of Parkinson's disease
    • 10.1146/annurev.neuro.28.061604.135718, 16022590
    • Moore DJ, West AB, Dawson VL, Dawson TM. Molecular pathophysiology of Parkinson's disease. Annu Rev Neurosci 2005, 28:57-87. 10.1146/annurev.neuro.28.061604.135718, 16022590.
    • (2005) Annu Rev Neurosci , vol.28 , pp. 57-87
    • Moore, D.J.1    West, A.B.2    Dawson, V.L.3    Dawson, T.M.4
  • 87
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • 10.1038/35006074, 10746727
    • Feany MB, Bender WW. A Drosophila model of Parkinson's disease. Nature 2000, 404:394-398. 10.1038/35006074, 10746727.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 88
    • 49549101116 scopus 로고    scopus 로고
    • Zebrafish as a new animal model for movement disorders
    • 10.1111/j.1471-4159.2008.05463.x, 18466340
    • Flinn L, Bretaud S, Lo C, Ingham PW, Bandmann O. Zebrafish as a new animal model for movement disorders. J Neurochem 2008, 106:1991-1997. 10.1111/j.1471-4159.2008.05463.x, 18466340.
    • (2008) J Neurochem , vol.106 , pp. 1991-1997
    • Flinn, L.1    Bretaud, S.2    Lo, C.3    Ingham, P.W.4    Bandmann, O.5
  • 89
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    • 10.1038/nature04779, 16672981
    • Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, Yoo SJ, Hay BA, Guo M. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 2006, 441:1162-1166. 10.1038/nature04779, 16672981.
    • (2006) Nature , vol.441 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3    Cao, J.H.4    Huh, J.R.5    Seol, J.H.6    Yoo, S.J.7    Hay, B.A.8    Guo, M.9
  • 90
    • 0034604583 scopus 로고    scopus 로고
    • Wild-type but not Parkinson's disease-related ala-53 Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli
    • da Costa CA, Ancolio K, Checler F. Wild-type but not Parkinson's disease-related ala-53 Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli. The J biol chem 2000, 275:24065-24069.
    • (2000) The J biol chem , vol.275 , pp. 24065-24069
    • da Costa, C.A.1    Ancolio, K.2    Checler, F.3
  • 91
    • 33746065340 scopus 로고    scopus 로고
    • Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity
    • 10.1523/JNEUROSCI.0096-06.2006, 16837598
    • Leng Y, Chuang DM. Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. J Neurosci 2006, 26:7502-7512. 10.1523/JNEUROSCI.0096-06.2006, 16837598.
    • (2006) J Neurosci , vol.26 , pp. 7502-7512
    • Leng, Y.1    Chuang, D.M.2
  • 92
    • 84868147021 scopus 로고    scopus 로고
    • Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis
    • 10.1007/s12035-012-8291-8, 22736079
    • Yadav S, Dixit A, Agrawal S, Singh A, Srivastava G, Singh AK, Srivastava PK, Prakash O, Singh MP. Rodent models and contemporary molecular techniques: notable feats yet incomplete explanations of Parkinson's disease pathogenesis. Mol Neurobiol 2012, 46:495-512. 10.1007/s12035-012-8291-8, 22736079.
    • (2012) Mol Neurobiol , vol.46 , pp. 495-512
    • Yadav, S.1    Dixit, A.2    Agrawal, S.3    Singh, A.4    Srivastava, G.5    Singh, A.K.6    Srivastava, P.K.7    Prakash, O.8    Singh, M.P.9
  • 93
    • 84859732716 scopus 로고    scopus 로고
    • Classic and new animal models of Parkinson's disease
    • 3321500, 22536024
    • Blesa J, Phani S, Jackson-Lewis V, Przedborski S. Classic and new animal models of Parkinson's disease. J Biomed Biotechnol 2012, 2012:845618. 3321500, 22536024.
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 845618
    • Blesa, J.1    Phani, S.2    Jackson-Lewis, V.3    Przedborski, S.4
  • 94
    • 84859108554 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease
    • 10.1111/j.1742-4658.2012.08491.x, 22251459
    • Blandini F, Armentero MT. Animal models of Parkinson's disease. Febs J 2012, 279:1156-1166. 10.1111/j.1742-4658.2012.08491.x, 22251459.
    • (2012) Febs J , vol.279 , pp. 1156-1166
    • Blandini, F.1    Armentero, M.T.2
  • 95
    • 0005444118 scopus 로고
    • Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Langston JW, Ballard PA. Parkinson's disease in a chemist working with 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. N Engl J Med 1983, 309:310.
    • (1983) N Engl J Med , vol.309 , pp. 310
    • Langston, J.W.1    Ballard, P.A.2
  • 96
    • 0021753399 scopus 로고
    • Chronic parkinsonism secondary to intranasal administration of a product of meperidine-analogue synthesis
    • Wright JM, Wall RA, Perry TL, Paty DW. Chronic parkinsonism secondary to intranasal administration of a product of meperidine-analogue synthesis. N Engl J Med 1984, 310:325.
    • (1984) N Engl J Med , vol.310 , pp. 325
    • Wright, J.M.1    Wall, R.A.2    Perry, T.L.3    Paty, D.W.4
  • 99
    • 84860615324 scopus 로고    scopus 로고
    • Neurotoxin-based models of Parkinson's disease
    • Bove J, Perier C. Neurotoxin-based models of Parkinson's disease. Neuroscience 2012, 211:51-76.
    • (2012) Neuroscience , vol.211 , pp. 51-76
    • Bove, J.1    Perier, C.2
  • 100
    • 15544366886 scopus 로고    scopus 로고
    • Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease
    • 10.1016/j.molbrainres.2005.01.012, 15790534
    • Shimoji M, Zhang L, Mandir AS, Dawson VL, Dawson TM. Absence of inclusion body formation in the MPTP mouse model of Parkinson's disease. Brain Res Mol Brain Res 2005, 134:103-108. 10.1016/j.molbrainres.2005.01.012, 15790534.
    • (2005) Brain Res Mol Brain Res , vol.134 , pp. 103-108
    • Shimoji, M.1    Zhang, L.2    Mandir, A.S.3    Dawson, V.L.4    Dawson, T.M.5
  • 101
    • 0016361127 scopus 로고
    • Behavioral, physiological, and neurochemical changes after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine neurons
    • Ungerstedt U, Ljungberg T, Steg G. Behavioral, physiological, and neurochemical changes after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine neurons. Adv Neurol 1974, 5:421-426.
    • (1974) Adv Neurol , vol.5 , pp. 421-426
    • Ungerstedt, U.1    Ljungberg, T.2    Steg, G.3
  • 102
    • 0014954436 scopus 로고
    • Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system
    • 10.1016/0006-8993(70)90187-3, 5494536
    • Ungerstedt U, Arbuthnott GW. Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Res 1970, 24:485-493. 10.1016/0006-8993(70)90187-3, 5494536.
    • (1970) Brain Res , vol.24 , pp. 485-493
    • Ungerstedt, U.1    Arbuthnott, G.W.2
  • 103
    • 0037127197 scopus 로고    scopus 로고
    • The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein
    • 10.1074/jbc.C100560200, 11707429
    • Manning-Bog AB, McCormack AL, Li J, Uversky VN, Fink AL, Di Monte DA. The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J Biol Chem 2002, 277:1641-1644. 10.1074/jbc.C100560200, 11707429.
    • (2002) J Biol Chem , vol.277 , pp. 1641-1644
    • Manning-Bog, A.B.1    McCormack, A.L.2    Li, J.3    Uversky, V.N.4    Fink, A.L.5    Di Monte, D.A.6
  • 104
  • 105
    • 0037126181 scopus 로고    scopus 로고
    • Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats
    • 10.1016/S0166-4328(02)00180-8, 12385818
    • Alam M, Schmidt WJ. Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats. Behav Brain Res 2002, 136:317-324. 10.1016/S0166-4328(02)00180-8, 12385818.
    • (2002) Behav Brain Res , vol.136 , pp. 317-324
    • Alam, M.1    Schmidt, W.J.2
  • 107
    • 0042521076 scopus 로고    scopus 로고
    • The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?
    • 10.1016/S1474-4422(03)00501-5, 12941575
    • Di Monte DA. The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?. Lancet Neurol 2003, 2:531-538. 10.1016/S1474-4422(03)00501-5, 12941575.
    • (2003) Lancet Neurol , vol.2 , pp. 531-538
    • Di Monte, D.A.1
  • 108
    • 34249814605 scopus 로고    scopus 로고
    • Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone
    • 10.1111/j.1471-4159.2006.04440.x, 17459145
    • Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, Taniguchi T, Yoshimoto K, Kaneko M, Okuma Y, Taira T, Ariga H, Shimohama S. Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. J Neurochem 2007, 101:1491-1504. 10.1111/j.1471-4159.2006.04440.x, 17459145.
    • (2007) J Neurochem , vol.101 , pp. 1491-1504
    • Inden, M.1    Kitamura, Y.2    Takeuchi, H.3    Yanagida, T.4    Takata, K.5    Kobayashi, Y.6    Taniguchi, T.7    Yoshimoto, K.8    Kaneko, M.9    Okuma, Y.10    Taira, T.11    Ariga, H.12    Shimohama, S.13
  • 110
    • 0031005815 scopus 로고    scopus 로고
    • Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra
    • 10.1016/S0006-8993(97)00008-5, 9125443
    • Ferrante RJ, Schulz JB, Kowall NW, Beal MF. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res 1997, 753:157-162. 10.1016/S0006-8993(97)00008-5, 9125443.
    • (1997) Brain Res , vol.753 , pp. 157-162
    • Ferrante, R.J.1    Schulz, J.B.2    Kowall, N.W.3    Beal, M.F.4
  • 111
    • 0037314540 scopus 로고    scopus 로고
    • Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats
    • 10.1046/j.1471-4159.2003.01533.x, 12558969
    • Hoeglinger GU, Feger J, Prigent A, Michel PP, Parain K, Champy P, Ruberg M, Oertel WH, Hirsch EC. Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats. J Neurochem 2003, 84:491-502. 10.1046/j.1471-4159.2003.01533.x, 12558969.
    • (2003) J Neurochem , vol.84 , pp. 491-502
    • Hoeglinger, G.U.1    Feger, J.2    Prigent, A.3    Michel, P.P.4    Parain, K.5    Champy, P.6    Ruberg, M.7    Oertel, W.H.8    Hirsch, E.C.9
  • 114
    • 0035816404 scopus 로고    scopus 로고
    • Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease
    • 10.1016/S0014-5793(01)02597-2, 11445065
    • Uversky VN, Li J, Fink AL. Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease. FEBS Lett 2001, 500:105-108. 10.1016/S0014-5793(01)02597-2, 11445065.
    • (2001) FEBS Lett , vol.500 , pp. 105-108
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 115
    • 0035941201 scopus 로고    scopus 로고
    • Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure
    • 10.1074/jbc.M105343200, 11553618
    • Uversky VN, Li J, Fink AL. Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure. J Biol Chem 2001, 276:44284-44296. 10.1074/jbc.M105343200, 11553618.
    • (2001) J Biol Chem , vol.276 , pp. 44284-44296
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 117
    • 33847119357 scopus 로고    scopus 로고
    • Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency
    • 10.1016/j.taap.2006.09.016, 17084875
    • Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicol Appl Pharmacol 2007, 219:181-189. 10.1016/j.taap.2006.09.016, 17084875.
    • (2007) Toxicol Appl Pharmacol , vol.219 , pp. 181-189
    • Giordano, G.1    Afsharinejad, Z.2    Guizzetti, M.3    Vitalone, A.4    Kavanagh, T.J.5    Costa, L.G.6
  • 118
    • 27944453586 scopus 로고    scopus 로고
    • Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation
    • 10.1093/toxsci/kfi334, 16177237
    • Schuh RA, Kristian T, Gupta RK, Flaws JA, Fiskum G. Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation. Toxicol Sci 2005, 88:495-504. 10.1093/toxsci/kfi334, 16177237.
    • (2005) Toxicol Sci , vol.88 , pp. 495-504
    • Schuh, R.A.1    Kristian, T.2    Gupta, R.K.3    Flaws, J.A.4    Fiskum, G.5
  • 119
    • 0346422397 scopus 로고    scopus 로고
    • The neurotoxicant trimethyltin induces apoptosis via caspase activation, p38 protein kinase, and oxidative stress in PC12 cells
    • 10.1016/j.toxlet.2003.10.023, 14700529
    • Jenkins SM, Barone S. The neurotoxicant trimethyltin induces apoptosis via caspase activation, p38 protein kinase, and oxidative stress in PC12 cells. Toxicol Lett 2004, 147:63-72. 10.1016/j.toxlet.2003.10.023, 14700529.
    • (2004) Toxicol Lett , vol.147 , pp. 63-72
    • Jenkins, S.M.1    Barone, S.2
  • 120
    • 33747191688 scopus 로고    scopus 로고
    • Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction
    • 10.1016/j.neuro.2006.07.009, 16889834
    • Domico LM, Zeevalk GD, Bernard LP, Cooper KR. Acute neurotoxic effects of mancozeb and maneb in mesencephalic neuronal cultures are associated with mitochondrial dysfunction. Neurotoxicology 2006, 27:816-825. 10.1016/j.neuro.2006.07.009, 16889834.
    • (2006) Neurotoxicology , vol.27 , pp. 816-825
    • Domico, L.M.1    Zeevalk, G.D.2    Bernard, L.P.3    Cooper, K.R.4
  • 121
    • 0029121992 scopus 로고
    • Microglial responsiveness as a sensitive marker for trimethyltin (TMT) neurotoxicity
    • 10.1016/0006-8993(95)00509-O, 7496810
    • Monnet-Tschudi F, Zurich MG, Pithon E, van Melle G, Honegger P. Microglial responsiveness as a sensitive marker for trimethyltin (TMT) neurotoxicity. Brain Res 1995, 690:8-14. 10.1016/0006-8993(95)00509-O, 7496810.
    • (1995) Brain Res , vol.690 , pp. 8-14
    • Monnet-Tschudi, F.1    Zurich, M.G.2    Pithon, E.3    van Melle, G.4    Honegger, P.5
  • 122
    • 0030602015 scopus 로고    scopus 로고
    • Comparison of the developmental effects of two mercury compounds on glial cells and neurons in aggregate cultures of rat telencephalon
    • 10.1016/S0006-8993(96)00895-5, 9001704
    • Monnet-Tschudi F, Zurich MG, Honegger P. Comparison of the developmental effects of two mercury compounds on glial cells and neurons in aggregate cultures of rat telencephalon. Brain Res 1996, 741:52-59. 10.1016/S0006-8993(96)00895-5, 9001704.
    • (1996) Brain Res , vol.741 , pp. 52-59
    • Monnet-Tschudi, F.1    Zurich, M.G.2    Honegger, P.3
  • 124
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • 10.1002/ana.410260606, 2557792
    • Parker WD, Boyson SJ, Parks JK. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 1989, 26:719-723. 10.1002/ana.410260606, 2557792.
    • (1989) Ann Neurol , vol.26 , pp. 719-723
    • Parker, W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 125
    • 0029050583 scopus 로고
    • Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease
    • 10.1002/ana.410370604, 7778844
    • Haas RH, Nasirian F, Nakano K, Ward D, Pay M, Hill R, Shults CW. Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease. Ann Neurol 1995, 37:714-722. 10.1002/ana.410370604, 7778844.
    • (1995) Ann Neurol , vol.37 , pp. 714-722
    • Haas, R.H.1    Nasirian, F.2    Nakano, K.3    Ward, D.4    Pay, M.5    Hill, R.6    Shults, C.W.7
  • 126
    • 84858765143 scopus 로고    scopus 로고
    • [Reactive oxygen species and 3,4-dihydroxyphenylacetaldehyde in pathogenesis of Parkinson disease]
    • Rybakowska I, Szreder G, Kaletha K, Barwina M, Waldman W, Sein Anand J. [Reactive oxygen species and 3,4-dihydroxyphenylacetaldehyde in pathogenesis of Parkinson disease]. Przegl Lek 2011, 68:486-487.
    • (2011) Przegl Lek , vol.68 , pp. 486-487
    • Rybakowska, I.1    Szreder, G.2    Kaletha, K.3    Barwina, M.4    Waldman, W.5    Sein Anand, J.6
  • 127
    • 84555195856 scopus 로고    scopus 로고
    • Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
    • 10.1042/BJ20111451, 3258656, 22187934
    • Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J 2012, 441:523-540. 10.1042/BJ20111451, 3258656, 22187934.
    • (2012) Biochem J , vol.441 , pp. 523-540
    • Lee, J.1    Giordano, S.2    Zhang, J.3
  • 129
    • 52449117926 scopus 로고    scopus 로고
    • Research in motion: the enigma of Parkinson's disease pathology spread
    • 10.1038/nrn2477, 18769444
    • Brundin P, Li JY, Holton JL, Lindvall O, Revesz T. Research in motion: the enigma of Parkinson's disease pathology spread. Nat Rev Neurosci 2008, 9:741-745. 10.1038/nrn2477, 18769444.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 741-745
    • Brundin, P.1    Li, J.Y.2    Holton, J.L.3    Lindvall, O.4    Revesz, T.5
  • 130
    • 69149089854 scopus 로고    scopus 로고
    • Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    • 10.1073/pnas.0903691106, 2722313, 19651612
    • Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 2009, 106:13010-13015. 10.1073/pnas.0903691106, 2722313, 19651612.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13010-13015
    • Desplats, P.1    Lee, H.J.2    Bae, E.J.3    Patrick, C.4    Rockenstein, E.5    Crews, L.6    Spencer, B.7    Masliah, E.8    Lee, S.J.9
  • 131
    • 79954631518 scopus 로고    scopus 로고
    • Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
    • 10.1016/j.nbd.2011.01.029, 3107939, 21303699
    • Alvarez-Erviti L, Seow Y, Schapira AH, Gardiner C, Sargent IL, Wood MJ, Cooper JM. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol Dis 2011, 42:360-367. 10.1016/j.nbd.2011.01.029, 3107939, 21303699.
    • (2011) Neurobiol Dis , vol.42 , pp. 360-367
    • Alvarez-Erviti, L.1    Seow, Y.2    Schapira, A.H.3    Gardiner, C.4    Sargent, I.L.5    Wood, M.J.6    Cooper, J.M.7
  • 132
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • 10.1212/WNL.38.8.1285, 3399080
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988, 38:1285-1291. 10.1212/WNL.38.8.1285, 3399080.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 133
    • 1942454250 scopus 로고    scopus 로고
    • Inflammation and neurodegeneration in Parkinson's disease
    • McGeer PL, McGeer EG. Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism Relat Disord 2004, 10(Suppl 1):S3-S7.
    • (2004) Parkinsonism Relat Disord , vol.10 , Issue.SUPPL. 1
    • McGeer, P.L.1    McGeer, E.G.2
  • 134
    • 0028364696 scopus 로고
    • Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease
    • 10.1016/0304-3940(94)90684-X, 8084523
    • Boka G, Anglade P, Wallach D, Javoy-Agid F, Agid Y, Hirsch EC. Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease. Neurosci Lett 1994, 172:151-154. 10.1016/0304-3940(94)90684-X, 8084523.
    • (1994) Neurosci Lett , vol.172 , pp. 151-154
    • Boka, G.1    Anglade, P.2    Wallach, D.3    Javoy-Agid, F.4    Agid, Y.5    Hirsch, E.C.6
  • 135
    • 0037378023 scopus 로고    scopus 로고
    • Neuroinflammatory processes in Parkinson's disease
    • discussion S58-60
    • Hunot S, Hirsch EC. Neuroinflammatory processes in Parkinson's disease. Ann Neurol 2003, 53(Suppl 3):S49-S58. discussion S58-60.
    • (2003) Ann Neurol , vol.53 , Issue.SUPPL. 3
    • Hunot, S.1    Hirsch, E.C.2
  • 136
    • 0037443073 scopus 로고    scopus 로고
    • Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease
    • Gao HM, Hong JS, Zhang W, Liu B. Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. J Neurosci 2003, 23:1228-1236.
    • (2003) J Neurosci , vol.23 , pp. 1228-1236
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3    Liu, B.4
  • 137
    • 0026098843 scopus 로고
    • L-dopa-responsive movement disorder caused by Nocardia asteroides localized in the brains of mice
    • 257724, 1670928
    • Kohbata S, Beaman BL. L-dopa-responsive movement disorder caused by Nocardia asteroides localized in the brains of mice. Infect Immun 1991, 59:181-191. 257724, 1670928.
    • (1991) Infect Immun , vol.59 , pp. 181-191
    • Kohbata, S.1    Beaman, B.L.2
  • 138
    • 0036316772 scopus 로고    scopus 로고
    • Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
    • 10.1046/j.1471-4159.2002.00928.x, 12068076
    • Gao HM, Jiang J, Wilson B, Zhang W, Hong JS, Liu B. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J Neurochem 2002, 81:1285-1297. 10.1046/j.1471-4159.2002.00928.x, 12068076.
    • (2002) J Neurochem , vol.81 , pp. 1285-1297
    • Gao, H.M.1    Jiang, J.2    Wilson, B.3    Zhang, W.4    Hong, J.S.5    Liu, B.6
  • 139
    • 52449115580 scopus 로고    scopus 로고
    • The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery
    • 10.1111/j.1472-8206.2008.00616.x, 2632601, 18710400
    • Dutta G, Zhang P, Liu B. The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery. Fundam Clin Pharmacol 2008, 22:453-464. 10.1111/j.1472-8206.2008.00616.x, 2632601, 18710400.
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 453-464
    • Dutta, G.1    Zhang, P.2    Liu, B.3
  • 140
    • 0033121299 scopus 로고    scopus 로고
    • FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells
    • Hunot S, Dugas N, Faucheux B, Hartmann A, Tardieu M, Debre P, Agid Y, Dugas B, Hirsch EC. FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells. J Neurosci 1999, 19:3440-3447.
    • (1999) J Neurosci , vol.19 , pp. 3440-3447
    • Hunot, S.1    Dugas, N.2    Faucheux, B.3    Hartmann, A.4    Tardieu, M.5    Debre, P.6    Agid, Y.7    Dugas, B.8    Hirsch, E.C.9
  • 141
    • 39049169272 scopus 로고    scopus 로고
    • Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury
    • 10.2174/092986708783330665, 18220759
    • Wong CH, Crack PJ. Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury. Curr Med Chem 2008, 15:1-14. 10.2174/092986708783330665, 18220759.
    • (2008) Curr Med Chem , vol.15 , pp. 1-14
    • Wong, C.H.1    Crack, P.J.2
  • 142
    • 47349093970 scopus 로고    scopus 로고
    • The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease
    • 10.1016/j.expneurol.2008.04.008, 18514193
    • McGeer PL, McGeer EG. The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease. Exp Neurol 2008, 212:235-238. 10.1016/j.expneurol.2008.04.008, 18514193.
    • (2008) Exp Neurol , vol.212 , pp. 235-238
    • McGeer, P.L.1    McGeer, E.G.2
  • 143
    • 79955921784 scopus 로고    scopus 로고
    • Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease
    • 10.1289/ehp.1003013, 3114815, 21245015
    • Gao HM, Zhang F, Zhou H, Kam W, Wilson B, Hong JS. Neuroinflammation and alpha-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. Environ Health Perspect 2011, 119:807-814. 10.1289/ehp.1003013, 3114815, 21245015.
    • (2011) Environ Health Perspect , vol.119 , pp. 807-814
    • Gao, H.M.1    Zhang, F.2    Zhou, H.3    Kam, W.4    Wilson, B.5    Hong, J.S.6
  • 144
    • 79952169319 scopus 로고    scopus 로고
    • Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD
    • 3026982, 21318163
    • Esteves AR, Arduino DM, Silva DF, Oliveira CR, Cardoso SM. Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD. Parkinsons Dis 2011, 2011:693761. 3026982, 21318163.
    • (2011) Parkinsons Dis , vol.2011 , pp. 693761
    • Esteves, A.R.1    Arduino, D.M.2    Silva, D.F.3    Oliveira, C.R.4    Cardoso, S.M.5
  • 146
    • 78049383132 scopus 로고    scopus 로고
    • Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
    • 10.1016/j.neulet.2010.09.061, 2967673, 20887775
    • Chinta SJ, Mallajosyula JK, Rane A, Andersen JK. Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo. Neurosci Lett 2010, 486:235-239. 10.1016/j.neulet.2010.09.061, 2967673, 20887775.
    • (2010) Neurosci Lett , vol.486 , pp. 235-239
    • Chinta, S.J.1    Mallajosyula, J.K.2    Rane, A.3    Andersen, J.K.4
  • 148
    • 33750121865 scopus 로고    scopus 로고
    • Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells
    • 10.1096/fj.06-6183com, 17012252
    • Klegeris A, Giasson BI, Zhang H, Maguire J, Pelech S, McGeer PL. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. FASEB J 2006, 20:2000-2008. 10.1096/fj.06-6183com, 17012252.
    • (2006) FASEB J , vol.20 , pp. 2000-2008
    • Klegeris, A.1    Giasson, B.I.2    Zhang, H.3    Maguire, J.4    Pelech, S.5    McGeer, P.L.6
  • 149
    • 50549085408 scopus 로고    scopus 로고
    • Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration
    • 10.1523/JNEUROSCI.0143-07.2008, 2702093, 18650345
    • Gao HM, Kotzbauer PT, Uryu K, Leight S, Trojanowski JQ, Lee VM. Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J Neurosci 2008, 28:7687-7698. 10.1523/JNEUROSCI.0143-07.2008, 2702093, 18650345.
    • (2008) J Neurosci , vol.28 , pp. 7687-7698
    • Gao, H.M.1    Kotzbauer, P.T.2    Uryu, K.3    Leight, S.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 151
    • 33947513592 scopus 로고    scopus 로고
    • Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model
    • 10.2353/ajpath.2007.060359, 1851868, 17255333
    • Norris EH, Uryu K, Leight S, Giasson BI, Trojanowski JQ, Lee VM. Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model. Am J Pathol 2007, 170:658-666. 10.2353/ajpath.2007.060359, 1851868, 17255333.
    • (2007) Am J Pathol , vol.170 , pp. 658-666
    • Norris, E.H.1    Uryu, K.2    Leight, S.3    Giasson, B.I.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 153
    • 70350002152 scopus 로고    scopus 로고
    • DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders
    • 10.1016/j.freeradbiomed.2009.08.003, 19686841
    • Kahle PJ, Waak J, Gasser T. DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders. Free Radic Biol Med 2009, 47:1354-1361. 10.1016/j.freeradbiomed.2009.08.003, 19686841.
    • (2009) Free Radic Biol Med , vol.47 , pp. 1354-1361
    • Kahle, P.J.1    Waak, J.2    Gasser, T.3
  • 154
    • 84884920554 scopus 로고    scopus 로고
    • Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes
    • 10.4161/epi.25865, 3891683, 23907097
    • Masliah E, Dumaop W, Galasko D, Desplats P. Distinctive patterns of DNA methylation associated with Parkinson disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics 2013, 8:1030-1038. 10.4161/epi.25865, 3891683, 23907097.
    • (2013) Epigenetics , vol.8 , pp. 1030-1038
    • Masliah, E.1    Dumaop, W.2    Galasko, D.3    Desplats, P.4
  • 155
    • 84882847104 scopus 로고    scopus 로고
    • Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool
    • 10.1016/j.ymgme.2013.07.012, 23920043
    • Iacobazzi V, Castegna A, Infantino V, Andria G. Mitochondrial DNA methylation as a next-generation biomarker and diagnostic tool. Mol Genet Metab 2013, 110:25-34. 10.1016/j.ymgme.2013.07.012, 23920043.
    • (2013) Mol Genet Metab , vol.110 , pp. 25-34
    • Iacobazzi, V.1    Castegna, A.2    Infantino, V.3    Andria, G.4
  • 156
    • 84894240705 scopus 로고    scopus 로고
    • Epigenetics in Parkinson's and Alzheimer's diseases
    • 10.1007/978-94-007-4525-4_22, 23150265
    • Marques S, Outeiro TF. Epigenetics in Parkinson's and Alzheimer's diseases. Sub-cellular biochemistry 2013, 61:507-525. 10.1007/978-94-007-4525-4_22, 23150265.
    • (2013) Sub-cellular biochemistry , vol.61 , pp. 507-525
    • Marques, S.1    Outeiro, T.F.2
  • 157
    • 84883788666 scopus 로고    scopus 로고
    • Epigenetic targeting of histone deacetylase: therapeutic potential in Parkinson's disease?
    • 10.1016/j.pharmthera.2013.05.010, 23711791
    • Harrison IF, Dexter DT. Epigenetic targeting of histone deacetylase: therapeutic potential in Parkinson's disease?. Pharmacol Ther 2013, 140:34-52. 10.1016/j.pharmthera.2013.05.010, 23711791.
    • (2013) Pharmacol Ther , vol.140 , pp. 34-52
    • Harrison, I.F.1    Dexter, D.T.2


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