Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: Possible relevance for atypical parkinsonism in Guadeloupe

Journal of Neurochemistry

Volumn 88, Issue 1, 2004, Pages 63-69

  Champy, Pierre ^a,b   Höglinger, Günter U ^a   Féger, Jean ^a   Gleye, Christophe ^b   Hocquemiller, Reynald ^b   Laurens, Alain ^b   Guérineau, Vincent ^c   Laprévote, Olivier ^c   Medja, Fadia ^a   Lombès, Anne ^a   Michel, Patrick P ^a   Lannuzel, Annie ^d   Hirsch, Etienne C ^a   Ruberg, Merle ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b UNIVERSITÉ PARIS SUD   (France)

^c INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^d Department of Neurology   (Guadeloupe)

Author keywords

Acetogenin; Annonacin; Atypical Parkinson syndrome; Guadeloupe; Mitochondrial complex I; Rotenone

Indexed keywords

ANNONACIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANNONACEAE; ARTICLE; BASAL GANGLION; CELL COUNT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DESORPTION; EPIDEMIOLOGICAL DATA; FRUIT; GUADELOUPE; IMMUNOREACTIVITY; IONIZATION; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROGLIA; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; OSMOTIC PUMP; PARKINSONISM; PRIORITY JOURNAL; RAT; STEREOMETRY; SUBSTANTIA NIGRA; TEA;

ANIMALIA; ANNONA; ANNONA MURICATA; ANNONACEAE;

EID: 9144275011     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02138.x     Document Type: Article

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