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Volumn 8, Issue 10, 2013, Pages 1030-1038

Distinctive patterns of DNA methylation associated with Parkinson disease: Identification of concordant epigenetic changes in brain and peripheral blood leukocytes

Author keywords

Brain; DNA methylation; Epigenetics; Genome wide methylation; Neurodegeneration; Parkinson disease; Peripheral blood leukocytes

Indexed keywords

BIOLOGICAL MARKER; CARBIDOPA PLUS LEVODOPA; CLONAZEPAM; ENTACAPONE; MEMANTINE; RASAGILINE; RIVASTIGMINE; SELEGILINE;

EID: 84884920554     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.25865     Document Type: Article
Times cited : (273)

References (53)
  • 1
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • PMID: 12971891
    • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 2003; 39: 889-909; PMID: 12971891; http://dx. doi. org/10. 1016/S0896-6273(03)00568-3
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 3
    • 0031907128 scopus 로고    scopus 로고
    • Abnormal accumulation of NACP/alphasynuclein in neurodegenerative disorders
    • PMID: 9466562
    • Takeda A, Mallory M, Sundsmo M, Honer W, Hansen L, Masliah E. Abnormal accumulation of NACP/alphasynuclein in neurodegenerative disorders. Am J Pathol 1998; 152: 367-72; PMID: 9466562
    • (1998) Am J Pathol , vol.152 , pp. 367-372
    • Takeda, A.1    Mallory, M.2    Sundsmo, M.3    Honer, W.4    Hansen, L.5    Masliah, E.6
  • 4
    • 62449129138 scopus 로고    scopus 로고
    • Cell death pathways in Parkinson's disease: Proximal triggers, distal effectors, and final steps
    • PMID: 19165601
    • Levy OA, Malagelada C, Greene LA. Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps. Apoptosis 2009; 14: 478-500; PMID: 19165601; http://dx. doi. org/10. 1007/s10495-008-0309-3
    • (2009) Apoptosis , vol.14 , pp. 478-500
    • Levy, O.A.1    Malagelada, C.2    Greene, L.A.3
  • 5
    • 67650070391 scopus 로고    scopus 로고
    • Gene expression profiling of substantia nigra dopamine neurons: Further insights into Parkinson's disease pathology
    • PMID: 19052140
    • Simunovic F, Yi M, Wang Y, Macey L, Brown LT, Krichevsky AM, et al. Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology. Brain 2009; 132: 1795-809; PMID: 19052140; http://dx. doi. org/10. 1093/brain/awn323
    • (2009) Brain , vol.132 , pp. 1795-1809
    • Simunovic, F.1    Yi, M.2    Wang, Y.3    Macey, L.4    Brown, L.T.5    Krichevsky, A.M.6
  • 6
    • 39249084455 scopus 로고    scopus 로고
    • Transcriptional dysregulation in a transgenic model of Parkinson disease
    • PMID: 18191405
    • Yacoubian TA, Cantuti-Castelvetri I, Bouzou B, Asteris G, McLean PJ, Hyman BT, et al. Transcriptional dysregulation in a transgenic model of Parkinson disease. Neurobiol Dis 2008; 29: 515-28; PMID: 18191405; http://dx. doi. org/10. 1016/j. nbd. 2007. 11. 008
    • (2008) Neurobiol Dis , vol.29 , pp. 515-528
    • Yacoubian, T.A.1    Cantuti-Castelvetri, I.2    Bouzou, B.3    Asteris, G.4    McLean, P.J.5    Hyman, B.T.6
  • 7
    • 80053270332 scopus 로고    scopus 로고
    • Neuronal activity modifies the DNA methylation landscape in the adult brain
    • PMID: 21874013
    • Guo JU, Ma DK, Mo H, Ball MP, Jang MH, Bonaguidi MA, et al. Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci 2011; 14: 1345-51; PMID: 21874013; http://dx. doi. org/10. 1038/nn. 2900
    • (2011) Nat Neurosci , vol.14 , pp. 1345-1351
    • Guo, J.U.1    Ma, D.K.2    Mo, H.3    Ball, M.P.4    Jang, M.H.5    Bonaguidi, M.A.6
  • 8
    • 77958580776 scopus 로고    scopus 로고
    • DNA methylation and memory formation
    • PMID: 20975755
    • Day JJ, Sweatt JD. DNA methylation and memory formation. Nat Neurosci 2010; 13: 1319-23; PMID: 20975755; http://dx. doi. org/10. 1038/nn. 2666
    • (2010) Nat Neurosci , vol.13 , pp. 1319-1323
    • Day, J.J.1    Sweatt, J.D.2
  • 9
    • 70449725209 scopus 로고    scopus 로고
    • Epigenetic mechanisms in neurological diseases: Genes, syndromes, and therapies
    • PMID: 19833297
    • Urdinguio RG, Sanchez-Mut JV, Esteller M. Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol 2009; 8: 1056-72; PMID: 19833297; http://dx. doi. org/10. 1016/S1474-4422(09)70262-5
    • (2009) Lancet Neurol , vol.8 , pp. 1056-1072
    • Urdinguio, R.G.1    Sanchez-Mut, J.V.2    Esteller, M.3
  • 10
    • 79953178935 scopus 로고    scopus 로고
    • Alpha-synuclein sequesters Dnmt1 from the nucleus: A novel mechanism for epigenetic alterations in Lewy body diseases
    • PMID: 21296890
    • Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, et al. Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem 2011; 286: 9031-7; PMID: 21296890; http://dx. doi. org/10. 1074/jbc. C110. 212589
    • (2011) J Biol Chem , vol.286 , pp. 9031-9037
    • Desplats, P.1    Spencer, B.2    Coffee, E.3    Patel, P.4    Michael, S.5    Patrick, C.6
  • 11
    • 77951842993 scopus 로고    scopus 로고
    • Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains
    • PMID: 20445061
    • Jowaed A, Schmitt I, Kaut O, Wüllner U. Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains. J Neurosci 2010; 30: 6355-9; PMID: 20445061; http://dx. doi. org/10. 1523/JNEUROSCI. 6119-09. 2010
    • (2010) J Neurosci , vol.30 , pp. 6355-6359
    • Jowaed, A.1    Schmitt, I.2    Kaut, O.3    Wüllner, U.4
  • 12
    • 78649652766 scopus 로고    scopus 로고
    • CpG Demethylation Enhances Apha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease
    • Matsumoto L, Takuma H, Tamaoka A, Kurisaki H, Date H, Tsuji T, et al. CpG Demethylation Enhances Apha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease. PLoS ONE 2010; 5: 1-9; http://dx. doi. org/10. 1371/journal. pone. 0015522
    • (2010) PLoS ONE , vol.5 , pp. 1-9
    • Matsumoto, L.1    Takuma, H.2    Tamaoka, A.3    Kurisaki, H.4    Date, H.5    Tsuji, T.6
  • 13
    • 62049086159 scopus 로고    scopus 로고
    • Biomarkers for Parkinson's disease
    • PMID: 19166835
    • Graeber MB. Biomarkers for Parkinson's disease. Exp Neurol 2009; 216: 249-53; PMID: 19166835; http://dx. doi. org/10. 1016/j. expneurol. 2008. 12. 017
    • (2009) Exp Neurol , vol.216 , pp. 249-253
    • Graeber, M.B.1
  • 14
    • 25144438960 scopus 로고    scopus 로고
    • Gene promoter methylation in plasma and sputum increases with lung cancer risk
    • PMID: 16166426
    • Belinsky SA, Klinge DM, Dekker JD, Smith MW, Bocklage TJ, Gilliland FD, et al. Gene promoter methylation in plasma and sputum increases with lung cancer risk. Clin Cancer Res 2005; 11: 6505-11; PMID: 16166426; http://dx. doi. org/10. 1158/1078-0432. CCR-05-0625
    • (2005) Clin Cancer Res , vol.11 , pp. 6505-6511
    • Belinsky, S.A.1    Klinge, D.M.2    Dekker, J.D.3    Smith, M.W.4    Bocklage, T.J.5    Gilliland, F.D.6
  • 15
    • 77956143206 scopus 로고    scopus 로고
    • Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer
    • PMID: 20804913
    • He Q, Chen HY, Bai EQ, Luo YX, Fu RJ, He YS, et al. Development of a multiplex MethyLight assay for the detection of multigene methylation in human colorectal cancer. Cancer Genet Cytogenet 2010; 202: 1-10; PMID: 20804913; http://dx. doi. org/10. 1016/j. cancergencyto. 2010. 05. 018
    • (2010) Cancer Genet Cytogenet , vol.202 , pp. 1-10
    • He, Q.1    Chen, H.Y.2    Bai, E.Q.3    Luo, Y.X.4    Fu, R.J.5    He, Y.S.6
  • 16
    • 2942737264 scopus 로고    scopus 로고
    • Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer
    • PMID: 15197197
    • Kim H, Kwon YM, Kim JS, Lee H, Park JH, Shim YM, et al. Tumor-specific methylation in bronchial lavage for the early detection of non-small-cell lung cancer. J Clin Oncol 2004; 22: 2363-70; PMID: 15197197; http://dx. doi. org/10. 1200/JCO. 2004. 10. 077
    • (2004) J Clin Oncol , vol.22 , pp. 2363-2370
    • Kim, H.1    Kwon, Y.M.2    Kim, J.S.3    Lee, H.4    Park, J.H.5    Shim, Y.M.6
  • 17
    • 85027954125 scopus 로고    scopus 로고
    • DNA methylation profiling in the clinic: Applications and challenges
    • PMID: 22945394
    • Heyn H, Esteller M. DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet 2012; 13: 679-92; PMID: 22945394; http://dx. doi. org/10. 1038/nrg3270
    • (2012) Nat Rev Genet , vol.13 , pp. 679-692
    • Heyn, H.1    Esteller, M.2
  • 19
    • 33751031873 scopus 로고    scopus 로고
    • Cortical Lewy body disease and Parkinson's disease dementia
    • PMID: 17102696
    • Burn DJ. Cortical Lewy body disease and Parkinson's disease dementia. Curr Opin Neurol 2006; 19: 572-9; PMID: 17102696; http://dx. doi. org/10. 1097/01. wco. 0000247607. 34697. a2
    • (2006) Curr Opin Neurol , vol.19 , pp. 572-579
    • Burn, D.J.1
  • 20
    • 84880743928 scopus 로고    scopus 로고
    • Brain volumetry in Parkinson's disease with and without dementia: Where are the differences?
    • PMID: 23474765
    • Lee SH, Kim SS, Tae WS, Lee SY, Lee KU, Jhoo J. Brain volumetry in Parkinson's disease with and without dementia: where are the differences? Acta Radiol 2013; PMID: 23474765; http://dx. doi. org/10. 1177/0284185113476029
    • (2013) Acta Radiol
    • Lee, S.H.1    Kim, S.S.2    Tae, W.S.3    Lee, S.Y.4    Lee, K.U.5    Jhoo, J.6
  • 21
    • 84879909621 scopus 로고    scopus 로고
    • Cortical thinning is associated with disease stages and dementia in Parkinson's disease
    • PMID: 23463873
    • Zarei M, Ibarretxe-Bilbao N, Compta Y, Hough M, Junque C, Bargallo N, et al. Cortical thinning is associated with disease stages and dementia in Parkinson's disease. J Neurol Neurosurg Psychiatry 2013; 84: 875-82; PMID: 23463873; http://dx. doi. org/10. 1136/jnnp-2012-304126
    • (2013) J Neurol Neurosurg Psychiatry , vol.84 , pp. 875-882
    • Zarei, M.1    Ibarretxe-Bilbao, N.2    Compta, Y.3    Hough, M.4    Junque, C.5    Bargallo, N.6
  • 22
    • 84867185999 scopus 로고    scopus 로고
    • Heterogeneity in white blood cells has potential to confound DNA methylation measurements
    • PMID: 23071618
    • Adalsteinsson BT, Gudnason H, Aspelund T, Harris TB, Launer LJ, Eiriksdottir G, et al. Heterogeneity in white blood cells has potential to confound DNA methylation measurements. PLoS One 2012; 7: e46705; PMID: 23071618; http://dx. doi. org/10. 1371/journal. pone. 0046705
    • (2012) PLoS One , vol.7
    • Adalsteinsson, B.T.1    Gudnason, H.2    Aspelund, T.3    Harris, T.B.4    Launer, L.J.5    Eiriksdottir, G.6
  • 23
    • 84864359044 scopus 로고    scopus 로고
    • Differential DNA methylation in purified human blood cells: Implications for cell lineage and studies on disease susceptibility
    • PMID: 22848472
    • Reinius LE, Acevedo N, Joerink M, Pershagen G, Dahlén SE, Greco D, et al. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS One 2012; 7: e41361; PMID: 22848472; http://dx. doi. org/10. 1371/journal. pone. 0041361
    • (2012) PLoS One , vol.7
    • Reinius, L.E.1    Acevedo, N.2    Joerink, M.3    Pershagen, G.4    Dahlén, S.E.5    Greco, D.6
  • 24
    • 84862210732 scopus 로고    scopus 로고
    • Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
    • PMID: 22703893
    • Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol 2012; 13: R43; PMID: 22703893; http://dx. doi. org/10. 1186/gb-2012-13-6-r43
    • (2012) Genome Biol , vol.13
    • Davies, M.N.1    Volta, M.2    Pidsley, R.3    Lunnon, K.4    Dixit, A.5    Lovestone, S.6
  • 25
    • 84874969184 scopus 로고    scopus 로고
    • PANTHER in 2013: Modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees
    • DATABASE ISSUE, PMID: 23193289
    • Mi H, Muruganujan A, Thomas PD. PANTHER in 2013: modeling the evolution of gene function, and other gene attributes, in the context of phylogenetic trees. Nucleic Acids Res 2013; 41(Database issue): D377-86; PMID: 23193289; http://dx. doi. org/10. 1093/nar/gks1118
    • (2013) Nucleic Acids Res , vol.41
    • Mi, H.1    Muruganujan, A.2    Thomas, P.D.3
  • 26
    • 84866540615 scopus 로고    scopus 로고
    • Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases
    • PMID: 22771760
    • Nakamura T, Cho DH, Lipton SA. Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Exp Neurol 2012; 238: 12-21; PMID: 22771760; http://dx. doi. org/10. 1016/j. expneurol. 2012. 06. 032
    • (2012) Exp Neurol , vol.238 , pp. 12-21
    • Nakamura, T.1    Cho, D.H.2    Lipton, S.A.3
  • 27
    • 80053304450 scopus 로고    scopus 로고
    • High density DNA methylation array with single CpG site resolution
    • PMID: 21839163
    • Bibikova M, Barnes B, Tsan C, Ho V, Klotzle B, Le JM, et al. High density DNA methylation array with single CpG site resolution. Genomics 2011; 98: 288-95; PMID: 21839163; http://dx. doi. org/10. 1016/j. ygeno. 2011. 07. 007
    • (2011) Genomics , vol.98 , pp. 288-295
    • Bibikova, M.1    Barnes, B.2    Tsan, C.3    Ho, V.4    Klotzle, B.5    Le, J.M.6
  • 28
    • 79959399677 scopus 로고    scopus 로고
    • A genome-wide DNA methylation study in colorectal carcinoma
    • PMID: 21699707
    • Kibriya MG, Raza M, Jasmine F, Roy S, Paul-Brutus R, Rahaman R, et al. A genome-wide DNA methylation study in colorectal carcinoma. BMC Med Genomics 2011; 4: 50; PMID: 21699707; http://dx. doi. org/10. 1186/1755-8794-4-50
    • (2011) BMC Med Genomics , vol.4 , pp. 50
    • Kibriya, M.G.1    Raza, M.2    Jasmine, F.3    Roy, S.4    Paul-Brutus, R.5    Rahaman, R.6
  • 29
    • 84863057173 scopus 로고    scopus 로고
    • Differential patterns of wholegenome DNA methylation in institutionalized children and children raised by their biological parents
    • PMID: 22123582
    • Naumova OY, Lee M, Koposov R, Szyf M, Dozier M, Grigorenko EL. Differential patterns of wholegenome DNA methylation in institutionalized children and children raised by their biological parents. Dev Psychopathol 2012; 24: 143-55; PMID: 22123582; http://dx. doi. org/10. 1017/S0954579411000605
    • (2012) Dev Psychopathol , vol.24 , pp. 143-155
    • Naumova, O.Y.1    Lee, M.2    Koposov, R.3    Szyf, M.4    Dozier, M.5    Grigorenko, E.L.6
  • 31
    • 77958590561 scopus 로고    scopus 로고
    • Ontology-based metaanalysis of global collections of high-throughput public data
    • PMID: 20927376
    • Kupershmidt I, Su QJ, Grewal A, Sundaresh S, Halperin I, Flynn J, et al. Ontology-based metaanalysis of global collections of high-throughput public data. PLoS One 2010; 5: 5; PMID: 20927376; http://dx. doi. org/10. 1371/journal. pone. 0013066
    • (2010) PLoS One , vol.5 , pp. 5
    • Kupershmidt, I.1    Su, Q.J.2    Grewal, A.3    Sundaresh, S.4    Halperin, I.5    Flynn, J.6
  • 32
    • 84866710021 scopus 로고    scopus 로고
    • Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease
    • PMID: 23017109
    • Desplats P, Patel P, Kosberg K, Mante M, Patrick C, Rockenstein E, et al. Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease. Mol Neurodegener 2012; 7: 49; PMID: 23017109; http://dx. doi. org/10. 1186/1750-1326-7-49
    • (2012) Mol Neurodegener , vol.7 , pp. 49
    • Desplats, P.1    Patel, P.2    Kosberg, K.3    Mante, M.4    Patrick, C.5    Rockenstein, E.6
  • 33
    • 84885430428 scopus 로고    scopus 로고
    • Prefrontal Cortical Dysfunction After Overexpression of Histone Deacetylase 1
    • PMID: 23664640
    • Jakovcevski M, Bharadwaj R, Straubhaar J, Gao G, Gavin DP, Jakovcevski I, et al. Prefrontal Cortical Dysfunction After Overexpression of Histone Deacetylase 1. Biol Psychiatry 2013; PMID: 23664640; http://dx. doi. org/10. 1016/j. biopsych. 2013. 03. 020
    • (2013) Biol Psychiatry
    • Jakovcevski, M.1    Bharadwaj, R.2    Straubhaar, J.3    Gao, G.4    Gavin, D.P.5    Jakovcevski, I.6
  • 34
    • 84880898110 scopus 로고    scopus 로고
    • Upregulation of a small vault RNA (svtRNA2-1a) is an early event in Parkinson disease and induces neuronal dysfunction
    • PMID: 23673382
    • Miñones-Moyano E, Friedländer MR, Pallares J, Kagerbauer B, Porta S, Escaramís G, et al. Upregulation of a small vault RNA (svtRNA2-1a) is an early event in Parkinson disease and induces neuronal dysfunction. RNA Biol 2013; 10: 10; PMID: 23673382; http://dx. doi. org/10. 4161/rna. 24813
    • (2013) RNA Biol , vol.10 , pp. 10
    • Miñones-Moyano, E.1    Friedländer, M.R.2    Pallares, J.3    Kagerbauer, B.4    Porta, S.5    Escaramís, G.6
  • 35
    • 84866868744 scopus 로고    scopus 로고
    • Aging effects on DNA methylation modules in human brain and blood tissue
    • PMID: 23034122
    • Horvath S, Zhang Y, Langfelder P, Kahn RS, Boks MP, van Eijk K, et al. Aging effects on DNA methylation modules in human brain and blood tissue. Genome Biol 2012; 13: R97; PMID: 23034122; http://dx. doi. org/10. 1186/gb-2012-13-10-r97
    • (2012) Genome Biol , vol.13
    • Horvath, S.1    Zhang, Y.2    Langfelder, P.3    Kahn, R.S.4    Boks, M.P.5    van Eijk, K.6
  • 37
    • 33644658492 scopus 로고    scopus 로고
    • Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease
    • PMID: 16344956
    • Moran LB, Duke DC, Deprez M, Dexter DT, Pearce RK, Graeber MB. Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease. Neurogenetics 2006; 7: 1-11; PMID: 16344956; http://dx. doi. org/10. 1007/s10048-005-0020-2
    • (2006) Neurogenetics , vol.7 , pp. 1-11
    • Moran, L.B.1    Duke, D.C.2    Deprez, M.3    Dexter, D.T.4    Pearce, R.K.5    Graeber, M.B.6
  • 39
    • 77958072667 scopus 로고    scopus 로고
    • PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease
    • Global PD Gene Expression (GPEX) Consortium, PMID: 20926834
    • Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, et al.; Global PD Gene Expression (GPEX) Consortium. PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med 2010; 2: 52ra73; PMID: 20926834; http://dx. doi. org/10. 1126/scitranslmed. 3001059
    • (2010) Sci Transl Med , vol.2
    • Zheng, B.1    Liao, Z.2    Locascio, J.J.3    Lesniak, K.A.4    Roderick, S.S.5    Watt, M.L.6
  • 41
    • 34347338776 scopus 로고    scopus 로고
    • A genomic pathway approach to a complex disease: Axon guidance and Parkinson disease
    • PMID: 17571925
    • Lesnick TG, Papapetropoulos S, Mash DC, Ffrench-Mullen J, Shehadeh L, de Andrade M, et al. A genomic pathway approach to a complex disease: axon guidance and Parkinson disease. PLoS Genet 2007; 3: e98; PMID: 17571925; http://dx. doi. org/10. 1371/journal. pgen. 0030098
    • (2007) PLoS Genet , vol.3
    • Lesnick, T.G.1    Papapetropoulos, S.2    Mash, D.C.3    Ffrench-Mullen, J.4    Shehadeh, L.5    de Andrade, M.6
  • 42
    • 78049272757 scopus 로고    scopus 로고
    • Polyamine pathway contributes to the pathogenesis of Parkinson disease
    • PMID: 20837543
    • Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, et al. Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci U S A 2010; 107: 16970-5; PMID: 20837543; http://dx. doi. org/10. 1073/pnas. 1011751107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 16970-16975
    • Lewandowski, N.M.1    Ju, S.2    Verbitsky, M.3    Ross, B.4    Geddie, M.L.5    Rockenstein, E.6
  • 43
    • 21144484123 scopus 로고
    • Power calculations for general multivariate models including repeated measures applications
    • Muller KE, LaVange L. M., Ramey, S. L. and Ramey, C. T. Power calculations for general multivariate models including repeated measures applications. J Am Stat Assoc 1992; 87: 1209-26; http://dx. doi. org/10. 1080/01 621459. 1992. 10476281
    • (1992) J Am Stat Assoc , vol.87 , pp. 1209-1226
    • Muller, K.E.1    LaVange, L.M.2    Ramey, S.L.3    Ramey, C.T.4
  • 44
    • 23044502947 scopus 로고    scopus 로고
    • Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms
    • PMID: 15965975
    • Zhang Y, James M, Middleton FA, Davis RL. Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms. Am J Med Genet B Neuropsychiatr Genet 2005; 137B: 5-16; PMID: 15965975; http://dx. doi. org/10. 1002/ajmg. b. 30195
    • (2005) Am J Med Genet B Neuropsychiatr Genet , vol.137 B , pp. 5-16
    • Zhang, Y.1    James, M.2    Middleton, F.A.3    Davis, R.L.4
  • 45
    • 60849100524 scopus 로고    scopus 로고
    • Decline in genomic DNA methylation through aging in a cohort of elderly subjects
    • PMID: 19150625
    • Bollati V, Schwartz J, Wright R, Litonjua A, Tarantini L, Suh H, et al. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 2009; 130: 234-9; PMID: 19150625; http://dx. doi. org/10. 1016/j. mad. 2008. 12. 003
    • (2009) Mech Ageing Dev , vol.130 , pp. 234-239
    • Bollati, V.1    Schwartz, J.2    Wright, R.3    Litonjua, A.4    Tarantini, L.5    Suh, H.6
  • 46
    • 0034744639 scopus 로고    scopus 로고
    • Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer
    • PMID: 11257100
    • Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet 2001; 10: 687-92; PMID: 11257100; http://dx. doi. org/10. 1093/hmg/10. 7. 687
    • (2001) Hum Mol Genet , vol.10 , pp. 687-692
    • Baylin, S.B.1    Esteller, M.2    Rountree, M.R.3    Bachman, K.E.4    Schuebel, K.5    Herman, J.G.6
  • 48
    • 85011938876 scopus 로고
    • Controlling the False Discovery Rate: A Practical and Powerful Approch to Multiple Testing
    • Benjamini YaHY. Controlling the False Discovery Rate: A Practical and Powerful Approch to Multiple Testing. J R Stat Soc Ser A Stat Soc 1995; 57: 289-300
    • (1995) J R Stat Soc Ser A Stat Soc , vol.57 , pp. 289-300
    • Benjamini, Y.H.Y.1
  • 49
    • 79959841853 scopus 로고    scopus 로고
    • Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease
    • PMID: 21738487
    • Do CB, Tung JY, Dorfman E, Kiefer AK, Drabant EM, Francke U, et al. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. PLoS Genet 2011; 7: e1002141; PMID: 21738487; http://dx. doi. org/10. 1371/journal. pgen. 1002141
    • (2011) PLoS Genet , vol.7
    • Do, C.B.1    Tung, J.Y.2    Dorfman, E.3    Kiefer, A.K.4    Drabant, E.M.5    Francke, U.6
  • 50
    • 77951185469 scopus 로고    scopus 로고
    • Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease
    • PMID: 20070850
    • Edwards TL, Scott WK, Almonte C, Burt A, Powell EH, Beecham GW, et al. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Ann Hum Genet 2010; 74: 97-109; PMID: 20070850; http://dx. doi. org/10. 1111/j. 1469-1809. 2009. 00560. x
    • (2010) Ann Hum Genet , vol.74 , pp. 97-109
    • Edwards, T.L.1    Scott, W.K.2    Almonte, C.3    Burt, A.4    Powell, E.H.5    Beecham, G.W.6
  • 51
    • 78650550275 scopus 로고    scopus 로고
    • Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21
    • UK Parkinson's Disease Consortium; Wellcome Trust Case Control Consortium 2, PMID: 21044948
    • Spencer CC, Plagnol V, Strange A, Gardner M, Paisan-Ruiz C, Band G, et al.; UK Parkinson's Disease Consortium; Wellcome Trust Case Control Consortium 2. Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet 2011; 20: 345-53; PMID: 21044948; http://dx. doi. org/10. 1093/hmg/ddq469
    • (2011) Hum Mol Genet , vol.20 , pp. 345-353
    • Spencer, C.C.1    Plagnol, V.2    Strange, A.3    Gardner, M.4    Paisan-Ruiz, C.5    Band, G.6
  • 52
    • 34247145010 scopus 로고    scopus 로고
    • Impact of inflammation on epigenetic DNA methylation-a novel risk factor for cardiovascular disease?
    • PMID: 17444888
    • Stenvinkel P, Karimi M, Johansson S, Axelsson J, Suliman M, Lindholm B, et al. Impact of inflammation on epigenetic DNA methylation-a novel risk factor for cardiovascular disease? J Intern Med 2007; 261: 488-99; PMID: 17444888; http://dx. doi. org/10. 1111/j. 1365-2796. 2007. 01777. x
    • (2007) J Intern Med , vol.261 , pp. 488-499
    • Stenvinkel, P.1    Karimi, M.2    Johansson, S.3    Axelsson, J.4    Suliman, M.5    Lindholm, B.6
  • 53
    • 84872645713 scopus 로고
    • The assumptions underlying the analysis of variance
    • PMID: 20240414
    • Eisenhart C. The assumptions underlying the analysis of variance. Biometrics 1947; 3: 1-21; PMID: 20240414; http://dx. doi. org/10. 2307/3001534
    • (1947) Biometrics , vol.3 , pp. 1-21
    • Eisenhart, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.