Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation

Toxicological Sciences

Volumn 88, Issue 2, 2005, Pages 495-504

  Schuh, Rosemary A ^a   Kristián, Tibor ^a   Gupta, Rupesh K ^a   Flaws, Jodi A ^a   Fiskum, Gary ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

CREB; Methoxychlor; Mitochondria; Oxidative stress

Indexed keywords

ADENOSINE DIPHOSPHATE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYDROGEN PEROXIDE; METHOXYCHLOR; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; BRAIN TOXICITY; CELL ISOLATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN ELECTRODE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; BRAIN; CELL RESPIRATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYDROGEN PEROXIDE; INJECTIONS, INTRAPERITONEAL; INSECTICIDES; MALE; METHOXYCHLOR; MICE; MICE, INBRED STRAINS; MITOCHONDRIA; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 27944453586     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi334     Document Type: Article

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