메뉴 건너뛰기




Volumn 16, Issue 5, 2014, Pages 941-963

Microfluidic platforms for discovery and detection of molecular biomarkers

Author keywords

Detection of biomarkers; Discovery of biomarkers; Microfluidics; Molecular biomarker

Indexed keywords

BIOMOLECULES; FLUIDIC DEVICES; MICROFLUIDICS; NUCLEIC ACIDS; PUMPS;

EID: 84899914378     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-014-1354-6     Document Type: Article
Times cited : (18)

References (179)
  • 1
    • 0037435030 scopus 로고    scopus 로고
    • Mass spectrometry-based proteomics
    • Aebersold R, Mann M (2003) Mass spectrometry-based proteomics. Nature 422(6928):198-207
    • (2003) Nature , vol.422 , Issue.6928 , pp. 198-207
    • Aebersold, R.1    Mann, M.2
  • 2
    • 79954608952 scopus 로고    scopus 로고
    • A sol-gel-based microfluidics system enhances the efficiency of RNA aptamer selection
    • Ahn JY, Jo M, Dua P, Lee DK, Kim S (2011) A sol-gel-based microfluidics system enhances the efficiency of RNA aptamer selection. Oligonucleotides 21(2):93-100
    • (2011) Oligonucleotides , vol.21 , Issue.2 , pp. 93-100
    • Ahn, J.Y.1    Jo, M.2    Dua, P.3    Lee, D.K.4    Kim, S.5
  • 3
    • 77953555196 scopus 로고    scopus 로고
    • Chip-based reversed-phase liquid chromatography-mass spectrometry of permethylated N-linked glycans: A potential methodology for cancer-biomarker discovery
    • Alley WR, Madera M, Mechref Y, Novotny MV (2010) Chip-based reversed-phase liquid chromatography-mass spectrometry of permethylated N-linked glycans: a potential methodology for cancer-biomarker discovery. Anal Chem 82(12):5095-5106
    • (2010) Anal Chem , vol.82 , Issue.12 , pp. 5095-5106
    • Alley, W.R.1    Madera, M.2    Mechref, Y.3    Novotny, M.V.4
  • 5
    • 65949084250 scopus 로고    scopus 로고
    • Microfluidic chips for protein differential expression profiling
    • Armenta JM, Dawoud AA, Lazar IM (2009) Microfluidic chips for protein differential expression profiling. Electrophoresis 30(7):1145-1156
    • (2009) Electrophoresis , vol.30 , Issue.7 , pp. 1145-1156
    • Armenta, J.M.1    Dawoud, A.A.2    Lazar, I.M.3
  • 9
    • 84878468245 scopus 로고    scopus 로고
    • Droplet digital PCR measurement of HER2 copy number alteration in formalin-fixed paraffin-embedded breast carcinoma tissue
    • Belgrader P, Tanner SC, Regan JF, Koehler R, Hindson BJ, Brown AS (2013) Droplet digital PCR measurement of HER2 copy number alteration in formalin-fixed paraffin-embedded breast carcinoma tissue. Clin Chem 59(6):991-994
    • (2013) Clin Chem , vol.59 , Issue.6 , pp. 991-994
    • Belgrader, P.1    Tanner, S.C.2    Regan, J.F.3    Koehler, R.4    Hindson, B.J.5    Brown, A.S.6
  • 13
    • 84874606427 scopus 로고    scopus 로고
    • Fast surface acoustic wave-matrix-assisted laser desorption ionization mass spectrometry of cell response from islets of Langerhans
    • Bllaci L, Kjellstrom S, Eliasson L, Friend JR, Yeo LY, Nilsson S (2013) Fast surface acoustic wave-matrix-assisted laser desorption ionization mass spectrometry of cell response from islets of Langerhans. Anal Chem 85(5):2623-2629
    • (2013) Anal Chem , vol.85 , Issue.5 , pp. 2623-2629
    • Bllaci, L.1    Kjellstrom, S.2    Eliasson, L.3    Friend, J.R.4    Yeo, L.Y.5    Nilsson, S.6
  • 14
    • 84860848068 scopus 로고    scopus 로고
    • Mass spectrometry-based targeted quantitative proteomics: Achieving sensitive and reproducible detection of proteins
    • Boja ES, Rodriguez H (2012) Mass spectrometry-based targeted quantitative proteomics: achieving sensitive and reproducible detection of proteins. Proteomics 12(8):1093-1110
    • (2012) Proteomics , vol.12 , Issue.8 , pp. 1093-1110
    • Boja, E.S.1    Rodriguez, H.2
  • 15
    • 35148835708 scopus 로고    scopus 로고
    • Genetics of cardiovascular diseases - From single mutations to the whole genome
    • Cambien F, Tiret L (2007) Genetics of cardiovascular diseases - from single mutations to the whole genome. Circulation 116(15):1714-1724
    • (2007) Circulation , vol.116 , Issue.15 , pp. 1714-1724
    • Cambien, F.1    Tiret, L.2
  • 17
    • 77953222106 scopus 로고    scopus 로고
    • Using 'omics' to define pathogenesis and biomarkers of Parkinson's disease
    • Caudle WM, Bammler TK, Lin Y, Pan S, Zhang J (2010) Using 'omics' to define pathogenesis and biomarkers of Parkinson's disease. Expert Rev Neurother 10(6):925-942
    • (2010) Expert Rev Neurother , vol.10 , Issue.6 , pp. 925-942
    • Caudle, W.M.1    Bammler, T.K.2    Lin, Y.3    Pan, S.4    Zhang, J.5
  • 18
    • 0242617623 scopus 로고
    • The properties of streptavidin, a biotin-binding protein produced by streptomycetes
    • Chaiet L, Wolf FJ (1964) The properties of streptavidin, a biotin-binding protein produced by streptomycetes. Arch Biochem Biophys 106:1-5
    • (1964) Arch Biochem Biophys , vol.106 , pp. 1-5
    • Chaiet, L.1    Wolf, F.J.2
  • 20
    • 84871809253 scopus 로고    scopus 로고
    • An automatic microfluidic system that continuously performs the systematic evolution of ligands by exponential enrichment
    • Chen YH, Lin HI, Huang CJ, Shiesh SC, Lee GB (2012) An automatic microfluidic system that continuously performs the systematic evolution of ligands by exponential enrichment. Microfluid Nanofluid 13(6):929-939
    • (2012) Microfluid Nanofluid , vol.13 , Issue.6 , pp. 929-939
    • Chen, Y.H.1    Lin, H.I.2    Huang, C.J.3    Shiesh, S.C.4    Lee, G.B.5
  • 21
  • 23
    • 79551486836 scopus 로고    scopus 로고
    • Microfluidic-based biosensors toward point-of-care detection of nucleic acids and proteins
    • Choi S, Goryll M, Sin LYM, Wong PK, Chae J (2011) Microfluidic-based biosensors toward point-of-care detection of nucleic acids and proteins. Microfluid Nanofluid 10(2):231-247
    • (2011) Microfluid Nanofluid , vol.10 , Issue.2 , pp. 231-247
    • Choi, S.1    Goryll, M.2    Sin, L.Y.M.3    Wong, P.K.4    Chae, J.5
  • 25
    • 0025835310 scopus 로고
    • Making antibody fragments using phage display libraries
    • Clackson T, Hoogenboom HR, Griffiths AD, Winter G (1991) Making antibody fragments using phage display libraries. Nature 352(6336):624-628
    • (1991) Nature , vol.352 , Issue.6336 , pp. 624-628
    • Clackson, T.1    Hoogenboom, H.R.2    Griffiths, A.D.3    Winter, G.4
  • 27
    • 84881259783 scopus 로고    scopus 로고
    • Proteomics in colorectal cancer translational research: Biomarker discovery for clinical applications
    • de Wit M, Fijneman RJA, Verheul HMW, Meijer GA, Jimenez CR (2013) Proteomics in colorectal cancer translational research: biomarker discovery for clinical applications. Clin Biochem 46(6):466-479
    • (2013) Clin Biochem , vol.46 , Issue.6 , pp. 466-479
    • De Wit, M.1    Fijneman, R.J.A.2    Verheul, H.M.W.3    Meijer, G.A.4    Jimenez, C.R.5
  • 28
    • 77957809832 scopus 로고    scopus 로고
    • Neuropeptide y modifies the disease course in the R6/2 transgenic model of Huntington's disease
    • Decressac M, Wright B, Tyers P, Gaillard A, Barker RA (2010) Neuropeptide y modifies the disease course in the R6/2 transgenic model of Huntington's disease. Exp Neurol 226(1):24-32
    • (2010) Exp Neurol , vol.226 , Issue.1 , pp. 24-32
    • Decressac, M.1    Wright, B.2    Tyers, P.3    Gaillard, A.4    Barker, R.A.5
  • 29
    • 84871958447 scopus 로고    scopus 로고
    • Mass spectrometry-based targeted proteomics
    • 3004805
    • Doerr A (2013) Mass spectrometry-based targeted proteomics. Nat Methods 10(1):23
    • (2013) Nat Methods , vol.10 , Issue.1 , pp. 23
    • Doerr, A.1
  • 32
    • 75449119505 scopus 로고    scopus 로고
    • Aptamers generated from cell-SELEX for molecular medicine: A chemical biology approach
    • Fang XH, Tan WH (2010) Aptamers generated from cell-SELEX for molecular medicine: a chemical biology approach. Acc Chem Res 43(1):48-57
    • (2010) Acc Chem Res , vol.43 , Issue.1 , pp. 48-57
    • Fang, X.H.1    Tan, W.H.2
  • 33
    • 79751489596 scopus 로고    scopus 로고
    • Molecular genetics of colorectal cancer
    • Fearon ER (2011) Molecular genetics of colorectal cancer. Annu Rev Pathol Mech Dis 6:479-507
    • (2011) Annu Rev Pathol Mech Dis , vol.6 , pp. 479-507
    • Fearon, E.R.1
  • 34
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics - The link between genotypes and phenotypes
    • Fiehn O (2002) Metabolomics - the link between genotypes and phenotypes. Plant Mol Biol 48(1-2):155-171
    • (2002) Plant Mol Biol , vol.48 , Issue.1-2 , pp. 155-171
    • Fiehn, O.1
  • 36
    • 15444380450 scopus 로고    scopus 로고
    • Integrated microfluidic device for mass spectrometry-based proteomics and its application to biomarker discovery programs
    • Fortier MH, Bonneil E, Goodley P, Thibault P (2005) Integrated microfluidic device for mass spectrometry-based proteomics and its application to biomarker discovery programs. Anal Chem 77(6):1631-1640
    • (2005) Anal Chem , vol.77 , Issue.6 , pp. 1631-1640
    • Fortier, M.H.1    Bonneil, E.2    Goodley, P.3    Thibault, P.4
  • 37
    • 1342324055 scopus 로고    scopus 로고
    • Enhanced determination of glucose by microchip electrophoresis with pulsed amperometric detection
    • Garcia CD, Henry CS (2004) Enhanced determination of glucose by microchip electrophoresis with pulsed amperometric detection. Anal Chim Acta 508(1):1-9
    • (2004) Anal Chim Acta , vol.508 , Issue.1 , pp. 1-9
    • Garcia, C.D.1    Henry, C.S.2
  • 40
    • 77956912827 scopus 로고    scopus 로고
    • Enzyme-coated microelectrodes to monitor Lactate production in a nanoliter microfluidic cell culture device
    • Ges IA, Baudenbacher F (2010) Enzyme-coated microelectrodes to monitor Lactate production in a nanoliter microfluidic cell culture device. Biosens Bioelectron 26(2):828-833
    • (2010) Biosens Bioelectron , vol.26 , Issue.2 , pp. 828-833
    • Ges, I.A.1    Baudenbacher, F.2
  • 41
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    • Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, Hitman G, Walker M, Levy JC, Sampson M, Halford S, McCarthy MI, Hattersley AT, Frayling TM (2003) Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52(2):568-572
    • (2003) Diabetes , vol.52 , Issue.2 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3    Turner, M.J.4    Knight, B.A.5    Hitman, G.6    Walker, M.7    Levy, J.C.8    Sampson, M.9    Halford, S.10    McCarthy, M.I.11    Hattersley, A.T.12    Frayling, T.M.13
  • 43
    • 77953961017 scopus 로고    scopus 로고
    • IgE antibody-specific activity in human allergic disease
    • Hamilton RG, MacGlashan DW, Saini SS (2010) IgE antibody-specific activity in human allergic disease. Immunol Res 47(1-3):273-284
    • (2010) Immunol Res , vol.47 , Issue.1-3 , pp. 273-284
    • Hamilton, R.G.1    Macglashan, D.W.2    Saini, S.S.3
  • 44
    • 79952415252 scopus 로고    scopus 로고
    • Emerging molecular biomarkers-blood-based strategies to detect and monitor cancer
    • Hanash SM, Baik CS, Kallioniemi O (2011) Emerging molecular biomarkers-blood-based strategies to detect and monitor cancer. Nat Rev Clin Oncol 8(3):142-150
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.3 , pp. 142-150
    • Hanash, S.M.1    Baik, C.S.2    Kallioniemi, O.3
  • 45
    • 34447545685 scopus 로고    scopus 로고
    • HPLC-chip-mass spectrometry for protein signature identifications
    • Hardouin J, Joubert-Caron R, Caron M (2007) HPLC-chip-mass spectrometry for protein signature identifications. J Sep Sci 30(10):1482-1487
    • (2007) J Sep Sci , vol.30 , Issue.10 , pp. 1482-1487
    • Hardouin, J.1    Joubert-Caron, R.2    Caron, M.3
  • 46
    • 0037135111 scopus 로고    scopus 로고
    • Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J, Selkoe DJ (2002) Medicine - the amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580):353-356
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 48
    • 0242636458 scopus 로고    scopus 로고
    • C-reactive protein and cardiovascular disease: New insights from an old molecule
    • Hirschfield GM, Pepys MB (2003) C-reactive protein and cardiovascular disease: new insights from an old molecule. QJM-Int J Med 96(11):793-807
    • (2003) QJM-Int J Med , vol.96 , Issue.11 , pp. 793-807
    • Hirschfield, G.M.1    Pepys, M.B.2
  • 49
    • 34250306257 scopus 로고    scopus 로고
    • Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells
    • Ho MM, Ng AV, Lam S, Hung JY (2007) Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells. Cancer Res 67(10):4827-4833
    • (2007) Cancer Res , vol.67 , Issue.10 , pp. 4827-4833
    • Ho, M.M.1    Ng, A.V.2    Lam, S.3    Hung, J.Y.4
  • 50
    • 79953278962 scopus 로고    scopus 로고
    • Microfluidic enrichment of small proteins from complex biological mixture on nanoporous silica chip
    • Hu Y, Gopal A, Lin K, Peng Y, Tasciotti E, Zhang XJ, Ferrari M (2011) Microfluidic enrichment of small proteins from complex biological mixture on nanoporous silica chip. Biomicrofluidics 5(1):013410
    • (2011) Biomicrofluidics , vol.5 , Issue.1 , pp. 013410
    • Hu, Y.1    Gopal, A.2    Lin, K.3    Peng, Y.4    Tasciotti, E.5    Zhang, X.J.6    Ferrari, M.7
  • 51
    • 77952294160 scopus 로고    scopus 로고
    • Integrated microfluidic system for rapid screening of crp aptamers utilizing systematic evolution of ligands by exponential enrichment (SELEX)
    • Huang CJ, Lin HI, Shiesh SC, Lee GB (2010) Integrated microfluidic system for rapid screening of crp aptamers utilizing systematic evolution of ligands by exponential enrichment (SELEX). Biosens Bioelectron 25(7):1761-1766
    • (2010) Biosens Bioelectron , vol.25 , Issue.7 , pp. 1761-1766
    • Huang, C.J.1    Lin, H.I.2    Shiesh, S.C.3    Lee, G.B.4
  • 52
    • 84862791532 scopus 로고    scopus 로고
    • An integrated microfluidic system for rapid screening of alpha-fetoprotein-specific aptamers
    • Huang CJ, Lin HI, Shiesh SC, Lee GB (2012) An integrated microfluidic system for rapid screening of alpha-fetoprotein-specific aptamers. Biosens Bioelectron 35(1):50-55
    • (2012) Biosens Bioelectron , vol.35 , Issue.1 , pp. 50-55
    • Huang, C.J.1    Lin, H.I.2    Shiesh, S.C.3    Lee, G.B.4
  • 53
    • 84859950124 scopus 로고    scopus 로고
    • Microfluidic integration for automated targeted proteomic assays
    • Hughes AJ, Lin RKC, Peehl DM, Herr AE (2012) Microfluidic integration for automated targeted proteomic assays. Proc Natl Acad Sci USA 109(16):5972-5977
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.16 , pp. 5972-5977
    • Hughes, A.J.1    Lin, R.K.C.2    Peehl, D.M.3    Herr, A.E.4
  • 57
    • 79956101040 scopus 로고    scopus 로고
    • Microfluidic whole-blood immunoassays
    • Jiang H, Weng XA, Li DQ (2011) Microfluidic whole-blood immunoassays. Microfluid Nanofluid 10(5):941-964
    • (2011) Microfluid Nanofluid , vol.10 , Issue.5 , pp. 941-964
    • Jiang, H.1    Weng, X.A.2    Li, D.Q.3
  • 58
    • 33646550512 scopus 로고    scopus 로고
    • Molecular biomarkers: Their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer
    • Jimeno A, Hidalgo M (2006) Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer. Mol Cancer Ther 5(4):787-796
    • (2006) Mol Cancer Ther , vol.5 , Issue.4 , pp. 787-796
    • Jimeno, A.1    Hidalgo, M.2
  • 60
    • 0016215422 scopus 로고
    • Alpha-fetoprotein in primary liver cancer and other diseases
    • Kew M (1974) Alpha-fetoprotein in primary liver cancer and other diseases. Gut 15(10):814-821
    • (1974) Gut , vol.15 , Issue.10 , pp. 814-821
    • Kew, M.1
  • 61
    • 67651245201 scopus 로고    scopus 로고
    • Protein arrays as tools for serum autoantibody marker discovery in cancer
    • Kijanka G, Murphy D (2009) Protein arrays as tools for serum autoantibody marker discovery in cancer. J Proteomics 72(6):936-944
    • (2009) J Proteomics , vol.72 , Issue.6 , pp. 936-944
    • Kijanka, G.1    Murphy, D.2
  • 62
    • 72749088774 scopus 로고    scopus 로고
    • Protein kinase Calpha: Disease regulator and therapeutic target
    • Konopatskaya O, Poole AW (2010) Protein kinase Calpha: disease regulator and therapeutic target. Trends Pharmacol Sci 31(1):8-14
    • (2010) Trends Pharmacol Sci , vol.31 , Issue.1 , pp. 8-14
    • Konopatskaya, O.1    Poole, A.W.2
  • 64
    • 70349459265 scopus 로고    scopus 로고
    • Review: Microfluidic applications in metabolomics and metabolic profiling
    • Kraly JR, Holcomb RE, Guan Q, Henry CS (2009) Review: microfluidic applications in metabolomics and metabolic profiling. Anal Chim Acta 653(1):23-35
    • (2009) Anal Chim Acta , vol.653 , Issue.1 , pp. 23-35
    • Kraly, J.R.1    Holcomb, R.E.2    Guan, Q.3    Henry, C.S.4
  • 65
    • 33646925831 scopus 로고    scopus 로고
    • Botulinum toxin type a for drooling in Parkinson's disease: A double-blind, randomized, placebo-controlled study
    • Lagalla G, Millevolte M, Capecci M, Provinciali L, Ceravolo MG (2006) Botulinum toxin type a for drooling in Parkinson's disease: a double-blind, randomized, placebo-controlled study. Mov Disord 21(5):704-707
    • (2006) Mov Disord , vol.21 , Issue.5 , pp. 704-707
    • Lagalla, G.1    Millevolte, M.2    Capecci, M.3    Provinciali, L.4    Ceravolo, M.G.5
  • 66
    • 33746784676 scopus 로고    scopus 로고
    • Microfluidic liquid chromatography system for proteomic applications and biomarker screening
    • Lazar IM, Trisiripisal P, Sarvaiya HA (2006) Microfluidic liquid chromatography system for proteomic applications and biomarker screening. Anal Chem 78(15):5513-5524
    • (2006) Anal Chem , vol.78 , Issue.15 , pp. 5513-5524
    • Lazar, I.M.1    Trisiripisal, P.2    Sarvaiya, H.A.3
  • 67
    • 0027751663 scopus 로고
    • The C. Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75(5):843-854
    • (1993) Cell , vol.75 , Issue.5 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 68
    • 0036463576 scopus 로고    scopus 로고
    • Application of microfluidic devices to proteomics research - Identification of trace-level protein digests and affinity capture of target peptides
    • Li JJ, LeRiche T, Tremblay TL, Wang C, Bonneil E, Harrison DJ, Thibault P (2002) Application of microfluidic devices to proteomics research - identification of trace-level protein digests and affinity capture of target peptides. Mol Cell Proteomics 1(2):157-168
    • (2002) Mol Cell Proteomics , vol.1 , Issue.2 , pp. 157-168
    • Li, J.J.1    Leriche, T.2    Tremblay, T.L.3    Wang, C.4    Bonneil, E.5    Harrison, D.J.6    Thibault, P.7
  • 69
    • 84867325152 scopus 로고    scopus 로고
    • Microsieve lab-chip device for rapid enumeration and fluorescence in situ hybridization of circulating tumor cells
    • Lim LS, Hu M, Huang MC, Cheong WC, Gan ATL, Looi XL, Leong SM, Koay ESC, Li MH (2012) Microsieve lab-chip device for rapid enumeration and fluorescence in situ hybridization of circulating tumor cells. Lab Chip 12(21):4388-4396
    • (2012) Lab Chip , vol.12 , Issue.21 , pp. 4388-4396
    • Lim, L.S.1    Hu, M.2    Huang, M.C.3    Cheong, W.C.4    Gan, A.T.L.5    Looi, X.L.6    Leong, S.M.7    Koay, E.S.C.8    Li, M.H.9
  • 71
    • 2442719174 scopus 로고    scopus 로고
    • Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis
    • Lindon JC, Holmes E, Bollard ME, Stanley EG, Nicholson JK (2004) Metabonomics technologies and their applications in physiological monitoring, drug safety assessment and disease diagnosis. Biomarkers 9(1):1-31
    • (2004) Biomarkers , vol.9 , Issue.1 , pp. 1-31
    • Lindon, J.C.1    Holmes, E.2    Bollard, M.E.3    Stanley, E.G.4    Nicholson, J.K.5
  • 72
    • 64649105841 scopus 로고    scopus 로고
    • Controlling the selection stringency of phage display using a microfluidic device
    • Liu Y, Adams JD, Turner K, Cochran FV, Gambhir SS, Soh HT (2009) Controlling the selection stringency of phage display using a microfluidic device. Lab Chip 9(8):1033-1036
    • (2009) Lab Chip , vol.9 , Issue.8 , pp. 1033-1036
    • Liu, Y.1    Adams, J.D.2    Turner, K.3    Cochran, F.V.4    Gambhir, S.S.5    Soh, H.T.6
  • 73
    • 42249110521 scopus 로고    scopus 로고
    • Fto: The first gene contributing to common forms of human obesity
    • Loos RJF, Bouchard C (2008) Fto: the first gene contributing to common forms of human obesity. Obes Rev 9(3):246-250
    • (2008) Obes Rev , vol.9 , Issue.3 , pp. 246-250
    • Loos, R.J.F.1    Bouchard, C.2
  • 75
  • 76
    • 0028792459 scopus 로고
    • A mathematical-model for biopanning (affinity selection) using peptide libraries on filamentous phage
    • Mandecki W, Chen YCJ, Grihalde N (1995) A mathematical-model for biopanning (affinity selection) using peptide libraries on filamentous phage. J Theor Biol 176(4):523-530
    • (1995) J Theor Biol , vol.176 , Issue.4 , pp. 523-530
    • Mandecki, W.1    Chen, Y.C.J.2    Grihalde, N.3
  • 77
    • 84856428949 scopus 로고    scopus 로고
    • Nucleic acid and peptide aptamers: Fundamentals and bioanalytical aspects
    • Mascini M, Palchetti I, Tombelli S (2012) Nucleic acid and peptide aptamers: fundamentals and bioanalytical aspects. Angew Chem Int Ed 51(6):1316-1332
    • (2012) Angew Chem Int Ed , vol.51 , Issue.6 , pp. 1316-1332
    • Mascini, M.1    Palchetti, I.2    Tombelli, S.3
  • 78
    • 56549118219 scopus 로고    scopus 로고
    • An integrated microfluidic platform for sensitive and rapid detection of biological toxins
    • Meagher RJ, Hatch AV, Renzi RF, Singh AK (2008) An integrated microfluidic platform for sensitive and rapid detection of biological toxins. Lab Chip 8(12):2046-2053
    • (2008) Lab Chip , vol.8 , Issue.12 , pp. 2046-2053
    • Meagher, R.J.1    Hatch, A.V.2    Renzi, R.F.3    Singh, A.K.4
  • 79
    • 4544303216 scopus 로고    scopus 로고
    • In vitro selection of high-affinity DNA ligands for human IgE using capillary electrophoresis
    • Mendonsa SD, Bowser MT (2004) In vitro selection of high-affinity DNA ligands for human IgE using capillary electrophoresis. Anal Chem 76(18):5387-5392
    • (2004) Anal Chem , vol.76 , Issue.18 , pp. 5387-5392
    • Mendonsa, S.D.1    Bowser, M.T.2
  • 80
    • 21644454857 scopus 로고    scopus 로고
    • In vitro selection of aptamers with affinity for neuropeptide y using capillary electrophoresis
    • Mendonsa SD, Bowser MT (2005) In vitro selection of aptamers with affinity for neuropeptide y using capillary electrophoresis. J Am Chem Soc 127(26):9382-9383
    • (2005) J Am Chem Soc , vol.127 , Issue.26 , pp. 9382-9383
    • Mendonsa, S.D.1    Bowser, M.T.2
  • 81
    • 78651080869 scopus 로고    scopus 로고
    • The genetic basis of hyperuricaemia and gout
    • Merriman TR, Dalbeth N (2011) The genetic basis of hyperuricaemia and gout. Joint Bone Spine 78(1):35-40
    • (2011) Joint Bone Spine , vol.78 , Issue.1 , pp. 35-40
    • Merriman, T.R.1    Dalbeth, N.2
  • 83
    • 79551623770 scopus 로고    scopus 로고
    • Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: A review
    • Mohammed MI, Desmulliez MPY (2011) Lab-on-a-chip based immunosensor principles and technologies for the detection of cardiac biomarkers: a review. Lab Chip 11(4):569-595
    • (2011) Lab Chip , vol.11 , Issue.4 , pp. 569-595
    • Mohammed, M.I.1    Desmulliez, M.P.Y.2
  • 86
    • 34447579098 scopus 로고    scopus 로고
    • Microfluidic selection and applications of aptamers
    • Mosing RK, Bowser MT (2007) Microfluidic selection and applications of aptamers. J Sep Sci 30(10):1420-1426
    • (2007) J Sep Sci , vol.30 , Issue.10 , pp. 1420-1426
    • Mosing, R.K.1    Bowser, M.T.2
  • 87
    • 26444463933 scopus 로고    scopus 로고
    • Capillary electrophoresis-SELEX selection of aptamers with affinity for HIV-1 reverse transcriptase
    • Mosing RK, Mendonsa SD, Bowser MT (2005) Capillary electrophoresis-SELEX selection of aptamers with affinity for HIV-1 reverse transcriptase. Anal Chem 77(19):6107-6112
    • (2005) Anal Chem , vol.77 , Issue.19 , pp. 6107-6112
    • Mosing, R.K.1    Mendonsa, S.D.2    Bowser, M.T.3
  • 88
    • 38349151181 scopus 로고    scopus 로고
    • Competitive immunoassays for simultaneous detection of metabolites and proteins using micromosaic patterning
    • Murphy BM, He X, Dandy D, Henry CS (2008) Competitive immunoassays for simultaneous detection of metabolites and proteins using micromosaic patterning. Anal Chem 80(2):444-450
    • (2008) Anal Chem , vol.80 , Issue.2 , pp. 444-450
    • Murphy, B.M.1    He, X.2    Dandy, D.3    Henry, C.S.4
  • 89
    • 76749148657 scopus 로고    scopus 로고
    • An integrative -omics approach to identify functional sub-networks in human colorectal cancer
    • Nibbe RK, Koyutuerk M, Chance MR (2010) An integrative -omics approach to identify functional sub-networks in human colorectal cancer. PLoS Comput Biol 6(1):e1000639
    • (2010) PLoS Comput Biol , vol.6 , Issue.1 , pp. 1000639
    • Nibbe, R.K.1    Koyutuerk, M.2    Chance, M.R.3
  • 91
    • 57649218844 scopus 로고    scopus 로고
    • A microfluidic technique for monitoring bloodstream analytes indicative of C-peptide resistance in type 2 diabetes
    • Oblak TD, Meyer JA, Spence DM (2009) A microfluidic technique for monitoring bloodstream analytes indicative of C-peptide resistance in type 2 diabetes. Analyst 134(1):188-193
    • (2009) Analyst , vol.134 , Issue.1 , pp. 188-193
    • Oblak, T.D.1    Meyer, J.A.2    Spence, D.M.3
  • 92
    • 84862228997 scopus 로고    scopus 로고
    • Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3a cells
    • Ouattara DA, Prot J-M, Bunescu A, Dumas M-E, Elena-Herrmann B, Leclerc E, Brochot C (2012) Metabolomics-on-a-chip and metabolic flux analysis for label-free modeling of the internal metabolism of HepG2/C3a cells. Mol BioSyst 8(7):1908-1920
    • (2012) Mol BioSyst , vol.8 , Issue.7 , pp. 1908-1920
    • Ouattara, D.A.1    Prot, J.-M.2    Bunescu, A.3    Dumas, M.-E.4    Elena-Herrmann, B.5    Leclerc, E.6    Brochot, C.7
  • 93
    • 65349091927 scopus 로고    scopus 로고
    • Selection and elution of aptamers using nanoporous sol-gel arrays with integrated microheaters
    • Park SM, Ahn JY, Jo M, Lee DK, Lis JT, Craighead HG, Kim S (2009) Selection and elution of aptamers using nanoporous sol-gel arrays with integrated microheaters. Lab Chip 9(9):1206-1212
    • (2009) Lab Chip , vol.9 , Issue.9 , pp. 1206-1212
    • Park, S.M.1    Ahn, J.Y.2    Jo, M.3    Lee, D.K.4    Lis, J.T.5    Craighead, H.G.6    Kim, S.7
  • 100
    • 4143066121 scopus 로고    scopus 로고
    • Use of proteomic patterns in serum to identify ovarian cancer
    • Petricoin EF, Ardekani AM, Hitt BA (2004) Use of proteomic patterns in serum to identify ovarian cancer. Lancet 364(9434):582
    • (2004) Lancet , vol.364 , Issue.9434 , pp. 582
    • Petricoin, E.F.1    Ardekani, A.M.2    Hitt, B.A.3
  • 101
    • 33745954240 scopus 로고    scopus 로고
    • Diagnostics and biomarker development: Priming the pipeline
    • Phillips KA, Van Bebber S, Issa AM (2006) Diagnostics and biomarker development: priming the pipeline. Nat Rev Drug Discov 5(6):463-469
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.6 , pp. 463-469
    • Phillips, K.A.1    Van Bebber, S.2    Issa, A.M.3
  • 102
    • 84859892863 scopus 로고    scopus 로고
    • MicroRNA profiling: Approaches and considerations
    • Pritchard CC, Cheng HH, Tewari M (2012) MicroRNA profiling: approaches and considerations. Nat Rev Genet 13(5):358-369
    • (2012) Nat Rev Genet , vol.13 , Issue.5 , pp. 358-369
    • Pritchard, C.C.1    Cheng, H.H.2    Tewari, M.3
  • 103
    • 84862153039 scopus 로고    scopus 로고
    • The current status of alternatives to animal testing and predictive toxicology methods using liver microfluidic biochips
    • Prot JM, Leclerc E (2012) The current status of alternatives to animal testing and predictive toxicology methods using liver microfluidic biochips. Ann Biomed Eng 40(6):1228-1243
    • (2012) Ann Biomed Eng , vol.40 , Issue.6 , pp. 1228-1243
    • Prot, J.M.1    Leclerc, E.2
  • 104
    • 67649988369 scopus 로고    scopus 로고
    • Generation of highly specific aptamers via micromagnetic selection
    • Qian JR, Lou XH, Zhang YT, Xiao Y, Soh HT (2009) Generation of highly specific aptamers via micromagnetic selection. Anal Chem 81(13):5490-5495
    • (2009) Anal Chem , vol.81 , Issue.13 , pp. 5490-5495
    • Qian, J.R.1    Lou, X.H.2    Zhang, Y.T.3    Xiao, Y.4    Soh, H.T.5
  • 106
    • 67449161036 scopus 로고    scopus 로고
    • Applications of protein microarrays for biomarker discovery
    • Ramachandran N, Srivastava S, LaBaer J (2008) Applications of protein microarrays for biomarker discovery. Proteomics Clin App 2(10-11):1444-1459
    • (2008) Proteomics Clin App , vol.2 , Issue.10-11 , pp. 1444-1459
    • Ramachandran, N.1    Srivastava, S.2    Labaer, J.3
  • 108
    • 58149242824 scopus 로고    scopus 로고
    • Point-of-care testing of cholesterol and triglycerides for epidemiologic studies; Evaluation of the multicare-in system
    • Rapi S, Bazzini C, Tozzetti C, Sbolci V, Modesti PA (2009) Point-of-care testing of cholesterol and triglycerides for epidemiologic studies; evaluation of the multicare-in system. Transl Res 153(2):71-76
    • (2009) Transl Res , vol.153 , Issue.2 , pp. 71-76
    • Rapi, S.1    Bazzini, C.2    Tozzetti, C.3    Sbolci, V.4    Modesti, P.A.5
  • 112
    • 0035897688 scopus 로고    scopus 로고
    • Novel risk factors for systemic atherosclerosis - A comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease
    • Ridker PM, Stampfer MJ, Rifai N (2001) Novel risk factors for systemic atherosclerosis - a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease. J Am Med Assoc (JAMA) 285(19):2481-2485
    • (2001) J Am Med Assoc (JAMA) , vol.285 , Issue.19 , pp. 2481-2485
    • Ridker, P.M.1    Stampfer, M.J.2    Rifai, N.3
  • 113
    • 33747030845 scopus 로고    scopus 로고
    • Protein biomarker discovery and validation: The long and uncertain path to clinical utility
    • Rifai N, Gillette MA, Carr SA (2006) Protein biomarker discovery and validation: the long and uncertain path to clinical utility. Nat Biotechnol 24(8):971-983
    • (2006) Nat Biotechnol , vol.24 , Issue.8 , pp. 971-983
    • Rifai, N.1    Gillette, M.A.2    Carr, S.A.3
  • 118
    • 77956851321 scopus 로고    scopus 로고
    • Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer
    • Rusling JF, Kumar CV, Gutkind JS, Patel V (2010) Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. Analyst 135(10):2496-2511
    • (2010) Analyst , vol.135 , Issue.10 , pp. 2496-2511
    • Rusling, J.F.1    Kumar, C.V.2    Gutkind, J.S.3    Patel, V.4
  • 119
    • 18744398125 scopus 로고    scopus 로고
    • Large-scale database searching using tandem mass spectra: Looking up the answer in the back of the book
    • Sadygov RG, Cociorva D, Yates JR (2004) Large-scale database searching using tandem mass spectra: looking up the answer in the back of the book. Nat Methods 1(3):195-202
    • (2004) Nat Methods , vol.1 , Issue.3 , pp. 195-202
    • Sadygov, R.G.1    Cociorva, D.2    Yates, J.R.3
  • 120
    • 2542596183 scopus 로고    scopus 로고
    • Parkinson's disease
    • Samii A, Nutt JG, Ransom BR (2004) Parkinson's disease. Lancet 363(9423):1783-1793
    • (2004) Lancet , vol.363 , Issue.9423 , pp. 1783-1793
    • Samii, A.1    Nutt, J.G.2    Ransom, B.R.3
  • 121
    • 38149098447 scopus 로고    scopus 로고
    • Reduction of C-reactive protein and the use of anti-hypertensives
    • Savoia C, Schiffrin EL (2007) Reduction of C-reactive protein and the use of anti-hypertensives. Vasc Health Risk Manage 3(6):975-983
    • (2007) Vasc Health Risk Manage , vol.3 , Issue.6 , pp. 975-983
    • Savoia, C.1    Schiffrin, E.L.2
  • 122
    • 0028806048 scopus 로고
    • Quantitative monitoring of gene-expression patterns with a complementary-DNA microarray
    • Schena M, Shalon D, Davis RW, Brown PO (1995) Quantitative monitoring of gene-expression patterns with a complementary-DNA microarray. Science 270(5235):467-470
    • (1995) Science , vol.270 , Issue.5235 , pp. 467-470
    • Schena, M.1    Shalon, D.2    Davis, R.W.3    Brown, P.O.4
  • 123
    • 10144231462 scopus 로고    scopus 로고
    • Phage display: A molecular tool for the generation of antibodies - A review
    • Schmitz U, Versmold A, Kaufmann P, Frank HG (2000) Phage display: a molecular tool for the generation of antibodies - a review. Placenta 21:S106-S112
    • (2000) Placenta , vol.21
    • Schmitz, U.1    Versmold, A.2    Kaufmann, P.3    Frank, H.G.4
  • 125
    • 77955464013 scopus 로고    scopus 로고
    • Assessment of the Nova StatSensor whole blood point-of-care creatinine analyzer for the measurement of kidney function in screening for chronic kidney disease
    • Shephard M, Peake M, Corso O, Shephard A, Mazzachi B, Spaeth B, Barbara J, Mathew T (2010) Assessment of the Nova StatSensor whole blood point-of-care creatinine analyzer for the measurement of kidney function in screening for chronic kidney disease. Clin Chem Lab Med 48(8):1113-1119
    • (2010) Clin Chem Lab Med , vol.48 , Issue.8 , pp. 1113-1119
    • Shephard, M.1    Peake, M.2    Corso, O.3    Shephard, A.4    Mazzachi, B.5    Spaeth, B.6    Barbara, J.7    Mathew, T.8
  • 127
    • 0037415014 scopus 로고    scopus 로고
    • Exploring protein-protein interactions with phage display
    • Sidhu SS, Fairbrother WJ, Deshayes K (2003) Exploring protein-protein interactions with phage display. ChemBioChem 4(1):14-25
    • (2003) ChemBioChem , vol.4 , Issue.1 , pp. 14-25
    • Sidhu, S.S.1    Fairbrother, W.J.2    Deshayes, K.3
  • 129
    • 37049183697 scopus 로고
    • Human-breast cancer - Correlation of relapse and survival with amplification of the HER-2 neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, Mcguire WL (1987) Human-breast cancer - correlation of relapse and survival with amplification of the HER-2 neu oncogene. Science 235(4785):177-182
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 130
    • 0021818675 scopus 로고
    • Filamentous fusion phage - Novel expression vectors that display cloned antigens on the virion surface
    • Smith GP (1985) Filamentous fusion phage - novel expression vectors that display cloned antigens on the virion surface. Science 228(4705):1315-1317
    • (1985) Science , vol.228 , Issue.4705 , pp. 1315-1317
    • Smith, G.P.1
  • 131
    • 84876504162 scopus 로고    scopus 로고
    • Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips
    • Snouber LC, Bunescu A, Naudot M, Legallais C, Brochot C, Dumas ME, Elena-Herrmann B, Leclerc E (2013) Metabolomics-on-a-chip of hepatotoxicity induced by anticancer drug flutamide and its active metabolite hydroxyflutamide using HepG2/C3a microfluidic biochips. Toxicol Sci 132(1):8-20
    • (2013) Toxicol Sci , vol.132 , Issue.1 , pp. 8-20
    • Snouber, L.C.1    Bunescu, A.2    Naudot, M.3    Legallais, C.4    Brochot, C.5    Dumas, M.E.6    Elena-Herrmann, B.7    Leclerc, E.8
  • 132
    • 45849087630 scopus 로고    scopus 로고
    • High throughput gene expression measurement with real time PCR in a microfluidic dynamic array
    • Spurgeon SL, Jones RC, Ramakrishnan R (2008) High throughput gene expression measurement with real time PCR in a microfluidic dynamic array. PLoS ONE 3(2):e1662
    • (2008) PLoS ONE , vol.3 , Issue.2 , pp. 1662
    • Spurgeon, S.L.1    Jones, R.C.2    Ramakrishnan, R.3
  • 135
    • 34548551398 scopus 로고    scopus 로고
    • SELEX-A (r)evolutionary method to generate high-affinity nucleic acid ligands
    • Stoltenburg R, Reinemann C, Strehlitz B (2007) SELEX-A (r)evolutionary method to generate high-affinity nucleic acid ligands. Biomol Eng 24(4):381-403
    • (2007) Biomol Eng , vol.24 , Issue.4 , pp. 381-403
    • Stoltenburg, R.1    Reinemann, C.2    Strehlitz, B.3
  • 137
    • 19744366758 scopus 로고    scopus 로고
    • Integrated microfluidic system for the simultaneous determination of ammonia, creatinine, and urea
    • Suzuki H, Matsugi Y (2005) Integrated microfluidic system for the simultaneous determination of ammonia, creatinine, and urea. Sensor Actuat B-Chem 108(1-2):700-707
    • (2005) Sensor Actuat B-Chem , vol.108 , Issue.1-2 , pp. 700-707
    • Suzuki, H.1    Matsugi, Y.2
  • 138
    • 84893672268 scopus 로고    scopus 로고
    • A novel integrated microfluidic platform to perform fluorescence in situ hybridization for chromosomal analysis
    • 10.1007/s10404-10013-11190-10400
    • Tai CH, Ho CL, Chen YL, Chen WL, Lee GB (2013) A novel integrated microfluidic platform to perform fluorescence in situ hybridization for chromosomal analysis. Microfluid Nanofluid. doi: 10.1007/s10404-10013-11190- 10400
    • (2013) Microfluid Nanofluid
    • Tai, C.H.1    Ho, C.L.2    Chen, Y.L.3    Chen, W.L.4    Lee, G.B.5
  • 139
    • 84867639216 scopus 로고    scopus 로고
    • Biomarkers in the diagnosis of primary and recurrent breast cancer
    • 3026724
    • Tang SSK, Gui GPH (2012) Biomarkers in the diagnosis of primary and recurrent breast cancer. Biomark Med 6(5):567-585
    • (2012) Biomark Med , vol.6 , Issue.5 , pp. 567-585
    • Tang, S.S.K.1    Gui, G.P.H.2
  • 140
    • 33645837248 scopus 로고    scopus 로고
    • The DNA aptamers that specifically recognize ricin toxin are selected by two in vitro selection methods
    • Tang J, Xie J, Shao N, Yan Y (2006) The DNA aptamers that specifically recognize ricin toxin are selected by two in vitro selection methods. Electrophoresis 27(7):1303-1311
    • (2006) Electrophoresis , vol.27 , Issue.7 , pp. 1303-1311
    • Tang, J.1    Xie, J.2    Shao, N.3    Yan, Y.4
  • 141
    • 70349482671 scopus 로고    scopus 로고
    • C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
    • Teesalu T, Sugahara KN, Kotamraju VR, Ruoslahti E (2009) C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration. Proc Natl Acad Sci USA 106(38):16157-16162
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.38 , pp. 16157-16162
    • Teesalu, T.1    Sugahara, K.N.2    Kotamraju, V.R.3    Ruoslahti, E.4
  • 142
    • 34249300780 scopus 로고    scopus 로고
    • Urinary proteome profiling using microfluidic technology on a chip
    • Thongboonkerd V, Songtawee N, Sritippayawan S (2007) Urinary proteome profiling using microfluidic technology on a chip. J Proteome Res 6(5):2011-2018
    • (2007) J Proteome Res , vol.6 , Issue.5 , pp. 2011-2018
    • Thongboonkerd, V.1    Songtawee, N.2    Sritippayawan, S.3
  • 143
    • 0023252262 scopus 로고
    • HLA-DQ-beta gene contributes to susceptibility and resistance to insulin-dependent diabetes-mellitus
    • Todd JA, Bell JI, McDevitt HO (1987) HLA-DQ-beta gene contributes to susceptibility and resistance to insulin-dependent diabetes-mellitus. Nature 329(6140):599-604
    • (1987) Nature , vol.329 , Issue.6140 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 144
    • 77953824591 scopus 로고    scopus 로고
    • Selection of aptamers for signal transduction proteins by capillary electrophoresis
    • Tok J, Lai J, Leung T, Li SFY (2010) Selection of aptamers for signal transduction proteins by capillary electrophoresis. Electrophoresis 31(12):2055-2062
    • (2010) Electrophoresis , vol.31 , Issue.12 , pp. 2055-2062
    • Tok, J.1    Lai, J.2    Leung, T.3    Li, S.F.Y.4
  • 145
    • 33845327545 scopus 로고    scopus 로고
    • Multichannel reverse transcription-polymerase chain reaction microdevice for rapid gene expression and biomarker analysis
    • Toriello NM, Liu CN, Mathies RA (2006) Multichannel reverse transcription-polymerase chain reaction microdevice for rapid gene expression and biomarker analysis. Anal Chem 78(23):7997-8003
    • (2006) Anal Chem , vol.78 , Issue.23 , pp. 7997-8003
    • Toriello, N.M.1    Liu, C.N.2    Mathies, R.A.3
  • 146
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment - RNA ligands to bacteriophage T4 DNA-polymerase
    • Tuerk C, Gold L (1990) Systematic evolution of ligands by exponential enrichment - RNA ligands to bacteriophage T4 DNA-polymerase. Science 249(4968):505-510
    • (1990) Science , vol.249 , Issue.4968 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 148
    • 0034891347 scopus 로고    scopus 로고
    • Class iii alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes
    • Vafiadis P, Ounissi-Benkalha H, Palumbo M, Grabs R, Rousseau M, Goodyer CG, Polychronakos C (2001) Class iii alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes. J Clin Endocr Metab 86(8):3705-3710
    • (2001) J Clin Endocr Metab , vol.86 , Issue.8 , pp. 3705-3710
    • Vafiadis, P.1    Ounissi-Benkalha, H.2    Palumbo, M.3    Grabs, R.4    Rousseau, M.5    Goodyer, C.G.6    Polychronakos, C.7
  • 155
    • 1542617944 scopus 로고    scopus 로고
    • Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometry
    • Villanueva J, Philip J, Entenberg D, Chaparro CA, Tanwar MK, Holland EC, Tempst P (2004) Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometry. Anal Chem 76(6):1560-1570
    • (2004) Anal Chem , vol.76 , Issue.6 , pp. 1560-1570
    • Villanueva, J.1    Philip, J.2    Entenberg, D.3    Chaparro, C.A.4    Tanwar, M.K.5    Holland, E.C.6    Tempst, P.7
  • 160
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang Z, Gerstein M, Snyder M (2009) RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10(1):57-63
    • (2009) Nat Rev Genet , vol.10 , Issue.1 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 162
    • 84861460606 scopus 로고    scopus 로고
    • Microfluidic extraction and stretching of chromosomal DNA from single cell nuclei for DNA fluorescence in situ hybridization
    • Wang XZ, Takebayashi SI, Bernardin E, Gilbert DM, Chella R, Guan JJ (2012) Microfluidic extraction and stretching of chromosomal DNA from single cell nuclei for DNA fluorescence in situ hybridization. Biomed Microdevices 14(3):443-451
    • (2012) Biomed Microdevices , vol.14 , Issue.3 , pp. 443-451
    • Wang, X.Z.1    Takebayashi, S.I.2    Bernardin, E.3    Gilbert, D.M.4    Chella, R.5    Guan, J.J.6
  • 163
    • 84888100481 scopus 로고    scopus 로고
    • A DNA methylation assay for detection of ovarian cancer cells using a HpaII/MspI digestion-based PCR assay in an integrated microfluidic system
    • Wang CH, Lai HC, Liou TML, Hsu KFH, Chou CYC, Lee GB (2013) A DNA methylation assay for detection of ovarian cancer cells using a HpaII/MspI digestion-based PCR assay in an integrated microfluidic system. Microfluid Nanofluid 15(5):575-585
    • (2013) Microfluid Nanofluid , vol.15 , Issue.5 , pp. 575-585
    • Wang, C.H.1    Lai, H.C.2    Liou, T.M.L.3    Hsu, K.F.H.4    Chou, C.Y.C.5    Lee, G.B.6
  • 164
    • 40849093600 scopus 로고    scopus 로고
    • Genome-wide association studies in Alzheimer disease
    • Waring SC, Rosenberg RN (2008) Genome-wide association studies in Alzheimer disease. Arch Neurol 65(3):329-334
    • (2008) Arch Neurol , vol.65 , Issue.3 , pp. 329-334
    • Waring, S.C.1    Rosenberg, R.N.2
  • 165
    • 70649097388 scopus 로고    scopus 로고
    • Label-free quantitation of a cancer biomarker in complex media using silicon photonic microring resonators
    • Washburn AL, Gunn LC, Bailey RC (2009) Label-free quantitation of a cancer biomarker in complex media using silicon photonic microring resonators. Anal Chem 81(22):9499-9506
    • (2009) Anal Chem , vol.81 , Issue.22 , pp. 9499-9506
    • Washburn, A.L.1    Gunn, L.C.2    Bailey, R.C.3
  • 166
    • 75749143500 scopus 로고    scopus 로고
    • Quantitative, label-free detection of five protein biomarkers using multiplexed arrays of silicon photonic microring resonators
    • Washburn AL, Luchansky MS, Bowman AL, Bailey RC (2010) Quantitative, label-free detection of five protein biomarkers using multiplexed arrays of silicon photonic microring resonators. Anal Chem 82(1):69-72
    • (2010) Anal Chem , vol.82 , Issue.1 , pp. 69-72
    • Washburn, A.L.1    Luchansky, M.S.2    Bowman, A.L.3    Bailey, R.C.4
  • 167
  • 169
    • 0029685702 scopus 로고    scopus 로고
    • Analytical properties of the nanoelectrospray ion source
    • Wilm M, Mann M (1996) Analytical properties of the nanoelectrospray ion source. Anal Chem 68(1):1-8
    • (1996) Anal Chem , vol.68 , Issue.1 , pp. 1-8
    • Wilm, M.1    Mann, M.2
  • 171
    • 3142608724 scopus 로고    scopus 로고
    • Evaluation of a point-of-care assay for cardiac markers for patients suspected of acute myocardial infarction
    • Wu AHB, Smith A, Christenson RH, Murakami MM, Apple FS (2004) Evaluation of a point-of-care assay for cardiac markers for patients suspected of acute myocardial infarction. Clin Chim Acta 346(2):211-219
    • (2004) Clin Chim Acta , vol.346 , Issue.2 , pp. 211-219
    • Wu, A.H.B.1    Smith, A.2    Christenson, R.H.3    Murakami, M.M.4    Apple, F.S.5
  • 172
    • 82755162006 scopus 로고    scopus 로고
    • 2-D t-ITP/CZE determination of clinical urinary proteins using a microfluidic-chip capillary electrophoresis device
    • Wu RG, Yeung WSB, Fung YS (2011) 2-D t-ITP/CZE determination of clinical urinary proteins using a microfluidic-chip capillary electrophoresis device. Electrophoresis 32(23):3406-3414
    • (2011) Electrophoresis , vol.32 , Issue.23 , pp. 3406-3414
    • Wu, R.G.1    Yeung, W.S.B.2    Fung, Y.S.3
  • 173
    • 27544508864 scopus 로고    scopus 로고
    • Microfluidic platform for liquid chromatography-tandem mass spectrometry analyses of complex peptide mixtures
    • Xie J, Miao YN, Shih J, Tai YC, Lee TD (2005) Microfluidic platform for liquid chromatography-tandem mass spectrometry analyses of complex peptide mixtures. Anal Chem 77(21):6947-6953
    • (2005) Anal Chem , vol.77 , Issue.21 , pp. 6947-6953
    • Xie, J.1    Miao, Y.N.2    Shih, J.3    Tai, Y.C.4    Lee, T.D.5
  • 174
    • 56349096465 scopus 로고    scopus 로고
    • Integrative genomic data mining for discovery of potential blood-borne biomarkers for early diagnosis of cancer
    • Yang Y, Iyer LK, Adelstein SJ, Kassis AI (2008) Integrative genomic data mining for discovery of potential blood-borne biomarkers for early diagnosis of cancer. PLoS ONE 3(11):e3661
    • (2008) PLoS ONE , vol.3 , Issue.11 , pp. 3661
    • Yang, Y.1    Iyer, L.K.2    Adelstein, S.J.3    Kassis, A.I.4
  • 175
    • 66449102696 scopus 로고    scopus 로고
    • Phage display screening against a set of targets to establish peptide-based sugar mimetics and molecular docking to predict binding site
    • Yu LM, Yu S, Mui EYY, McKelvie JC, Pham TPT, Yap YW, Wong WQ, Wu JW, Deng WQ, Orner BP (2009) Phage display screening against a set of targets to establish peptide-based sugar mimetics and molecular docking to predict binding site. Bioorg Med Chem 17(13):4825-4832
    • (2009) Bioorg Med Chem , vol.17 , Issue.13 , pp. 4825-4832
    • Yu, L.M.1    Yu, S.2    Mui, E.Y.Y.3    McKelvie, J.C.4    Pham, T.P.T.5    Yap, Y.W.6    Wong, W.Q.7    Wu, J.W.8    Deng, W.Q.9    Orner, B.P.10
  • 176
    • 79953330159 scopus 로고    scopus 로고
    • Circulating microRNAs: Potential biomarkers for cancer
    • Yu D-C, Li Q-G, Ding X-W, Ding Y-T (2011a) Circulating microRNAs: potential biomarkers for cancer. Int J Mol Sci 12(3):2055-2063
    • (2011) Int J Mol Sci , vol.12 , Issue.3 , pp. 2055-2063
    • Yu, D.-C.1    Li, Q.-G.2    Ding, X.-W.3    Ding, Y.-T.4
  • 177
    • 79955562971 scopus 로고    scopus 로고
    • Multilayer polymer microchip capillary array electrophoresis devices with integrated on-chip labeling for high-throughput protein analysis
    • Yu M, Wang QS, Patterson JE, Woolley AT (2011b) Multilayer polymer microchip capillary array electrophoresis devices with integrated on-chip labeling for high-throughput protein analysis. Anal Chem 83(9):3541-3547
    • (2011) Anal Chem , vol.83 , Issue.9 , pp. 3541-3547
    • Yu, M.1    Wang, Q.S.2    Patterson, J.E.3    Woolley, A.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.