-
2
-
-
33746909044
-
Protein kinase Cα but not PKCζ suppresses intestinal tumor formation in ApcMin/+ mice
-
Oster H., and Leitges M. Protein kinase Cα but not PKCζ suppresses intestinal tumor formation in ApcMin/+ mice. Cancer Res. 66 (2006) 6955-6963
-
(2006)
Cancer Res.
, vol.66
, pp. 6955-6963
-
-
Oster, H.1
Leitges, M.2
-
3
-
-
1642388834
-
PKCα regulates cardiac contractility and propensity toward heart failure
-
Braz J.C., et al. PKCα regulates cardiac contractility and propensity toward heart failure. Nat. Med. 10 (2004) 248-254
-
(2004)
Nat. Med.
, vol.10
, pp. 248-254
-
-
Braz, J.C.1
-
4
-
-
61749097572
-
PKCα regulates platelet granule secretion and thrombus formation in mice
-
Konopatskaya O., et al. PKCα regulates platelet granule secretion and thrombus formation in mice. J. Clin. Invest. 119 (2009) 399-407
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 399-407
-
-
Konopatskaya, O.1
-
5
-
-
41149161288
-
PKC isozymes in chronic cardiac disease: possible therapeutic targets?
-
Churchill E., et al. PKC isozymes in chronic cardiac disease: possible therapeutic targets?. Annu. Rev. Pharmacol. Toxicol. 48 (2008) 569-599
-
(2008)
Annu. Rev. Pharmacol. Toxicol.
, vol.48
, pp. 569-599
-
-
Churchill, E.1
-
6
-
-
67449132316
-
Protein kinase C in heart failure: a therapeutic target?
-
Palaniyandi S.S., et al. Protein kinase C in heart failure: a therapeutic target?. Cardiovasc. Res. 82 (2009) 229-239
-
(2009)
Cardiovasc. Res.
, vol.82
, pp. 229-239
-
-
Palaniyandi, S.S.1
-
7
-
-
34250902930
-
Targeting the protein kinase C family: are we there yet?
-
Mackay H.J., and Twelves C.J. Targeting the protein kinase C family: are we there yet?. Nat. Rev. Cancer 7 (2007) 554-562
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 554-562
-
-
Mackay, H.J.1
Twelves, C.J.2
-
8
-
-
0033830338
-
Protein kinase C isozymes and the regulation of diverse cell responses
-
Dempsey E.C., et al. Protein kinase C isozymes and the regulation of diverse cell responses. Am. J. Physiol. Lung Cell Mol. Physiol. 279 (2000) L429-438
-
(2000)
Am. J. Physiol. Lung Cell Mol. Physiol.
, vol.279
-
-
Dempsey, E.C.1
-
9
-
-
52449088793
-
The life and death of protein kinase C
-
Gould C.M., and Newton A.C. The life and death of protein kinase C. Curr. Drug Targets 9 (2008) 614-625
-
(2008)
Curr. Drug Targets
, vol.9
, pp. 614-625
-
-
Gould, C.M.1
Newton, A.C.2
-
10
-
-
0036855463
-
Protein kinase Cα (PKCα): regulation and biological function
-
Nakashima S. Protein kinase Cα (PKCα): regulation and biological function. J. Biochem. 132 (2002) 669-675
-
(2002)
J. Biochem.
, vol.132
, pp. 669-675
-
-
Nakashima, S.1
-
11
-
-
0036214616
-
Knockout of PKCα enhances insulin signaling through PI3K
-
Leitges M., et al. Knockout of PKCα enhances insulin signaling through PI3K. Mol. Endocrinol. 16 (2002) 847-858
-
(2002)
Mol. Endocrinol.
, vol.16
, pp. 847-858
-
-
Leitges, M.1
-
12
-
-
33646481323
-
Defective IgG2a/2b class switching in PKCα-/- mice
-
Pfeifhofer C., et al. Defective IgG2a/2b class switching in PKCα-/- mice. J. Immunol. 176 (2006) 6004-6011
-
(2006)
J. Immunol.
, vol.176
, pp. 6004-6011
-
-
Pfeifhofer, C.1
-
13
-
-
33744923428
-
Protein kinase C (PKC) α and PKCθ are the major PKC isotypes involved in TCR down-regulation
-
von Essen M., et al. Protein kinase C (PKC) α and PKCθ are the major PKC isotypes involved in TCR down-regulation. J. Immunol. 176 (2006) 7502-7510
-
(2006)
J. Immunol.
, vol.176
, pp. 7502-7510
-
-
von Essen, M.1
-
14
-
-
9344258622
-
Protein kinase Cα-induced hypertrophy of neonatal rat ventricular myocytes
-
Vijayan K., et al. Protein kinase Cα-induced hypertrophy of neonatal rat ventricular myocytes. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H2777-2789
-
(2004)
Am. J. Physiol. Heart Circ. Physiol.
, vol.287
-
-
Vijayan, K.1
-
15
-
-
0036885610
-
Identification of PKCα isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides
-
Kerkela R., et al. Identification of PKCα isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides. Mol. Pharmacol. 62 (2002) 1482-1491
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 1482-1491
-
-
Kerkela, R.1
-
16
-
-
0037018154
-
PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)
-
Braz J.C., et al. PKCα regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2). J. Cell Biol. 156 (2002) 905-919
-
(2002)
J. Cell Biol.
, vol.156
, pp. 905-919
-
-
Braz, J.C.1
-
17
-
-
34547578672
-
Augmented protein kinase Cα-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure
-
Belin R.J., et al. Augmented protein kinase Cα-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Circ. Res. 101 (2007) 195-204
-
(2007)
Circ. Res.
, vol.101
, pp. 195-204
-
-
Belin, R.J.1
-
18
-
-
0041816273
-
Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T
-
Sumandea M.P., et al. Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T. J. Biol. Chem. 278 (2003) 35135-35144
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 35135-35144
-
-
Sumandea, M.P.1
-
19
-
-
67649695506
-
Atherosclerotic plaque development and instability: a dual role for VEGF
-
Holm P.W., et al. Atherosclerotic plaque development and instability: a dual role for VEGF. Ann. Med. 41 (2009) 257-264
-
(2009)
Ann. Med.
, vol.41
, pp. 257-264
-
-
Holm, P.W.1
-
20
-
-
42149116966
-
Differential regulation of VEGF signaling by PKCα and PKCε in endothelial cells
-
Rask-Madsen C., and King G.L. Differential regulation of VEGF signaling by PKCα and PKCε in endothelial cells. Arterioscler Thromb. Vasc. Biol. 28 (2008) 919-924
-
(2008)
Arterioscler Thromb. Vasc. Biol.
, vol.28
, pp. 919-924
-
-
Rask-Madsen, C.1
King, G.L.2
-
21
-
-
2642709170
-
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
-
Xia P., et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J. Clin. Invest. 98 (1996) 2018-2026
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 2018-2026
-
-
Xia, P.1
-
22
-
-
0035657643
-
Protein kinase C inhibitors as novel anticancer drugs
-
Goekjian P.G., and Jirousek M.R. Protein kinase C inhibitors as novel anticancer drugs. Expert Opin. Investig. Drugs 10 (2001) 2117-2140
-
(2001)
Expert Opin. Investig. Drugs
, vol.10
, pp. 2117-2140
-
-
Goekjian, P.G.1
Jirousek, M.R.2
-
23
-
-
0037155777
-
Inhibition of protein kinase Cα prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo
-
Wang A., et al. Inhibition of protein kinase Cα prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo. Circ. Res. 90 (2002) 609-616
-
(2002)
Circ. Res.
, vol.90
, pp. 609-616
-
-
Wang, A.1
-
24
-
-
42349108136
-
Protein kinase Cα promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor
-
Xu H., et al. Protein kinase Cα promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc. Res. 78 (2008) 349-355
-
(2008)
Cardiovasc. Res.
, vol.78
, pp. 349-355
-
-
Xu, H.1
-
25
-
-
0034630749
-
Endothelial proliferation, migration, and differentiation are blunted by conditionally expressed protein kinase C pseudosubstrate peptides
-
Harrington E.O., et al. Endothelial proliferation, migration, and differentiation are blunted by conditionally expressed protein kinase C pseudosubstrate peptides. Biochem. Biophys Res. Commun. 271 (2000) 499-508
-
(2000)
Biochem. Biophys Res. Commun.
, vol.271
, pp. 499-508
-
-
Harrington, E.O.1
-
26
-
-
33847042684
-
Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKCalpha/beta1 and MAPKs
-
Mountain D.J., et al. Interleukin-1beta increases expression and activity of matrix metalloproteinase-2 in cardiac microvascular endothelial cells: role of PKCalpha/beta1 and MAPKs. Am. J. Physiol. Cell Physiol. 292 (2007) C867-875
-
(2007)
Am. J. Physiol. Cell Physiol.
, vol.292
-
-
Mountain, D.J.1
-
27
-
-
49849097005
-
Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration
-
Aghajanian A., et al. Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration. J. Thromb. Haemost. 6 (2008) 1453-1460
-
(2008)
J. Thromb. Haemost.
, vol.6
, pp. 1453-1460
-
-
Aghajanian, A.1
-
28
-
-
0028121374
-
Regulation of vascular endothelial barrier function
-
Lum H., and Malik A.B. Regulation of vascular endothelial barrier function. Am. J. Physiol. 267 (1994) L223-241
-
(1994)
Am. J. Physiol.
, vol.267
-
-
Lum, H.1
Malik, A.B.2
-
29
-
-
0035368773
-
Ca(2+) signalling and PKCα activate increased endothelial permeability by disassembly of VE-cadherin junctions
-
Sandoval R., et al. Ca(2+) signalling and PKCα activate increased endothelial permeability by disassembly of VE-cadherin junctions. J. Physiol. 533 (2001) 433-445
-
(2001)
J. Physiol.
, vol.533
, pp. 433-445
-
-
Sandoval, R.1
-
30
-
-
0042845703
-
Role of Ca2+ signaling in the regulation of endothelial permeability
-
Tiruppathi C., et al. Role of Ca2+ signaling in the regulation of endothelial permeability. Vascul. Pharmacol. 39 (2002) 173-185
-
(2002)
Vascul. Pharmacol.
, vol.39
, pp. 173-185
-
-
Tiruppathi, C.1
-
31
-
-
2442685287
-
Protein kinase Cα phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells
-
Ahmmed G.U., et al. Protein kinase Cα phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. J. Biol. Chem. 279 (2004) 20941-20949
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20941-20949
-
-
Ahmmed, G.U.1
-
32
-
-
0035933870
-
Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
-
Mehta D., et al. Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function. J. Biol. Chem. 276 (2001) 22614-22620
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22614-22620
-
-
Mehta, D.1
-
33
-
-
33646823302
-
Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability
-
Stamatovic S.M., et al. Protein kinase Calpha-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability. J. Biol. Chem. 281 (2006) 8379-8388
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 8379-8388
-
-
Stamatovic, S.M.1
-
34
-
-
0033949332
-
Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha
-
Ferro T., et al. Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha. Am. J. Physiol. Lung Cell Mol. Physiol. 278 (2000) L1107-1117
-
(2000)
Am. J. Physiol. Lung Cell Mol. Physiol.
, vol.278
-
-
Ferro, T.1
-
35
-
-
0034822445
-
Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction
-
Lum H., et al. Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunction. Am. J. Physiol. Lung Cell Mol. Physiol. 281 (2001) L546-555
-
(2001)
Am. J. Physiol. Lung Cell Mol. Physiol.
, vol.281
-
-
Lum, H.1
-
36
-
-
0030743466
-
High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alpha
-
Hempel A., et al. High glucose concentrations increase endothelial cell permeability via activation of protein kinase C alpha. Circ. Res. 81 (1997) 363-371
-
(1997)
Circ. Res.
, vol.81
, pp. 363-371
-
-
Hempel, A.1
-
37
-
-
0026333959
-
Role of oxidized low density lipoprotein in atherogenesis
-
Witztum J.L., and Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88 (1991) 1785-1792
-
(1991)
J. Clin. Invest.
, vol.88
, pp. 1785-1792
-
-
Witztum, J.L.1
Steinberg, D.2
-
38
-
-
13844255039
-
Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha
-
Fleming I., et al. Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha. Cardiovasc. Res. 65 (2005) 897-906
-
(2005)
Cardiovasc. Res.
, vol.65
, pp. 897-906
-
-
Fleming, I.1
-
39
-
-
33750439866
-
SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition
-
Takahashi K., et al. SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition. Eur. J. Pharmacol. 552 (2006) 162-169
-
(2006)
Eur. J. Pharmacol.
, vol.552
, pp. 162-169
-
-
Takahashi, K.1
-
40
-
-
33847013084
-
Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation
-
Kawakami A., et al. Apolipoprotein CIII-induced THP-1 cell adhesion to endothelial cells involves pertussis toxin-sensitive G protein- and protein kinase C alpha-mediated nuclear factor-kappaB activation. Arterioscler Thromb. Vasc. Biol. 27 (2007) 219-225
-
(2007)
Arterioscler Thromb. Vasc. Biol.
, vol.27
, pp. 219-225
-
-
Kawakami, A.1
-
41
-
-
2342523261
-
Lactosylceramide recruits PKCalpha/epsilon and phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells
-
Gong N., et al. Lactosylceramide recruits PKCalpha/epsilon and phospholipase A2 to stimulate PECAM-1 expression in human monocytes and adhesion to endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 6490-6495
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 6490-6495
-
-
Gong, N.1
-
42
-
-
13544273188
-
Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression
-
Fu J., et al. Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. J. Biol. Chem. 280 (2005) 3178-3184
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 3178-3184
-
-
Fu, J.1
-
43
-
-
34248371253
-
Clinical aspects of platelet inhibitors and thrombus formation
-
Meadows T.A., and Bhatt D.L. Clinical aspects of platelet inhibitors and thrombus formation. Circ. Res. 100 (2007) 1261-1275
-
(2007)
Circ. Res.
, vol.100
, pp. 1261-1275
-
-
Meadows, T.A.1
Bhatt, D.L.2
-
44
-
-
36749062608
-
Isoform-specific functions of protein kinase C: the platelet paradigm
-
Harper M.T., and Poole A.W. Isoform-specific functions of protein kinase C: the platelet paradigm. Biochem. Soc. Trans. 35 (2007) 1005-1008
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 1005-1008
-
-
Harper, M.T.1
Poole, A.W.2
-
45
-
-
0035914445
-
Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in platelets
-
Yoshioka A., et al. Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in platelets. J. Biol. Chem. 276 (2001) 39379-39385
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39379-39385
-
-
Yoshioka, A.1
-
46
-
-
0038712739
-
Direct demonstration of involvement of protein kinase Calpha in the Ca2+-induced platelet aggregation
-
Tabuchi A., et al. Direct demonstration of involvement of protein kinase Calpha in the Ca2+-induced platelet aggregation. J. Biol. Chem. 278 (2003) 26374-26379
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 26374-26379
-
-
Tabuchi, A.1
-
47
-
-
14844302394
-
Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets
-
Pula G., et al. Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets. J. Biol. Chem. 280 (2005) 7194-7205
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7194-7205
-
-
Pula, G.1
-
48
-
-
33748454742
-
Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3
-
Han J., et al. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr. Biol. 16 (2006) 1796-1806
-
(2006)
Curr. Biol.
, vol.16
, pp. 1796-1806
-
-
Han, J.1
-
49
-
-
51349135500
-
Protein kinase C isozymes as therapeutic targets for treatment of human cancers
-
Fields A.P., and Murray N.R. Protein kinase C isozymes as therapeutic targets for treatment of human cancers. Adv. Enzyme Regul. 48 (2008) 166-178
-
(2008)
Adv. Enzyme Regul.
, vol.48
, pp. 166-178
-
-
Fields, A.P.1
Murray, N.R.2
-
50
-
-
4143112597
-
Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells
-
Koivunen J., et al. Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells. Cancer Res. 64 (2004) 5693-5701
-
(2004)
Cancer Res.
, vol.64
, pp. 5693-5701
-
-
Koivunen, J.1
-
51
-
-
0035150233
-
High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells
-
Masur K., et al. High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. Mol. Biol. Cell 12 (2001) 1973-1982
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1973-1982
-
-
Masur, K.1
-
52
-
-
0034980135
-
Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer
-
Fournier D.B., et al. Protein kinase C alpha expression is inversely related to ER status in endometrial carcinoma: possible role in AP-1-mediated proliferation of ER-negative endometrial cancer. Gynecol. Oncol. 81 (2001) 366-372
-
(2001)
Gynecol. Oncol.
, vol.81
, pp. 366-372
-
-
Fournier, D.B.1
-
53
-
-
3242809148
-
Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate
-
Koren R., et al. Expression of protein kinase C isoenzymes in benign hyperplasia and carcinoma of prostate. Oncol. Rep. 11 (2004) 321-326
-
(2004)
Oncol. Rep.
, vol.11
, pp. 321-326
-
-
Koren, R.1
-
54
-
-
0034848941
-
Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy
-
Langzam L., et al. Patterns of protein kinase C isoenzyme expression in transitional cell carcinoma of bladder. Relation to degree of malignancy. Am. J. Clin. Pathol. 116 (2001) 377-385
-
(2001)
Am. J. Clin. Pathol.
, vol.116
, pp. 377-385
-
-
Langzam, L.1
-
55
-
-
4444275128
-
Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas
-
Varga A., et al. Tumor grade-dependent alterations in the protein kinase C isoform pattern in urinary bladder carcinomas. Eur. Urol. 46 (2004) 462-465
-
(2004)
Eur. Urol.
, vol.46
, pp. 462-465
-
-
Varga, A.1
-
56
-
-
31144449363
-
The role of protein kinase C-alpha in hematologic malignancies
-
Lahn M., et al. The role of protein kinase C-alpha in hematologic malignancies. Acta Haematol. 115 (2006) 1-8
-
(2006)
Acta Haematol.
, vol.115
, pp. 1-8
-
-
Lahn, M.1
-
57
-
-
0043136680
-
Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma
-
Neill G.W., et al. Loss of protein kinase Calpha expression may enhance the tumorigenic potential of Gli1 in basal cell carcinoma. Cancer Res. 63 (2003) 4692-4697
-
(2003)
Cancer Res.
, vol.63
, pp. 4692-4697
-
-
Neill, G.W.1
-
58
-
-
5644271449
-
Protein kinase C alpha expression in breast and ovarian cancer
-
Lahn M., et al. Protein kinase C alpha expression in breast and ovarian cancer. Oncology 67 (2004) 1-10
-
(2004)
Oncology
, vol.67
, pp. 1-10
-
-
Lahn, M.1
-
59
-
-
33744936606
-
Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors
-
Tan M., et al. Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. Oncogene 25 (2006) 3286-3295
-
(2006)
Oncogene
, vol.25
, pp. 3286-3295
-
-
Tan, M.1
-
60
-
-
1242273836
-
Immunohistochemical analysis of advanced human breast carcinomas reveals downregulation of protein kinase C alpha
-
Kerfoot C., et al. Immunohistochemical analysis of advanced human breast carcinomas reveals downregulation of protein kinase C alpha. J. Histochem. Cytochem. 52 (2004) 419-422
-
(2004)
J. Histochem. Cytochem.
, vol.52
, pp. 419-422
-
-
Kerfoot, C.1
-
61
-
-
2442543262
-
The role of protein kinase C-alpha (PKC-alpha) in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen
-
Hanauske A.R., et al. The role of protein kinase C-alpha (PKC-alpha) in cancer and its modulation by the novel PKC-alpha-specific inhibitor aprinocarsen. Curr. Pharm. Des. 10 (2004) 1923-1936
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 1923-1936
-
-
Hanauske, A.R.1
-
62
-
-
0034781901
-
ISIS-3521. Isis Pharmaceuticals
-
Li K., and Zhang J. ISIS-3521. Isis Pharmaceuticals. Curr. Opin. Investig. Drugs 2 (2001) 1454-1461
-
(2001)
Curr. Opin. Investig. Drugs
, vol.2
, pp. 1454-1461
-
-
Li, K.1
Zhang, J.2
-
63
-
-
4644262519
-
A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer
-
Villalona-Calero M.A., et al. A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer. Clin. Cancer Res. 10 (2004) 6086-6093
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 6086-6093
-
-
Villalona-Calero, M.A.1
-
64
-
-
19944422076
-
A phase II trial of ISIS 3521 in patients with metastatic colorectal cancer
-
Marshall J.L., et al. A phase II trial of ISIS 3521 in patients with metastatic colorectal cancer. Clin. Colorectal. Cancer 4 (2004) 268-274
-
(2004)
Clin. Colorectal. Cancer
, vol.4
, pp. 268-274
-
-
Marshall, J.L.1
-
65
-
-
9144226837
-
A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma
-
Advani R., et al. A Phase II trial of aprinocarsen, an antisense oligonucleotide inhibitor of protein kinase C alpha, administered as a 21-day infusion to patients with advanced ovarian carcinoma. Cancer 100 (2004) 321-326
-
(2004)
Cancer
, vol.100
, pp. 321-326
-
-
Advani, R.1
-
66
-
-
0037397817
-
Antisense therapy directed to protein kinase C-alpha (Affinitak, LY900003/ISIS 3521): potential role in breast cancer
-
Roychowdhury D., and Lahn M. Antisense therapy directed to protein kinase C-alpha (Affinitak, LY900003/ISIS 3521): potential role in breast cancer. Semin Oncol. 30 (2003) 30-33
-
(2003)
Semin Oncol.
, vol.30
, pp. 30-33
-
-
Roychowdhury, D.1
Lahn, M.2
-
67
-
-
0036023413
-
A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer
-
Tolcher A.W., et al. A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. Clin. Cancer Res. 8 (2002) 2530-2535
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 2530-2535
-
-
Tolcher, A.W.1
-
68
-
-
4644305430
-
Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma
-
Rao S., et al. Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma. Ann. Oncol. 15 (2004) 1413-1418
-
(2004)
Ann. Oncol.
, vol.15
, pp. 1413-1418
-
-
Rao, S.1
-
69
-
-
33645453677
-
Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer
-
Paz-Ares L., et al. Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer. J. Clin. Oncol. 24 (2006) 1428-1434
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 1428-1434
-
-
Paz-Ares, L.1
-
70
-
-
64149103614
-
Protein kinase C intervention: the state of play
-
Roffey J., et al. Protein kinase C intervention: the state of play. Curr. Opin. Cell Biol. 21 (2009) 268-279
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 268-279
-
-
Roffey, J.1
-
71
-
-
53549089928
-
Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors
-
Cole D.C., et al. Identification, characterization and initial hit-to-lead optimization of a series of 4-arylamino-3-pyridinecarbonitrile as protein kinase C theta (PKCtheta) inhibitors. J. Med. Chem. 51 (2008) 5958-5963
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5958-5963
-
-
Cole, D.C.1
-
72
-
-
68049086486
-
Protein Kinase C{alpha}, but Not PKC{beta} or PKC{gamma}, Regulates Contractility and Heart Failure Susceptibility. Implications for Ruboxistaurin As a Novel Therapeutic Approach
-
Liu Q., et al. Protein Kinase C{alpha}, but Not PKC{beta} or PKC{gamma}, Regulates Contractility and Heart Failure Susceptibility. Implications for Ruboxistaurin As a Novel Therapeutic Approach. Circ. Res. 105 (2009) 194-200
-
(2009)
Circ. Res.
, vol.105
, pp. 194-200
-
-
Liu, Q.1
-
74
-
-
34250702110
-
The role of protein kinase C activation and the vascular complications of diabetes
-
Das Evcimen N., and King G.L. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol. Res. 55 (2007) 498-510
-
(2007)
Pharmacol. Res.
, vol.55
, pp. 498-510
-
-
Das Evcimen, N.1
King, G.L.2
-
75
-
-
34547687425
-
Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer
-
Rademaker-Lakhai J.M., et al. Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer. Clin. Cancer Res. 13 (2007) 4474-4481
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 4474-4481
-
-
Rademaker-Lakhai, J.M.1
-
76
-
-
0025258567
-
Chelerythrine is a potent and specific inhibitor of protein kinase C
-
Herbert J.M., et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem. Biophys Res. Commun. 172 (1990) 993-999
-
(1990)
Biochem. Biophys Res. Commun.
, vol.172
, pp. 993-999
-
-
Herbert, J.M.1
-
77
-
-
0028055160
-
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts
-
Szallasi Z., et al. Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts. J. Biol. Chem. 269 (1994) 2118-2124
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2118-2124
-
-
Szallasi, Z.1
-
78
-
-
38949138457
-
Function-oriented synthesis, step economy, and drug design
-
Wender P.A., et al. Function-oriented synthesis, step economy, and drug design. Acc. Chem. Res. 41 (2008) 40-49
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 40-49
-
-
Wender, P.A.1
-
79
-
-
0025784927
-
Inhibition of protein kinase C by calphostin C is light-dependent
-
Bruns R.F., et al. Inhibition of protein kinase C by calphostin C is light-dependent. Biochem. Biophys Res. Commun. 176 (1991) 288-293
-
(1991)
Biochem. Biophys Res. Commun.
, vol.176
, pp. 288-293
-
-
Bruns, R.F.1
-
80
-
-
4544323559
-
PKC-interacting proteins: from function to pharmacology
-
Poole A.W., et al. PKC-interacting proteins: from function to pharmacology. Trends Pharmacol. Sci. 25 (2004) 528-535
-
(2004)
Trends Pharmacol. Sci.
, vol.25
, pp. 528-535
-
-
Poole, A.W.1
-
81
-
-
58149175775
-
Rationally designed peptide regulators of protein kinase C
-
Churchill E.N., et al. Rationally designed peptide regulators of protein kinase C. Trends Endocrinol. Metab. 20 (2009) 25-33
-
(2009)
Trends Endocrinol. Metab.
, vol.20
, pp. 25-33
-
-
Churchill, E.N.1
-
82
-
-
39449092458
-
Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction
-
Bates E., et al. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation 117 (2008) 886-896
-
(2008)
Circulation
, vol.117
, pp. 886-896
-
-
Bates, E.1
-
83
-
-
0035986315
-
Molecular characterization of protein kinase C-alpha binding to lamin A
-
Martelli A.M., et al. Molecular characterization of protein kinase C-alpha binding to lamin A. J. Cell Biochem. 86 (2002) 320-330
-
(2002)
J. Cell Biochem.
, vol.86
, pp. 320-330
-
-
Martelli, A.M.1
-
84
-
-
0035996587
-
Binding of elements of protein kinase C-alpha regulatory domain to lamin B1
-
Tabellini G., et al. Binding of elements of protein kinase C-alpha regulatory domain to lamin B1. Cell Signal. 14 (2002) 819-827
-
(2002)
Cell Signal.
, vol.14
, pp. 819-827
-
-
Tabellini, G.1
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