Characterization of variable regions of monoclonal antibodies by top-down mass spectrometry

Analytical Chemistry

Volumn 79, Issue 15, 2007, Pages 5723-5729

  Zhang, Zhongqi ^a   Shah, Bhavana ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKING; DISSOCIATION; ION SOURCES; MASS SPECTROMETRY; SENSITIVITY ANALYSIS;

CHARGE STATES; COLLISION-INDUCED DISSOCIATION; CYSTEINE RESIDUES; HYDROPEROXIDES;

MONOCLONAL ANTIBODIES;

CYSTEINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; METHIONINE; MONOCLONAL ANTIBODY; TERT BUTYL HYDROPEROXIDE;

AMINO TERMINAL SEQUENCE; ANALYTIC METHOD; ARTICLE; COLLISIONALLY ACTIVATED DISSOCIATION; DISULFIDE BOND; HEAVY CHAIN; LIGHT CHAIN; MASS SPECTROMETER; MASS SPECTROMETRY; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; SENSITIVITY AND SPECIFICITY;

ANTIBODIES, MONOCLONAL; CYSTEINE; DISULFIDES; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IONS; MASS SPECTROMETRY; METHIONINE; TERT-BUTYLHYDROPEROXIDE;

EID: 34547751263     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac070483q     Document Type: Article

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