Human pluripotent stem cell-derived cardiomyocytes as research and therapeutic tools

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Acimovic, Ivana ^a   Vilotic, Aleksandra ^a   Pesl, Martin ^a,b   Lacampagne, Alain ^c   Dvorak, Petr ^a,b   Rotrekl, Vladimir ^a   Meli, Albano C ^a,c  

^a MASARYK UNIVERSITY   (Czech Republic)

^b ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^c UNIVERSITY OF MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR;

CARDIAC CHANNELOPATHY; CARDIOMYOPATHY; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CELL DIFFERENTIATION; CELL MATURATION; CELL THERAPY; CELL TRANSDIFFERENTIATION; CELL TYPE; COCULTURE; DISEASE MODEL; DRUG SCREENING; EMBRYOID BODY; EMBRYONIC STEM CELL; EXCITATION CONTRACTION COUPLING; GERM LAYER; HEART; HEART DISEASE; HEART MUSCLE CELL; HUMAN; LEOPARD SYNDROME; LONG QT SYNDROME; LONG QT SYNDROME 1; LONG QT SYNDROME 2; LONG QT SYNDROME 3; LONG QT SYNDROME 8; MOLECULE; NONHUMAN; PLURIPOTENT STEM CELL; REVIEW; SOMATIC CELL; TISSUE ENGINEERING; WNT SIGNALING PATHWAY; STEM CELL RESEARCH;

HUMANS; MYOCYTES, CARDIAC; PLURIPOTENT STEM CELLS; STEM CELL RESEARCH;

EID: 84899545927     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/512831     Document Type: Review

References (172)

1. Nichols M., Townsend N., Scarborough P., Rayner M., European cardiovascular disease statistics 4th edition 2012: EuroHeart II. European Heart Journal 2013 34 39 3007
2. Whelan R. S., Kaplinskiy V., Kitsis R. N., Cell death in the pathogenesis of heart disease: mechanisms and significance. Annual Review of Physiology 2009 72 19 44 2-s2.0-77951901715 10.1146/annurev.physiol.010908.163111
3. Bergmann O., Bhardwaj R. D., Bernard S., Zdunek S., Barnabé-Heide F., Walsh S., Zupicich J., Alkass K., Buchholz B. A., Druid H., Jovinge S., Frisén J., Evidence for cardiomyocyte renewal in humans. Science 2009 324 5923 98 102 2-s2.0-64249107059 10.1126/science.1164680
4. Kajstura J., Gurusamy N., Ogórek B., Goichberg P., Clavo-Rondon C., Hosoda T., D'Amario D., Bardelli S., Beltrami A. P., Cesselli D., Bussani R., Del Monte F., Quaini F., Rota M., Beltrami C. A., Buchholz B. A., Leri A., Anversa P., Myocyte turnover in the aging human heart. Circulation Research 2010 107 11 1374 1386 2-s2.0-78650419568 10.1161/CIRCRESAHA.110.231498
5. Kajstura J., Rota M., Cappetta D., Ogorek B., Arranto C., Bai Y., Ferreira-Martins J., Signore S., Sanada F., Matsuda A., Kostyla J., Caballero M. V., Fiorini C., D'Alessandro D. A., Michler R. E., del Monte F., Hosoda T., Perrella M. A., Leri A., Buchholz B. A., Loscalzo J., Anversa P., Cardiomyogenesis in the aging and failing human heart. Circulation 2012 126 15 1869 1881
6. Mollova M., Bersell K., Walsh S., Savla J., Das L. T., Park S. Y., Silberstein L. E., Dos Remedios C. G., Graham D., Colan S., Kuhn B., Cardiomyocyte proliferation contributes to heart growth in young humans. Proceedings of the National Academy of Sciences of the United States of America 2013 110 1446 1451
7. Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007 131 5 861 872 2-s2.0-36248966518 10.1016/j.cell.2007.11.019 (Pubitemid 350138099)
8. Aasen T., Belmonte J. C. I., Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nature Protocols 2010 5 2 371 382 2-s2.0-76549260925 10.1038/nprot.2009.241
9. Ohmine S., Squillace K. A., Hartjes K. A., Deeds M. C., Armstrong A. S., Thatava T., Sakuma T., Terzic A., Kudva Y., Ikeda Y., Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency. Aging 2012 4 1 60 73 2-s2.0-84859491432
10. Phillips M. J., Wallace K. A., Dickerson S. J., Miller M. J., Verhoeven A. D., Martin J. M., Wright L. S., Shen W., Capowski E. E., Percin E. F., Perez E. T., Zhong X., Canto-Soler M. V., Gamm D. M., Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses. Investigative Ophthalmology and Visual Science 2012 53 2007 2019
11. Streckfuss-Bomeke K., Wolf F., Azizian A., Stauske M., Tiburcy M., Wagner S., Hubscher D., Dressel R., Chen S., Jende J., Wulf G., Lorenz V., Schon M. P., Maier L. S., Zimmermann W. H., Hasenfuss G., Guan K., Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts. European Heart Journal 2013 34 2618 2629
12. Xue Y., Cai X., Wang L., Liao B., Zhang H., Shan Y., Chen Q., Zhou T., Li X., Hou J., Chen S., Luo R., Qin D., Pei D., Pan G., Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells. PLoS ONE 2013 8 e70573
13. Evans M. J., Kaufman M. H., Establishment in culture of pluripotential cells from mouse embryos. Nature 1981 292 5819 154 156 2-s2.0-0019826665 (Pubitemid 11050741)
14. Thomson J. A., Itskovitz-Eldor J., Shapiro S. S., Waknitz M. A., Swiergiel J. J., Marshall V. S., Jones J. M., Embryonic stem cell lines derived from human blastocysts. Science 1998 282 5391 1145 1147 2-s2.0-0032491416 (Pubitemid 28516247)
15. Andrews P. W., Human teratocarcinomas. Biochimica et Biophysica Acta 1988 948 1 17 36 2-s2.0-0023792795
16. Blum B., Benvenisty N., The tumorigenicity of human embryonic stem cells. Advances in Cancer Research 2008 100 133 158 2-s2.0-46449113364 10.1016/S0065-230X(08)00005-5 (Pubitemid 351932182)
17. Bulic-Jakus F., Ulamec M., Vlahovic M., Sincic N., Katusic A., Juric-Lekc G., Serman L., Kruslin B., Belicza M., Of mice and men: teratomas and teratocarcinomas. Collegium Antropologicum 2006 30 921 924
18. Damjanov I., Andrews P. W., The terminology of teratocarcinomas and teratomas. Nature Biotechnology 2007 25 11 1212 2-s2.0-35948988905 10.1038/nbt1107-1212a (Pubitemid 350076498)
19. Ben-David U., Benvenisty N., The tumorigenicity of human embryonic and induced pluripotent stem cells. Nature Reviews Cancer 2011 11 4 268 277 2-s2.0-79953058250 10.1038/nrc3034
20. Lister R., Pelizzola M., Kida Y. S., Hawkins R. D., Nery J. R., Hon G., Antosiewicz-Bourget J., Ogmalley R., Castanon R., Klugman S., Downes M., Yu R., Stewart R., Ren B., Thomson J. A., Evans R. M., Ecker J. R., Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 2011 471 7336 68 73 2-s2.0-79952264847 10.1038/nature09798
21. Damjanov I., Teratocarcinoma: neoplastic lessons about normal embryogenesis. International Journal of Developmental Biology 1993 37 1 39 46 2-s2.0-0027286117 (Pubitemid 23145236)
22. Yu J., Vodyanik M. A., Smuga-Otto K., Antosiewicz-Bourget J., Frane J. L., Tian S., Nie J., Jonsdottir G. A., Ruotti V., Stewart R., Slukvin I. I., Thomson J. A., Induced pluripotent stem cell lines derived from human somatic cells. Science 2007 318 5858 1917 1920 2-s2.0-36749043230 10.1126/science. 1151526
23. Nakagawa M., Koyanagi M., Tanabe K., Takahashi K., Ichisaka T., Aoi T., Okita K., Mochiduki Y., Takizawa N., Yamanaka S., Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nature Biotechnology 2008 26 1 101 106 2-s2.0-38049028459 10.1038/nbt1374
24. Huangfu D., Osafune K., Maehr R., Guo W., Eijkelenboom A., Chen S., Muhlestein W., Melton D. A., Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature Biotechnology 2008 26 11 1269 1275 2-s2.0-55749104227 10.1038/nbt.1502
25. Woltjen K., Michael I. P., Mohseni P., Desai R., Mileikovsky M., Hämäläinen R., Cowling R., Wang W., Liu P., Gertsenstein M., Kaji K., Sung H.-K., Nagy A., PiggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009 458 7239 766 770 2-s2.0-64749083939 10.1038/nature07863
26. Huber I., Habib M., Winterstern A., Gepstein A., Arbel G., Gepstein L., Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients. European Heart Journal 2013 34 21 1575 1586
27. Stadtfeld M., Nagaya M., Utikal J., Weir G., Hochedlinger K., Induced pluripotent stem cells generated without viral integration. Science 2008 322 5903 945 949 2-s2.0-55849115999 10.1126/science.1162494
28. Warren L., Manos P. D., Ahfeldt T., Loh Y.-H., Li H., Lau F., Ebina W., Mandal P. K., Smith Z. D., Meissner A., Daley G. Q., Brack A. S., Collins J. J., Cowan C., Schlaeger T. M., Rossi D. J., Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 2010 7 5 618 630 2-s2.0-77958536106 10.1016/j.stem.2010. 08.012
29. Zhou H., Wu S., Joo J. Y., Zhu S., Han D. W., Lin T., Trauger S., Bien G., Yao S., Zhu Y., Siuzdak G., Schöler H. R., Duan L., Ding S., Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 2009 4 5 381 384 2-s2.0-66049135249 10.1016/j.stem.2009.04.005
30. Kim D., Kim C.-H., Moon J.-I., Chung Y.-G., Chang M.-Y., Han B.-S., Ko S., Yang E., Cha K. Y., Lanza R., Kim K.-S., Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009 4 6 472 476 2-s2.0-66049143859 10.1016/j.stem.2009.05.005
31. Lee J., Sayed N., Hunter A., Au K. F., Wong W. H., Mocarski E. S., Pera R. R., Yakubov E., Cooke J. P., Activation of innate immunity is required for efficient nuclear reprogramming. Cell 2012 151 547 558
32. Mummery C., Ward-Van Oostwaard D., Doevendans P., Spijker R., Van den Brink S., Hassink R., Van der Heyden M., Opthof T., Pera M., Brutel de la Riviere A., Passier R., Tertoolen L., Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 2003 107 21 2733 2740 2-s2.0-0038210217 (Pubitemid 36667249)
33. Passier R., Ward-Van Oostwaard D., Snapper J., Kloots J., Hassink R. J., Kuijk E., Roelen B., Brutel De La Riviere A., Mummery C., Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures. Stem Cells 2005 23 6 772 780 2-s2.0-20344372655 10.1634/stemcells. 2004-0184 (Pubitemid 40791792)
34. Freund C., Davis R. P., Gkatzis K., Ward-Van Oostwaard D., Mummery C. L., The first reported generation of human induced pluripotent stem cells (iPS cells) and iPS cell-derived cardiomyocytes in the Netherlands. Netherlands Heart Journal 2010 18 1 51 54 2-s2.0-77149150311
35. McLean A. B., D'Amour K. A., Jones K. L., Krishnamoorthy M., Kulik M. J., Reynolds D. M., Sheppard A. M., Liu H., Xu Y., Baetge E. E., Dalton S., Activin A efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 2007 25 1 29 38 2-s2.0-33845996144 10.1634/stemcells.2006-0219 (Pubitemid 46052972)
36. Freund C., Ward-Van Oostwaard D., Monshouwer-Kloots J., Van Den Brink S., Van Rooijen M., Xu X., Zweigerdt R., Mummery C., Passier R., Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells. Stem Cells 2008 26 3 724 733 2-s2.0-43049122179 10.1634/stemcells.2007-0617
37. Takahashi T., Lord B., Schulze P. C., Fryer R. M., Sarang S. S., Gullans S. R., Lee R. T., Ascorbic acid enhances differentiation of embryonic stem cells into cardiac myocytes. Circulation 2003 107 14 1912 1916 2-s2.0-0037446546 10.1161/01.CIR.0000064899.53876.A3 (Pubitemid 36444134)
38. Cao N., Liu Z., Chen Z., Wang J., Chen T., Zhao X., Ma Y., Qin L., Kang J., Wei B., Wang L., Jin Y., Yang H.-T., Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Research 2012 22 1 219 236 2-s2.0-84855487976 10.1038/cr.2011.195
39. Kehat I., Kenyagin-Karsenti D., Snir M., Segev H., Amit M., Gepstein A., Livne E., Binah O., Itskovitz-Eldor J., Gepstein L., Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. Journal of Clinical Investigation 2001 108 3 407 414 2-s2.0-0034904645 10.1172/JCI200112131 (Pubitemid 32730787)
40. Takei S., Ichikawa H., Johkura K., Mogi A., No H., Yoshie S., Tomotsune D., Sasaki K., Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development. The American Journal of Physiology 2009 296 6 H1793 H1803 2-s2.0-66949175935 10.1152/ajpheart.01288.2008
41. Bettiol E., Sartiani L., Chicha L., Krause K. H., Cerbai E., Jaconi M. E., Fetal bovine serum enables cardiac differentiation of human embryonic stem cells. Differentiation 2007 75 8 669 681 2-s2.0-35148883017 10.1111/j.1432-0436. 2007.00174.x (Pubitemid 47537526)
42. Xu C., Police S., Rao N., Carpenter M. K., Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circulation Research 2002 91 6 501 508 2-s2.0-0037144701 10.1161/01.RES. 0000035254.80718.91
43. Xu C., He J.-Q., Kamp T. J., Police S., Hao X., O'Sullivan C., Carpenter M. K., Lebkowski J., Gold J. D., Human embryonic stem cell-derived cardiomyocytes can be maintained in defined medium without serum. Stem Cells and Development 2006 15 6 931 941 2-s2.0-33846406040 10.1089/scd.2006.15.931 (Pubitemid 46147863)
44. Dai W., Field L. J., Rubart M., Reuter S., Hale S. L., Zweigerdt R., Graichen R. E., Kay G. L., Jyrala A. J., Colman A., Davidson B. P., Pera M., Kloner R. A., Survival and maturation of human embryonic stem cell-derived cardiomyocytes in rat hearts. Journal of Molecular and Cellular Cardiology 2007 43 4 504 516 2-s2.0-34648847052 10.1016/j.yjmcc.2007.07.001 (Pubitemid 47454736)
45. Xu X. Q., Graichen R., Soo S. Y., Balakrishnan T., Bte Rahmat S. N., Sieh S., Tham S. C., Freund C., Moore J., Mummery C., Colman A., Zweigerdt R., Davidson B. P., Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells. Differentiation 2008 76 9 958 970 2-s2.0-54249098708 10.1111/j.1432-0436.2008.00284.x
46. Graichen R., Xu X., Braam S. R., Balakrishnan T., Norfiza S., Sieh S., Soo S. Y., Tham S. C., Mummery C., Colman A., Zweigerdt R., Davidson B. P., Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation 2008 76 4 357 370 2-s2.0-42149094990 10.1111/j.1432-0436.2007.00236.x (Pubitemid 351522761)
47. Zhang P., Li J., Tan Z., Wang C., Liu T., Chen L., Yong J., Jiang W., Sun X., Du L., Ding M., Deng H., Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood 2008 111 4 1933 1941 2-s2.0-39349091570 10.1182/blood-2007-02-074120 (Pubitemid 351451502)
48. Xu R.-H., Chen X., Li D. S., Li R., Addicks G. C., Glennon C., Zwaka T. P., Thomson J. A., BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nature Biotechnology 2002 20 12 1261 1264 2-s2.0-1842853507 10.1038/nbt761 (Pubitemid 35462493)
49. Conley B. J., Ellis S., Gulluyan L., Mollard R., BMPs regulate differentiation of a putative visceral endoderm layer within human embryonic stem-cell-derived embryoid bodies. Biochemistry and Cell Biology 2007 85 1 121 132 2-s2.0-34249931655 10.1139/O06-145 (Pubitemid 46877395)
50. Lian X., Hsiao C., Wilson G., Zhu K., Hazeltine L. B., Azarin S. M., Raval K. K., Zhang J., Kamp T. J., Palecek S. P., Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America 2012 109 E1848 E1857
51. Tran T. H., Wang X., Browne C., Zhang Y., Schinke M., Izumo S., Burcin M., Wnt3a-induced mesoderm formation and cardiomyogenesis in human embryonic stem cells. Stem Cells 2009 27 8 1869 1878 2-s2.0-69249121687 10.1002/stem.95
52. Minami I., Yamada K., Otsuji T. G., Yamamoto T., Shen Y., Otsuka S., Kadota S., Morone N., Barve M., Asai Y., Tenkova-Heuser T., Heuser J. E., Uesugi M., Aiba K., Nakatsuji N., A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Reports 2012 2 1448 1460
53. Ren Y., Lee M. Y., Schliffke S., Paavola J., Amos P. J., Ge X., Ye M., Zhu S., Senyei G., Lum L., Ehrlich B. E., Qyang Y., Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. Journal of Molecular and Cellular Cardiology 2011 51 3 280 287 2-s2.0-79960913156 10.1016/j.yjmcc.2011.04.012
54. Willems E., Spiering S., Davidovics H., Lanier M., Xia Z., Dawson M., Cashman J., Mercola M., Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm. Circulation Research 2011 109 4 360 364 2-s2.0-80051796581 10.1161/CIRCRESAHA. 111.249540
55. Yang L., Soonpaa M. H., Adler E. D., Roepke T. K., Kattman S. J., Kennedy M., Henckaerts E., Bonham K., Abbott G. W., Linden R. M., Field L. J., Keller G. M., Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 2008 453 7194 524 528 2-s2.0-44349175948 10.1038/nature06894 (Pubitemid 351733312)
56. Kattman S. J., Witty A. D., Gagliardi M., Dubois N. C., Niapour M., Hotta A., Ellis J., Keller G., Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell 2011 8 2 228 240 2-s2.0-79551597211 10.1016/j.stem.2010.12.008
57. Pesl M., Acimovic I., Pribyl J., Hezova R., Vilotic A., Fauconnier J., Vrbsky J., Kruzliak P., Skladal P., Kara T., Rotrekl V., Lacampagne A., Dvorak P., Meli A. C., Forced aggregation and defined factors allow highly uniform-sized embryoid bodies and functional cardiomyocytes from human embryonic and induced pluripotent stem cells. Heart and Vessels 2013 10.1007/s00380-013- 0436-9
58. Lim S. Y., Sivakumaran P., Crombie D. E., Dusting G. J., Pebay A., Dilley R. J., Trichostatin A enhances differentiation of human induced pluripotent stem cells to cardiogenic cells for cardiac tissue engineering. Stem Cells Translational Medicine 2013 2 715 725
59. Bader A., Gruss A., Höllrigl A., Al-Dubai H., Capetanaki Y., Weitzer G., Paracrine promotion of cardiomyogenesis in embryoid bodies by LIF modulated endoderm. Differentiation 2001 68 1 31 43 2-s2.0-0035724851 10.1046/j.1432-0436.2001.068001031.x (Pubitemid 34203526)
60. Lee M. Y., Cagavi Bozkulak E., Schliffke S., Amos P. J., Ren Y., Ge X., Ehrlich B. E., Qyang Y., High density cultures of embryoid bodies enhanced cardiac differentiation of murine embryonic stem cells. Biochemical and Biophysical Research Communications 2011 416 1-2 51 57 2-s2.0-83055173311 10.1016/j.bbrc.2011.10.140
61. Bauwens C. L., Peerani R., Niebruegge S., Woodhouse K. A., Kumacheva E., Husain M., Zandstra P. W., Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories. Stem Cells 2008 26 9 2300 2310 2-s2.0-55049120510 10.1634/stemcells.2008-0183
62. Ungrin M. D., Joshi C., Nica A., Bauwens C., Zandstra P. W., Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates. PLoS ONE 2008 3 2 2-s2.0-45349084219 10.1371/journal.pone.0001565 e1565 (Pubitemid 351843814)
63. Watanabe K., Ueno M., Kamiya D., Nishiyama A., Matsumura M., Wataya T., Takahashi J. B., Nishikawa S., Nishikawa S.-I., Muguruma K., Sasai Y., A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnology 2007 25 6 681 686 2-s2.0-34250206996 10.1038/nbt1310 (Pubitemid 46897207)
64. Ng E. S., Davis R. P., Azzola L., Stanley E. G., Elefanty A. G., Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation. Blood 2005 106 5 1601 1603 2-s2.0-23944454402 10.1182/blood-2005-03-0987 (Pubitemid 41208571)
65. Burridge P. W., Anderson D., Priddle H., Barbadillo Muñoz M. D., Chamberlain S., Allegrucci C., Young L. E., Denning C., Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells 2007 25 4 929 938 2-s2.0-34147124971 10.1634/stemcells.2006-0598 (Pubitemid 46572590)
66. Burridge P. W., Thompson S., Millrod M. A., Weinberg S., Yuan X., Peters A., Mahairaki V., Koliatsos V. E., Tung L., Zambidis E. T., A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability. PLoS ONE 2011 6 4 2-s2.0-79954543387 10.1371/journal.pone.0018293 e18293
67. Laflamme M. A., Chen K. Y., Naumova A. V., Muskheli V., Fugate J. A., Dupras S. K., Reinecke H., Xu C., Hassanipour M., Police S., O'Sullivan C., Collins L., Chen Y., Minami E., Gill E. A., Ueno S., Yuan C., Gold J., Murry C. E., Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nature Biotechnology 2007 25 9 1015 1024 2-s2.0-34948891467 10.1038/nbt1327 (Pubitemid 47517637)
68. Melkoumian Z., Weber J. L., Weber D. M., Fadeev A. G., Zhou Y., Dolley-Sonneville P., Yang J., Qiu L., Priest C. A., Shogbon C., Martin A. W., Nelson J., West P., Beltzer J. P., Pal S., Brandenberger R., Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells. Nature Biotechnology 2010 28 6 606 610 2-s2.0-77953284319 10.1038/nbt.1629
69. Paige S. L., Osugi T., Afanasiev O. K., Pabon L., Reinecke H., Murry C. E., Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells. PLoS ONE 2010 5 6 e11134 2-s2.0-77956213260 10.1371/journal.pone.0011134
70. Hudson J., Titmarsh D., Hidalgo A., Wolvetang E., Cooper-White J., Primitive cardiac cells from human embryonic stem cells. Stem Cells and Development 2012 21 9 1513 1523 10.1089/scd.2011.0254
71. Zhang Q., Jiang J., Han P., Yuan Q., Zhang J., Zhang X., Xu Y., Cao H., Meng Q., Chen L., Tian T., Wang X., Li P., Hescheler J., Ji G., Ma Y., Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Research 2011 21 4 579 587 2-s2.0-79954418253 10.1038/cr.2010.163
72. Uosaki H., Fukushima H., Takeuchi A., Matsuoka S., Nakatsuji N., Yamanaka S., Yamashita J. K., Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression. PLoS ONE 2011 6 e23657
73. Zhang J., Klos M., Wilson G. F., Herman A. M., Lian X., Raval K. K., Barron M. R., Hou L., Soerens A. G., Yu J., Palecek S. P., Lyons G. E., Thomson J. A., Herron T. J., Jalife J., Kamp T. J., Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circulation Research 2012 111 1125 1136
74. Lian X., Zhang J., Azarin S. M., Zhu K., Hazeltine L. B., Bao X., Hsiao C., Kamp T. J., Palecek S. P., Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/beta-catenin signaling under fully defined conditions. Nature Protocols 2013 8 162 175
75. Lian X., Zhang J., Zhu K., Kamp T. J., Palecek S. P., Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Stem Cells 2013 31 447 457
76. Steiner D., Khaner H., Cohen M., Even-Ram S., Gil Y., Itsykson P., Turetsky T., Idelson M., Aizenman E., Ram R., Berman-Zaken Y., Reubinoff B., Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension. Nature Biotechnology 2010 28 4 361 364 2-s2.0-77950677122 10.1038/nbt.1616
77. Singh H., Mok P., Balakrishnan T., Rahmat S. N. B., Zweigerdt R., Up-scaling single cell-inoculated suspension culture of human embryonic stem cells. Stem Cell Research 2010 4 3 165 179 2-s2.0-77952429809 10.1016/j.scr.2010.03.001
78. Olmer R., Haase A., Merkert S., Cui W., Paleček J., Ran C., Kirschning A., Scheper T., Glage S., Miller K., Curnow E. C., Hayes E. S., Martin U., Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium. Stem Cell Research 2010 5 1 51 64 2-s2.0-77953291028 10.1016/j.scr.2010.03.005
79. Zweigerdt R., Olmer R., Singh H., Haverich A., Martin U., Scalable expansion of human pluripotent stem cells in suspension culture. Nature Protocols 2011 6 5 689 700 2-s2.0-79955541641 10.1038/nprot.2011.318
80. Krawetz R., Taiani J. T., Liu S., Meng G., Li X., Kallos M. S., Rancourt D. E., Large-scale expansion of pluripotent human embryonic stem cells in stirred-suspension bioreactors. Tissue Engineering C 2010 16 4 573 582 2-s2.0-77955004097 10.1089/ten.tec.2009.0228
81. Olmer R., Lange A., Selzer S., Kasper C., Haverich A., Martin U., Zweigerdt R., Suspension culture of human pluripotent stem cells in controlled, stirred bioreactors. Tissue Engineering C 2012 18 772 784
82. Shafa M., Sjonnesen K., Yamashita A., Liu S., Michalak M., Kallos M. S., Rancourt D. E., Expansion and long-term maintenance of induced pluripotent stem cells in stirred suspension bioreactors. Journal of Tissue Engineering and Regenerative Medicine 2012 6 462 472 2-s2.0-79960317533 10.1002/term.450
83. Abbasalizadeh S., Larijani M. R., Samadian A., Baharvand H., Bioprocess development for mass production of size-controlled human pluripotent stem cell aggregates in stirred suspension bioreactor. Tissue Engineering C 2012 18 831 851
84. Bauwens C., Yin T., Dang S., Peerani R., Zandstra P. W., Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: oxygen-mediated enhancement of cardiomyocyte output. Biotechnology and Bioengineering 2005 90 4 452 461 2-s2.0-20344382984 10.1002/bit.20445 (Pubitemid 40779195)
85. Schroeder M., Niebruegge S., Werner A., Willbold E., Burg M., Ruediger M., Field L. J., Lehmann J., Zweigerdt R., Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control. Biotechnology and Bioengineering 2005 92 7 920 933 2-s2.0-33644821605 10.1002/bit.20668
86. Niebruegge S., Bauwens C. L., Peerani R., Thavandiran N., Masse S., Sevaptisidis E., Nanthakumar K., Woodhouse K., Husain M., Kumacheva E., Zandstra P. W., Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor. Biotechnology and Bioengineering 2009 102 2 493 507 2-s2.0-58249090413 10.1002/bit.22065
87. Jing D., Parikh A., Tzanakakis E. S., Cardiac cell generation from encapsulated embryonic stem cells in static and scalable culture systems. Cell Transplantation 2010 19 11 1397 1412 2-s2.0-78651513849 10.3727/096368910X513955
88. Yirme G., Amit M., Laevsky I., Osenberg S., Itskovitz-Eldor J., Establishing a dynamic process for the formation, propagation, and differentiation of human embryoid bodies. Stem Cells and Development 2008 17 6 1227 1241 2-s2.0-57449091705 10.1089/scd.2007.0272
89. Vunjak-Novakovic G., Scadden D. T., Biomimetic platforms for human stem cell research. Cell Stem Cell 2011 8 3 252 261 2-s2.0-79952158210 10.1016/j.stem.2011.02.014
90. Schaaf S., Shibamiya A., Mewe M., Eder A., Stöhr A., Hirt M. N., Rau T., Zimmermann W.-H., Conradi L., Eschenhagen T., Hansen A., Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology. PLoS ONE 2011 6 10 2-s2.0-80054783465 10.1371/journal.pone.0026397 e26397
91. Zimmermann W.-H., Melnychenko I., Wasmeier G., Didié M., Naito H., Nixdorff U., Hess A., Budinsky L., Brune K., Michaelis B., Dhein S., Schwoerer A., Ehmke H., Eschenhagen T., Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts. Nature Medicine 2006 12 4 452 458 2-s2.0-33645737594 10.1038/nm1394
92. Furuta A., Miyoshi S., Itabashi Y., Shimizu T., Kira S., Hayakawa K., Nishiyama N., Tanimoto K., Hagiwara Y., Satoh T., Fukuda K., Okano T., Ogawa S., Pulsatile cardiac tissue grafts using a novel three-dimensional cell sheet manipulation technique functionally integrates with the host heart, in vivo. Circulation Research 2006 98 5 705 712 2-s2.0-33645322993 10.1161/01.RES. 0000209515.59115.70
93. Shimizu T., Yamato M., Isoi Y., Akutsu T., Setomaru T., Abe K., Kikuchi A., Umezu M., Okano T., Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces. Circulation Research 2002 90 3, article e40 2-s2.0-0037155176
94. Bel A., Planat-Bernard V., Saito A., Bonnevie L., Bellamy V., Sabbah L., Bellabas L., Brinon B., Vanneaux V., Pradeau P., Peyrard S., Larghero J., Pouly J., Binder P., Garcia S., Shimizu T., Sawa Y., Okano T., Bruneval P., Desnos M., Hagège A. A., Casteilla L., Pucéat M., Menasché P., Composite cell sheets: a further step toward safe and effective myocardial regeneration by cardiac progenitors derived from embryonic stem cells. Circulation 2010 122 11 S118 S123 2-s2.0-77957223360 10.1161/CIRCULATIONAHA.109. 927293
95. Zimmermann W.-H., Schneiderbanger K., Schubert P., Didié M., Münzel F., Heubach J. F., Kostin S., Neuhuber W. L., Eschenhagen T., Tissue engineering of a differentiated cardiac muscle construct. Circulation Research 2002 90 2 223 230 2-s2.0-0037040160 10.1161/hh0202.103644 (Pubitemid 34627092)
96. Radisic M., Deen W., Langer R., Vunjak-Novakovic G., Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers. The American Journal of Physiology 2005 288 3 H1278 H1289 2-s2.0-13944255075 10.1152/ajpheart.00787. 2004 (Pubitemid 40270035)
97. Radisic M., Malda J., Epping E., Geng W., Langer R., Vunjak-Novakovic G., Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue. Biotechnology and Bioengineering 2006 93 2 332 343 2-s2.0-33645560618 10.1002/bit.20722
98. Radisic M., Park H., Chen F., Salazar-Lazzaro J. E., Wang Y., Dennis R., Langer R., Freed L. E., Vunjak-Novakovic G., Biomimetic approach to cardiac tissue engineering: oxygen carriers and channeled scaffolds. Tissue Engineering 2006 12 8 2077 2091 2-s2.0-33749460831 10.1089/ten.2006.12.2077 (Pubitemid 44734968)
99. Radisic M., Park H., Shing H., Consi T., Schoen F. J., Langer R., Freed L. E., Vunjak-Novakovic G., Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proceedings of the National Academy of Sciences of the United States of America 2004 101 52 18129 18134 2-s2.0-11144248959 10.1073/pnas.0407817101 (Pubitemid 40054085)
100. Tandon N., Cannizzaro C., Chao P.-H. G., Maidhof R., Marsano A., Au H. T. H., Radisic M., Vunjak-Novakovic G., Electrical stimulation systems for cardiac tissue engineering. Nature Protocols 2009 4 2 155 173 2-s2.0-59849092074 10.1038/nprot.2008.183
101. Chiu L. L. Y., Iyer R. K., King J.-P., Radisic M., Biphasic electrical field stimulation aids in tissue engineering of multicell-type cardiac organoids. Tissue Engineering A 2011 17 11-12 1465 1475 2-s2.0-79957599705 10.1089/ten.tea.2007.0244
102. Lu T. Y., Lin B., Kim J., Sullivan M., Tobita K., Salama G., Yang L., Repopulation of decellularized mouse heart with human induced pluripotent stem cell-derived cardiovascular progenitor cells. Nature Communications 2013 4 2307 10.1038/ncomms3307
103. Ott H. C., Matthiesen T. S., Goh S.-K., Black L. D., Kren S. M., Netoff T. I., Taylor D. A., Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nature Medicine 2008 14 2 213 221 2-s2.0-38949168818 10.1038/nm1684 (Pubitemid 351214548)
104. Caspi O., Lesman A., Basevitch Y., Gepstein A., Arbel G., Huber I., Habib M., Gepstein L., Levenberg S., Tissue engineering of vascularized cardiac muscle from human embryonic stem cells. Circulation Research 2007 100 2 263 272 2-s2.0-33846818621 10.1161/01.RES.0000257776.05673.ff (Pubitemid 46208727)
105. Stevens K. R., Pabon L., Muskheli V., Murry C. E., Scaffold-free human cardiac tissue patch created from embryonic stem cells. Tissue Engineering A 2009 15 6 1211 1222 2-s2.0-66249089481 10.1089/ten.tea.2008.0151
106. Lesman A., Habib M., Caspi O., Gepstein A., Arbel G., Levenberg S., Gepstein L., Transplantation of a tissue-engineered human vascularized cardiac muscle. Tissue Engineering A 2010 16 1 115 125 2-s2.0-77049110164 10.1089/ten.tea.2009.0130
107. Liau B., Christoforou N., Leong K. W., Bursac N., Pluripotent stem cell-derived cardiac tissue patch with advanced structure and function. Biomaterials 2011 32 35 9180 9187 2-s2.0-80053597056 10.1016/j.biomaterials. 2011.08.050
108. Matsuura K., Masuda S., Haraguchi Y., Yasuda N., Shimizu T., Hagiwara N., Zandstra P. W., Okano T., Creation of mouse embryonic stem cell-derived cardiac cell sheets. Biomaterials 2011 32 30 7355 7362 2-s2.0-80051545066 10.1016/j.biomaterials.2011.05.042
109. Satin J., Itzhaki I., Rapoport S., Schroder E. A., Izu L., Arbel G., Beyar R., Balke C. W., Schiller J., Gepstein L., Calcium handling in human embryonic stem cell-derived cardiomyocytes. Stem Cells 2008 26 8 1961 1972 2-s2.0-54249111025 10.1634/stemcells.2007-0591
110. Itzhaki I., Rapoport S., Huber I., Mizrahi I., Zwi-Dantsis L., Arbel G., Schiller J., Gepstein L., Calcium handling in human induced pluripotent stem cell derived cardiomyocytes. PLoS ONE 2011 6 4 2-s2.0-79953655401 10.1371/journal.pone.0018037 e18037
111. Zhang D., Shadrin I. Y., Lam J., Xian H. Q., Snodgrass H. R., Bursac N., Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. Biomaterials 2013 34 5813 5820
112. Davis R. L., Weintraub H., Lassar A. B., Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 1987 51 6 987 1000 2-s2.0-0023663888
113. Ambasudhan R., Talantova M., Coleman R., Yuan X., Zhu S., Lipton S. A., Ding S., Direct reprogramming of adult human fibroblasts to functional neurons
114. Caiazzo M., Dell'Anno M. T., Dvoretskova E., Lazarevic D., Taverna S., Leo D., Sotnikova T. D., Menegon A., Roncaglia P., Colciago G., Russo G., Carninci P., Pezzoli G., Gainetdinov R. R., Gustincich S., Dityatev A., Broccoli V., Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 2011 476 7359 224 227 2-s2.0-80051674431 10.1038/nature10284
115. Son E. Y., Ichida J. K., Wainger B. J., Toma J. S., Rafuse V. F., Woolf C. J., Eggan K., Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell 2011 9 3 205 218 2-s2.0-80052295767 10.1016/j.stem.2011.07.014
116. Huang P., He Z., Ji S., Sun H., Xiang D., Liu C., Hu Y., Wang X., Hui L., Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors. Nature 2011 475 7356 386 391 2-s2.0-79960637387 10.1038/nature10116
117. Sekiya S., Suzuki A., Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature 2011 475 7356 390 395 2-s2.0-79960649307 10.1038/nature10263
118. Ieda M., Fu J.-D., Delgado-Olguin P., Vedantham V., Hayashi Y., Bruneau B. G., Srivastava D., Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 2010 142 3 375 386 2-s2.0-77955321344 10.1016/j.cell.2010.07.002
119. Fu J. D., Stone N. R., Liu L., Spencer C. I., Qian L., Hayashi Y., Delgado-Olguin P., Ding S., Bruneau B. G., Srivastava D., Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports 2013 1 235 247
120. Wada R., Muraoka N., Inagawa K., Yamakawa H., Miyamoto K., Sadahiro T., Umei T., Kaneda R., Suzuki T., Kamiya K., Tohyama S., Yuasa S., Kokaji K., Aeba R., Yozu R., Yamagishi H., Kitamura T., Fukuda K., Ieda M., Induction of human cardiomyocyte-like cells from fibroblasts by defined factors. Proceedings of the National Academy of Sciences of the United States of America 2013 110 12667 12672
121. Inagawa K., Miyamoto K., Yamakawa H., Muraoka N., Sadahiro T., Umei T., Wada R., Katsumata Y., Kaneda R., Nakade K., Kurihara C., Obata Y., Miyake K., Fukuda K., Ieda M., Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5. Circulation Research 2012 111 1147 1156
122. Song K., Nam Y. J., Luo X., Qi X., Tan W., Huang G. N., Acharya A., Smith C. L., Tallquist M. D., Neilson E. G., Hill J. A., Bassel-Duby R., Olson E. N., Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 2012 485 599 604
123. Qian L., Huang Y., Spencer C. I., Foley A., Vedantham V., Liu L., Conway S. J., Fu J. D., Srivastava D., In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 2012 485 593 598
124. Anversa P., Kajstura J., Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circulation Research 1998 83 1 1 14 2-s2.0-0032514228 (Pubitemid 28322094)
125. Beltrami A. P., Urbanek K., Kajstura J., Yan S.-M., Finato N., Bussani R., Nadal-Ginard B., Silvestri F., Leri A., Beltrami C. A., Anversa P., Evidence that human cardiac myocytes divide after myocardial infarction. The New England Journal of Medicine 2001 344 23 1750 1757 2-s2.0-0035821988 10.1056/NEJM200106073442303 (Pubitemid 32497029)
126. Bergmann O., Zdunek S., Frisén J., Bernard S., Druid H., Jovinge S., Cardiomyocyte renewal in humans. Circulation Research 2012 110 1 e17 e18 2-s2.0-84855369318 10.1161/CIRCRESAHA.111.259598
127. Ivashchenko C. Y., Pipes G. C., Lozinskaya I. M., Lin Z., Xiaoping X., Needle S., Grygielko E. T., Hu E., Toomey J. R., Lepore J. J., Willette R. N., Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype. The American Journal of Physiology 2013 305 H913 H922
128. Lee Y.-K., Ng K.-M., Lai W.-H., Chan Y.-C., Lau Y.-M., Lian Q., Tse H.-F., Siu C.-W., Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Reviews and Reports 2011 7 4 976 986 2-s2.0-82355168775 10.1007/s12015-011-9273-3
129. Lundy S. D., Zhu W. Z., Regnier M., Laflamme M. A., Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells. Stem Cells and Development 2013 22 1991 2002
130. Moorman A. F. M., de Jong F., Denyn M. M. F. J., Lamers W. H., Development of the cardiac conduction system. Circulation Research 1998 82 6 629 644 2-s2.0-0032489857 (Pubitemid 28160704)
131. Cai C.-L., Liang X., Shi Y., Chu P.-H., Pfaff S. L., Chen J., Evans S., Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Developmental Cell 2003 5 6 877 889 2-s2.0-0346783332 10.1016/S1534-5807(03)00363-0 (Pubitemid 37527688)
132. Chen L., Fulcoli F. G., Tang S., Baldini A., Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circulation Research 2009 105 9 842 851 2-s2.0-70350719507 10.1161/CIRCRESAHA.109.200295
133. Blin G., Nury D., Stefanovic S., Neri T., Guillevic O., Brinon B., Bellamy V., Rücker-Martin C., Barbry P., Bel A., Bruneval P., Cowan C., Pouly J., Mitalipov S., Gouadon E., Binder P., Hagège A., Desnos M., Renaud J.-F., Menasché P., Pucéat M., A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. Journal of Clinical Investigation 2010 120 4 1125 1139 2-s2.0-77951181560 10.1172/JCI40120
134. Stanley E. G., Biben C., Elefanty A., Barnett L., Koentgen F., Robb L., Harvey R. P., Efficient cre-mediated deletion in cardiac progenitor cells conferred by a 3′UTR-ires-Cre allele of the homeobox gene Nkx2-5. International Journal of Developmental Biology 2002 46 4 431 439 2-s2.0-0036362978 (Pubitemid 36841010)
135. Nunes S. S., Miklas J. W., Liu J., Aschar-Sobbi R., Xiao Y., Zhang B., Jiang J., Masse S., Gagliardi M., Hsieh A., Thavandiran N., Laflamme M. A., Nanthakumar K., Gross G. J., Backx P. H., Keller G., Radisic M., Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes. Nature Methods 2013 10 781 787
136. Tulloch N. L., Muskheli V., Razumova M. V., Korte F. S., Regnier M., Hauch K. D., Pabon L., Reinecke H., Murry C. E., Growth of engineered human myocardium with mechanical loading and vascular coculture. Circulation Research 2011 109 1 47 59 2-s2.0-79960023610 10.1161/CIRCRESAHA.110.237206
137. Carvajal-Vergara X., Sevilla A., Dsouza S. L., Ang Y.-S., Schaniel C., Lee D.-F., Yang L., Kaplan A. D., Adler E. D., Rozov R., Ge Y., Cohen N., Edelmann L. J., Chang B., Waghray A., Su J., Pardo S., Lichtenbelt K. D., Tartaglia M., Gelb B. D., Lemischka I. R., Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 2010 465 7299 808 812 2-s2.0-77953443251 10.1038/nature09005
138. Moretti A., Bellin M., Welling A., Jung C. B., Lam J. T., Bott-Flügel L., Dorn T., Goedel A., Höhnke C., Hofmann F., Seyfarth M., Sinnecker D., Schömig A., Laugwitz K.-L., Patient-specific induced pluripotent stem-cell models for long-QT syndrome. The New England Journal of Medicine 2010 363 15 1397 1409 2-s2.0-77957729169 10.1056/NEJMoa0908679
139. Egashira T., Yuasa S., Suzuki T., Aizawa Y., Yamakawa H., Matsuhashi T., Ohno Y., Tohyama S., Okata S., Seki T., Kuroda Y., Yae K., Hashimoto H., Tanaka T., Hattori F., Sato T., Miyoshi S., Takatsuki S., Murata M., Kurokawa J., Furukawa T., Makita N., Aiba T., Shimizu W., Horie M., Kamiya K., Kodama I., Ogawa S., Fukuda K., Disease characterization using LQTS-specific induced pluripotent stem cells. Cardiovascular Research 2012 95 419 429
140. Itzhaki I., Maizels L., Huber I., Zwi-Dantsis L., Caspi O., Winterstern A., Feldman O., Gepstein A., Arbel G., Hammerman H., Boulos M., Gepstein L., Modelling the long QT syndrome with induced pluripotent stem cells. Nature 2011 471 7337 225 230 2-s2.0-79952446402 10.1038/nature09747
141. Matsa E., Rajamohan D., Dick E., Young L., Mellor I., Staniforth A., Denning C., Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. European Heart Journal 2011 32 8 952 962 2-s2.0-79954523845 10.1093/eurheartj/ehr073
142. Lahti A. L., Kujala V. J., Chapman H., Koivisto A.-P., Pekkanen-Mattila M., Kerkelä E., Hyttinen J., Kontula K., Swan H., Conklin B. R., Yamanaka S., Silvennoinen O., Aalto-Setälä K., Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture. DMM Disease Models and Mechanisms 2012 5 2 220 230 2-s2.0-84858040591 10.1242/dmm.008409
143. Davis R. P., Casini S., van den Berg C. W., Hoekstra M., Remme C. A., Dambrot C., Salvatori D., Ward-Van Oostwaard D., Wilde A. A., Bezzina C. R., Verkerk A. O., Freund C., Mummery C. L., Cardiomyocytes derived from pluripotent stem cells recapitulate electrophysiological characteristics of an overlap syndrome of cardiac sodium channel disease. Circulation 2012 125 3079 3091
144. Yazawa M., Hsueh B., Jia X., Pasca A. M., Bernstein J. A., Hallmayer J., Dolmetsch R. E., Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature 2011 471 7337 230 236 2-s2.0-79952438377 10.1038/nature09855
145. Fatima A., Xu G., Shao K., Papadopoulos S., Lehmann M., Arnáiz-Cot J. J., Rosa A. O., Nguemo F., Matzkies M., Dittmann S., Stone S. L., Linke M., Zechner U., Beyer V., Hennies H. C., Rosenkranz S., Klauke B., Parwani A. S., Haverkamp W., Pfitzer G., Farr M., Cleemann L., Morad M., Milting H., Hescheler J., Šaric T., In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells. Cellular Physiology and Biochemistry 2011 28 4 579 592 2-s2.0-83755195408 10.1159/000335753
146. Itzhaki I., Maizels L., Huber I., Gepstein A., Arbel G., Caspi O., Miller L., Belhassen B., Nof E., Glikson M., Gepstein L., Modeling of catecholaminergic polymorphic ventricular tachycardia with patient-specific human-induced pluripotent stem cells. Journal of the American College of Cardiology 2012 60 990 1000
147. Kujala K., Paavola J., Lahti A., Larsson K., Pekkanen-Mattila M., Viitasalo M., Lahtinen A. M., Toivonen L., Kontula K., Swan H., Laine M., Silvennoinen O., Aalto-Setala K., Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations. PLoS ONE 2012 7 e44660
148. Di Pasquale E., Lodola F., Miragoli M., Denegri M., Avelino-Cruz J. E., Buonocore M., Nakahama H., Portararo P., Bloise R., Napolitano C., Condorelli G., Priori S. G., CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia. Cell Death and Disease 2013 4 e843 10.1038/cddis.2013.369
149. Novak A., Barad L., Zeevi-Levin N., Shick R., Shtrichman R., Lorber A., Itskovitz-Eldor J., Binah O., Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to β -adrenergic stimulation. Journal of Cellular and Molecular Medicine 2012 16 3 468 482 2-s2.0-84857547828 10.1111/j.1582-4934.2011.01476.x
150. Sun N., Yazawa M., Liu J., Han L., Sanchez-Freire V., Abilez O. J., Navarrete E. G., Hu S., Wang L., Lee A., Pavlovic A., Lin S., Chen R., Hajjar R. J., Snyder M. P., Dolmetsch R. E., Butte M. J., Ashley E. A., Longaker M. T., Robbins R. C., Wu J. C., Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Science Translational Medicine 2012 4 130 2-s2.0-84860156650 10.1126/scitranslmed.3003552 130ra47
151. Ma D., Wei H., Lu J., Ho S., Zhang G., Sun X., Oh Y., Tan S. H., Ng M. L., Shim W., Wong P., Liew R., Generation of patient-specific induced pluripotent stem cell-derived cardiomyocytes as a cellular model of arrhythmogenic right ventricular cardiomyopathy. European Heart Journal 2012 34 1122 1133
152. Kamdar F., Doyle M. J., Chapman C., Lohr J., Koyano Nakagawa N., Garry D. J., In vitro modeling of duchenne muscular dystrophy (DMD) cardiomyopathy using human induced pluripotent stem cells (hiPSC). The Journal of Heart and Lung Transplantation 2013 32 4 S245
153. Kim C., Wong J., Wen J., Wang S., Wang C., Spiering S., Kan N. G., Forcales S., Puri P. L., Leone T. C., Marine J. E., Calkins H., Kelly D. P., Judge D. P., Chen H. S., Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature 2013 494 105 110
154. Okata S., Yuasa S., Yamane T., Furukawa T., Fukuda K., The generation of induced pluripotent stem cells from a patient with KCNH2 G603D, without LQT2 disease associated symptom. Journal of Medical and Dental Sciences 2013 60 17 22
155. Matsa E., Dixon J. E., Medway C., Georgiou O., Patel M. J., Morgan K., Kemp P. J., Staniforth A., Mellor I., Denning C., Allele-specific RNA interference rescues the long-QT syndrome phenotype in human-induced pluripotency stem cell cardiomyocytes. European Heart Journal 2013 10.1093/eurheartj/eht067
156. Ma D., Wei H., Zhao Y., Lu J., Li G., Sahib N. B., Tan T. H., Wong K. Y., Shim W., Wong P., Cook S. A., Liew R., Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells. International Journal of Cardiology 2013 168 5277 5286
157. Jung C. B., Moretti A., Mederos y Schnitzler M., Iop L., Storch U., Bellin M., Dorn T., Ruppenthal S., Pfeiffer S., Goedel A., Dirschinger R. J., Seyfarth M., Lam J. T., Sinnecker D., Gudermann T., Lipp P., Laugwitz K.-L., Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Molecular Medicine 2012 4 3 180 191 2-s2.0-84858129398 10.1002/emmm.201100194
158. Zhang X. H., Haviland S., Wei H., Saric T., Fatima A., Hescheler J., Cleemann L., Morad M., Ca2+ signaling in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CM) from normal and catecholaminergic polymorphic ventricular tachycardia (CPVT)-afflicted subjects. Cell Calcium 2013 54 2 57 70 10.1016/j.ceca.2013.04.004
159. Lan F., Lee A. S., Liang P., Sanchez-Freire V., Nguyen P. K., Wang L., Han L., Yen M., Wang Y., Sun N., Abilez O. J., Hu S., Ebert A. D., Navarrete E. G., Simmons C. S., Wheeler M., Pruitt B., Lewis R., Yamaguchi Y., Ashley E. A., Bers D. M., Robbins R. C., Longaker M. T., Wu J. C., Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell 2013 12 101 113
160. Bellin M., Casini S., Davis R. P., 'Aniello C D., Haas J., Ward-Van Oostwaard D., Tertoolen L. G., Jung C. B., Elliott D. A., Welling A., Laugwitz K. L., Moretti A., Mummery C. L., Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome. The EMBO Journal 2013 32 3161 3175
161. Cheng L.-T., Sun L.-T., Tada T., Genome editing in induced pluripotent stem cells. Genes to Cells 2012 2-s2.0-84859166667 10.1111/j.1365-2443.2012. 01599.x
162. Ousterout D. G., Perez-Pinera P., Thakore P. I., Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients. Molecular Therapy Advance 2013 10.1038/mt.2013.111
163. Soldner F., Laganière J., Cheng A. W., Hockemeyer D., Gao Q., Alagappan R., Khurana V., Golbe L. I., Myers R. H., Lindquist S., Zhang L., Guschin D., Fong L. K., Vu B. J., Meng X., Urnov F. D., Rebar E. J., Gregory P. D., Zhang H. S., Jaenisch R., Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations. Cell 2011 146 318 331 2-s2.0-80051995204
164. Kim K., Doi A., Wen B., Ng K., Zhao R., Cahan P., Kim J., Aryee M. J., Ji H., Ehrlich L. I. R., Yabuuchi A., Takeuchi A., Cunniff K. C., Hongguang H., McKinney-Freeman S., Naveiras O., Yoon T. J., Irizarry R. A., Jung N., Seita J., Hanna J., Murakami P., Jaenisch R., Weissleder R., Orkin S. H., Weissman I. L., Feinberg A. P., Daley G. Q., Epigenetic memory in induced pluripotent stem cells. Nature 2010 467 7313 285 290 2-s2.0-77955449906 10.1038/nature09342
165. Schwartz P. J., Stramba-Badiale M., Crotti L., Pedrazzini M., Besana A., Bosi G., Gabbarini F., Goulene K., Insolia R., Mannarino S., Mosca F., Nespoli L., Rimini A., Rosati E., Salice P., Spazzolini C., Prevalence of the congenital long-qt syndrome. Circulation 2009 120 18 1761 1767 2-s2.0-70449367296 10.1161/CIRCULATIONAHA.109.863209
166. Bokil N. J., Baisden J. M., Radford D. J., Summers K. M., Molecular genetics of long QT syndrome. Molecular Genetics and Metabolism 2010 101 1 1 8 2-s2.0-77955662261 10.1016/j.ymgme.2010.05.011
167. Terrenoire C., Wang K., Tung K. W., Chung W. K., Pass R. H., Lu J. T., Jean J. C., Omari A., Sampson K. J., Kotton D. N., Keller G., Kass R. S., Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics. Journal of General Physiology 2013 141 61 72
168. Roux-Buisson N., Cacheux M., Fourest-Lieuvin A., Fauconnier J., Brocard J., Denjoy I., Durand P., Guicheney P., Kyndt F., Leenhardt A., Le Marec H., Lucet V., Mabo P., Probst V., Monnier N., Ray P. F., Santoni E., Tremeaux P., Lacampagne A., Faure J., Lunardi J., Marty I., Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human. Human Molecular Genetics 2012 21 2759 2767
169. Shiba Y., Fernandes S., Zhu W. Z., Filice D., Muskheli V., Kim J., Palpant N. J., Gantz J., Moyes K. W., Reinecke H., Van Biber B., Dardas T., Mignone J. L., Izawa A., Hanna R., Viswanathan M., Gold J. D., Kotlikoff M. I., Sarvazyan N., Kay M. W., Murry C. E., Laflamme M. A., Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature 2012 489 322 325
170. Van Laake L. W., Passier R., Doevendans P. A., Mummery C. L., Human embryonic stem cell-derived cardiomyocytes and cardiac repair in rodents. Circulation Research 2008 102 9 1008 1010 2-s2.0-43449126812 10.1161/CIRCRESAHA.108.175505 (Pubitemid 351667854)
171. Kehat I., Khimovich L., Caspi O., Gepstein A., Shofti R., Arbel G., Huber I., Satin J., Itskovitz-Eldor J., Gepstein L., Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nature Biotechnology 2004 22 10 1282 1289 2-s2.0-5044221669 10.1038/nbt1014 (Pubitemid 39341201)
172. Ebelt H., Jungblut M., Zhang Y., Kubin T., Kostin S., Technau A., Oustanina S., Niebrügge S., Lehmann J., Werdan K., Braun T., Cellular cardiomyoplasty: improvement of left ventricular function correlates with the release of cardioactive cytokines. Stem Cells 2007 25 1 236 244 2-s2.0-33846024314 10.1634/stemcells.2006-0374 (Pubitemid 46052995)