Establishing a dynamic process for the formation, propagation, and differentiation of human embryoid bodies

Stem Cells and Development

Volumn 17, Issue 6, 2008, Pages 1227-1241

  Yirme, Galia ^a   Amit, Michal ^a   Laevsky, Ilana ^a   Osenberg, Sivan ^a   Itskovitz Eldor, Joseph ^a,b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID;

ANGIOGENESIS; APOPTOSIS; ARTICLE; BIOREACTOR; CELL DIFFERENTIATION; CELL EXPANSION; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENDOTHELIUM; GERM LAYER; GROWTH RATE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDRODYNAMICS; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ANIMALS; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; HUMANS; MICE; TIME FACTORS;

EID: 57449091705     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2007.0272     Document Type: Article

References (34)

1. Thomson JA, J Itskovitz-Eldor, SS Shapiro, MA Waknitz, JJ Swiergiel, VS Marshall and JM Jones. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147. (Erratum in: Science 1998;282:1827).
2. Zandstra PW and A Nagy. (2001). Stem cell bioengineering. Annu Rev Biomed Eng 3:275-305. Review.
3. Itskovitz-Eldor J, M Schuldiner, D Karsenti, A Eden, O Yanuka, M Amit, H Soreq and N Benvenisty. (2000). Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Mol Med 6:88-95.
4. Dang SM, M Kyba, R Perlingeiro, GQ Daley and PW Zandstra. (2002). Efficiency of embryoid body formation and hematopoietic development from embryonic stem cells in different culture systems. Biotechnol Bioeng 78:442-453.
5. Gerecht-Nir S, S Cohen and J Itskovitz-Eldor. (2004). Bioreactor cultivation enhances the efficiency of human embryoid body (hEB) formation and differentiation. Biotechnol Bioeng. 86:493-502.
6. Wartenberg M, F Dönmez, FC Ling, H Acker, J Hescheler and H Sauer. (2001). Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells. FASEB J 15:995-1005.
7. Schroeder M, S Niebruegge, A Werner, E Willbold, M Burg, M Ruediger, LJ Field, J Lehmann and R Zweigerdt. (2005). Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control. Biotechnol Bioeng 92:920-933.
8. Chisti Y. (2001). Hydrodynamic damage to animal cells. Crit Rev Biotechnol. 21:67-110. Review. Croughan MS, JF Hamel and DI Wang. (2000). Hydrodynamic effects on animal cells grown in microcarrier cultures. Biotechnol Bioeng 67:841-852.
9. Magyar JP, M Nemir, E Ehler, N Suter, JC Perriard and HM Eppenberger. (2001). Mass production of embryoid bodies in microbeads. Ann NY Acad Sci 944:135-143.
10. Dang SM, S Gerecht-Nir, J Chen, J Itskovitz-Eldor and PW Zandstra. (2004). Controlled, scalable embryonic stem cell differentiation culture. Stem Cells 22:275-282.
11. Levenberg S, NF Huang, E Lavik, AB Rogers, J Itskovitz-Eldor and R Langer. (2003). Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci USA 100:12741-12746.
12. Zandstra PW, C Bauwens, T Yin, Q Liu, H Schiller, R Zweigerdt, KB Pasumarthi and LJ Field. (2003). Scalable production of embryonic stem cell-derived cardiomyocytes. Tissue Eng 9:767-778. (Erratum in Tissue Eng 9:1331).
13. Zweigerdt R, M Burg, E Willbold, H Abts and M Ruediger. (2003). Generation of confluent cardiomyocyte monolayers derived from embryonic stem cells in suspension: a cell source for new therapies and screening strategies. Cytotherapy 5:399-413.
14. Carpenedo RL, CY Sargent and TC McDevitt. (2007). Rotary suspension culture enhances the efficiency, yield, and homogeneity of embryoid body differentiation. Stem Cells 25:2224-2234.
15. Wartenberg M, J Gunther, J Hescheler and H Sauer. (1998). The embryoid body as a novel in vitro assay system for antiangiogenic agents. Lab Invest 78:1301-1314.
16. Wang H, S Yan, H Chai, GM Riha, M Li, Q Yao and C Chen. (2006). Shear stress induces endothelial transdifferentiation from mouse smooth muscle cells. Biochem Biophys Res Commun 346:860-865.
17. Begley CM and SJ Kleis. (2000). The fluid dynamic and shear environment in the NASA/JSC rotating-wall perfused-vessel bioreactor. Biotechnol Bioeng 70:32-40.
18. Begley CM and SJ Kleis. (2002). RWPV bioreactor mass transport: earth-based and in microgravity. Biotechnol Bioeng 80:465-476.
19. Amit M, MK Carpenter, MS Inokuma, CP Chiu, CP Harris, MA Waknitz, J Itskovitz-Eldor and JA Thomson. (2000). Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol 227:271-278.
20. Kehat I, D Kenyagin-Karsenti, M Snir, H Segev, M Amit, A Gepstein, E Livne, O Binah, J Itskovitz-Eldor and L Gepstein. (2001). Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 108:407-414.
21. Xu C, S Police, N Rao and MK Carpenter. (2002). Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ Res 91:501-508.
22. Dolnikov K, M Shilkrut, N Zeevi-Levin, S Gerecht-Nir, M Amit, M Danon, J Itskovitz-Eldor and O Binah. (2006). Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction. Stem Cells 24:236-245.
23. Illi B, A Scopece, S Nanni, A Farsetti, L Morgante, P Biglioli, MC Capogrossi and C Gaetano. (2005). Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. Circ Res 96:501-508.
24. Schmelter M, B Ateghang, S Helmig, M Wartenberg and H Sauer. (2006). Embryonic stem cells utilize reactive oxygen species as transducers of mechanical strain-induced cardiovascular differentiation. FASEB J 20:1182-1184.
25. Yamamoto K, T Sokabe, T Watabe, K Miyazono, JK Yamashita, S Obi, N Ohura, A Matsushita, A Kamiya and J Ando. (2005). Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol 288:H1915-H1924.
26. Huang H, Y Nakayama, K Qin, K Yamamoto, J Ando, J Yamashita, H Itoh, K Kanda, H Yaku, Y Okamoto and Y Nemoto. (2005). Differentiation from embryonic stem cells to vascular wall cells under in vitro pulsatile flow loading. J Artif Organs 8:110-118.
27. Cameron CM, WS Hu and DS Kaufman. (2006). Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation. Biotechnol Bioeng 94:938-948.
28. Kallos MS and LA Behie. (1999). Inoculation and growth conditions for high-cell-density expansion of mammalian neural stem cells in suspension bioreactors. Biotechnol Bioeng 63:473-483.
29. Sen A, MS Kallos and LA Behie. (2002). Expansion of mammalian neural stem cells in bioreactors: effect of power input and medium viscosity. Brain Res Dev Brain Res 134:103-113.
30. Sen A, MS Kallos and LA Behie. (2002). Passaging protocols for mammalian neural stem cells in suspension bioreactors. Biotechnol Prog 18:337-345.
31. Croughan MS, JF Hamel and DI Wang. (2000). Hydrodynamic effects on animal cells grown in microcarrier cultures. Biotechnol Bioeng 67:841-852.
32. Fok EY and PW Zandstra. (2005). Shear-controlled single-step mouse embryonic stem cell expansion and embryoid body-based differentiation. Stem Cells 23:1333-1342.
33. Levenberg S, J Rouwkema, M Macdonald, ES Garfein, DS Kohane, DC Darland, R Marini, CA van Blitterswijk, RC Mulligan, PA D'Amore and R Langer. (2005). Engineering vascularized skeletal muscle tissue. Nat Biotechnol 23:879-884.
34. Bauwens C, T Yin, S Dang, R Peerani and PW Zandstra. (2005). Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: oxygen-mediated enhancement of cardiomyocyte output. Biotechnol Bioeng 90:452-461.