Mitochondria and arrhythmias

Free Radical Biology and Medicine

Volumn 71, Issue , 2014, Pages 351-361

  Yang, Kai Chien ^a   Bonini, Marcelo G ^b   Dudley Jr , Samuel C ^a  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Calcium; Free radicals; Heart; Ion channels; Reactive oxygen species; Sudden death

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; CALCIUM; CALCIUM CHANNEL; CARDIOTONIC AGENT; POTASSIUM CHANNEL; REACTIVE OXYGEN METABOLITE; SODIUM CHANNEL;

ANIMAL; ANTAGONISTS AND INHIBITORS; ARRHYTHMIAS, CARDIAC; BIOSYNTHESIS; DRUG EFFECTS; HEART MITOCHONDRION; HEART MUSCLE; HEART MUSCLE CELL; HUMAN; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; ARRHYTHMIAS, CARDIAC; CALCIUM; CALCIUM CHANNELS; CARDIOTONIC AGENTS; HUMANS; MITOCHONDRIA, HEART; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; POTASSIUM CHANNELS; REACTIVE OXYGEN SPECIES; SODIUM CHANNELS;

EID: 84899441965     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.03.033     Document Type: Review

References (210)

1. B. O'Rourke, S. Cortassa, and M.A. Aon Mitochondrial ion channels: gatekeepers of life and death Physiology (Bethesda) 20 2005 303 315 (Pubitemid 41457396)
2. D.A. Harris, and A.M. Das Control of mitochondrial ATP synthesis in the heart Biochem. J. 280 1991 561 573
3. J. Schaper, E. Meiser, and G. Stammler Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human hearts Circ. Res. 56 1985 377 391 (Pubitemid 15119514)
4. +-ATPase in guinea-pig cardiac ventricular muscle J. Physiol. 481 1994 647 662
5. C.L. Overend, D.A. Eisner, and S.C. O'Neill Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition Circ. Res. 88 2001 181 187 (Pubitemid 32147306)
6. H.S. Silverman, and M.D. Stern Ionic basis of ischaemic cardiac injury: insights from cellular studies Cardiovasc. Res. 28 1994 581 597 (Pubitemid 24199170)
7. S.A. Broadley, and F.U. Hartl Mitochondrial stress signaling: a pathway unfolds Trends Cell Biol. 18 2008 1 4
8. N.S. Zinkevich, and D.D. Gutterman ROS-induced ROS release in vascular biology: redox-redox signaling Am. J. Physiol. Heart Circ. Physiol 301 2011 H647 653
9. Y.F. Pung, W.J. Sam, K. Stevanov, M. Enrick, C.L. Chen, C. Kolz, P. Thakker, J.P. Hardwick, Y.R. Chen, J.R. Dyck, L. Yin, and W.M. Chilian Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-alpha signaling Arterioscler. Thromb. Vasc. Biol. 33 2013 1911 1919
10. S.R. Sripathi, W. He, C.L. Atkinson, J.J. Smith, Z. Liu, B.M. Elledge, and W.J. Jahng Mitochondrial-nuclear communication by prohibitin shuttling under oxidative stress Biochemistry 50 2011 8342 8351
11. J.Z. Sun, X.L. Tang, S.W. Park, Y. Qiu, J.F. Turrens, and R. Bolli Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs J. Clin. Invest. 97 1996 562 576 (Pubitemid 26039424)
12. T.L. Vanden Hoek, L.B. Becker, Z. Shao, C. Li, and P.T. Schumacker Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes J. Biol. Chem. 273 1998 18092 18098 (Pubitemid 28334725)
13. A.A. Sovari, C.A. Rutledge, E.M. Jeong, E. Dolmatova, D. Arasu, H. Liu, N. Vahdani, L. Gu, S. Zandieh, L. Xiao, M.G. Bonini, H.S. Duffy, and S.C. Dudley Jr. Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death Circ. Arrhythmia Electrophysiol 6 2013 623 631
14. P.N. Sanders, O.M. Koval, O.A. Jaffer, A.M. Prasad, T.R. Businga, J.A. Scott, P.J. Hayden, E.D. Luczak, D.D. Dickey, C. Allamargot, A.K. Olivier, D.K. Meyerholz, A.J. Robison, D.G. Winder, T.S. Blackwell, R. Dworski, D. Sammut, B.A. Wagner, G.R. Buettner, R.M. Pope, F.J. Miller Jr., M.E. Dibbern, H.M. Haitchi, P.J. Mohler, P.H. Howarth, J. Zabner, J.N. Kline, I.M. Grumbach, and M.E. Anderson CaMKII is essential for the proasthmatic effects of oxidation Sci. Transl. Med. 5 2013 195ra197
15. A.M. Zafari, and D.G. Harrison Free radicals in heart failure: therapeutic targets for old and new drugs Congest. Heart Fail 8 2002 129 130 (Pubitemid 34665623)
16. D. Sorescu, and K.K. Griendling Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure Congest. Heart Fail 8 2002 132 140 (Pubitemid 34669892)
17. N.T. Aggarwal, and J.C. Makielski Redox control of cardiac excitability Antioxid. Redox Signaling 18 2013 432 468
18. 2+ channel Mol. Pharmacol. 53 1998 497 503 (Pubitemid 28162873)
19. L. Xu, J.P. Eu, G. Meissner, and J.S. Stamler Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation Science 279 1998 234 237 (Pubitemid 28103882)
20. A. Clerk, A. Michael, and P.H. Sugden Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes Biochem. J. 333 1998 581 589 (Pubitemid 28398524)
21. 2-terminal kinase activation in the heart: cross-talk between cardiac hypertrophic signaling pathways J. Biol. Chem. 275 2000 13571 13579 (Pubitemid 30257424)
22. L.L. Shang, S. Sanyal, A.E. Pfahnl, Z. Jiao, J. Allen, H. Liu, and S.C. Dudley Jr. NF-kappaB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II Am. J. Physiol. Cell Physiol 294 2008 C372 379
23. E. Murphy, and D.A. Eisner Regulation of intracellular and mitochondrial sodium in health and disease Circ. Res. 104 2009 292 303
24. 2+-linked health and disease. J. Gen. Physiol. 139:435-443; 2012.
25. G.S. Williams, L. Boyman, A.C. Chikando, R.J. Khairallah, and W.J. Lederer Mitochondrial calcium uptake Proc. Natl. Acad. Sci. USA 110 2013 10479 10486
26. 2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes Circ. Res. 99 2006 172 182 (Pubitemid 44297041)
27. 2+ peaks in cardiomyocytes Proc. Natl. Acad. Sci. USA 109 2012 12986 12991
28. + cycle Biochim. Biophys. Acta 1606 2003 23 41 (Pubitemid 37267868)
29. A. Kaasik, D. Safiulina, A. Zharkovsky, and V. Veksler Regulation of mitochondrial matrix volume Am. J. Physiol. Cell Physiol 292 2007 C157 163
30. 2, NADH, and light scattering J. Biol. Chem. 276 2001 2586 2599
31. 2+ activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase Am. J. Physiol. Cell Physiol 278 2000 C423 435
32. J.N. Weiss, P. Korge, H.M. Honda, and P. Ping Role of the mitochondrial permeability transition in myocardial disease Circ. Res. 93 2003 292 301 (Pubitemid 37048241)
33. D.A. Brown, and B. O'Rourke Cardiac mitochondria and arrhythmias Cardiovasc. Res. 88 2010 241 249
34. E.K. Weir, J. Lopez-Barneo, K.J. Buckler, and S.L. Archer Acute oxygen-sensing mechanisms N. Engl. J. Med. 353 2005 2042 2055
35. M.A. Aon, S. Cortassa, E. Marban, and B. O'Rourke Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes J. Biol. Chem. 278 2003 44735 44744 (Pubitemid 37377231)
36. F.G. Akar, M.A. Aon, G.F. Tomaselli, and B. O'Rourke The mitochondrial origin of postischemic arrhythmias J. Clin. Invest. 115 2005 3527 3535 (Pubitemid 43121840)
37. H.A. Fozzard Excitation-contraction coupling in the heart Adv. Exp. Med. Biol. 308 1991 135 142
38. D.M. Roden, J.R. Balser, A.L. George Jr, and M.E. Anderson Cardiac ion channels Annu. Rev. Physiol. 64 2002 431 475 (Pubitemid 34259236)
39. J.M. Nerbonne, and R.S. Kass Molecular physiology of cardiac repolarization Physiol. Rev. 85 2005 1205 1253 (Pubitemid 41362269)
40. S. Kanno, and J.E. Saffitz The role of myocardial gap junctions in electrical conduction and arrhythmogenesis Cardiovasc. Pathol. 10 2001 169 177 (Pubitemid 32916370)
41. H.E. ter Keurs Electromechanical coupling in the cardiac myocyte; stretch-arrhythmia feedback Pflugers Arch. 462 2011 165 175
42. M.S. Jafri, S.J. Dudycha, and B. O'Rourke Cardiac energy metabolism: models of cellular respiration Annu. Rev. Biomed. Eng. 3 2001 57 81 (Pubitemid 32928033)
43. J.F. Turrens Mitochondrial formation of reactive oxygen species J. Physiol. 552 2003 335 344 (Pubitemid 37321833)
44. M.P. Murphy How mitochondria produce reactive oxygen species Biochem. J. 417 2009 1 13
45. R.A. Weisiger, and I. Fridovich Superoxide dismutase: organelle specificity J. Biol. Chem. 248 1973 3582 3592
46. T. Nishikawa, and E. Araki Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications Antioxid. Redox Signaling 9 2007 343 353 (Pubitemid 46150966)
47. E.J. Anderson, A.P. Kypson, E. Rodriguez, C.A. Anderson, E.J. Lehr, and P.D. Neufer Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart J. Am. Coll. Cardiol. 54 2009 1891 1898
48. D.F. Dai, T. Chen, H. Szeto, M. Nieves-Cintron, V. Kutyavin, L.F. Santana, and P.S. Rabinovitch Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy J. Am. Coll. Cardiol. 58 2011 73 82
49. E. Novalija, L.G. Kevin, J.T. Eells, M.M. Henry, and D.F. Stowe Anesthetic preconditioning improves adenosine triphosphate synthesis and reduces reactive oxygen species formation in mitochondria after ischemia by a redox dependent mechanism Anesthesiology 98 2003 1155 1163 (Pubitemid 36520202)
50. A.J. Tompkins, L.S. Burwell, S.B. Digerness, C. Zaragoza, W.L. Holman, and P.S. Brookes Mitochondrial dysfunction in cardiac ischemia-reperfusion injury: ROS from complex I, without inhibition Biochim. Biophys. Acta 1762 2006 223 231 (Pubitemid 43006028)
51. T. Ide, H. Tsutsui, S. Kinugawa, H. Utsumi, D. Kang, N. Hattori, K. Uchida, K. Arimura, K. Egashira, and A. Takeshita Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium Circ. Res. 85 1999 357 363 (Pubitemid 29398868)
52. M. Liu, L. Gu, M.S. Sulkin, H. Liu, E.M. Jeong, I. Greener, A. Xie, I.R. Efimov, and S.C. Dudley Jr. Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy J. Mol. Cell. Cardiol. 54 2013 25 34
53. C. Brenner Moulin, M. Physiological roles of the permeability transition pore Circ. Res. 111 2012 1237 1247
54. D.B. Zorov, M. Juhaszova, and S.J. Sollott Mitochondrial ROS-induced ROS release: an update and review Biochim. Biophys. Acta 1757 2006 509 517
55. N.R. Brady, A. Hamacher-Brady, H.V. Westerhoff, and R.A. Gottlieb A wave of reactive oxygen species (ROS)-induced ROS release in a sea of excitable mitochondria Antioxid. Redox Signaling 8 2006 1651 1665 (Pubitemid 44726339)
56. S.W. Werns, J.C. Fantone, A. Ventura, and B.R. Lucchesi Myocardial glutathione depletion impairs recovery of isolated blood-perfused hearts after global ischaemia J. Mol. Cell. Cardiol. 24 1992 1215 1220 (Pubitemid 23016045)
57. K.S. Echtay, D. Roussel, J. St-Pierre, M.B. Jekabsons, S. Cadenas, J.A. Stuart, J.A. Harper, S.J. Roebuck, A. Morrison, S. Pickering, J.C. Clapham, and M.D. Brand Superoxide activates mitochondrial uncoupling proteins Nature 415 2002 96 99 (Pubitemid 34062457)
58. K.S. Echtay, T.C. Esteves, J.L. Pakay, M.B. Jekabsons, A.J. Lambert, M. Portero-Otin, R. Pamplona, A.J. Vidal-Puig, S. Wang, S.J. Roebuck, and M.D.A Brand signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling EMBO J. 22 2003 4103 4110 (Pubitemid 37021739)
59. J. Murray, S.W. Taylor, B. Zhang, S.S. Ghosh, and R.A. Capaldi Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry J. Biol. Chem. 278 2003 37223 37230 (Pubitemid 37175238)
60. Z. Tatarkova, S. Kuka, P. Racay, J. Lehotsky, D. Dobrota, D. Mistuna, and P. Kaplan Effects of aging on activities of mitochondrial electron transport chain complexes and oxidative damage in rat heart Physiol. Res. 60 2011 281 289
61. G. Paradies, G. Petrosillo, M. Pistolese, and F.M. Ruggiero The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles FEBS Lett. 466 2000 323 326 (Pubitemid 30069850)
62. D.C. Wallace, W. Fan, and V. Procaccio Mitochondrial energetics and therapeutics Annu. Rev. Pathol 5 2010 297 348
63. R.M. Denton, P.J. Randle, and B.R. Martin Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase Biochem. J. 128 1972 161 163
64. T.E. Gunter, K.K. Gunter, S.S. Sheu, and C.E. Gavin Mitochondrial calcium transport: physiological and pathological relevance Am. J. Physiol. 267 1994 C313 339
65. J.R. Hom, J.S. Gewandter, L. Michael, S.S. Sheu, and Y. Yoon Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis J. Cell. Physiol. 212 2007 498 508 (Pubitemid 47025640)
66. +-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues Biochem. J. 176 1978 899 906 (Pubitemid 9090473)
67. L.S. Jouaville, P. Pinton, C. Bastianutto, G.A. Rutter, and R. Rizzuto Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming Proc. Natl. Acad. Sci. USA 96 1999 13807 13812
68. 2+ signaling Biochim. Biophys. Acta 1763 2006 442 449 (Pubitemid 44015947)
69. T. Przygodzki, A. Sokal, and M. Bryszewska Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species Biochim. Biophys. Acta 1740 2005 481 488 (Pubitemid 40804760)
70. 2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity J. Physiol. 585 2007 741 758 (Pubitemid 350278713)
71. 2+ Arch. Biochem. Biophys. 359 1998 77 81 (Pubitemid 28492433)
72. J.M. Baughman, F. Perocchi, H.S. Girgis, M. Plovanich, C.A. Belcher-Timme, Y. Sancak, X.R. Bao, L. Strittmatter, O. Goldberger, R.L. Bogorad, V. Koteliansky, and V.K. Mootha Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter Nature 476 2011 341 345
73. D. De Stefani, A. Raffaello, E. Teardo, I. Szabo, and R. Rizzuto A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter Nature 476 2011 336 340
74. 2+ uptake mechanism PLoS One 6 2011 e21324
75. L. Buntinas, K.K. Gunter, G.C. Sparagna, and T.E. Gunter The rapid mode of calcium uptake into heart mitochondria (RaM): comparison to RaM in liver mitochondria Biochim. Biophys. Acta 1504 2001 248 261 (Pubitemid 32201897)
76. G. Beutner, V.K. Sharma, D.R. Giovannucci, D.I. Yule, and S.S. Sheu Identification of a ryanodine receptor in rat heart mitochondria J. Biol. Chem. 276 2001 21482 21488
77. B.A. Altschafl, G. Beutner, V.K. Sharma, S.S. Sheu, and H.H. Valdivia The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile Biochim. Biophys. Acta 1768 2007 1784 1795 (Pubitemid 46890802)
78. 2+ channels Circulation 119 2009 2435 2443
79. 2+ responses Science 280 1998 1763 1766 (Pubitemid 28283502)
80. 2+ transfer from the ER to mitochondria: when, how and why Biochim. Biophys. Acta 1787 2009 1342 1351
81. 2+ from sarcoplasmic reticulum to mitochondria in rat ventricular myocytes J. Bioenerg. Biomembr. 32 2000 97 104 (Pubitemid 30241262)
82. 2+ uptake in myocytes from failing hearts restores energy supply and demand matching Circ. Res. 103 2008 279 288
83. E.K. Seppet, T. Kaambre, P. Sikk, T. Tiivel, H. Vija, M. Tonkonogi, K. Sahlin, L. Kay, F. Appaix, U. Braun, M. Eimre, and V.A. Saks Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells Biochim. Biophys. Acta 1504 2001 379 395 (Pubitemid 32201910)
84. M. Ruiz-Meana, A. Abellan, E. Miro-Casas, E. Agullo, and D. Garcia-Dorado Role of sarcoplasmic reticulum in mitochondrial permeability transition and cardiomyocyte death during reperfusion Am. J. Physiol. Heart Circ. Physiol 297 2009 H1281 1289
85. M. Ruiz-Meana, C. Fernandez-Sanz, and D. Garcia-Dorado The SR-mitochondria interaction: a new player in cardiac pathophysiology Cardiovasc. Res. 88 2010 30 39
86. 2+ exchange Proc. Natl. Acad. Sci. USA 107 2010 436 441
87. + antiporter Science 326 2009 144 147
88. 2+ release channel: new answers to an old question Cell Calcium 52 2012 22 27
89. M. Zoratti, and I. Szabo The mitochondrial permeability transition Biochim. Biophys. Acta 1241 1995 139 176
90. 2+ loads from rat adrenal chromaffin cells Neuron 16 1996 219 228
91. 2+ waves in rat cortical astrocytes J. Cell Biol. 145 1999 795 808 (Pubitemid 29240856)
92. 2+ uptake: tortoise or hare? J. Mol. Cell. Cardiol. 46 2009 767 774
93. + in isolated heart mitochondria estimated using a fluorescent probe Am. J. Physiol. 262 1992 C1047 1055
94. 2+ exchange J. Physiol. 586 2008 1683 1697 (Pubitemid 351404969)
95. P. Donoso, J.G. Mill, S.C. O'Neill, and D.A. Eisner Fluorescence measurements of cytoplasmic and mitochondrial sodium concentration in rat ventricular myocytes J. Physiol. 448 1992 493 509
96. +]i in pressure-overloaded guinea pig heart Am. J. Hypertens. 8 1995 934 943
97. S.M. Pogwizd, K.R. Sipido, F. Verdonck, and D.M. Bers Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesis Cardiovasc. Res. 57 2003 887 896 (Pubitemid 36324594)
98. + channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A Circulation 111 2005 198 203 (Pubitemid 40139732)
99. + channels in the cardiac inner mitochondrial membrane Science 298 2002 1029 1033 (Pubitemid 35247311)
100. + channel from rat liver and beef heart mitochondria J. Biol. Chem. 267 1992 26062 26069 (Pubitemid 23014017)
101. + antiport in heart mitochondria J. Biol. Chem. 259 1984 14672 14678 (Pubitemid 15221128)
102. + influx increases respiration and enhances ROS production while maintaining membrane potential Am. J. Physiol. Cell Physiol 292 2007 C148 156
103. + channels and their role in cardioprotection Circ. Res. 94 2004 420 432 (Pubitemid 38326277)
104. ATP channels in preconditioning Circ. Res. 87 2000 845 855
105. C.R. Bezzina, M.B. Rook, and A.A. Wilde Cardiac sodium channel and inherited arrhythmia syndromes Cardiovasc. Res. 49 2001 257 271 (Pubitemid 32119543)
106. J.J. Schott, C. Alshinawi, F. Kyndt, V. Probst, T.M. Hoorntje, M. Hulsbeek, A.A. Wilde, D. Escande, M.M. Mannens, and H. Le Marec Cardiac conduction defects associate with mutations in SCN5A Nat. Genet. 23 1999 20 21 (Pubitemid 29418782)
107. M.J. Janse, and A.L. Wit Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction Physiol. Rev. 69 1989 1049 1169 (Pubitemid 19255835)
108. H.A. Fozzard, and J.C. Makielski The electrophysiology of acute myocardial ischemia Annu. Rev. Med 36 1985 275 284
109. M.J. Janse Electrophysiological changes in heart failure and their relationship to arrhythmogenesis Cardiovasc. Res. 61 2004 208 217 (Pubitemid 38091761)
110. C.R. Valdivia, W.W. Chu, J. Pu, J.D. Foell, R.A. Haworth, M.R. Wolff, T.J. Kamp, and J.C. Makielski Increased late sodium current in myocytes from a canine heart failure model and from failing human heart J. Mol. Cell. Cardiol. 38 2005 475 483 (Pubitemid 40331938)
111. Y. Song, J.C. Shryock, S. Wagner, L.S. Maier, and L. Belardinelli Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction J. Pharmacol. Exp. Ther. 318 2006 214 222
112. J.H. Ma, A.T. Luo, and P.H. Zhang Effect of hydrogen peroxide on persistent sodium current in guinea pig ventricular myocytes Acta Pharmacol. Sin. 26 2005 828 834
113. M. Liu, H. Liu, and S.C. Dudley Jr. Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel Circ. Res. 107 2010 967 974
114. + current and causes inherited arrhythmias Circulation 116 2007 2260 2268 (Pubitemid 350100331)
115. + current regulation by pyridine nucleotides Circ. Res. 105 2009 737 745
116. D.M. Bers Calcium cycling and signaling in cardiac myocytes Annu. Rev. Physiol. 70 2008 23 49 (Pubitemid 351738170)
117. 2+ dynamics in single cardiac myocytes from renovascular hypertensive rats Am. J. Physiol. 260 1991 C327 337
118. L.A. Bentivegna, L.W. Ablin, Y. Kihara, and J.P. Morgan Altered calcium handling in left ventricular pressure-overload hypertrophy as detected with aequorin in the isolated, perfused ferret heart Circ. Res. 69 1991 1538 1545
119. B. O'Rourke, D.A. Kass, G.F. Tomaselli, S. Kaab, R. Tunin, and E. Marban Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure. I. Experimental studies Circ. Res. 84 1999 562 570 (Pubitemid 29138593)
120. 2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure Circ. Res. 85 1999 1009 1019
121. 2+], and NADH with dysfunction after global ischemia in intact hearts Am. J. Physiol. Heart Circ. Physiol 280 2001 H280 293
122. 2+ responses in intact hearts Am. J. Physiol. Heart Circ. Physiol 281 2001 H1508 1523
123. A.O. Grant Cardiac ion channels Circ. Arrhythmia Electrophysiol 2 2009 185 194
124. J.I. Goldhaber, S. Ji, S.T. Lamp, and J.N. Weiss Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle: implications for ischemia and reperfusion injury J. Clin. Invest. 83 1989 1800 1809 (Pubitemid 19148847)
125. 2+ channel function in the absence of apoptosis in ventricular myocytes Circ. Res. 100 2007 1036 1044 (Pubitemid 46598928)
126. 2+ currents via lysophosphatidylcholine-induced mitochondrial reactive oxygen species (ROS) production Cardiovasc. Res. 69 2006 855 864 (Pubitemid 43227984)
127. W.A. Coetzee, and L.H. Opie Effects of oxygen free radicals on isolated cardiac myocytes from guinea-pig ventricle: electrophysiological studies J. Mol. Cell. Cardiol. 24 1992 651 663
128. S. Hammerschmidt, and H. Wahn The effect of the oxidant hypochlorous acid on the L-type calcium current in isolated ventricular cardiomyocytes J. Mol. Cell. Cardiol. 30 1998 1855 1867 (Pubitemid 28430198)
129. 2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes Cardiovasc. Res. 77 2008 432 441 (Pubitemid 351197642)
130. 2+-ATPase Arch. Biochem. Biophys. 246 1986 589 601 (Pubitemid 16072580)
131. 2+-ATPase of cardiac sarcoplasmic reticulum Circ. Res. 69 1991 1003 1014
132. 2+-ATPase function by direct attack on the ATP binding site Circ. Res. 80 1997 76 81 (Pubitemid 27030371)
133. 2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart Cardiovasc. Res. 73 2007 631 640 (Pubitemid 46227343)
134. 2+/calmodulin-dependent kinase II (CaMKII) Circulation 126 2012 2125 2139
135. 2+ exchanger in hypoxic reoxygenated guinea pig ventricular myocytes Am. J. Physiol. Heart Circ. Physiol 286 2004 H955 963
136. 2+ exchange in ventricular myocytes Am. J. Physiol. 271 1996 H823 833
137. G. Choudhary, and S.C. Dudley Jr. Heart failure, oxidative stress, and ion channel modulation Congest. Heart Fail 8 2002 148 155 (Pubitemid 34665625)
138. S.M. Florea, and L.A. Blatter The role of mitochondria for the regulation of cardiac alternans Front. Physiol 1 2010 141
139. J. Garcia-Rivas Gde, K. Carvajal, F. Correa, and C. Zazueta Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post-ischaemic functional recovery in rats in vivo Br. J. Pharmacol. 149 2006 829 837 (Pubitemid 44851707)
140. J. Deng, G. Wang, Q. Huang, Y. Yan, K. Li, W. Tan, C. Jin, Y. Wang, and J. Liu Oxidative stress-induced leaky sarcoplasmic reticulum underlying acute heart failure in severe burn trauma Free Radic. Biol. Med. 44 2008 375 385
141. 2+ and ROS. Front. Biosci. (Landmark Ed.) 14:1197-1218; 2009.
142. F. Di Lisa, P.S. Blank, R. Colonna, G. Gambassi, H.S. Silverman, M.D. Stern, and R.G. Hansford Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition J. Physiol. 486 1995 1 13
143. E.J. Griffiths, C.J. Ocampo, J.S. Savage, G.A. Rutter, R.G. Hansford, M.D. Stern, and H.S. Silverman Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes Cardiovasc. Res. 39 1998 423 433 (Pubitemid 28346538)
144. R. Perez-Campo, M. Lopez-Torres, S. Cadenas, C. Rojas, and G. Barja The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach J. Comp. Physiol. B 168 1998 149 158 (Pubitemid 28202995)
145. R.S. Sohal, and R.G. Allen Relationship between metabolic rate, free radicals, differentiation and aging: a unified theory Basic Life Sci. 35 1985 75 104
146. M.W. Cleeter, J.M. Cooper, V.M. Darley-Usmar, S. Moncada, and A.H. Schapira Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide: implications for neurodegenerative diseases FEBS Lett. 345 1994 50 54
147. M. Ott, J.D. Robertson, V. Gogvadze, B. Zhivotovsky, and S. Orrenius Cytochrome c release from mitochondria proceeds by a two-step process Proc. Natl. Acad. Sci. USA 99 2002 1259 1263 (Pubitemid 34136480)
148. 2+-stimulated generation of reactive oxygen species by the respiratory chain Biochemistry 38 1999 13279 13287
149. ATP increases superoxide generation from complex I of the electron transport chain Am. J. Physiol. Heart Circ. Physiol 291 2006 H2067 2074
150. G.W. Abbott, X. Xu, and T.K. Roepke Impact of ancillary subunits on ventricular repolarization J. Electrocardiol. 40 2007 S42 46
151. G. Schram, M. Pourrier, P. Melnyk, and S. Nattel Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function Circ. Res. 90 2002 939 950 (Pubitemid 34633859)
152. C.G. Nichols, and A.N. Lopatin Inward rectifier potassium channels Annu. Rev. Physiol. 59 1997 171 191 (Pubitemid 27142438)
153. K1 J. Mol. Cell. Cardiol. 33 2001 625 638 (Pubitemid 32538976)
154. K1 in the mouse heart leads to altered cardiac excitability J. Mol. Cell. Cardiol. 35 2003 367 378 (Pubitemid 36411698)
155. K1 in rabbit cardiomyocytes: evidence for heteromeric co-assembly of Kir2.1 and Kir2.2 J. Physiol. 550 2003 365 372 (Pubitemid 36889298)
156. K1 as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes J. Physiol. 533 2001 697 710 (Pubitemid 32600525)
157. +-mediated vasodilation Circ. Res. 87 2000 160 166 (Pubitemid 30616913)
158. C.G. Nichols, E.N. Makhina, W.L. Pearson, Q. Sha, and A.N. Lopatin Inward rectification and implications for cardiac excitability Circ. Res. 78 1996 1 7 (Pubitemid 26004114)
159. ATP channels and implications for health and disease IUBMB Life 61 2009 971 978
160. ATP channel: relation with cell metabolism and role in the cardiovascular system Int. J. Biochem. Cell Biol. 37 2005 751 764 (Pubitemid 40202997)
161. M. Suzuki, T. Saito, T. Sato, M. Tamagawa, T. Miki, S. Seino, and H. Nakaya Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice Circulation 107 2003 682 685 (Pubitemid 36222593)
162. E. Cerbai, G. Ambrosio, F. Porciatti, M. Chiariello, A. Giotti, and A. Mugelli Cellular electrophysiological basis for oxygen radical-induced arrhythmias: a patch-clamp study in guinea pig ventricular myocytes Circulation 84 1991 1773 1782
163. H. Liang, X. Li, S. Li, M.Q. Zheng, and G.J. Rozanski Oxidoreductase regulation of Kv currents in rat ventricle J. Mol. Cell. Cardiol. 44 2008 1062 1071
164. X. Li, K. Tang, B. Xie, S. Li, and G.J. Rozanski Regulation of Kv4 channel expression in failing rat heart by the thioredoxin system Am. J. Physiol. Heart Circ. Physiol 295 2008 H416 424
165. S. Li, X. Li, Y.L. Li, C.H. Shao, K.R. Bidasee, and G.J. Rozanski Insulin regulation of glutathione and contractile phenotype in diabetic rat ventricular myocytes Am. J. Physiol. Heart Circ. Physiol 292 2007 H1619 1629
166. + channels in diabetic rat ventricular myocytes by insulin and glutathione Cardiovasc. Res. 53 2002 80 88 (Pubitemid 34020768)
167. P. Chiarugi PTPs versus PTKs: the redox side of the coin Free Radic. Res. 39 2005 353 364 (Pubitemid 40613714)
168. + current, by PKC Am. J. Physiol. 273 1997 H1775 1786
169. + current in human atrial myocytes Circ. Res. 78 1996 903 915 (Pubitemid 26131375)
170. J.F. Faivre, and I. Findlay Action potential duration and activation of ATP-sensitive potassium current in isolated guinea-pig ventricular myocytes Biochim. Biophys. Acta 1029 1990 167 172 (Pubitemid 20346436)
171. A. Bhatnagar Contribution of ATP to oxidative stress-induced changes in action potential of isolated cardiac myocytes Am. J. Physiol. 272 1997 H1598 1608
172. M.A. Aon, S. Cortassa, F.G. Akar, D.A. Brown, L. Zhou, and B. O'Rourke From mitochondrial dynamics to arrhythmias Int. J. Biochem. Cell Biol. 41 2009 1940 1948
173. ATP channel inhibition is defibrillatory and improves survival during acute myocardial ischemia and reperfusion Eur. J. Pharmacol. 577 2007 115 123 (Pubitemid 47632518)
174. P.S. Fischbach, A. White, T.D. Barrett, and B.R. Lucchesi Risk of ventricular proarrhythmia with selective opening of the myocardial sarcolemmal versus mitochondrial ATP-gated potassium channel J. Pharmacol. Exp. Ther. 309 2004 554 559 (Pubitemid 38542607)
175. Wirth, K. J.; Rosenstein, B.; Uhde, J.; Englert, H. C.; Busch, A. E.; Scholkens, B. A. ATP-sensitive potassium channel blocker HMR 1883 reduces mortality and ischemia-associated electrocardiographic changes in pigs with coronary occlusion. J. Pharmacol. Exp. Ther. 291:474-481; 1999. (Pubitemid 29503514)
176. F. Cacciapuoti, R. Spiezia, U. Bianchi, D. Lama, M. D'Avino, and M. Varricchio Effectiveness of glibenclamide on myocardial ischemic ventricular arrhythmias in non-insulin-dependent diabetes mellitus Am. J. Cardiol. 67 1991 843 847
177. D. Aronson, M.A. Mittleman, and A.J. Burger Effects of sulfonylurea hypoglycemic agents and adenosine triphosphate dependent potassium channel antagonists on ventricular arrhythmias in patients with decompensated heart failure Pacing Clin. Electrophysiol 26 2003 1254 1261 (Pubitemid 36570896)
178. A. Lomuscio, D. Vergani, L. Marano, M. Castagnone, and C. Fiorentini Effects of glibenclamide on ventricular fibrillation in non-insulin-dependent diabetics with acute myocardial infarction Coron. Artery Dis 5 1994 767 771 (Pubitemid 24338677)
179. M.A. Aon, S. Cortassa, and B. O'Rourke Mitochondrial oscillations in physiology and pathophysiology Adv. Exp. Med. Biol. 641 2008 98 117
180. ATP and ATP synthase during simulated ischemia in ventricular myocytes J. Mol. Cell. Cardiol. 39 2005 874 881
181. D.B. Zorov, C.R. Filburn, L.O. Klotz, J.L. Zweier, and S.J. Sollott Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes J. Exp. Med. 192 2000 1001 1014
182. D.A. Brown, M.A. Aon, F.G. Akar, T. Liu, N. Sorarrain, and B. O'Rourke Effects of 4′-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart Cardiovasc. Res. 79 2008 141 149 (Pubitemid 351881926)
183. D.A. Brown, M.A. Aon, C.R. Frasier, R.C. Sloan, A.H. Maloney, E.J. Anderson, and B. O'Rourke Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization J. Mol. Cell. Cardiol. 48 2010 673 679
184. + channel in cardiac function and cardioprotection Biochim. Biophys. Acta 1606 2003 1 21 (Pubitemid 37267867)
185. ATP channels in antiarrhythmic effects of ischaemic preconditioning in dogs Br. J. Pharmacol. 137 2002 1107 1115 (Pubitemid 35440752)
186. J.P. Headrick, L. Willems, K.J. Ashton, K. Holmgren, J. Peart, and G.P. Matherne Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression J. Physiol. 549 2003 823 833 (Pubitemid 36889772)
187. ATP channel activation important in the antiarrhythmic and cardioprotective effects during acute ischemia/reperfusion in the intact anesthetized rabbit model? Life Sci. 77 2005 1226 1248 (Pubitemid 40898322)
188. ATP Circ. Res. 111 2012 446 454
189. C.W. Lo Role of gap junctions in cardiac conduction and development: insights from the connexin knockout mice Circ. Res. 87 2000 346 348
190. W.H. Litchenberg, L.W. Norman, A.K. Holwell, K.L. Martin, K.W. Hewett, and R.G. Gourdie The rate and anisotropy of impulse propagation in the postnatal terminal crest are correlated with remodeling of Cx43 gap junction pattern Cardiovasc. Res. 45 2000 379 387 (Pubitemid 30069503)
191. S. Kostin, S. Dammer, S. Hein, W.P. Klovekorn, E.P. Bauer, and J. Schaper Connexin 43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stenosis Cardiovasc. Res. 62 2004 426 436 (Pubitemid 38496555)
192. E. Dupont, T. Matsushita, R.A. Kaba, C. Vozzi, S.R. Coppen, N. Khan, R. Kaprielian, M.H. Yacoub, and N.J. Severs Altered connexin expression in human congestive heart failure J. Mol. Cell. Cardiol. 33 2001 359 371 (Pubitemid 32537933)
193. S. Kostin, M. Rieger, S. Dammer, S. Hein, M. Richter, W.P. Klovekorn, E.P. Bauer, and J. Schaper Gap junction remodeling and altered connexin43 expression in the failing human heart Mol. Cell. Biochem. 242 2003 135 144 (Pubitemid 36240539)
194. R.R. Kaprielian, M. Gunning, E. Dupont, M.N. Sheppard, S.M. Rothery, R. Underwood, D.J. Pennell, K. Fox, J. Pepper, P.A. Poole-Wilson, and N.J. Severs Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle Circulation 97 1998 651 660 (Pubitemid 28090958)
195. N.S. Peters, C.R. Green, P.A. Poole-Wilson, and N.J. Severs Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts Circulation 88 1993 864 875 (Pubitemid 23264001)
196. H.J. Jongsma, and R. Wilders Gap junctions in cardiovascular disease Circ. Res. 86 2000 1193 1197 (Pubitemid 30436657)
197. D.E. Gutstein, G.E. Morley, H. Tamaddon, D. Vaidya, M.D. Schneider, J. Chen, K.R. Chien, H. Stuhlmann, and G.I. Fishman Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43 Circ. Res. 88 2001 333 339 (Pubitemid 32173758)
198. I.R. Efimov Connections, connections, connexins: towards systems biology paradigm of cardiac arrhythmia J. Mol. Cell. Cardiol. 41 2006 949 951 (Pubitemid 44791337)
199. H.V. van Rijen, T.A. van Veen, D. Gros, R. Wilders, and J.M. de Bakker Connexins and cardiac arrhythmias Adv. Cardiol. 42 2006 150 160 (Pubitemid 43805862)
200. E.M. Lonn, S. Yusuf, P. Jha, T.J. Montague, K.K. Teo, C.R. Benedict, and B. Pitt Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection Circulation 90 1994 2056 2069 (Pubitemid 24320959)
201. T. Unger, and J. Li The role of the renin-angiotensin-aldosterone system in heart failure J. Renin Angiotensin Aldosterone Syst 5 Suppl. 1 2004 S7 10
202. W.C. Renin-angiotensin De Mello system and cell communication in the failing heart Hypertension 27 1996 1267 1272
203. W.C. De Mello Is an intracellular renin-angiotensin system involved in control of cell communication in heart? J. Cardiovasc. Pharmacol. 23 1994 640 646 (Pubitemid 24100151)
204. H.D. Xiao, S. Fuchs, D.J. Campbell, W. Lewis, S.C. Dudley Jr, V.S. Kasi, B.D. Hoit, G. Keshelava, H. Zhao, M.R. Capecchi, and K.E. Bernstein Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death Am. J. Pathol. 165 2004 1019 1032 (Pubitemid 39129307)
205. M. Donoghue, H. Wakimoto, C.T. Maguire, S. Acton, P. Hales, N. Stagliano, V. Fairchild-Huntress, J. Xu, J.N. Lorenz, V. Kadambi, C.I. Berul, and R.E. Breitbart Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins J. Mol. Cell. Cardiol. 35 2003 1043 1053 (Pubitemid 37083248)
206. A.A. Sovari, S. Iravanian, E. Dolmatova, Z. Jiao, H. Liu, S. Zandieh, V. Kumar, K. Wang, K.E. Bernstein, M.G. Bonini, H.S. Duffy, and S.C. Dudley Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death J. Am. Coll. Cardiol. 58 2011 2332 2339
207. S. Iravanian, A.A. Sovari, H.A. Lardin, H. Liu, H.D. Xiao, E. Dolmatova, Z. Jiao, B.S. Harris, E.A. Witham, R.G. Gourdie, H.S. Duffy, K.E. Bernstein, and S.C. Dudley Jr. Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43 J. Mol. Med. (Berlin) 89 2011 677 687
208. F. Kieken, N. Mutsaers, E. Dolmatova, K. Virgil, A.L. Wit, A. Kellezi, B.J. Hirst-Jensen, H.S. Duffy, and P.L. Sorgen Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction Circ. Res. 104 2009 1103 1112
209. T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Tada, and M. Hori Functional role of c-Src in gap junctions of the cardiomyopathic heart Circ. Res. 85 1999 672 681 (Pubitemid 29480807)
210. 2 radicals in intact hearts with ischemia and reperfusion Am. J. Physiol. Heart Circ. Physiol 284 2003 H566 574