Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death

Journal of the American College of Cardiology

Volumn 58, Issue 22, 2011, Pages 2332-2339

  Sovari, Ali A ^a   Iravanian, Shahriar ^b   Dolmatova, Elena ^c   Jiao, Zhe ^b   Liu, Hong ^a   Zandieh, Shadi ^a   Kumar, Vibhash ^a   Wang, Kun ^a   Bernstein, Kenneth E ^d   Bonini, Marcelo G ^a   Duffy, Heather S ^c   Dudley, Samuel C ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b EMORY UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

angiotensin II; c Src tyrosine kinase; connexin43; sudden cardiac death

Indexed keywords

1 (1,1, DIMETHYLETHYL) 1 (4 METHYLPHENYL) 1H PYRAZOLO[3,4 D]PYRIMIDIN 4 AMINE; ANGIOTENSIN CONVERTING ENZYME 8; ANGIOTENSIN II; CONNEXIN 43; DIPEPTIDYL CARBOXYPEPTIDASE; FLUORESCENT DYE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CAUSE OF DEATH; CONTROLLED STUDY; DIFFUSION; DRUG ACTIVITY; ELECTROPHYSIOLOGY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; FUNCTIONAL ASSESSMENT; GAP JUNCTION; HEART ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUDDEN DEATH; SURVIVAL TIME; TELEMETRY; WESTERN BLOTTING;

ANGIOTENSIN II; ANIMALS; BLOTTING, WESTERN; CONNEXIN 43; DEATH, SUDDEN, CARDIAC; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GAP JUNCTIONS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PYRAZOLES; PYRIMIDINES; TACHYCARDIA, VENTRICULAR; TELEMETRY; VENTRICULAR FIBRILLATION;

EID: 81255163198     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2011.07.048     Document Type: Article

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