Structural and molecular mechanisms of gap junction remodeling in epicardial border zone myocytes following myocardial infarction

Circulation Research

Volumn 104, Issue 9, 2009, Pages 1103-1112

  Kieken, Fabien ^a   Mutsaers, Nancy ^b   Dolmatova, Elena ^c   Virgil, Kelly ^a   Wit, Andrew L ^b   Kellezi, Admir ^a   Hirst Jensen, Bethany J ^a   Duffy, Heather S ^c   Sorgen, Paul L ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b Columbia University ^*  (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Arrhythmia; Cardiac gap junction connexins; Cell' cell coupling; Myocardial ischemia

Indexed keywords

CHAPERONE; CONNEXIN 43; PROTEIN SH3; PROTEIN ZO1; MEMBRANE PROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE P60; ZONULA OCCLUDENS 1 PROTEIN; ZONULA OCCLUDENS-1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BABESIOSIS; BINDING AFFINITY; CONTROLLED STUDY; EPICARDIUM; GAP JUNCTION; HEART INFARCTION; IMMUNOLOCALIZATION; IMMUNOPRECIPITATION; MOLECULAR MECHANICS; MUSCLE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SURFACE PLASMON RESONANCE; TWO HYBRID SYSTEM; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; CELL JUNCTION; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DOG; ENZYMOLOGY; HEART MUSCLE CELL; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PDZ DOMAIN; PERICARDIUM; PHOSPHORYLATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN TRANSPORT; SRC HOMOLOGY DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CONNEXIN 43; DISEASE MODELS, ANIMAL; DOGS; GAP JUNCTIONS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; PDZ DOMAINS; PERICARDIUM; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SRC HOMOLOGY DOMAINS; SURFACE PLASMON RESONANCE; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 66149087287     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.190454     Document Type: Article

References (25)

1. Peters NS, Coromilas J, Severs NJ, Wit AL. Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation. 1997;95:988-996.
2. Smith JH, Green CR, Peters NS, Rothery S, Severs NJ. Altered patterns of gap junction distribution in ischemic heart disease. An immunohisto-chemical study of human myocardium using laser scanning confocal microscopy. Am J Pathol. 1991;139:801-821.
3. Yao JA, Hussain W, Patel P, Peters NS, Boyden PA, Wit AL. Remodeling of gap junctional channel function in epicardial border zone of healing canine infarcts. Circ Res. 2003;92:437-443.
4. Akar FG, Nass RD, Hahn S, Cingolani E, Shah M, Hesketh GG, DiSil-vestre D, Tunin RS, Kass DA, Tomaselli GF. Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure. Am J Physiol Heart Circ Physiol. 2007;293: H1223-H1230.
5. Kaplan SR, Gard JJ, Carvajal-Huerta L, Ruiz-Cabezas JC, Thiene G, Saffitz JE. Structural and molecular pathology of the heart in Carvajal syndrome. Cardiovasc Pathol. 2004;13:26-32.
6. Giepmans BN, Moolenaar WH. The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein. Curr Biol. 1998;8:931-934.
7. Toyofuku T, Yabuki M, Otsu K, Kuzuya T, Hori M, Tada M. Direct association of the gap junction protein connexin-43 with ZO-1 in cardiac myocytes. J Biol Chem. 1998;273:12725-12731.
8. Duffy HS, Ashton AW, O'Donnell P, Coombs W, Taffet SM, Delmar M, Spray DC. Regulation of connexin43 protein complexes by intracellular acidification. Circ Res. 2004;94:215-222.
9. Solan JL, Lampe PD. Connexin phosphorylation as a regulatory event linked to gap junction channel assembly. Biochim Biophys Acta. 2005; 1711:154-163.
10. Sorgen PL, Duffy HS, Sahoo P, Coombs W, Delmar M, Spray DC. Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1. J Biol Chem. 2004;279:54695-54701.
11. Ursell PC, Gardner PI, Albala A, Fenoglio JJ Jr, Wit AL. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ Res. 1985;56: 436-451.
12. Duffy HS, Iacobas I, Hotchkiss K, Hirst-Jensen BJ, Bosco A, Dandachi N, Dermietzel R, Sorgen PL, Spray DC. The gap junction protein con-nexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. J Biol Chem. 2007;282:9789-9796.
13. Kieken F, Jovic M, Naslavsky N, Caplan S, Sorgen PL. EH domain of EHD1. J Biomol NMR. 2007;39:323-329.
14. Hirst-Jensen BJ, Sahoo P, Kieken F, Delmar M, Sorgen PL. Characterization of the pH-dependent interaction between the gap junction protein connexin43 carboxyl terminus and cytoplasmic loop domains. J Biol Chem. 2007;282:5801-5813.
15. Feng S, Chen JK, Yu H, Simon JA, Schreiber SL. Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science. 1994;266:1241-1247.
16. Sorgen PL, Duffy HS, Spray DC, Delmar M. pH-dependent dimerization of the carboxyl terminal domain of Cx43. Biophys J. 2004;87:574-581.
17. MacDonald PN, ed. Methods in Molecular Biology. Vol 177. Two-Hybrid Systems: Methods and Protocols. Totowa, NJ: Humana Press; 2001;175-205.
18. Yamaji Y, Tsuganezawa H, Moe OW, Alpern RJ. Intracellular acidosis activates c-Src. Am J Physiol. 1997;272:C886-C893.
19. Zhou L, Kasperek EM, Nicholson BJ. Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels. J Cell Biol. 1999;144:1033-1045.
20. Lampe PD, Lau AF. The effects of connexin phosphorylation on gap junctional communication. Int J Biochem Cell Biol. 2004;36: 1171-1186.
21. Beardslee MA, Lerner DL, Tadros PN, Laing JG, Beyer EC, Yamada KA, Kleber AG, Schuessler RB, Saffitz JE. Dephosphorylation and intra-cellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia. Circ Res. 2000;87:656-662.
22. Lampe PD, TenBroek EM, Burt JM, Kurata WE, Johnson RG, Lau AF. Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J Cell Biol. 2000;149: 1503-1512.
23. Toyofuku T, Akamatsu Y, Zhang H, Kuzuya T, Tada M, Hori M. c-Src regulates the interaction between connexin-43 and ZO-1 in cardiac myocytes. J Biol Chem. 2001;276:1780-1788.
24. Hunter AW, Barker RJ, Zhu C, Gourdie RG. Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell. 2005;16:5686-5698.
25. Bruce AF, Rothery S, Dupont E, Severs NJ. Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1. Cardiovasc Res. 2008;77:757-765.