NF-κB-dependent transcriptional regulation of the cardiac scn5a sodium channel by angiotensin II

American Journal of Physiology - Cell Physiology

Volumn 294, Issue 1, 2008, Pages

  Shang, Lijuan L ^b   Sanyal, Shamarendra ^b   Pfahnl, Arnold E ^b   Jiao, Zhe ^b   Allen, Jon ^b   Liu, Hong ^b   Dudley Jr , Samuel C ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NONE

Author keywords

Arrhythmia, gene expression; Redox signaling; Renin angiotensin system; Sodium channel

Indexed keywords

ANGIOTENSIN II; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SODIUM CHANNEL; ENZYME INHIBITOR; SCAVENGER; SODIUM; UNCLASSIFIED DRUG; VOLTAGE GATED NA+ CHANNEL NA(V)1.5A; VOLTAGE-GATED NA+ CHANNEL NA(V)1.5A;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; IMMUNOPRECIPITATION; MUSCLE CELL; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SODIUM CURRENT; TRANSCRIPTION REGULATION; ANIMAL; CELL CULTURE; CELL LINE; CELL MEMBRANE POTENTIAL; CELL SURVIVAL; DOSE RESPONSE; DOWN REGULATION; DRUG ANTAGONISM; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HEART MUSCLE CELL; KINETICS; METABOLISM; MUTATION; NEWBORN; PROMOTER REGION; SPRAGUE DAWLEY RAT;

ANGIOTENSIN II; ANIMALS; ANIMALS, NEWBORN; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; HYDROGEN PEROXIDE; KINETICS; MEMBRANE POTENTIALS; MUTATION; MYOCYTES, CARDIAC; NADPH OXIDASE; NF-KAPPA B P50 SUBUNIT; OXIDATIVE STRESS; PROMOTER REGIONS (GENETICS); RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SODIUM; SODIUM CHANNELS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 38349099238     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00186.2007     Document Type: Article

References (49)

1. Armoundas AA, Wu R, Juang G, Marban E, Tomaselli GF. Electrical and structural remodeling of the failing ventricle. Pharmacol Ther 92: 213-230, 2001.
2. Bhatnagar A, Srivastava SK, Szabo G. Oxidative stress alters specific membrane currents in isolated cardiac myocytes. Circ Res 67: 535-549, 1990.
3. Borlak J, Thum T. Hallmarks of ion channel gene expression in endstage heart failure. FASEB J 17: 1592-1608, 2003.
4. Brasier AR, Jamaluddin M, Han Y, Patterson C, Runge MS. Angiotensin II induces gene transcription through cell-type-dependent effects on the nuclear factor-κB transcription factor. Mol Cell Biochem 212: 155-169, 2000.
5. Brigadeau F, Gele P, Marquie C, Soudan B, Lacroix D. Ventricular arrhythmias following exposure of failing hearts to oxidative stress in vitro. J Cardiovasc Electrophysiol 16: 629-636, 2005.
6. Byrne JA, Grieve DJ, Bendall JK, Li JM, Gove C, Lambeth JD, Cave AC, Shah AM. Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy. Circ Res 93: 802-805, 2003.
7. Carnes CA, Chung MK, Nakayama T, Nakayama H, Baliga RS, Piao S, Kanderian A, Pavia S, Hamlin RL, McCarthy PM, Bauer JA, Van Wagoner DR. Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circ Res 89: E32-E38, 2001.
8. Chandra D, Choy G, Daniel PT, Tang DG. Bax-dependent regulation of Bak by voltage-dependent anion channel 2. J Biol Chem 280: 19051-19061, 2005.
9. Chen K, Chen J, Li D, Zhang X, Mehta JL. Angiotensin II regulation of collagen type I expression in cardiac fibroblasts: modulation by PPAR-λ ligand pioglitazone. Hypertension 44: 655-661, 2004.
10. Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang Z, Antzelevitch C, OBrien RE, Schulze-Bahr E, Keating MT, Towbin JA, Wang Q. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 392: 293-296, 1998.
11. De Mello WC. Intracellular angiotensin II regulates the inward calcium current in cardiac myocytes. Hypertension 32: 976-982, 1998.
12. Dhalla NS, Temsah RM, Netticadan T. Role of oxidative stress in cardiovascular diseases. J Hypertens 18: 655-673, 2000.
13. Dodge SM, Beardslee MA, Darrow BJ, Green KG, Beyer EC, Saffitz JE. Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes. J Am Coll Cardiol 32: 800-807, 1998.
14. Dupont E, Matsushita T, Kaba RA, Vozzi C, Coppen SR, Khan N, Kaprielian R, Yacoub MH, Severs NJ. Altered connexin expression in human congestive heart failure. J Mol Cell Cardiol 33: 359-371, 2001.
15. Ebrahimian T, He Y, Schiffrin EL, Touyz RM. Differential regulation of thioredoxin and NAD(P)H oxidase by angiotensin II in male and female mice. J Hypertens 25: 1263-1271, 2007.
16. Frantz S, Kelly RA, Bourcier T. Role of TLR-2 in the activation of nuclear factor κB by oxidative stress in cardiac myocytes. J Biol Chem 276: 5197-5203, 2001.
17. Gavras I, Gavras H. The antiarrhythmic potential of angiotensin II antagonism: experience with losartan. Am J Hypertens 13: 512-517, 2000.
18. Grall F, Gu X, Tan L, Cho JY, Inan MS, Pettit AR, Thamrongsak U, Choy BK, Manning C, Akbarali Y, Zerbini L, Rudders S, Goldring SR, Gravallese EM, Oettgen P, Goldring MB, Libermann TA. Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor κB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum 48: 1249-1260, 2003.
19. Griendling KK, Ushio-Fukai M. Reactive oxygen species as mediators of angiotensin II signaling. Regul Pept 91: 21-27, 2000.
20. Ide T, Tsutsui H, Kinugawa S, Suematsu N, Hayashidani S, Ichikawa K, Utsumi H, Machida Y, Egashira K, Takeshita A. Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium. Circ Res 86: 152-157, 2000.
21. Jiao Z, De J, V, Iravanian S, Campbell DP, Xu J, Vitali JA, Banach K, Fahrenbach J, Dudley SC Jr. A possible mechanism of halocarbon-induced cardiac sensitization arrhythmias. J Mol Cell Cardiol 41: 698-705, 2006.
22. Laufs U, Kilter H, Konkol C, Wassmann S, Bohm M, Nickenig G. Impact of HMG CoA reductase inhibition on small GTPases in the heart. Cardiovasc Res 53: 911-920, 2002.
23. Li D, Shinagawa K, Pang L, Leung TK, Cardin S, Wang Z, Nattel S. Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure. Circulation 104: 2608-2614, 2001.
24. Libbus I, Rosenbaum DS. Remodeling of cardiac repolarization: mechanisms and implications of memory. Card Electrophysiol Rev 6: 302-310, 2002.
25. Lindholm LH, Persson M, Alaupovic P, Carlberg B, Svensson A, Samuelsson O. Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive Treatment and Lipid Profile in a North of Sweden Efficacy Evaluation (ALPINE study). J Hypertens 21: 1563-1574, 2003.
26. Maltsev VA, Sabbah HN, Higgins RS, Silverman N, Lesch M, Undrovinas AI. Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes. Circulation 98: 2545-2552, 1998.
27. Natarajan K, Singh S, Burke TR Jr, Grunberger D, Aggarwal BB. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc Natl Acad Sci USA 93: 9090-9095, 1996.
28. Patberg KW, Rosen MR. Molecular determinants of cardiac memory and their regulation. J Mol Cell Cardiol 36: 195-204, 2004.
29. Persson F, Carlsson L, Duker G, Jacobson I. Blocking characteristics of hERG, hNav1.5, and hKvLQT1/hminK after administration of the novel anti-arrhythmic compound AZD7009. J Cardiovasc Electrophysiol 16: 329-341, 2005.
30. Qin F, Patel R, Yan C, Liu W. NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin. Free Radic Biol Med 40: 236-246, 2006.
31. Ravingerova T, Slezak J, Tribulova N, Dzurba A, Uhrik B, Ziegelhoffer A. Free oxygen radicals contribute to high incidence of reperfusion-induced arrhythmias in isolated rat heart. Life Sci 65: 1927-1930, 1999.
32. Rouet-Benzineb P, Gontero B, Dreyfus P, Lafuma C. Angiotensin II induces nuclear factor-κB activation in cultured neonatal rat cardiomyocytes through protein kinase C signaling pathway. J Mol Cell Cardiol 32: 1767-1778, 2000.
33. + current during cardiac ischemia and hypoxia. J Cardiovasc Electrophysiol 17, Suppl 1: S96-S103, 2006.
34. Schulze-Bahr E, Eckardt L, Breithardt G, Seidl K, Wichter T, Wolpert C, Borggrefe M, Haverkamp W. Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: different incidences in familial and sporadic disease. Hum Mutat 21: 651-652, 2003.
35. Shang LL, Dudley SC Jr. Tandem promoters and developmentally regulated 5′- and 3′-mRNA untranslated regions of the mouse Scn5a cardiac sodium channel. J Biol Chem 280: 933-940, 2005.
36. Shang LL, Pfahnl AE, Sanyal S, Jiao Z, Allen J, Banach K, Fahrenbach J, Weiss D, Taylor WR, Zafari AM, Dudley SC Jr. Human heart failure is associated with abnormal c-terminal splicing variants in the cardiac sodium channel. Circ Res 101: 1146-1154, 2007.
37. Shi Y, Li D, Tardif JC, Nattel S. Enalapril effects on atrial remodeling and atrial fibrillation in experimental congestive heart failure. Cardiovasc Res 54: 456-461, 2002.
38. Shimada Y, Gunasegaram S, Yokoyama H, Avkiran M. Inhibition of angiotensin-converting enzyme reduces susceptibility of hypertrophied rat myocardium to ventricular fibrillation. Circ J 66: 1045-1053, 2002.
39. Song Y, Shryock JC, Wagner S, Maier LS, Belardinelli L. Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction. J Pharmacol Exp Ther 318: 214-222, 2006.
40. Stansfield WE, Moss NC, Willis MS, Tang R, Selzman CH. Proteasome inhibition attenuates infarct size and preserves cardiac function in a murine model of myocardial ischemia-reperfusion injury. Ann Thorac Surg 84: 120-125, 2007.
41. Stier CT Jr, Koenig S, Lee DY, Chawla M, Frishman WH. Aldosterone and aldosterone antagonism in cardiovascular disease: focus on eplerenone (Inspra). Heart Dis 5: 102-118, 2003.
42. Teo K, Yusuf S, Sleight P, Anderson C, Mookadam F, Ramos B, Hilbrich L, Pogue J, Schumacher H. Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial/ Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease (ONTARGET/TRANSCEND) trials. Am Heart J 148: 52-61, 2004.
43. Tomaselli GF, Rose J. Molecular aspects of arrhythmias associated with cardiomyopathies. Curr Opin Cardiol 15: 202-208, 2000.
44. Tran K, Man RY, Choy PC. The enhancement of phosphatidylcholine biosynthesis by angiotensin II in H9c2 cells. Biochim Biophys Acta 1259: 283-290, 1995.
45. Valdivia CR, Chu WW, Pu J, Foell JD, Haworth RA, Wolff MR, Kamp TJ, Makielski JC. Increased late sodium current in myocytes from a canine heart failure model and from failing human heart. J Mol Cell Cardiol 38: 475-483, 2005.
46. Ward CA, Giles WR. Ionic mechanism of the effects of hydrogen peroxide in rat ventricular myocytes. J Physiol 500: 631-642, 1997.
47. Watabe M, Hishikawa K, Takayanagi A, Shimizu N, Nakaki T. Caffeic acid phenethyl ester induces apoptosis by inhibition of NFκB and activation of Fas in human breast cancer MCF-7 cells. J Biol Chem 279: 6017-6026, 2004.
48. Zhang TT, Takimoto K, Stewart AF, Zhu C, Levitan ES. Independent regulation of cardiac Kv4.3 potassium channel expression by angiotensin II and phenylephrine. Circ Res 88: 476-482, 2001.
49. Zhou LZ, Johnson AP, Rando TA. NF κB and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Radic Biol Med 31: 1405-1416, 2001.