메뉴 건너뛰기




Volumn 20, Issue 1, 2014, Pages 191-201

Molecular mechanisms of pulmonary arterial remodeling

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; DICHLOROACETIC ACID; ENDOTHELIN 1; FOUR AND A HALF LIM DOMAIN PROTEIN 1; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMATINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIM PROTEIN; NITRIC OXIDE; NOTCH3 RECEPTOR; OCTAMER TRANSCRIPTION FACTOR 4; PLACEBO; PLATELET DERIVED GROWTH FACTOR; POTASSIUM CHANNEL; PROSTACYCLIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 84899137231     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2013.00165     Document Type: Article
Times cited : (98)

References (97)
  • 1
    • 77951443168 scopus 로고    scopus 로고
    • Pharmacotherapeutic management of pulmonary arterial hypertension
    • Anderson JR, Nawarskas JJ. (2010) Pharmacotherapeutic management of pulmonary arterial hypertension. Cardiol. Rev. 18:148-62.
    • (2010) Cardiol. Rev. , vol.18 , pp. 148-162
    • Anderson, J.R.1    Nawarskas, J.J.2
  • 2
    • 67649599147 scopus 로고    scopus 로고
    • Cellular and molecular basis of pulmonary arterial hypertension
    • Morrell NW, et al. (2009) Cellular and molecular basis of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 54:S20-31.
    • (2009) J. Am. Coll. Cardiol. , vol.54
    • Morrell, N.W.1
  • 3
    • 0029055964 scopus 로고
    • Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
    • Giaid A, Saleh D. (1995) Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 333:214-21.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 214-221
    • Giaid, A.1    Saleh, D.2
  • 4
    • 0018195784 scopus 로고
    • Effects of prostaglandin E1 on pulmonary circulation in patients with pulmonary hypertension
    • Szczeklik J, et al. (1978) Effects of prostaglandin E1 on pulmonary circulation in patients with pulmonary hypertension. Br. Heart J. 40:1397-401.
    • (1978) Br. Heart J. , vol.40 , pp. 1397-1401
    • Szczeklik, J.1
  • 5
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • Christman BW, et al. (1992) An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med. 327:70-5.
    • (1992) N. Engl. J. Med. , vol.327 , pp. 70-75
    • Christman, B.W.1
  • 6
    • 0026034713 scopus 로고
    • Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease?
    • Stewart DJ, Levy RD, Cernacek P, Langleben D. (1991) Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann. Intern. Med. 114:464-9.
    • (1991) Ann. Intern. Med. , vol.114 , pp. 464-469
    • Stewart, D.J.1    Levy, R.D.2    Cernacek, P.3    Langleben, D.4
  • 7
    • 0036799278 scopus 로고    scopus 로고
    • Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
    • Launay JM, et al. (2002) Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nat. Med. 8:1129-35.
    • (2002) Nat. Med. , vol.8 , pp. 1129-1135
    • Launay, J.M.1
  • 8
    • 33646201514 scopus 로고    scopus 로고
    • Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: Critical role for serotonin-induced smooth muscle hyperplasia
    • Eddahibi S, et al. (2006) Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. Circulation. 113:1857-64.
    • (2006) Circulation. , vol.113 , pp. 1857-1864
    • Eddahibi, S.1
  • 9
    • 62749116746 scopus 로고    scopus 로고
    • An integrated approach for the systematic identification and characterization of heart-enriched genes with unknown functions
    • Uchida S, et al. (2009) An integrated approach for the systematic identification and characterization of heart-enriched genes with unknown functions. BMC Genomics. 10:100.
    • (2009) BMC Genomics. , vol.10 , pp. 100
    • Uchida, S.1
  • 10
    • 84868270815 scopus 로고    scopus 로고
    • Vascular inflammation and endothelial dysfunction in experimental hypertension
    • Savoia C, et al. (2011) Vascular inflammation and endothelial dysfunction in experimental hypertension. Int. J. Hypertens. 2011:281240.
    • (2011) Int. J. Hypertens. , vol.2011 , pp. 281240
    • Savoia, C.1
  • 11
    • 75149192272 scopus 로고    scopus 로고
    • Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension
    • Crosswhite P, Sun Z. (2010) Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension. J. Hypertens. 28:201-12.
    • (2010) J. Hypertens. , vol.28 , pp. 201-212
    • Crosswhite, P.1    Sun, Z.2
  • 12
    • 0037092565 scopus 로고    scopus 로고
    • CX(3)C chemokine fractalkine in pulmonary arterial hypertension
    • Balabanian K, et al. (2002) CX(3)C chemokine fractalkine in pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med. 165:1419-25.
    • (2002) Am. J. Respir. Crit. Care Med. , vol.165 , pp. 1419-1425
    • Balabanian, K.1
  • 13
    • 84857027921 scopus 로고    scopus 로고
    • The monocrotaline model of pulmonary hypertension in perspective
    • Gomez-Arroyo JG, et al. (2011) The monocrotaline model of pulmonary hypertension in perspective. Am. J. Physiol. Lung Cell. Mol. Physiol. 302:L363-9.
    • (2011) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.302
    • Gomez-Arroyo, J.G.1
  • 14
    • 2342667629 scopus 로고    scopus 로고
    • Primary pulmonary hypertension: An overview of epidemiology and pathogenesis
    • Ghamra ZW, Dweik RA. (2003) Primary pulmonary hypertension: an overview of epidemiology and pathogenesis. Cleve Clin. J. Med. 70 Suppl 1:S2-8.
    • (2003) Cleve Clin. J. Med. 70 Suppl , vol.1
    • Ghamra, Z.W.1    Dweik, R.A.2
  • 16
    • 2942541475 scopus 로고    scopus 로고
    • Cellular and molecular pathobiology of pulmonary arterial hypertension
    • Humbert M, et al. (2004) Cellular and molecular pathobiology of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 43:13S-24S.
    • (2004) J. Am. Coll. Cardiol. , vol.43
    • Humbert, M.1
  • 17
    • 0036875930 scopus 로고    scopus 로고
    • Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension
    • Jeffery TK, Morrell NW. (2002) Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog. Cardiovasc. Dis. 45:173-202.
    • (2002) Prog. Cardiovasc. Dis. , vol.45 , pp. 173-202
    • Jeffery, T.K.1    Morrell, N.W.2
  • 18
    • 34247124221 scopus 로고    scopus 로고
    • Endothelin-1-induced signaling pathways in vascular smooth muscle cells
    • Bouallegue A, Daou GB, Srivastava AK. (2007) Endothelin-1-induced signaling pathways in vascular smooth muscle cells. Curr. Vasc. Pharmacol. 5:45-52.
    • (2007) Curr. Vasc. Pharmacol. , vol.5 , pp. 45-52
    • Bouallegue, A.1    Daou, G.B.2    Srivastava, A.K.3
  • 19
    • 0036007307 scopus 로고    scopus 로고
    • Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery
    • Clapp LH, et al. (2002) Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery. Am. J. Respir. Cell Moll. Biol. 26:194-201.
    • (2002) Am. J. Respir. Cell Moll. Biol. , vol.26 , pp. 194-201
    • Clapp, L.H.1
  • 20
    • 0022706874 scopus 로고
    • Effect of prostaglandin E1 on DNA synthesis in vascular smooth muscle cells
    • Owen NE. (1986) Effect of prostaglandin E1 on DNA synthesis in vascular smooth muscle cells. Am. J. Physiol. 250:C584-8.
    • (1986) Am. J. Physiol. , vol.250
    • Owen, N.E.1
  • 21
    • 0021285044 scopus 로고
    • Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor
    • Nilsson J, Olsson AG. (1984) Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor. Atherosclerosis. 53:77-82.
    • (1984) Atherosclerosis. , vol.53 , pp. 77-82
    • Nilsson, J.1    Olsson, A.G.2
  • 22
    • 0033163137 scopus 로고    scopus 로고
    • Autocrine function of inducible nitric oxide synthase and cyclooxygenase-2 in proliferation of human and rat pulmonary artery smooth-muscle cells: Species variation
    • Jourdan KB, Evans TW, Lamb NJ, Goldstraw P, Mitchell JA. (1999) Autocrine function of inducible nitric oxide synthase and cyclooxygenase-2 in proliferation of human and rat pulmonary artery smooth-muscle cells: species variation. Am. J. Respir. Cell Mol. Biol. 21:105-10.
    • (1999) Am. J. Respir. Cell Mol. Biol. , vol.21 , pp. 105-110
    • Jourdan, K.B.1    Evans, T.W.2    Lamb, N.J.3    Goldstraw, P.4    Mitchell, J.A.5
  • 23
    • 78349286375 scopus 로고    scopus 로고
    • Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension
    • Rich S, et al. (2010) Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension. Chest. 138:1234-9.
    • (2010) Chest. , vol.138 , pp. 1234-1239
    • Rich, S.1
  • 24
    • 0033838125 scopus 로고    scopus 로고
    • Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
    • Deng Z, et al. (2000) Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am. J. Hum. Genet. 67:737-44.
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 737-744
    • Deng, Z.1
  • 25
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
    • Lane KB, et al. (2000) Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat. Genet. 26:81-4.
    • (2000) Nat. Genet. , vol.26 , pp. 81-84
    • Lane, K.B.1
  • 26
    • 0035797556 scopus 로고    scopus 로고
    • Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia
    • Trembath RC, et al. (2001) Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. N. Engl. J. Med. 345:325-34.
    • (2001) N. Engl. J. Med. , vol.345 , pp. 325-334
    • Trembath, R.C.1
  • 27
    • 2442519516 scopus 로고    scopus 로고
    • Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension
    • Chaouat A, et al. (2004) Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension. Thorax 59:446-8.
    • (2004) Thorax , vol.59 , pp. 446-448
    • Chaouat, A.1
  • 28
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGFbeta signaling
    • Massague J, Chen YG. (2000) Controlling TGFbeta signaling. Genes. Dev. 14:627-44.
    • (2000) Genes. Dev. , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 29
    • 0034193390 scopus 로고    scopus 로고
    • BMP type II receptor is required for gastrulation and early development of mouse embryos
    • Beppu H, et al. (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev. Biol. 221:249-58.
    • (2000) Dev. Biol. , vol.221 , pp. 249-258
    • Beppu, H.1
  • 30
    • 0037421604 scopus 로고    scopus 로고
    • Signaling molecules in nonfamilial pulmonary hypertension
    • Du L, et al. (2003) Signaling molecules in nonfamilial pulmonary hypertension. N. Engl. J. Med. 348:500-9.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 500-509
    • Du, L.1
  • 31
    • 0034747794 scopus 로고    scopus 로고
    • Regulation of endothelin-1 synthesis in human pulmonary arterial smooth muscle cells. Effects of transforming growth factor-beta and hypoxia
    • Markewitz BA, Farrukh IS, Chen Y, Li Y, Michael JR. (2001) Regulation of endothelin-1 synthesis in human pulmonary arterial smooth muscle cells. Effects of transforming growth factor-beta and hypoxia. Cardiovasc. Res. 49:200-6.
    • (2001) Cardiovasc. Res. , vol.49 , pp. 200-206
    • Markewitz, B.A.1    Farrukh, I.S.2    Chen, Y.3    Li, Y.4    Michael, J.R.5
  • 32
    • 34249854139 scopus 로고    scopus 로고
    • A review of pulmonary arterial hypertension: Role of ambrisentan
    • Barst RJ. (2007) A review of pulmonary arterial hypertension: role of ambrisentan. Vasc. Health Risk Manag. 3:11-22.
    • (2007) Vasc. Health Risk Manag. , vol.3 , pp. 11-22
    • Barst, R.J.1
  • 33
    • 33847020006 scopus 로고    scopus 로고
    • Nitric oxide-induced inhibition of smooth muscle cell proliferation involves S-nitrosation and inactivation of RhoA
    • Zuckerbraun BS, et al. (2007) Nitric oxide-induced inhibition of smooth muscle cell proliferation involves S-nitrosation and inactivation of RhoA. Am. J. Physiol. Cell Physiol. 292:C824-31.
    • (2007) Am. J. Physiol. Cell Physiol. , vol.292
    • Zuckerbraun, B.S.1
  • 34
    • 2342483718 scopus 로고    scopus 로고
    • Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation
    • Landsberg JW, Yuan JX. (2004) Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol. Sci. 19:44-50.
    • (2004) News Physiol. Sci. , vol.19 , pp. 44-50
    • Landsberg, J.W.1    Yuan, J.X.2
  • 35
    • 0027397544 scopus 로고
    • Inositol trisphosphate and calcium signalling
    • Berridge MJ. (1993) Inositol trisphosphate and calcium signalling. Nature. 361:315-25.
    • (1993) Nature. , vol.361 , pp. 315-325
    • Berridge, M.J.1
  • 36
    • 77951230045 scopus 로고    scopus 로고
    • Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cells
    • Yang XR, Lin MJ, Sham JS. (2010) Physiological functions of transient receptor potential channels in pulmonary arterial smooth muscle cells. Adv. Exp. Med. Biol. 661:109-22.
    • (2010) Adv. Exp. Med. Biol. , vol.661 , pp. 109-122
    • Yang, X.R.1    Lin, M.J.2    Sham, J.S.3
  • 37
    • 0035895596 scopus 로고    scopus 로고
    • The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel
    • Inoue R, et al. (2001) The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ. Res. 88:325-32.
    • (2001) Circ. Res. , vol.88 , pp. 325-332
    • Inoue, R.1
  • 38
    • 0036889520 scopus 로고    scopus 로고
    • Diacylglycerol and protein kinase C activate cation channels involved in myogenic tone
    • Slish DF, Welsh DG, Brayden JE. (2002) Diacylglycerol and protein kinase C activate cation channels involved in myogenic tone. Am. J. Physiol. Heart Circ. Physiol. 283:H2196-201.
    • (2002) Am. J. Physiol. Heart Circ. Physiol. , vol.283
    • Slish, D.F.1    Welsh, D.G.2    Brayden, J.E.3
  • 39
    • 0032491187 scopus 로고    scopus 로고
    • Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension
    • Yuan JX, et al. (1998) Dysfunctional voltage-gated K+ channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension. Circulation. 98:1400-6.
    • (1998) Circulation. , vol.98 , pp. 1400-1406
    • Yuan, J.X.1
  • 40
    • 0035970577 scopus 로고    scopus 로고
    • Gene expression patterns in the lungs of patients with primary pulmonary hypertension: A gene microarray analysis
    • Geraci MW, et al. (2001) Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis. Circ. Res. 88:555-62.
    • (2001) Circ. Res. , vol.88 , pp. 555-562
    • Geraci, M.W.1
  • 41
    • 63849294626 scopus 로고    scopus 로고
    • KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle
    • Joshi S, Sedivy V, Hodyc D, Herget J, Gurney AM. (2009) KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle. J. Pharmacol Exp. Ther. 329:368-76.
    • (2009) J. Pharmacol Exp. Ther. , vol.329 , pp. 368-376
    • Joshi, S.1    Sedivy, V.2    Hodyc, D.3    Herget, J.4    Gurney, A.M.5
  • 42
    • 0032994105 scopus 로고    scopus 로고
    • Tumor promotion by hydrogen peroxide in rat liver epithelial cells
    • Huang RP, et al. (1999) Tumor promotion by hydrogen peroxide in rat liver epithelial cells. Carcinogenesis. 20:485-92.
    • (1999) Carcinogenesis. , vol.20 , pp. 485-492
    • Huang, R.P.1
  • 43
    • 17944386754 scopus 로고    scopus 로고
    • Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells
    • Zhang S, et al. (2003) Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:L740-54.
    • (2003) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.285
    • Zhang, S.1
  • 44
    • 6344257102 scopus 로고    scopus 로고
    • Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    • McMurtry MS, et al. (2004) Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ. Res. 95:830-40.
    • (2004) Circ. Res. , vol.95 , pp. 830-840
    • McMurtry, M.S.1
  • 45
    • 0034001070 scopus 로고    scopus 로고
    • Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptorassociated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin
    • Liu H, Nishitoh H, Ichijo H, Kyriakis JM. (2000) Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptorassociated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol. Cell. Biol. 20:2198-208.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2198-2208
    • Liu, H.1    Nishitoh, H.2    Ichijo, H.3    Kyriakis, J.M.4
  • 47
    • 80052503319 scopus 로고    scopus 로고
    • Epigenetic regulation of pulmonary arterial hypertension
    • Xu XF, Cheng F, Du LZ. (2011) Epigenetic regulation of pulmonary arterial hypertension. Hypertens. Res. 34:981-6.
    • (2011) Hypertens. Res. , vol.34 , pp. 981-986
    • Xu, X.F.1    Cheng, F.2    Du, L.Z.3
  • 48
    • 77954083190 scopus 로고    scopus 로고
    • Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: A basis for excessive cell proliferation and a new therapeutic target
    • Archer SL, et al. (2010) Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Circulation. 121:2661-71.
    • (2010) Circulation. , vol.121 , pp. 2661-2671
    • Archer, S.L.1
  • 49
    • 77958450790 scopus 로고    scopus 로고
    • Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat
    • Xu XF, et al. (2011) Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat. J. Hypertens. 28:2227-35.
    • (2011) J. Hypertens. , vol.28 , pp. 2227-2235
    • Xu, X.F.1
  • 50
    • 84880758429 scopus 로고    scopus 로고
    • Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension
    • White K, Loscalzo J, Chan SY. (2012) Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension. Pulm. Circ. 2:278-90.
    • (2012) Pulm. Circ. , vol.2 , pp. 278-290
    • White, K.1    Loscalzo, J.2    Chan, S.Y.3
  • 51
    • 84862777565 scopus 로고    scopus 로고
    • MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: Results of a network bioinformatics approach
    • Parikh VN, et al. (2012) MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation. 125:1520-32.
    • (2012) Circulation. , vol.125 , pp. 1520-1532
    • Parikh, V.N.1
  • 52
    • 59849118025 scopus 로고    scopus 로고
    • Interleukin-6 overexpression induces pulmonary hypertension
    • Steiner MK, et al. (2009) Interleukin-6 overexpression induces pulmonary hypertension. Circ. Res. 104:236-44.
    • (2009) Circ. Res. , vol.104 , pp. 236-244
    • Steiner, M.K.1
  • 53
    • 84863293692 scopus 로고    scopus 로고
    • MiR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling
    • Yang S, et al. (2012) miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling. Am. J. Physiol. Lung Cell. Mol. Physiol. 302:L521-9.
    • (2012) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.302
    • Yang, S.1
  • 54
    • 78649892620 scopus 로고    scopus 로고
    • MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration
    • Sarkar J, et al. (2010) MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration. Am. J. Physiol. Lung Cell. Mol. Physiol. 299:L861-71.
    • (2010) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.299
    • Sarkar, J.1
  • 55
    • 84883426400 scopus 로고    scopus 로고
    • MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells
    • Kang K, et al. (2013) MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. J. Biol. Chem. 288:25414-27.
    • (2013) J. Biol. Chem. , vol.288 , pp. 25414-25427
    • Kang, K.1
  • 56
    • 84867360761 scopus 로고    scopus 로고
    • Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation
    • Jalali S, et al. (2012) Mir-206 regulates pulmonary artery smooth muscle cell proliferation and differentiation. PLoS One. 7:e46808.
    • (2012) PLoS One. , vol.7
    • Jalali, S.1
  • 57
    • 84867716694 scopus 로고    scopus 로고
    • MiR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia
    • Gou D, et al. (2012) miR-210 has an antiapoptotic effect in pulmonary artery smooth muscle cells during hypoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 303:L682-91.
    • (2012) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.303
    • Gou, D.1
  • 58
    • 79952733132 scopus 로고    scopus 로고
    • Role for miR-204 in human pulmonary arterial hypertension
    • Courboulin A, et al. (2011) Role for miR-204 in human pulmonary arterial hypertension. J. Exp. Med. 208:535-48.
    • (2011) J. Exp. Med. , vol.208 , pp. 535-548
    • Courboulin, A.1
  • 59
    • 84894382202 scopus 로고    scopus 로고
    • Role for DNA damage sig-naling in pulmonary arterial hypertension
    • Meloche J, et al. (2014) Role for DNA damage sig-naling in pulmonary arterial hypertension. Circulation. 129:786-97.
    • (2014) Circulation. , vol.129 , pp. 786-797
    • Meloche, J.1
  • 60
    • 84455168708 scopus 로고    scopus 로고
    • Altered microRNA processing in heritable pulmonary arterial hypertension: An important role for Smad-8
    • Drake KM, et al. (2011) Altered microRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8. Am. J. Respir. Crit. Care Med. 184:1400-8.
    • (2011) Am. J. Respir. Crit. Care Med. , vol.184 , pp. 1400-1408
    • Drake, K.M.1
  • 61
    • 84872078405 scopus 로고    scopus 로고
    • An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension
    • Kim J, et al. (2013) An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat. Med. 19:74-82.
    • (2013) Nat. Med. , vol.19 , pp. 74-82
    • Kim, J.1
  • 63
    • 84893630381 scopus 로고    scopus 로고
    • Therapeutic potential of microRNA modulation in pulmonary arterial hypertension
    • 2013, May 13. [Epub ahead of print]
    • Meloche J, Paulin R, Provencher S, Bonnet S. (2013) Therapeutic potential of microRNA modulation in pulmonary arterial hypertension. Curr. Vasc. Pharmacol. 2013, May 13. [Epub ahead of print]
    • (2013) Curr. Vasc. Pharmacol.
    • Meloche, J.1    Paulin, R.2    Provencher, S.3    Bonnet, S.4
  • 64
    • 80755153114 scopus 로고    scopus 로고
    • From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension
    • Paulin R, Courboulin A, Barrier M, Bonnet S. (2011) From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension. J Mol. Med. (Berl). 89:1089-101.
    • (2011) J Mol. Med. (Berl). , vol.89 , pp. 1089-1101
    • Paulin, R.1    Courboulin, A.2    Barrier, M.3    Bonnet, S.4
  • 65
    • 77951210914 scopus 로고    scopus 로고
    • PDGF receptor and its antagonists: Role in treatment of PAH
    • Grimminger F, Schermuly RT. (2010) PDGF receptor and its antagonists: role in treatment of PAH. Adv. Exp. Med. Biol. 661:435-46.
    • (2010) Adv. Exp. Med. Biol. , vol.661 , pp. 435-446
    • Grimminger, F.1    Schermuly, R.T.2
  • 67
    • 1842280753 scopus 로고
    • A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro
    • Ross R, Glomset J, Kariya B, Harker L. (1974) A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc. Natl. Acad. Sci. U. S. A. 71:1207-10.
    • (1974) Proc. Natl. Acad. Sci. U. S. A. , vol.71 , pp. 1207-1210
    • Ross, R.1    Glomset, J.2    Kariya, B.3    Harker, L.4
  • 68
    • 26444540768 scopus 로고    scopus 로고
    • Reversal of experimental pulmonary hypertension by PDGF inhibition
    • Schermuly RT, et al. (2005) Reversal of experimental pulmonary hypertension by PDGF inhibition. J. Clin. Invest. 115:2811-21.
    • (2005) J. Clin. Invest. , vol.115 , pp. 2811-2821
    • Schermuly, R.T.1
  • 69
    • 0031925331 scopus 로고    scopus 로고
    • Platelet-derived growth factor expression in primary pulmonary hypertension: Comparison of HIV seropositive and HIV seronegative patients
    • Humbert M, et al. (1998) Platelet-derived growth factor expression in primary pulmonary hypertension: comparison of HIV seropositive and HIV seronegative patients. Eur. Respir. J. 11:554-9.
    • (1998) Eur. Respir. J. , vol.11 , pp. 554-559
    • Humbert, M.1
  • 70
    • 0037303378 scopus 로고    scopus 로고
    • PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression
    • Yu Y, et al. (2003) PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression. Am. J. Physiol. Cell Physiol. 284:C316-30.
    • (2003) Am. J. Physiol. Cell Physiol. , vol.284
    • Yu, Y.1
  • 71
    • 0344837754 scopus 로고    scopus 로고
    • Role of plateletderived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus
    • Balasubramaniam V, et al. (2003) Role of plateletderived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus. Am. J. Physiol. Lung Cell. Mol. Physiol. 284:L826-33.
    • (2003) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.284
    • Balasubramaniam, V.1
  • 72
    • 18844441159 scopus 로고    scopus 로고
    • A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling
    • Jankov RP, et al. (2005) A role for platelet-derived growth factor beta-receptor in a newborn rat model of endothelin-mediated pulmonary vascular remodeling. Am. J. Physiol. Lung Cell. Mol. Physiol. 288:L1162-70.
    • (2005) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.288
    • Jankov, R.P.1
  • 73
    • 25444484658 scopus 로고    scopus 로고
    • Imatinib for the treatment of pulmonary arterial hypertension
    • Ghofrani HA, Seeger W, Grimminger F. (2005) Imatinib for the treatment of pulmonary arterial hypertension. N. Engl. J. Med. 353:1412-3.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1412-1413
    • Ghofrani, H.A.1    Seeger, W.2    Grimminger, F.3
  • 74
    • 84874948946 scopus 로고    scopus 로고
    • Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: Results of the randomized IMPRES study
    • Hoeper MM, et al. (2013) Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study. Circulation. 127:1128-38.
    • (2013) Circulation. , vol.127 , pp. 1128-1138
    • Hoeper, M.M.1
  • 75
    • 84875690569 scopus 로고    scopus 로고
    • The role of imatinib in the treatment of pulmonary hypertension
    • Mucke H. (2013) The role of imatinib in the treatment of pulmonary hypertension. Drugs Today. (Barc). 49:203-11.
    • (2013) Drugs Today. (Barc). , vol.49 , pp. 203-211
    • Mucke, H.1
  • 76
    • 58149100136 scopus 로고    scopus 로고
    • Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: Requirement for Smads, (beta)-CATENIN, AND GSK3(beta)
    • Clifford RL, Deacon K, Knox AJ. (2008) Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: requirement for Smads, (beta)-CATENIN, AND GSK3(beta). J. Biol. Chem. 283:35337-53.
    • (2008) J. Biol. Chem. , vol.283 , pp. 35337-35353
    • Clifford, R.L.1    Deacon, K.2    Knox, A.J.3
  • 77
    • 67649844313 scopus 로고    scopus 로고
    • Inflammation, growth factors, and pulmonary vascular remodeling
    • Hassoun PM, et al. (2009) Inflammation, growth factors, and pulmonary vascular remodeling. J. Am. Coll. Cardiol. 54:S10-9.
    • (2009) J. Am. Coll. Cardiol. , vol.54
    • Hassoun, P.M.1
  • 78
    • 0032429293 scopus 로고    scopus 로고
    • Heart and lung VEGF mRNA expression in rats with monocrotaline-or hypoxia-induced pulmonary hypertension
    • Partovian C, et al. (1998) Heart and lung VEGF mRNA expression in rats with monocrotaline-or hypoxia-induced pulmonary hypertension. Am. J. Physiol. 275:H1948-56.
    • (1998) Am. J. Physiol. , vol.275
    • Partovian, C.1
  • 79
    • 0035975944 scopus 로고    scopus 로고
    • Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension
    • Campbell AI, Zhao Y, Sandhu R, Stewart DJ. (2001) Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension. Circulation. 104:2242-8.
    • (2001) Circulation. , vol.104 , pp. 2242-2248
    • Campbell, A.I.1    Zhao, Y.2    Sandhu, R.3    Stewart, D.J.4
  • 80
    • 0034533016 scopus 로고    scopus 로고
    • Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats
    • Partovian C, et al. (2000) Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats. Am. J. Respir. Cell Mol. Biol. 23:762-71.
    • (2000) Am. J. Respir. Cell Mol. Biol. , vol.23 , pp. 762-771
    • Partovian, C.1
  • 81
    • 22444448911 scopus 로고    scopus 로고
    • Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species: A requirement for NAD(P)H oxidase
    • Mata-Greenwood E, Grobe A, Kumar S, Noskina Y, Black SM. (2005) Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-beta1 and reactive oxygen species: a requirement for NAD(P)H oxidase. Am. J. Physiol. Lung Cell. Mol. Physiol. 289:L288-9.
    • (2005) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.289
    • Mata-Greenwood, E.1    Grobe, A.2    Kumar, S.3    Noskina, Y.4    Black, S.M.5
  • 82
    • 0037974675 scopus 로고    scopus 로고
    • Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension
    • Mata-Greenwood E, Meyrick B, Soifer SJ, Fineman JR, Black SM. (2003) Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol 285: L222-31.
    • (2003) Am. J. Physiol. Lung Cell. Mol. Physiol , vol.285
    • Mata-Greenwood, E.1    Meyrick, B.2    Soifer, S.J.3    Fineman, J.R.4    Black, S.M.5
  • 83
    • 77950336491 scopus 로고    scopus 로고
    • Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension
    • Firth AL, Yao W, Remillard CV, Ogawa A, Yuan JX. (2010) Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am. J. Physiol. Lung Cell. Mol. Physiol. 298:L548-57.
    • (2010) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.298
    • Firth, A.L.1    Yao, W.2    Remillard, C.V.3    Ogawa, A.4    Yuan, J.X.5
  • 84
    • 37349051446 scopus 로고    scopus 로고
    • Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells
    • Greco SJ, Liu K, Rameshwar P. (2007) Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells. Stem Cells. 25:3143-54.
    • (2007) Stem Cells. , vol.25 , pp. 3143-3154
    • Greco, S.J.1    Liu, K.2    Rameshwar, P.3
  • 85
    • 48249113711 scopus 로고    scopus 로고
    • Conditional deletion of Kruppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury
    • Yoshida T, Kaestner KH, Owens GK. (2008) Conditional deletion of Kruppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circ. Res. 102:1548-57.
    • (2008) Circ. Res. , vol.102 , pp. 1548-1557
    • Yoshida, T.1    Kaestner, K.H.2    Owens, G.K.3
  • 86
    • 0025328511 scopus 로고
    • Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11
    • Freyd G, Kim SK, Horvitz HR. (1990) Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11. Nature. 344:876-9.
    • (1990) Nature. , vol.344 , pp. 876-879
    • Freyd, G.1    Kim, S.K.2    Horvitz, H.R.3
  • 87
    • 54049134751 scopus 로고    scopus 로고
    • Fhl-1, a new key protein in pulmonary hypertension
    • Kwapiszewska G, et al. (2008) Fhl-1, a new key protein in pulmonary hypertension. Circulation. 118:1183-94.
    • (2008) Circulation. , vol.118 , pp. 1183-1194
    • Kwapiszewska, G.1
  • 88
    • 33745155785 scopus 로고    scopus 로고
    • An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
    • Bonnet S, et al. (2006) An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation. 113:2630-41.
    • (2006) Circulation. , vol.113 , pp. 2630-2641
    • Bonnet, S.1
  • 89
    • 17644423994 scopus 로고    scopus 로고
    • Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1
    • Semenza GL. (2005) Pulmonary vascular responses to chronic hypoxia mediated by hypoxia-inducible factor 1. Proc. Am. Thorac. Soc. 2:68-70.
    • (2005) Proc. Am. Thorac. Soc. , vol.2 , pp. 68-70
    • Semenza, G.L.1
  • 90
    • 70449109145 scopus 로고    scopus 로고
    • Notch3 signaling promotes the development of pulmonary arterial hypertension
    • Li X, et al. (2009) Notch3 signaling promotes the development of pulmonary arterial hypertension. Nature Med. 15:1289-97.
    • (2009) Nature Med. , vol.15 , pp. 1289-1297
    • Li, X.1
  • 91
    • 0037195730 scopus 로고    scopus 로고
    • Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: Implications in cell-cycle regulation
    • Campos AH, Wang W, Pollman MJ, Gibbons GH. (2002) Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: implications in cell-cycle regulation. Circ. Res. 91:999-1006.
    • (2002) Circ. Res. , vol.91 , pp. 999-1006
    • Campos, A.H.1    Wang, W.2    Pollman, M.J.3    Gibbons, G.H.4
  • 92
    • 26844501163 scopus 로고    scopus 로고
    • Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro
    • Morrow D, et al. (2005) Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro. Am. J. Physiol. Cell Physiol. 289:C1188-96.
    • (2005) Am. J. Physiol. Cell Physiol. , vol.289
    • Morrow, D.1
  • 93
    • 0037077253 scopus 로고    scopus 로고
    • Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis
    • Wang W, Prince CZ, Mou Y, Pollman MJ. (2002) Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis. J Biol. Chem. 277:21723-9.
    • (2002) J Biol. Chem. , vol.277 , pp. 21723-21729
    • Wang, W.1    Prince, C.Z.2    Mou, Y.3    Pollman, M.J.4
  • 94
    • 0035137910 scopus 로고    scopus 로고
    • Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development
    • Berset T, Hoier EF, Battu G, Canevascini S, Hajnal A. (2001) Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development. Science 291:1055-8.
    • (2001) Science , vol.291 , pp. 1055-1058
    • Berset, T.1    Hoier, E.F.2    Battu, G.3    Canevascini, S.4    Hajnal, A.5
  • 95
    • 78649885341 scopus 로고    scopus 로고
    • ID family protein expression and regulation in hypoxic pulmonary hypertension
    • Lowery JW, et al. (2010) ID family protein expression and regulation in hypoxic pulmonary hypertension. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299:R1463-77.
    • (2010) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.299
    • Lowery, J.W.1
  • 96
    • 23144464750 scopus 로고    scopus 로고
    • Id family of helix-loop-helix proteins in cancer
    • Perk J, Iavarone A, Benezra R. (2005) Id family of helix-loop-helix proteins in cancer. Nat. Rev. Cancer. 5:603-14.
    • (2005) Nat. Rev. Cancer. , vol.5 , pp. 603-614
    • Perk, J.1    Iavarone, A.2    Benezra, R.3
  • 97
    • 77955172689 scopus 로고    scopus 로고
    • Smad-dependent and smadindependent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo
    • Yang J, et al. (2010) Smad-dependent and smadindependent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. Circ. Res. 107:252-62.
    • (2010) Circ. Res. , vol.107 , pp. 252-262
    • Yang, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.