Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 285, Issue 1 29-1, 2003, Pages

  Mata Greenwood, Eugenia ^a   Meyrick, Barbara ^c   Soifer, Scott J ^d,e   Fineman, Jeffrey R ^d,e   Black, Stephen M ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Shunted lambs; Vascular graft placement

Indexed keywords

UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LAMB; LUNG BLOOD FLOW; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; TISSUE DISTRIBUTION; VASCULAR SMOOTH MUSCLE;

EID: 0037974675     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00388.2002     Document Type: Article

References (41)

1. Asahara T, Bauters C, Pastore C, Kearney M, Rossow S, Bunting S, Ferrara N, Symes JF, and Isner JM. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in ballooninjured rat carotid artery. Circulation 91: 2793-2801, 1995.
2. Bhatt AJ, Amin SB, Chess PR, Watkins RH, and Maniscalco WM. Expression of vascular endothelial growth factor and Flk-1 in developing and glucocorticoid-treated mouse lung. Pediatr Res 47: 606-613, 2000.
3. Black SM, Bekker JM, Johengen MJ, Parry AJ, Soifer SJ, and Fineman JR. Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res 47: 97-106, 2000.
4. Black SM, Fineman JR, Steinhorn RH, Bristow J, and Soifer SJ. Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Heart Circ Physiol 275: H1643-H1651, 1998.
5. Black SM, Johengen MJ, Ma ZD, Bristow J, and Soifer SJ. Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs. J Clin Invest 100: 1448-1458, 1997.
6. Boussat S, Eddahibi S, Coste A, Fataccioli V, Gouge M, Housset B, Adnot S, and Maitre B. Expression and regulation of vascular endothelial growth factor in human pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol 279: L371-L378, 2000.
7. Brogi E, Wu T, Namiki A, and Isner JM. Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only. Circulation 90: 649-652, 1994.
8. Cavallaro U, Tenan M, Castelli V, Perilli A, Maggiano N, Van Meir EG, Montesano R, Soria MR, and Pepper MS. Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: relevance to the regulation of angiogenesis. J Cell Biochem 82: 619-633, 2001.
9. Ferrara N, Houck K, Jakeman L, and Leung DW. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 13: 18-32, 1992.
10. Fong GH, Rossant J, Gertsenstein M, and Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66-70, 1995.
11. Frelin C, Ladoux A, and D'Angelo G. Vascular endothelial growth factors and angiogenesis. Ann Endocrinol (Paris) 61: 70-74, 2000.
12. Gan L, Miocic M, Doroudi R, Selin-Sjogren L, and Jern S. Distinct regulation of vascular endothelial growth factor in intact human conduit vessels exposed to laminar fluid shear stress and pressure. Biochem Biophys Res Commun 272: 490-496, 2000.
13. Geiger R, Berger RM, Hess J, Bogers AJ, Sharma HS, and Mooi WJ. Enhanced expression of vascular endothelial growth factor in pulmonary plexogenic arteriopathy due to congenital heart disease. J Pathol 191: 202-207, 2000.
14. Gerber HP, Condorelli F, Park J, and Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. J Biol Chem 272: 23659-23667, 1997.
15. Gruden G, Thomas S, Burt D, Lane S, Chusney G, Sacks S, and Viberti G. Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction. Proc Natl Acad Sci USA 94: 12112-12116, 1997.
16. Hiratsuka S, Maru Y, Okada A, Seiki M, Noda T, and Shibuya M. Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res 61: 1207-1213, 2001.
17. Hirose S, Hosoda Y, Furuya S, Otsuki T, and Ikeda E. Expression of vascular endothelial growth factor and its receptors correlates closely with formation of the plexiform lesion in human pulmonary hypertension. Pathol Int 50: 472-479, 2000.
18. Hoffman JI, Rudolph AM, and Heyman MA. Pulmonary vascular disease with congenital heart lesion: pathologic features and causes. Circulation 64: 873-877, 1981.
19. Houch KA, Ferrara N, Winer J, Cachianes G, Li B, and Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5: 1806-1814, 1991.
20. Kearney JB, Ambler CA, Monaco KA, Johnson N, Rapoport RG, and Bautch VL. Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood 99: 2397-2407, 2002.
21. Laitinen M, Zachary I, Breier G, Pakkanen T, Hakkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, and Yla-Herttuala S. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. Hum Gene Ther 8: 1737-1744, 1997.
22. Lassus P, Ristimaki A, Ylikorkala O, Viinikka L, and Andersson S. Vascular endothelial growth factor in human preterm lung. Am J Respir Crit Care Med 159: 1429-1433, 1999.
23. Lassus P, Turanlahti M, Heikkila P, Andersson LC, Nupponen I, Sarnesto A, and Andersson S. Pulmonary vascular endothelial growth factor and Flt-1 in fetuses, in acute and chronic lung disease, and in persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 164: 1981-1987, 2001.
24. Milkiewicz M, Brown MD, Egginton S, and Hudlicka O. Association between shear stress, angiogenesis and VEGF in skeletal muscles in vivo. Microcirculation 8: 229-241, 2001.
25. Pepper MS, Ferrara N, Orci L, and Montesano R. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun 189: 824-831, 1992.
26. Pertovaara L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, and Alitalo K. Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J Biol Chem 269: 6271-6274, 1994.
27. Rabinovitch M, Haworth SG, Castaneda AR, Nadas AS, and Reid LM. Lung biopsy in congenital heart disease: a morphometric approach to pulmonary vascular disease. Circulation 58: 1107-1122, 1978.
28. Reddy VM, Meyrick B, Wong J, Khoor A, Liddicoat JR, Hanley FL, and Fineman JR. In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation 92: 606-613, 1995.
29. Robinson CJ and Stringer SE. The splice variants of vascular endothelial growth factor (VEGF) and their receptors. J Cell Sci 114: 853-865, 2001.
30. Schuh AC, Faloon P, Hu QL, Bhimani M, and Choi K. In vitro hematopoietic and endothelial potential of flk-1 -/- embryonic stem cells and embryos. Proc Natl Acad Sci USA 96: 2159-2164, 1999.
31. Seko Y, Fujikura H, Pang J, Tokoro T, and Shimokawa H. Induction of vascular endothelial growth factor after application of mechanical stress to retinal pigment epithelium of the rat in vitro. Invest Ophthalmol Vis Sci 40: 3287-3291, 1999.
32. Seko Y, Nishimura H, Takahashi N, Ashida T, and Nagai R. Serum levels of vascular endothelial growth factor and transforming growth factor-β1 in patients with atrial fibrillation undergoing defibrillation therapy. Jpn Heart J 41: 27-32, 2000.
33. Semenza GL, Agani F, Feldser D, Iyer N, Kotch L, Laughner E, and Yu A. Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol 475: 123-130, 2000.
34. Shehata SM, Mooir WJ, Okazaki T, El-Banna I, Sharma HS, and Tibboel D. Enhanced expression of vascular endothelial growth factor in lungs of newborn infants with congenital diaphragmatic hernia and pulmonary hypertension. Thorax 54: 427-431, 1999.
35. Shen BQ, Lee DY, and Zioncheck TF. Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway. J Biol Chem 274: 33057-33063, 1999.
36. Shifren JL, Doldi N, Ferrara N, Mesiano S, and Jaffe RB. In the human fetus, vascular endothelial growth factor is expressed in epithelial cells and myocytes, but not vascular endothelium: implications for mode of action. J Clin Endocrinol Metab 79: 316-322, 1994.
37. Smith JD, Davies N, Willis AI, Sumpio BE, and Zilla P. Cyclic stretch induces the expression of vascular endothelial growth factor in vascular smooth muscle cells. Endothelium 8: 41-48, 2001.
38. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, and Abraham JA. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 266: 11947-11954, 1991.
39. Tuder RM, Chacon M, Alger L, Wang J, TarasevicieneStewart L, Kasahara Y, Cool CD, Bishop AE, Geraci M, Semenza GL, Yacoub M, Polak JM, and Voelkel NF. Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis. J Pathol 195: 367-374, 2001.
40. Zheng W, Brown MD, Brock TA, Bjercke RJ, and Tomanek RJ. Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor. Circ Res 85: 192-198, 1999.
41. Zheng W, Seftor EA, Meininger CJ, Hendrix MJ, and Tomanek RJ. Mechanisms of coronary angiogenesis in response to stretch: role of VEGF and TGF-β. Am J Physiol Heart Circ Physiol 280: H909-H917, 2001.