Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 6 44-6, 1998, Pages

  Partovian, Chohreh ^a   Adnot, Serge ^a,c   Eddahibi, Saadia ^a   Teiger, Emmanuel ^a   Levame, Micheline ^a   Dreyfus, Patrick ^a   Raffestin, Bernadette ^a   Frelin, Christian ^b  

^a HENRI MONDOR HOSPITAL   (France)

^b CNRS   (France)

^c INSERM   (France)

Author keywords

Hypoxia; Monocrotaline; Pulmonary hypertension; Right ventricular hypertrophy; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAPILLARY FLOW; HEART RIGHT VENTRICLE HYPERTROPHY; HYPOXIA; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; VASCULAR ENDOTHELIUM;

EID: 0032429293     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.6.h1948     Document Type: Article

References (33)

1. Adnot, S., B. Raffestin, S. Eddahibi, P. Braquet, and P. E. Chabrier. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest. 87: 155-162, 1991.
2. Arcot, S. S., D. W. Lipke, M. N. Gillespie, and J. W. Olson. Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension. Biochem. Pharmacol. 46: 1086-1091, 1993.
3. Asahara, T., C. Bauters, C. Pastore, M. Kearny, S. Rossow, S. Bunting, N. Ferrara, J. Symes, and J. M. Isner. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery. Circulation 91: 2793-2801, 1995.
4. Banai, S., D. Shweiki, A. Pinson, M. Chandra, G. Lazarovici, and E. Keshet. Upregulation of vascular endothelial growth factor expression induced by myocardial ischemia: implications for coronary angiogenesis. Cardiovasc. Res. 28: 1176-1179, 1994.
5. Boor, P. J., A. I. Gotlieb, E. C. Joseph, W. D. Kerns, R. A. Roth, and K. E. Tomaszewski. Chemical-induced vasculature injury. Summary of the symposium presented at the 32nd annual meeting of the Society of Toxicology, New Orleans, Louisiana, March 1993. Toxicol. Appl. Pharmacol. 132: 177-195, 1995.
6. Chilian, W. M., R. D. Wangler, K. G. Peters, R. J. Tomanek, and M. L. Marcus. Thyroxine-induced left ventricular hypertrophy in the rat. Anatomical and physiological evidence for angiogenesis. Circ. Res. 57: 591-598, 1985.
7. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
8. Ferrara, N., and W. J. Henzel. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun. 161: 851-858, 1989.
9. Forsythe, J. A., B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung, R. D. Koos, and G. L. Semenza. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 4604-4613, 1996.
10. Hashimoto, E., T. Ogita, T. Nakaoka, R. Matsuoka, A. Takao, and Y. Kira. Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1948-H1954, 1994.
11. Ladoux, A., and C. Frelin. Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart. Biochem. Biophys. Res. Commun. 195: 1005-1010, 1993.
12. Leung, D. W., G. Cachianes, W. J. Kuang, D. V. Goeddel, and N. Ferrara. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306-1309, 1989.
13. Levy, A. P., N. S. Levy, and M. A. Goldberg. Post-transcriptional regulation of vascular endothelial growth factor mRNA by hypoxia. J. Biol. Chem. 271: 2746-2753, 1996.
14. Levy, B. I., J. L. Samuel, V. E. Kotelianski, F. Marott, P. Poitevin, and R. S. Chadwick. Morphometric measurement of subendocardial vessel dimensions in systolic and diastolic arrested rat heart. In: Recent Advances in Coronary Circulation, edited by Y. Maruyama, F. Kajia, J. I. E. Hoffman, and J. A. E. Spaan. Tokyo: Springer Verlag, 1993, p. 83-90.
15. Li, J., L. F. Brown, M. G. Hibberd, J. D. Grossman, J. P. Morgan, and M. Simons. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1803-H1811, 1996.
16. Marcus, M. L., D. G. Harrison, W. M. Chilian, S. Koyanagi, T. Inou, R. J. Tomanek, J. B. Martins, C. L. Eastham, and L. F. Hiratzka. Alterations in the coronary circulation in hypertrophied ventricles. Circulation 75, Suppl. I: I-19-I-25, 1987.
17. Matsubara, H., J. Yamamoto, Y. Hirata, Y. Mori, S. Oikawa, and M. Inada. Changes of atrial natriuretic peptide and its messenger RNA with development and regression of cardiac hypertrophy in renovascular hypertensive rats. Circ. Res. 66: 176-184, 1990.
18. Meyrick, B., W. Gamble, and L. Reid. Development of Crotalaria pulmonary hypertension: hemodynamic and structural study. Am. J. Physiol. 239 (Heart Circ. Physiol. 8): H692-H702, 1980.
19. Minchenko, A., T. Bauer, S. Salceda, and J. Caro. Hypoxic stimulation of vascular endothelial growth factor expression in vivo and in vitro. Lab. Invest. 71: 374-379, 1994.
20. Miyata, M., F. Sakuma, A. Yoshimura, H. Ishikawa, T. Nishimaki, and R. Kasukawa. Pulmonary hypertension in rats. 1. Role of bromodeoxyuridine-positive mononuclear cells and alveolar macrophages. Int. Arch. Allergy Immunol. 108: 281-286, 1995.
21. Monacci, W. T., M. J. Merrill, and E. H. Oldfield. Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues. Am. J. Physiol. 264 (Cell Physiol. 33): C995-C1002, 1993.
22. Murray, P. A., and S. F. Vatner. Reduction of maximal coronary vasodilator capacity in conscious dogs with severe right ventricular hypertrophy. Circ. Res. 48: 27-33, 1981.
23. Murray, P. A., S. F. Vatner, and P. B. Brigham. Abnormal coronary vascular response to exercise in dogs with severe right ventricular hypertrophy. J. Clin. Invest. 67: 1314-1323, 1981.
24. Perkett, E. A., R. M. Lyons, H. L. Moses, K. L. Brigham, and B. Meyrick. Transforming growth factor-β activity in sheep lung lymph during the development of pulmonary hypertension. J. Clin. Invest. 86: 1459-1464, 1990.
25. Pfeifer, M., F. C. Blumberg, K. Wolf, P. Sander, D. Elsner, G. A. J. Riegger, and A. Kurtz. Vascular remodeling and growth factor gene expression in the rat lung during hypoxia. Respir. Physiol. 111: 201-212, 1998.
26. Plate, K. H., G. Breier, H. A. Weich, and W. Risau. Vascular endothelial growth is a potential tumor angiogenesis factor in vivo. Nature 359: 845-847, 1992.
27. Rabinovitch, M., W. Gamble, A. Nadas, O. S. Miettinen, and L. Reid. Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am. J. Physiol. 236 (Heart Circ. Physiol. 5): H818-H827, 1979.
28. Sandner, P., B. Gess, K. Wolf, and A. Kurtz. Divergent regulation of vascular endothelial growth factor and of erythropoietin gene expression in vivo. Pflügers Arch. 431: 905-912, 1996.
29. Shweiki, D., A. Itin, D. Soffer, and E. Keshet. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843-845, 1992.
30. Stein, I., M. Neeman, D. Shweiki, A. Itin, and E. Keshet. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemic and coregulation with other ischemia-induced genes. Mol. Cell. Biol. 15: 5363-5368, 1995.
31. Tuder, R. M., B. E. Flook, and N. F. Voelkel. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J. Clin. Invest. 95: 1798-1807, 1995.
32. Vlahakes, G. J., K. Turley, E. D. Verrier, and J. I. E. Hoffman. Greater maximal coronary flow in conscious lambs with experimental congenital right ventricular hypertrophy (Abstract). Circulation 62, Suppl. III: III-111, 1980.
33. Voelkel, N. F., R. M. Tuder, J. Bridges, and W. P. Arend. Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline. Am. J. Respir. Cell Mol. Biol. 11: 664-675, 1994.