Adenovirus-mediated lung vascular endothelial growth factor overexpression protects against hypoxic pulmonary hypertension in rats

American Journal of Respiratory Cell and Molecular Biology

Volumn 23, Issue 6, 2000, Pages 762-771

  Partovian, C ^a   Adnot, S ^a   Raffestin, B ^a   Louzier, V ^a   Levame, M ^a   Mavier, I M ^a   Lemarchand, P ^a   Eddahibi, S ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIMYCIN; CELL WALL; ENDOTHELIUM CELL; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC REGULATION; HUMAN GENE; PLAQUE FORMING UNIT; PROMOTER REGION; PULMONARY HYPERTENSION; THICKNESS; VASCULOTROPIN; VIRUS GENE;

ADENOVIRIDAE; CYTOMEGALOVIRUS;

EID: 0034533016     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.23.6.4106     Document Type: Article

References (35)

1. Rat pulmonary circulation after chronic hypoxia: Hemodynamic and structural features
2. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
3. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
4. Functional upregulation of the vascular endothelial growth factor receptor KDR by hypoxia
5. Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues
6. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension
7. Vascular endothelial permeability/growth factor expression in plexogenic pulmonary hypertension
8. Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension
9. Vascular remodeling and growth factor gene expression in the rat lung during hypoxia
10. Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension
11. Accelerated restitution of endothelial integrity and endothelium-dependent function after phVEGF165 gene transfer
12. Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor
13. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries
14. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia
15. Adenovirus-vector-mediated cytokine gene transfer to lung tissue
16. Gene therapy for oxidant injury-related diseases: Adenovirus-mediated transfer of superoxide dismutase and catalase cDNAs protects against hyperoxia but not against ischemia-reperfusion lung injury
17. Adenoviral-mediated transfer of the human endothelial nitric oxide synthase gene reduces acute hypoxic pulmonary vasoconstriction in rats
18. VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo
19. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
20. Hypoxia-induced increases in pulmonary transvascular protein escape in rats
21. Continuous inhalation of nitric oxide protects against development of pulmonary hypertension in chronically hypoxic rats
22. Distribution of NOS in normoxic vs. hypoxic rat lung: Upregulation of NOS by chronic hypoxia
23. Regional angiogenesis induced in nonischemic tissue by an adenoviral vector expressing vascular endothelial growth factor
24. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo
25. Direct intramuscular transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion
26. Vascular endothelial growth factor administration in chronic myocardial ischemia
27. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia
28. Monocyte activation in angiogenesis and collateral growth in the rabbit hinlimb
29. Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in ballon-injured rat carotid artery
30. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries
31. Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension
32. L-arginine restores endothelium-dependent relaxation in pulmonary circulation of chronically hypoxic rats
33. VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
34. The endothelial nitric-oxide synthase-caveolin regulatory cycle
35. Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway