메뉴 건너뛰기




Volumn 102, Issue 2, 2014, Pages 281-289

STAT3, a key regulator of cell-to-cell communication in the heart

Author keywords

Angiogenesis; Cardiomyopathy; Fibrosis; Inflammation; STAT3

Indexed keywords

DNA METHYLTRANSFERASE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEU DIFFERENTIATION FACTOR; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A;

EID: 84899111807     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu034     Document Type: Review
Times cited : (92)

References (105)
  • 1
    • 78649324875 scopus 로고    scopus 로고
    • Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion
    • Boengler K Hilfiker-Kleiner D Heusch G Schulz R. Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol 2010;105:771-785
    • (2010) Basic Res Cardiol , vol.105 , pp. 771-785
    • Boengler, K.1    Hilfiker-Kleiner, D.2    Heusch, G.3    Schulz, R.4
  • 2
    • 84870375907 scopus 로고    scopus 로고
    • Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells
    • Elschami M Scherr M Philippens B Gerardy-Schahn R. Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells. Eur J Cell Biol 2013;92:21-29
    • (2013) Eur J Cell Biol , vol.92 , pp. 21-29
    • Elschami, M.1    Scherr, M.2    Philippens, B.3    Gerardy-Schahn, R.4
  • 3
    • 81355146580 scopus 로고    scopus 로고
    • Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/ reperfusion
    • Heusch G Musiolik J Gedik N Skyschally A. Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/ reperfusion. Circul Res 2011;109:1302-1308
    • (2011) Circul Res , vol.109 , pp. 1302-1308
    • Heusch, G.1    Musiolik, J.2    Gedik, N.3    Skyschally, A.4
  • 6
    • 3342889421 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 is required for myocardial capillary growth control of interstitial matrix deposition and heart protection from ischemic injury
    • Hilfiker-Kleiner D Hilfiker A Fuchs M Kaminski K Schaefer A Schieffer B et al. Signal transducer and activator of transcription 3 is required for myocardial capillary growth control of interstitial matrix deposition and heart protection from ischemic injury. Circul Res 2004;95:187-195
    • (2004) Circul Res , vol.95 , pp. 187-195
    • Hilfiker-Kleiner, D.1    Hilfiker, A.2    Fuchs, M.3    Kaminski, K.4    Schaefer, A.5    Schieffer, B.6
  • 7
    • 84893395842 scopus 로고    scopus 로고
    • Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart
    • Zouein FA Kurdi M Booz GW. Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart. Jak-Stat 2013;2:e24352
    • (2013) Jak-Stat , vol.2
    • Zouein, F.A.1    Kurdi, M.2    Booz, G.W.3
  • 8
    • 0035895711 scopus 로고    scopus 로고
    • Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family
    • Zachary I Gliki G. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 2001;49:568-581
    • (2001) Cardiovasc Res , vol.49 , pp. 568-581
    • Zachary, I.1    Gliki, G.2
  • 10
    • 84886608005 scopus 로고    scopus 로고
    • Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway
    • Wang SG Xu Y Chen JD Yang CH Chen XH. Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway. Molecules 2013;18:12809-12819
    • (2013) Molecules , vol.18 , pp. 12809-12819
    • Wang, S.G.1    Xu, Y.2    Chen, J.D.3    Yang, C.H.4    Chen, X.H.5
  • 12
    • 32344435013 scopus 로고    scopus 로고
    • Cardiotrophin-1 induces monocyte chemoattractant protein-1 synthesis in human umbilical vein endothelial cells
    • Fritzenwanger M Kuethe F Haase D Jandt E Figulla HR. Cardiotrophin-1 induces monocyte chemoattractant protein-1 synthesis in human umbilical vein endothelial cells. Cytokine 2006;33:46-51
    • (2006) Cytokine , vol.33 , pp. 46-51
    • Fritzenwanger, M.1    Kuethe, F.2    Haase, D.3    Jandt, E.4    Figulla, H.R.5
  • 13
    • 33847061235 scopus 로고    scopus 로고
    • Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells
    • Fritzenwanger M Meusel K Foerster M Kuethe F Krack A Figulla HR. Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells. Cytokine 2006; 36:101-106
    • (2006) Cytokine , vol.36 , pp. 101-106
    • Fritzenwanger, M.1    Meusel, K.2    Foerster, M.3    Kuethe, F.4    Krack, A.5    Figulla, H.R.6
  • 14
    • 84863242853 scopus 로고    scopus 로고
    • Janex-1 a JAK3 inhibitor ameliorates tumor necrosis factor-Alpha-induced expression of cell adhesion molecules and improves myocardial vascular permeability in endotoxemic mice
    • Lee JE Lee AS Kim DH Jung YJ Lee S Park BH et al. Janex-1 a JAK3 inhibitor ameliorates tumor necrosis factor-Alpha-induced expression of cell adhesion molecules and improves myocardial vascular permeability in endotoxemic mice. Int J Mol Med 2012; 29:864-870
    • (2012) Int J Mol Med , vol.29 , pp. 864-870
    • Lee, J.E.1    Lee, A.S.2    Kim, D.H.3    Jung, Y.J.4    Lee, S.5    Park, B.H.6
  • 15
    • 79959504793 scopus 로고    scopus 로고
    • STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo
    • Iwakura T Mohri T Hamatani T Obana M Yamashita T Maeda M et al. STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivo. J Mol Cell Cardiol 2011;51:207-214
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 207-214
    • Iwakura, T.1    Mohri, T.2    Hamatani, T.3    Obana, M.4    Yamashita, T.5    Maeda, M.6
  • 16
    • 84885029327 scopus 로고    scopus 로고
    • STAT1/3 and ERK1/2 synergistically regulate cardiac fibrosis induced by high glucose
    • Dai B Cui M Zhu M Su WL Qiu MC Zhang H. STAT1/3 and ERK1/2 synergistically regulate cardiac fibrosis induced by high glucose. Cell Physiol Biochem 2013;32:960-971
    • (2013) Cell Physiol Biochem , vol.32 , pp. 960-971
    • Dai, B.1    Cui, M.2    Zhu, M.3    Su, W.L.4    Qiu, M.C.5    Zhang, H.6
  • 17
    • 84856076539 scopus 로고    scopus 로고
    • Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart
    • Mir SA Chatterjee A Mitra A Pathak K Mahata SK Sarkar S. Inhibition of signal transducer and activator of transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart. J Biol Chem 2012;287: 2666-2677
    • (2012) J Biol Chem , vol.287 , pp. 2666-2677
    • Mir, S.A.1    Chatterjee, A.2    Mitra, A.3    Pathak, K.4    Mahata, S.K.5    Sarkar, S.6
  • 18
    • 79952071351 scopus 로고    scopus 로고
    • Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity
    • Skoumal R Toth M Serpi R Rysa J Leskinen H Ulvila J et al. Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity. J Mol Cell Cardiol 2011;50:634-641
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 634-641
    • Skoumal, R.1    Toth, M.2    Serpi, R.3    Rysa, J.4    Leskinen, H.5    Ulvila, J.6
  • 19
    • 79957523514 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: A key role for ubiquitinconjugating enzymes
    • Haghikia A Missol-Kolka E Tsikas D Venturini L Brundiers S Castoldi M et al. Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: A key role for ubiquitinconjugating enzymes. Eur Heart J 2011;32:1287-1297
    • (2011) Eur Heart J , vol.32 , pp. 1287-1297
    • Haghikia, A.1    Missol-Kolka, E.2    Tsikas, D.3    Venturini, L.4    Brundiers, S.5    Castoldi, M.6
  • 21
  • 22
    • 77954762928 scopus 로고    scopus 로고
    • Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation left ventricular rupture and adverse outcomein subacute myocardial infarction
    • Hilfiker-Kleiner D Shukla P Klein G Schaefer A Stapel B Hoch M et al. Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation left ventricular rupture and adverse outcomein subacute myocardial infarction. Circulation 2010;122:145-155
    • (2010) Circulation , vol.122 , pp. 145-155
    • Hilfiker-Kleiner, D.1    Shukla, P.2    Klein, G.3    Schaefer, A.4    Stapel, B.5    Hoch, M.6
  • 23
    • 79961150780 scopus 로고    scopus 로고
    • Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies
    • Hoch M Fischer P Stapel B Missol-Kolka E Sekkali B Scherr M et al. Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies. Cell Stem Cell 2011;9:131-143.
    • (2011) Cell Stem Cell , vol.9 , pp. 131-143
    • Hoch, M.1    Fischer, P.2    Stapel, B.3    Missol-Kolka, E.4    Sekkali, B.5    Scherr, M.6
  • 24
    • 0242268405 scopus 로고    scopus 로고
    • Cardiomyocyterestricted knockout of STAT3 results in higher sensitivity to inflammation cardiac fibrosis and heart failure with advanced age
    • Jacoby JJ Kalinowski A Liu MG Zhang SS Gao Q Chai GX et al. Cardiomyocyterestricted knockout of STAT3 results in higher sensitivity to inflammation cardiac fibrosis and heart failure with advanced age. Proc Natl Acad Sci USA 2003;100: 12929-12934
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12929-12934
    • Jacoby, J.J.1    Kalinowski, A.2    Liu, M.G.3    Zhang, S.S.4    Gao, Q.5    Chai, G.X.6
  • 26
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE Jr Kerr IM Stark GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994;264: 1415-1421
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 27
    • 0028349735 scopus 로고
    • Stat3: A STAT family memberactivated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
    • Zhong ZWenZ Darnell JE Jr. Stat3: A STAT family memberactivated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science 1994; 264:95-98
    • (1994) Science , vol.264 , pp. 95-98
    • Zhong, Z.1    Wen, Z.2    Darnell Jr., J.E.3
  • 28
    • 0036256836 scopus 로고    scopus 로고
    • Series introduction. JAK-STAT signaling in human Disease
    • Schindler CW. Series introduction. JAK-STAT signaling in human Disease. J Clin Invest 2002;109:1133-1137
    • (2002) J Clin Invest , vol.109 , pp. 1133-1137
    • Schindler, C.W.1
  • 29
    • 0037304469 scopus 로고    scopus 로고
    • Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts
    • Ng DC Court NW dos Remedios CG Bogoyevitch MA. Activation of signal transducer and activator of transcription (STAT) pathways in failing human hearts. Cardiovasc Res 2003;57:333-346
    • (2003) Cardiovasc Res , vol.57 , pp. 333-346
    • Ng, D.C.1    Court, N.W.2    Dos Remedios, C.G.3    Bogoyevitch, M.A.4
  • 30
    • 0037448803 scopus 로고    scopus 로고
    • Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy
    • Podewski EK Hilfiker-Kleiner D Hilfiker A Morawietz H Lichtenberg AWollert KC et al. Alterations in Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling in patients with end-stage dilated cardiomyopathy. Circulation 2003; 107:798-802
    • (2003) Circulation , vol.107 , pp. 798-802
    • Podewski, E.K.1    Hilfiker-Kleiner, D.2    Hilfiker, A.3    Morawietz, H.4    Lichtenberg, A.5    Wollert, K.C.6
  • 31
    • 0034616164 scopus 로고    scopus 로고
    • Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis
    • Stephanou A Brar BK Scarabelli TM Jonassen AK Yellon DM Marber MS et al. Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis. J Biol Chem 2000;275:10002-10008
    • (2000) J Biol Chem , vol.275 , pp. 10002-10008
    • Stephanou, A.1    Brar, B.K.2    Scarabelli, T.M.3    Jonassen, A.K.4    Yellon, D.M.5    Marber, M.S.6
  • 32
    • 79953881238 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription-from cytokine signalling to cancer biology
    • Santos CI Costa-Pereira AP. Signal transducers and activators of transcription-from cytokine signalling to cancer biology. Biochim Biophys Acta 2011;1816:38-49
    • (2011) Biochim Biophys Acta , vol.1816 , pp. 38-49
    • Santos, C.I.1    Costa-Pereira, A.P.2
  • 33
    • 10844234013 scopus 로고    scopus 로고
    • IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart
    • Fairweather D Frisancho-Kiss S Yusung SA Barrett MA Davis SE SteeleRA et al. IL-12 protects against coxsackievirus B3-induced myocarditis by increasing IFN-gamma and macrophage and neutrophil populations in the heart. J Immunol 2005;174:261-269
    • (2005) J Immunol , vol.174 , pp. 261-269
    • Fairweather, D.1    Frisancho-Kiss, S.2    Yusung, S.A.3    Barrett, M.A.4    Davis, S.E.5    Steele, R.A.6
  • 35
    • 40349100263 scopus 로고    scopus 로고
    • Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects
    • Fischer P Hilfiker-Kleiner D. Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspects. Br J Pharmacol 2008;153(Suppl. 1): S414-S427
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL. 1
    • Fischer, P.1    Hilfiker-Kleiner, D.2
  • 36
    • 0036098154 scopus 로고    scopus 로고
    • Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation
    • Kirito K Nakajima KWatanabe T UchidaM Tanaka M Ozawa K et al. Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation. Blood 2002;99:102-110
    • (2002) Blood , vol.99 , pp. 102-110
    • Kirito, K.1    Nakajima, K.2    Watanabe, T.3    Uchida, M.4    Tanaka, M.5    Ozawa, K.6
  • 37
    • 33751568137 scopus 로고    scopus 로고
    • Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure
    • Li Y Takemura G Okada H Miyata S Maruyama R Li L et al. Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure. Cardiovasc Res 2006;71:684-694
    • (2006) Cardiovasc Res , vol.71 , pp. 684-694
    • Li, Y.1    Takemura, G.2    Okada, H.3    Miyata, S.4    Maruyama, R.5    Li, L.6
  • 38
  • 39
    • 34748877708 scopus 로고    scopus 로고
    • Leptin signaling and obesity: Cardiovascular consequences
    • Yang R Barouch LA. Leptin signaling and obesity: Cardiovascular consequences. Circul Res 2007;101:545-559
    • (2007) Circul Res , vol.101 , pp. 545-559
    • Yang, R.1    Barouch, L.A.2
  • 40
    • 0032498573 scopus 로고    scopus 로고
    • Biphasic activation of the JAK/STAT pathway by angiotensin II in rat cardiomyocytes
    • Kodama H Fukuda K Pan J Makino S Sano M Takahashi T et al. Biphasic activation of the JAK/STAT pathway by angiotensin II in rat cardiomyocytes. Circul Res 1998;82: 244-250
    • (1998) Circul Res , vol.82 , pp. 244-250
    • Kodama, H.1    Fukuda, K.2    Pan, J.3    Makino, S.4    Sano, M.5    Takahashi, T.6
  • 41
    • 0036256644 scopus 로고    scopus 로고
    • What does Stat3 do?
    • Levy DE Lee CK. What does Stat3 do?. J Clin Invest 2002;109:1143-1148
    • (2002) J Clin Invest , vol.109 , pp. 1143-1148
    • Levy, D.E.1    Lee, C.K.2
  • 43
    • 0034658024 scopus 로고    scopus 로고
    • Serine phosphorylation of stats
    • Decker T Kovarik P. Serine phosphorylation of STATs. Oncogene 2000;19:2628-2637
    • (2000) Oncogene , vol.19 , pp. 2628-2637
    • Decker, T.1    Kovarik, P.2
  • 44
    • 34548051362 scopus 로고    scopus 로고
    • Survival pathways in hypertrophy and heart failure: The gp130-STAT axis
    • Fischer P Hilfiker-Kleiner D. Survival pathways in hypertrophy and heart failure: The gp130-STAT axis. Basic Res Cardiol 2007;102:393-411
    • (2007) Basic Res Cardiol , vol.102 , pp. 393-411
    • Fischer, P.1    Hilfiker-Kleiner, D.2
  • 45
    • 84861215508 scopus 로고    scopus 로고
    • Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in Demethylation
    • Lee H Zhang P Herrmann A Yang C Xin HWang Z et al. Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in Demethylation. Proc Natl Acad Sci USA 2012;109:7765-7769
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7765-7769
    • Lee, H.1    Zhang, P.2    Herrmann, A.3    Yang, C.4    Xin, H.5    Wang, Z.6
  • 46
    • 48349105443 scopus 로고    scopus 로고
    • Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution
    • Ray S Lee C Hou T Boldogh I Brasier AR. Requirement of histone deacetylase1 (HDAC1) in signal transducer and activator of transcription 3 (STAT3) nucleocytoplasmic distribution. Nucleic Acids Res 2008;36:4510-4520
    • (2008) Nucleic Acids Res , vol.36 , pp. 4510-4520
    • Ray, S.1    Lee, C.2    Hou, T.3    Boldogh, I.4    Brasier, A.R.5
  • 47
    • 78049300452 scopus 로고    scopus 로고
    • Modulation of gene expression and tumor cell growth by redox modification of STAT3
    • Li L Cheung SH Evans EL Shaw PE. Modulation of gene expression and tumor cell growth by redox modification of STAT3. Cancer Res 2010;70:8222-8232
    • (2010) Cancer Res , vol.70 , pp. 8222-8232
    • Li, L.1    Cheung, S.H.2    Evans, E.L.3    Shaw, P.E.4
  • 48
    • 84864315728 scopus 로고    scopus 로고
    • Multi-Tasking nuclear transcription factors with novel roles in the mitochondria
    • Szczepanek K Lesnefsky EJ LarnerAC. Multi-Tasking: Nuclear transcription factors with novel roles in the mitochondria. Trends Cell Biol 2012;22:429-437
    • (2012) Trends Cell Biol , vol.22 , pp. 429-437
    • Szczepanek, K.1    Lesnefsky, E.J.2    Larner, A.C.3
  • 50
    • 0037207468 scopus 로고    scopus 로고
    • Cardiac endothelial-myocardial signaling: Its role in cardiac growth contractile performance and rhythmicity
    • Brutsaert DL. Cardiac endothelial-myocardial signaling: Its role in cardiac growth contractile performance and rhythmicity. Physiol Rev 2003;83:59-115
    • (2003) Physiol Rev , vol.83 , pp. 59-115
    • Brutsaert, D.L.1
  • 51
    • 0142243367 scopus 로고    scopus 로고
    • Molecular mechanisms in endothelial regulation of cardiac function
    • Kuruvilla L Kartha CC. Molecular mechanisms in endothelial regulation of cardiac function. Mol Cell Biochem 2003;253:113-123
    • (2003) Mol Cell Biochem , vol.253 , pp. 113-123
    • Kuruvilla, L.1    Kartha, C.C.2
  • 52
    • 0037155205 scopus 로고    scopus 로고
    • Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart
    • Osugi T Oshima Y Fujio Y Funamoto M Yamashita A Negoro S et al. Cardiac-specific activation of signal transducer and activator of transcription 3 promotes vascular formation in the heart. J Biol Chem 2002;277:6676-6681
    • (2002) J Biol Chem , vol.277 , pp. 6676-6681
    • Osugi, T.1    Oshima, Y.2    Fujio, Y.3    Funamoto, M.4    Yamashita, A.5    Negoro, S.6
  • 55
    • 78249278186 scopus 로고    scopus 로고
    • Activation of host tissue trophic factors through JAK-STAT3 signaling: A mechanism of mesenchymal stem cellmediated cardiac repair
    • Shabbir A Zisa D Lin H Mastri M Roloff G Suzuki G et al. Activation of host tissue trophic factors through JAK-STAT3 signaling: A mechanism of mesenchymal stem cellmediated cardiac repair. Am J Physiol Heart Circul Physiol 2010;299:H1428-H1438
    • (2010) Am J Physiol Heart Circul Physiol , vol.299
    • Shabbir, A.1    Zisa, D.2    Lin, H.3    Mastri, M.4    Roloff, G.5    Suzuki, G.6
  • 56
    • 84855375368 scopus 로고    scopus 로고
    • Protective effects of recombinant human erythropoietin against pressure overload-induced left ventricular remodeling and premature death in mice
    • WangW Kagaya Y Asaumi Y Fukui S Takeda M Shimokawa H. Protective effects of recombinant human erythropoietin against pressure overload-induced left ventricular remodeling and premature death in mice. Tohoku J Exp Med 2011;225:131-143
    • (2011) Tohoku J Exp Med , vol.225 , pp. 131-143
    • Wang, W.1    Kagaya, Y.2    Asaumi, Y.3    Fukui, S.4    Takeda, M.5    Shimokawa, H.6
  • 58
    • 20144388775 scopus 로고    scopus 로고
    • G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
    • Harada M Qin Y Takano H Minamino T Zou Y Toko H et al. G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes. Nat Med 2005;11:305-311
    • (2005) Nat Med , vol.11 , pp. 305-311
    • Harada, M.1    Qin, Y.2    Takano, H.3    Minamino, T.4    Zou, Y.5    Toko, H.6
  • 59
    • 79551692036 scopus 로고    scopus 로고
    • Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation reactive oxygen species production permeability intercellular adhesion molecule-1 and occludin expression
    • Chen YH Xu X Sheng MJ Zheng Z Gu Q. Effects of asymmetric dimethylarginine on bovine retinal capillary endothelial cell proliferation reactive oxygen species production permeability intercellular adhesion molecule-1 and occludin expression. Mol Vis 2011;17:332-340
    • (2011) Mol Vis , vol.17 , pp. 332-340
    • Chen, Y.H.1    Xu, X.2    Sheng, M.J.3    Zheng, Z.4    Gu, Q.5
  • 60
    • 70350084477 scopus 로고    scopus 로고
    • The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation
    • Nicholson TB Chen T Richard S. The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation. Pharmacol Res 2009;60:466-474
    • (2009) Pharmacol Res , vol.60 , pp. 466-474
    • Nicholson, T.B.1    Chen, T.2    Richard, S.3
  • 62
    • 84861058134 scopus 로고    scopus 로고
    • Cardiac angiogenic imbalance leads to peripartum cardiomyopathy
    • Patten IS Rana S Shahul S Rowe GC Jang C Liu L et al. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature 2012;485:333-338
    • (2012) Nature , vol.485 , pp. 333-338
    • Patten, I.S.1    Rana, S.2    Shahul, S.3    Rowe, G.C.4    Jang, C.5    Liu, L.6
  • 64
    • 77950902743 scopus 로고    scopus 로고
    • Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: A proof-of-concept pilot study
    • Sliwa K Blauwet L Tibazarwa K Libhaber E Smedema JP Becker A et al. Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: A proof-of-concept pilot study. Circulation 2010;121:1465-1473
    • (2010) Circulation , vol.121 , pp. 1465-1473
    • Sliwa, K.1    Blauwet, L.2    Tibazarwa, K.3    Libhaber, E.4    Smedema, J.P.5    Becker, A.6
  • 65
    • 84867915488 scopus 로고    scopus 로고
    • Extracellular miRNAs: The mystery of their origin and function
    • Turchinovich AWeiz L Burwinkel B. Extracellular miRNAs: The mystery of their origin and function. Trends Biochem Sci 2012;37:460-465
    • (2012) Trends Biochem Sci , vol.37 , pp. 460-465
    • Turchinovich, A.1    Weiz, L.2    Burwinkel, B.3
  • 66
    • 77957091969 scopus 로고    scopus 로고
    • Circulating microRNA in body fluid: A new potential biomarker for cancer diagnosis and prognosis
    • Kosaka N Iguchi H Ochiya T. Circulating microRNA in body fluid: A new potential biomarker for cancer diagnosis and prognosis. Cancer Sci 2010;101:2087-2092
    • (2010) Cancer Sci , vol.101 , pp. 2087-2092
    • Kosaka, N.1    Iguchi, H.2    Ochiya, T.3
  • 67
    • 79955052182 scopus 로고    scopus 로고
    • Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy
    • Lemmens K Doggen K De Keulenaer GW. Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy.AmJ Physiol Heart Circul Physiol 2011;300:H931-H942
    • (2011) AmJ Physiol Heart Circul Physiol , vol.300
    • Lemmens, K.1    Doggen, K.2    De Keulenaer, G.W.3
  • 68
    • 0036400204 scopus 로고    scopus 로고
    • Ras-MAP kinase signaling pathways and control of cell proliferation: Relevance to cancer therapy
    • Shapiro P. Ras-MAP kinase signaling pathways and control of cell proliferation: Relevance to cancer therapy. Crit Rev Clin Lab Sci 2002;39:285-330
    • (2002) Crit Rev Clin Lab Sci , vol.39 , pp. 285-330
    • Shapiro, P.1
  • 70
    • 33745805840 scopus 로고    scopus 로고
    • Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-Talk
    • Lemmens K Segers VF Demolder M De KeulenaerGW. Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-Talk. J Biol Chem 2006;281: 19469-19477
    • (2006) J Biol Chem , vol.281 , pp. 19469-19477
    • Lemmens, K.1    Segers, V.F.2    Demolder, M.3    De Keulenaer, G.W.4
  • 71
    • 84872031728 scopus 로고    scopus 로고
    • Neuregulin in cardiovascular development and disease
    • Odiete O Hill MF Sawyer DB. Neuregulin in cardiovascular development and disease. Circul Res 2012;111:1376-1385
    • (2012) Circul Res , vol.111 , pp. 1376-1385
    • Odiete, O.1    Hill, M.F.2    Sawyer, D.B.3
  • 72
    • 76649086709 scopus 로고    scopus 로고
    • Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction
    • Obana M Maeda M Takeda K Hayama A Mohri T Yamashita T et al. Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation 2010;121:684-691
    • (2010) Circulation , vol.121 , pp. 684-691
    • Obana, M.1    Maeda, M.2    Takeda, K.3    Hayama, A.4    Mohri, T.5    Yamashita, T.6
  • 73
    • 81355127625 scopus 로고    scopus 로고
    • Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium
    • Krishnamurthy P Thal M Verma S Hoxha E Lambers E Ramirez V et al. Interleukin-10 deficiency impairs bone marrow-derived endothelial progenitor cell survival and function in ischemic myocardium. Circul Res 2011;109:1280-1289
    • (2011) Circul Res , vol.109 , pp. 1280-1289
    • Krishnamurthy, P.1    Thal, M.2    Verma, S.3    Hoxha, E.4    Lambers, E.5    Ramirez, V.6
  • 75
    • 0032544187 scopus 로고    scopus 로고
    • Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion
    • Frangogiannis NG Perrard JL Mendoza LH Burns AR LindseyML BallantyneCMet al. Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion. Circulation 1998;98:687-698
    • (1998) Circulation , vol.98 , pp. 687-698
    • Frangogiannis, N.G.1    Perrard, J.L.2    Mendoza, L.H.3    Burns, A.R.4    Lindsey, M.L.5    Ballantyne, C.M.6
  • 77
    • 33646537851 scopus 로고    scopus 로고
    • Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells
    • Mohri T Fujio Y Maeda M Ito T Iwakura T Oshima Y et al. Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells. J Biol Chem 2006;281: 6442-6447
    • (2006) J Biol Chem , vol.281 , pp. 6442-6447
    • Mohri, T.1    Fujio, Y.2    Maeda, M.3    Ito, T.4    Iwakura, T.5    Oshima, Y.6
  • 78
    • 84864343534 scopus 로고    scopus 로고
    • Microrna-124 regulates cardiomyocyte differentiation of bone marrow-derived mesenchymal stem cells via targeting STAT3 signaling
    • Cai B Li JWang J Luo X Ai J Liu Y et al. microRNA-124 regulates cardiomyocyte differentiation of bone marrow-derived mesenchymal stem cells via targeting STAT3 signaling. Stem Cells 2012;30:1746-1755
    • (2012) Stem Cells , vol.30 , pp. 1746-1755
    • Cai, B.1    Li, J.2    Wang, J.3    Luo, X.4    Ai, J.5    Liu, Y.6
  • 79
    • 0037027504 scopus 로고    scopus 로고
    • Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms cardiovascular dysfunction and perinatal death in mice
    • Maki JM Rasanen J Tikkanen H Sormunen R Makikallio K Kivirikko KI et al. Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms cardiovascular dysfunction and perinatal death in mice. Circulation 2002;106:2503-2509
    • (2002) Circulation , vol.106 , pp. 2503-2509
    • Maki, J.M.1    Rasanen, J.2    Tikkanen, H.3    Sormunen, R.4    Makikallio, K.5    Kivirikko, K.I.6
  • 80
    • 36949038501 scopus 로고    scopus 로고
    • Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human Dilated cardiomyopathy
    • Sivakumar P Gupta S Sarkar S Sen S. Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human Dilated cardiomyopathy. Mol Cell Biochem 2008;307: 159-167
    • (2008) Mol Cell Biochem , vol.307 , pp. 159-167
    • Sivakumar, P.1    Gupta, S.2    Sarkar, S.3    Sen, S.4
  • 81
    • 0034705240 scopus 로고    scopus 로고
    • Interleukin-1beta and tumor necrosis factor-Alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro
    • Siwik DA Chang DL Colucci WS. Interleukin-1beta and tumor necrosis factor-Alpha decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro. Circul Res 2000;86:1259-1265
    • (2000) Circul Res , vol.86 , pp. 1259-1265
    • Siwik, D.A.1    Chang, D.L.2    Colucci, W.S.3
  • 83
    • 24044458235 scopus 로고    scopus 로고
    • Combination of tumor necrosis factor-Alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice
    • Kassiri Z Oudit GY Sanchez O Dawood F Mohammed FF Nuttall RK et al. Combination of tumor necrosis factor-Alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circul Res 2005;97:380-390
    • (2005) Circul Res , vol.97 , pp. 380-390
    • Kassiri, Z.1    Oudit, G.Y.2    Sanchez, O.3    Dawood, F.4    Mohammed, F.F.5    Nuttall, R.K.6
  • 84
    • 77955500182 scopus 로고    scopus 로고
    • Interleukin 6 mediates myocardial fibrosis concentric hypertrophy and diastolic dysfunction in rats
    • Melendez GC McLarty JL Levick SPDu Y Janicki JS Brower GL. Interleukin 6 mediates myocardial fibrosis concentric hypertrophy and diastolic dysfunction in rats. Hypertension 2010;56:225-231
    • (2010) Hypertension , vol.56 , pp. 225-231
    • Melendez, G.C.1    McLarty, J.L.2    Levick, S.P.3    Du, Y.4    Janicki, J.S.5    Brower, G.L.6
  • 85
    • 0037281151 scopus 로고    scopus 로고
    • Differential cytokine expression in myocytes and non-myocytes after myocardial infarction in rats
    • Deten A Volz HC BriestWZimmerHG. Differential cytokine expression in myocytes and non-myocytes after myocardial infarction in rats. Mol Cell Biochem 2003;242: 47-55
    • (2003) Mol Cell Biochem , vol.242 , pp. 47-55
    • Deten, A.1    Volz, H.C.2    Briest, W.3    Zimmer, H.G.4
  • 87
    • 0033612183 scopus 로고    scopus 로고
    • Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes
    • Pan J Fukuda K Saito M Matsuzaki J Kodama H Sano M et al. Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes. Circul Res 1999;84:1127-1136
    • (1999) Circul Res , vol.84 , pp. 1127-1136
    • Pan, J.1    Fukuda, K.2    Saito, M.3    Matsuzaki, J.4    Kodama, H.5    Sano, M.6
  • 88
    • 0034708368 scopus 로고    scopus 로고
    • Autocrine/Paracrine secretion of IL-6 family cytokines causes angiotensin II-induced delayed STAT3 activation
    • Sano M Fukuda K Kodama H TakahashiT KatoTHakunoDet al. Autocrine/Paracrine secretion of IL-6 family cytokines causes angiotensin II-induced delayed STAT3 activation. Biochem Biophys Res Commun 2000;269:798-802
    • (2000) Biochem Biophys Res Commun , vol.269 , pp. 798-802
    • Sano, M.1    Fukuda, K.2    Kodama, H.3    Takahashi, T.4    Kato, T.5    Hakuno, D.6
  • 89
    • 0034703035 scopus 로고    scopus 로고
    • Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes
    • Sano M Fukuda K Kodama H Pan J Saito M Matsuzaki J et al. Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes. J Biol Chem 2000;275:29717-29723
    • (2000) J Biol Chem , vol.275 , pp. 29717-29723
    • Sano, M.1    Fukuda, K.2    Kodama, H.3    Pan, J.4    Saito, M.5    Matsuzaki, J.6
  • 91
    • 84859925551 scopus 로고    scopus 로고
    • Beta-Adrenergic receptors stimulate interleukin-6 production through Epac-dependent activation of PKCdelta/p38 MAPK signalling in neonatal mouse cardiac fibroblasts
    • Chen C Du J FengW Song Y Lu Z Xu M et al. beta-Adrenergic receptors stimulate interleukin-6 production through Epac-dependent activation of PKCdelta/p38 MAPK signalling in neonatal mouse cardiac fibroblasts. Br J Pharmacol 2012;166:676-688
    • (2012) Br J Pharmacol , vol.166 , pp. 676-688
    • Chen, C.1    Du, J.2    Feng, W.3    Song, Y.4    Lu, Z.5    Xu, M.6
  • 92
    • 0032516498 scopus 로고    scopus 로고
    • Cytokine gene expression after myocardial infarction in rat hearts: Possible implication in left ventricular remodeling
    • Ono K Matsumori A Shioi T Furukawa Y Sasayama S. Cytokine gene expression after myocardial infarction in rat hearts: Possible implication in left ventricular remodeling. Circulation 1998;98:149-156
    • (1998) Circulation , vol.98 , pp. 149-156
    • Ono, K.1    Matsumori, A.2    Shioi, T.3    Furukawa, Y.4    Sasayama, S.5
  • 93
    • 46749144616 scopus 로고    scopus 로고
    • Interleukin-1 receptor type i signaling critically regulates infarct healing and cardiac remodeling
    • Bujak M Dobaczewski M Chatila K Mendoza LH Li N Reddy A et al. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol 2008;173:57-67
    • (2008) Am J Pathol , vol.173 , pp. 57-67
    • Bujak, M.1    Dobaczewski, M.2    Chatila, K.3    Mendoza, L.H.4    Li, N.5    Reddy, A.6
  • 94
    • 0032544201 scopus 로고    scopus 로고
    • Resident cardiacmast cells degranulate and release preformed TNF-Alpha initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion
    • Frangogiannis NG Lindsey ML Michael LH Youker KA Bressler RB Mendoza LHet al. Resident cardiacmast cells degranulate and release preformed TNF-Alpha initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion. Circulation 1998;98:699-710
    • (1998) Circulation , vol.98 , pp. 699-710
    • Frangogiannis, N.G.1    Lindsey, M.L.2    Michael, L.H.3    Youker, K.A.4    Bressler, R.B.5    Mendoza, L.H.6
  • 95
    • 0025283377 scopus 로고
    • IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA
    • Elias JA Lentz V. IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA. J Immunol 1990;145:161-166
    • (1990) J Immunol , vol.145 , pp. 161-166
    • Elias, J.A.1    Lentz, V.2
  • 96
    • 0024586781 scopus 로고
    • Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells
    • Jirik FR Podor TJ Hirano T Kishimoto T Loskutoff DJ Carson DA et al. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol 1989;142:144-147
    • (1989) J Immunol , vol.142 , pp. 144-147
    • Jirik, F.R.1    Podor, T.J.2    Hirano, T.3    Kishimoto, T.4    Loskutoff, D.J.5    Carson, D.A.6
  • 97
    • 0025292914 scopus 로고
    • Inducible production of interleukin-6 by human polymorphonuclear neutrophils: Role of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-Alpha
    • Cicco NA Lindemann A Content J Vandenbussche P Lubbert M Gauss J et al. Inducible production of interleukin-6 by human polymorphonuclear neutrophils: Role of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-Alpha. Blood 1990;75:2049-2052
    • (1990) Blood , vol.75 , pp. 2049-2052
    • Cicco, N.A.1    Lindemann, A.2    Content, J.3    Vandenbussche, P.4    Lubbert, M.5    Gauss, J.6
  • 98
    • 0028865771 scopus 로고
    • Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-Alpha in monocytic cells involves cooperation between interferon regulatory factor-1 NF kappa B and Sp1 transcription factors
    • Sanceau J Kaisho T Hirano T Wietzerbin J. Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-Alpha in monocytic cells involves cooperation between interferon regulatory factor-1 NF kappa B and Sp1 transcription factors. J Biol Chem 1995;270:27920-27931
    • (1995) J Biol Chem , vol.270 , pp. 27920-27931
    • Sanceau, J.1    Kaisho, T.2    Hirano, T.3    Wietzerbin, J.4
  • 99
    • 33644876126 scopus 로고    scopus 로고
    • Pharmacological preconditioning with tumor necrosis factor-Alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase
    • Lecour S Suleman N Deuchar GA Somers S Lacerda L Huisamen B et al. Pharmacological preconditioning with tumor necrosis factor-Alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase). Circulation 2005;112: 3911-3918
    • (2005) Circulation , vol.112 , pp. 3911-3918
    • Lecour, S.1    Suleman, N.2    Deuchar, G.A.3    Somers, S.4    Lacerda, L.5    Huisamen, B.6
  • 100
    • 0033523019 scopus 로고    scopus 로고
    • Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for antiinflammatory action
    • Riley JK Takeda K Akira S Schreiber RD. Interleukin-10 receptor signaling through the JAK-STAT pathway. Requirement for two distinct receptor-derived signals for antiinflammatory action. J Biol Chem 1999;274:16513-16521
    • (1999) J Biol Chem , vol.274 , pp. 16513-16521
    • Riley, J.K.1    Takeda, K.2    Akira, S.3    Schreiber, R.D.4
  • 101
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda K Clausen BE Kaisho T Tsujimura T Terada N Forster I et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999;10:39-49
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6
  • 102
    • 79960916464 scopus 로고    scopus 로고
    • Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway
    • Manukyan MC Alvernaz CH Poynter JA Wang Y Brewster BD Weil BR et al. Interleukin-10 protects the ischemic heart from reperfusion injury via the STAT3 pathway. Surgery 2011;150:231-239
    • (2011) Surgery , vol.150 , pp. 231-239
    • Manukyan, M.C.1    Alvernaz, C.H.2    Poynter, J.A.3    Wang, Y.4    Brewster, B.D.5    Weil, B.R.6
  • 103
    • 34248642536 scopus 로고    scopus 로고
    • STAT3-mediated anti-inflammatory signalling
    • Murray PJ. STAT3-mediated anti-inflammatory signalling. Biochem Soc Transactions2006; 34:1028-1031
    • Biochem Soc Transactions2006 , vol.34 , pp. 1028-1031
    • Murray, P.J.1
  • 104
    • 84859575047 scopus 로고    scopus 로고
    • STAT3 regulates monocyte TNF-Alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass
    • de Jong PR Schadenberg AW van Den Broek T Beekman JM van Wijk F Coffer PJ et al. STAT3 regulates monocyte TNF-Alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass. PLoS One 2012;7:e35070
    • (2012) PLoS One , vol.7
    • De Jong, P.R.1    Schadenberg, A.W.2    Van Den Broek, T.3    Beekman, J.M.4    Van Wijk, F.5    Coffer, P.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.