Extracellular miRNAs: The mystery of their origin and function

Trends in Biochemical Sciences

Volumn 37, Issue 11, 2012, Pages 460-465

  Turchinovich, Andrey ^a,b   Weiz, Ludmila ^a   Burwinkel, Barbara ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE 2 PROTEIN; ARGONAUTE PROTEIN; BIOLOGICAL MARKER; CXCL11 CHEMOKINE; MICRORNA;

ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; BODY FLUID; CELL ACTIVITY; CELL COMMUNICATION; CELL FUNCTION; CELL VACUOLE; EXOSOME; EXTRACELLULAR SPACE; GEL PERMEATION CHROMATOGRAPHY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SILENCING; GLIOBLASTOMA; HUMAN; IMMUNE RESPONSE; IMMUNOPRECIPITATION; LIMIT OF DETECTION; MEMBRANE VESICLE; NANOFILTRATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; PROTEIN STABILITY; PROTEIN SYNTHESIS; PROTEIN TARGETING; RNA ANALYSIS; RNA ISOLATION; RNA PROCESSING; SIGNAL TRANSDUCTION; SYNAPSE; ULTRACENTRIFUGATION;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BLOOD; CELL COMMUNICATION; EXTRACELLULAR FLUID; HUMANS; MICRORNAS; RNA STABILITY; SECRETORY VESICLES;

EID: 84867915488     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2012.08.003     Document Type: Article

References (59)

1. Lee R.C., Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science 2001, 294:862-864.
2. Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355.
3. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
4. Croce C.M., Calin G.A. miRNAs, cancer, and stem cell division. Cell 2005, 122:6-7.
5. Chim S.S., et al. Detection and characterization of placental microRNAs in maternal plasma. Clin. Chem. 2008, 54:482-490.
6. Lawrie C.H., et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br. J. Haematol. 2008, 141:672-675.
7. Mitchell P.S., et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:10513-10518.
8. Chen X., et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008, 18:997-1006.
9. Hanke M., et al. A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol. Oncol. 2010, 28:655-661.
10. Park N.J., et al. Salivary microRNA: discovery, characterization, and clinical utility for oral cancer detection. Clin. Cancer Res. 2009, 15:5473-5477.
11. Weber J.A., et al. The microRNA spectrum in 12 body fluids. Clin. Chem. 2010, 56:1733-1741.
12. Kosaka N., et al. microRNA as a new immune-regulatory agent in breast milk. Silence 2010, 1:7.
13. Valadi H., et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007, 9:654-659.
14. Hunter M.P., et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS ONE 2008, 3:e3694.
15. Wang K., et al. Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res. 2010, 38:7248-7259.
16. Arroyo J.D., et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:5003-5008.
17. Turchinovich A., et al. Characterization of extracellular circulating microRNA. Nucleic Acids Res. 2011, 39:7223-7233.
18. Winter J., et al. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat. Cell Biol. 2009, 11:228-234.
19. Zernecke A., et al. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci. Signal. 2009, 2:ra81.
20. Kosaka N., et al. Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 2010, 101:2087-2092.
21. Kosaka N., Ochiya T. Unraveling the mystery of cancer by secretory microRNA: horizontal microRNA transfer between living cells. Front. Genet. 2011, 2:97.
22. Chen X., et al. Horizontal transfer of microRNAs: molecular mechanisms and clinical applications. Protein Cell 2012, 3:28-37.
23. Vickers K.C., et al. MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat. Cell Biol. 2011, 13:423-433.
24. Gallo A., et al. The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS ONE 2012, 7:e30679.
25. Yoo B.C., et al. A systemic small RNA signaling system in plants. Plant Cell 2004, 16:1979-2000.
26. Laterza O.F., et al. Plasma microRNAs as sensitive and specific biomarkers of tissue injury. Clin. Chem. 2009, 55:1977-1983.
27. Corsten M.F., et al. Circulating microRNA-208b and microRNA-499 reflect myocardial damage in cardiovascular disease. Circ. Cardiovasc. Genet. 2010, 3:499-506.
28. Lewis A.P., Jopling C.L. Regulation and biological function of the liver-specific miR-122. Biochem. Soc. Trans. 2010, 38:1553-1557.
29. Zhang Y., et al. Plasma microRNA-122 as a biomarker for viral-, alcohol-, and chemical-related hepatic diseases. Clin. Chem. 2010, 56:1830-1838.
30. Pritchard C.C., et al. Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. Cancer Prev. Res. (Phila.) 2012, 5:492-497.
31. Skog J., et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 2008, 10:1470-1476.
32. Kosaka N., et al. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J. Biol. Chem. 2010, 285:17442-17452.
33. Pegtel D.M., et al. Functional delivery of viral miRNAs via exosomes. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:6328-6333.
34. Mittelbrunn M., et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat. Commun. 2011, 2:282.
35. Montecalvo A., et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 2012, 119:756-766.
36. Hergenreider E., et al. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat. Cell Biol. 2012, 14:249-256.
37. Xin H., et al. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells 2012, 30:1556-1564.
38. Kogure T., et al. Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology 2011, 54:1237-1248.
39. Yang M., et al. Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells. Mol. Cancer 2011, 10:117.
40. Zhang Y., et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol. Cell 2010, 39:133-144.
41. Trajkovic K., et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 2008, 319:1244-1247.
42. Thery C., et al. Exosomes: composition, biogenesis and function. Nat. Rev. Immunol. 2002, 2:569-579.
43. Cocucci E., et al. Shedding microvesicles: artefacts no more. Trends Cell Biol. 2009, 19:43-51.
44. Simons M., Raposo G. Exosomes-vesicular carriers for intercellular communication. Curr. Opin. Cell Biol. 2009, 21:575-581.
45. Bail S., et al. Differential regulation of microRNA stability. RNA 2010, 16:1032-1039.
46. Krol J., et al. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 2010, 11:597-610.
47. Kim Y.K., et al. Short structured RNAs with low GC content are selectively lost during extraction from a small number of cells. Mol. Cell 2012, 46:893-895.
48. Gibbings D.J., et al. Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat. Cell Biol. 2009, 11:1143-1149.
49. Taylor D.D., Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol. Oncol. 2008, 110:13-21.
50. Rabinowits G., et al. Exosomal microRNA: a diagnostic marker for lung cancer. Clin. Lung Cancer 2009, 10:42-46.
51. Ohshima K., et al. Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. PLoS ONE 2010, 5:e13247.
52. Muralidharan-Chari V., et al. Microvesicles: mediators of extracellular communication during cancer progression. J. Cell Sci. 2010, 123:1603-1611.
53. Thery C., et al. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol. 2006, Chapter 3, 3.22.1-3.22.29.
54. McDonald J.S., et al. Analysis of circulating microRNA: preanalytical and analytical challenges. Clin. Chem. 2011, 57:833-840.
55. Duttagupta R., et al. Impact of cellular miRNAs on circulating miRNA biomarker signatures. PLoS ONE 2011, 6:e20769.
56. Landry P., et al. Existence of a microRNA pathway in anucleate platelets. Nat. Struct. Mol. Biol. 2009, 16:961-966.
57. Pigati L., et al. Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS ONE 2010, 5:e13515.
58. Turchinovich A., Burwinkel B. Distinct AGO1 and AGO2 associated miRNA profiles in human cells and blood plasma. RNA Biol. 2012, 9. [Epub ahead of print].
59. Hristov M., et al. Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro. Blood 2004, 104:2761-2766.