β-Adrenergic receptors stimulate interleukin-6 production through Epac-dependent activation of PKCIδ/p38 MAPK signalling in neonatal mouse cardiac fibroblasts

British Journal of Pharmacology

Volumn 166, Issue 2, 2012, Pages 676-688

  Chen, Chao ^a   Du, Jianhai ^a   Feng, Wei ^a   Song, Yao ^a   Lu, Zhizhen ^a   Xu, Ming ^a   Li, Zijian ^a   Zhang, Youyi ^a  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

adrenoceptors; cardiac fibroblasts; Epac; interleukin 6; PKCI

Indexed keywords

BETA ADRENERGIC RECEPTOR; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP 1; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERLEUKIN 6; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C DELTA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARDIAC FIBROBLAST; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; FIBROBLAST; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-AGONISTS; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CYCLIC AMP; FIBROBLASTS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INTERLEUKIN-6; ISOPROTERENOL; MICE; MICE, INBRED BALB C; MYOCARDIUM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C-DELTA; RECEPTORS, ADRENERGIC, BETA;

EID: 84859925551     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01785.x     Document Type: Article

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