Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) attenuates interleukin-6 (IL-6)-induced collagen synthesis and resultant hypertrophy in rat heart

Journal of Biological Chemistry

Volumn 287, Issue 4, 2012, Pages 2666-2677

  Mir, Saiful Anam ^a   Chatterjee, Arunachal ^a   Mitra, Arkadeep ^a   Pathak, Kanchan ^a   Mahata, Sushil K ^b   Sarkar, Sagartirtha ^a  

^a UNIVERSITY OF CALCUTTA   (India)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY WEIGHT; CARDIAC FIBROBLASTS; CARDIAC FUNCTIONS; CARDIAC HYPERTROPHY; COLLAGEN SYNTHESIS; DOWN-REGULATION; FLUDARABINE; IN-VITRO; IN-VIVO; INTERLEUKIN-6; MYOSIN HEAVY CHAIN; NATRIURETIC FACTOR; P38 MAPK; RAT HEART; RENAL ARTERIES; SIGNAL TRANSDUCERS; SIGNALING MOLECULES; SPECIFIC INHIBITORS; THERAPEUTIC TARGETS; UP-REGULATION; WISTAR RAT;

ANIMALS; BIOCHEMISTRY; CELL CULTURE; COLLAGEN; ECHOCARDIOGRAPHY; FIBROBLASTS; HEART; PATHOLOGY; PHOSPHORYLATION; RATS; SYNTHESIS (CHEMICAL);

IMMUNOLOGY;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ATRIAL NATRIURETIC FACTOR; COLLAGEN; FLUDARABINE; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN HEAVY CHAIN BETA; PROTEIN INHIBITOR; S 31 201; SMALL INTERFERING RNA; STAT1 PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FIBROBLAST CULTURE; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; RENAL ARTERY;

ANIMALS; ANTINEOPLASTIC AGENTS; BUTADIENES; CARDIOMEGALY; CELLS, CULTURED; COLLAGEN; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; IMIDAZOLES; INTERLEUKIN-6; MALE; MAP KINASE SIGNALING SYSTEM; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; RATS; RATS, WISTAR; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; VIDARABINE;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84856076539     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.246173     Document Type: Article

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