JANEX-1, a JAK3 inhibitor, ameliorates tumor necrosis factor-α- induced expression of cell adhesion molecules and improves myocardial vascular permeability in endotoxemic mice

International Journal of Molecular Medicine

Volumn 29, Issue 5, 2012, Pages 864-870

  Lee, Jung Eun ^a   Lee, Ae Sin ^a   Kim, Duk Hoon ^a   Jung, Yu Jin ^a   Lee, Sik ^a   Park, Byung Hyun ^a   Lee, Sun Hwa ^a   Park, Sung Kwang ^a   Kim, Won ^a   Kang, Kyung Pyo ^a  

^a Chonbuk National University Medical School   (South Korea)

Author keywords

Cell adhesion molecules; Endotoxemia; JAK STAT pathway; NF B; Vascular permeability

Indexed keywords

4 (4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; CELL ADHESION MOLECULE; FRACTALKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; JANUS KINASE 3; LIPOPOLYSACCHARIDE; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL PERMEABILITY; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; DOWN REGULATION; ENDOTOXEMIA; ENZYME INHIBITION; HEART MUSCLE; HUMAN; HUMAN CELL; MALE; MOUSE; MYOCARDIAL VASCULAR LEAKAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR DISEASE; WESTERN BLOTTING;

ANIMALS; CAPILLARY PERMEABILITY; CELL ADHESION MOLECULES; CHEMOKINE CX3CL1; CORONARY VESSELS; ENDOTOXEMIA; HEART; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; JANUS KINASE 3; MALE; MICE; MICE, INBRED C57BL; QUINAZOLINES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84863242853     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.920     Document Type: Article

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