Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells

ACS Chemical Biology

Volumn 9, Issue 4, 2014, Pages 994-1002

  Sun, Haiying ^a   Lu, Jianfeng ^a   Liu, Liu ^a   Yang, Chao Yie ^a   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEPTIDOMIMETIC AGENT; PROTEIN BIR3; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SM 1280; SM 1295; SM 337; SM 406; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; BIRC3 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; MOLECULAR LIBRARY; OLIGOPEPTIDE; PROTEIN BINDING; SMAC PEPTIDE; UBIQUITIN PROTEIN LIGASE; XIAP PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; REGULATORY MECHANISM; TUMOR CELL; ANTAGONISTS AND INHIBITORS; BIOASSAY; BIOMIMETICS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECTS; FEMALE; METABOLISM; MOLECULAR LIBRARY; OVARIAN NEOPLASMS; PHARMACOLOGY; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL ASSAY; BIOMIMETICS; BLOTTING, WESTERN; CELL LINE, TUMOR; COMPUTER SIMULATION; FEMALE; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; OVARIAN NEOPLASMS; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; UBIQUITIN-PROTEIN LIGASES; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84899101340     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400889a     Document Type: Article

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