A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice

Journal of Medicinal Chemistry

Volumn 56, Issue 10, 2013, Pages 3969-3979

  Sheng, Rong ^a,d   Sun, Haiying ^a   Liu, Liu ^a   Lu, Jianfeng ^a   McEachern, Donna ^a   Wang, Guanfeng ^b,c   Wen, Jianfeng ^b,c   Min, Ping ^b,c   Du, Zhenyun ^b,c   Lu, Huirong ^b,c   Kang, Sanmao ^b,c   Guo, Ming ^b,c   Yang, Dajun ^b,c   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Yasheng Biomedical Inc   (China)

^c QB3 Building   (China)

^d ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

(5,5',8,8',10A,10A') 3,3' (2,2' (1,4 PHENYLENE)BIS (ACETYL))BIS(N BENZHYDRYL 5 (2 (METHYLAMINO)PROPANAMIDO) 6 OXODECAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 8 CARBOXAMIDE); (5,5',8,8',10A,10A') 3,3' (3,3' (1,4 PHENYLENE)BIS (PROPANOYL))BIS(N BENZHYDRYL 5 (2 (METHYLAMINO) PROPANAMIDO) 6 OXODECAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 8 CARBOXAMIDE); (5,5',8,8',10A,10A') 3,3' (PIPERAZINE 1,4 DICARBONYL)BIS (N BENZHYDRYL 5 (2 (METHYLAMINO)PROPANAMIDO) 6 OXODECAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 8 CARBOXAMIDE); (5,5',8,8',10A,10A') N3,N3' (1,3 PHENYLENE)BIS(N8 BENZ HYDRYL 5 (2 (METHYLAMINO) PROPANAMIDO) 6 OXOOCTAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 3,8(4H) DICARBOXAMIDE); (5,5',8,8',10A,10A') N3,N3' (1,3 PHENYLENEBIS (METHYLENE))BIS(N8 BENZHYDRYL 5 (2 (METHYLAMINO) PROPANAMIDO) 6 OXOOCTAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 3,8(4H) DICARBOXAMIDE); (5,5',8,8',10A,10A') N3,N3' (BUTANE 1,4 DIYL)BIS(N8 BENZHYDRYL 5 (2 (METHYLAMINO)PROPANAMIDO) 6 OXOOCTAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 3,8(4H) DICARBOXAMIDE); (5,5',8,8',10A,10A') N3,N3' (CYCLOHEXANE 1,4 DIYL)BIS (N8 BENZHYDRYL 5 (2 (METHYLAMINO)PROPANAMIDO) 6 OXOOCTAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 3,8(4H) DICARBOXAMIDE); (5,5',8,8',10A,10A') N3,N3' (METHYLENEBIS(4,1 PHENYLENE))BIS(N8 BENZHYDRYL 5 (2 (METHYLAMINO) PROPANAMIDO) 6 OXOOCTAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 3,8(4H) DICARBOXAMIDE); (5,5',8,8',10A,10A') N3,N3' (OCTANE 1,8 DIYL)BIS(N8 BENZHYDRYL 5 (2 (METHYLAMINO)PROPANAMIDO) 6 OXOOCTAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 3,8(4H) DICARBOXAMIDE); (5,5',8,8',10A,10A') N3,N3' (OXYBIS(4,1 PHENYLENE))BIS (N8 BENZHYDRYL 5 (2 (METHYLAMINO)PROPANAMIDO) 6 OXOOCTAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 3,8(4H) DICARBOXAMIDE); (5,5',8,8',10A,10A') N3,N3'-((1,4) CYCLOHEXANE 1,4 DIYL)BIS(N8 BENZHYDRYL 5 (2 (METHYLAMINO)PROPANAMIDO) 6 OXOOCTAHYDROPYRROLO[1,2 A][1,5]DIAZOCINE 3,8(4H) DICARBOXAMIDE); ANTINEOPLASTIC AGENT; AT 406; BIRINAPANT; DOCETAXEL; GDC 0152; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; LCL 161; SM 1200; SM 122; SM 164; SM 199; SM 406; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; RAT; TUMOR REGRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; AZOCINES; BLOTTING, WESTERN; CARRIER PROTEINS; CASPASE 3; CASPASE 9; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDICATORS AND REAGENTS; INHIBITOR OF APOPTOSIS PROTEINS; MALE; MICE; MICE, NUDE; MITOCHONDRIAL PROTEINS; PHENYLENEDIAMINES; RATS; RATS, SPRAGUE-DAWLEY; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84878024573     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400216d     Document Type: Article

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