Discovery of aminopiperidine-based Smac mimetics as IAP antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1690-1694

  Hennessy, Edward J ^a   Saeh, Jamal C ^a   Sha, Li ^a   MacIntyre, Terry ^a   Wang, Haiyun ^a   Larsen, Nicholas A ^a   Aquila, Brian M ^a   Ferguson, Andrew D ^a   Laing, Naomi M ^a   Omer, Charles A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Apoptosis; Inhibitor of apoptosis proteins; Isothermal titration calorimetry (ITC); Protein protein interactions; Smac

Indexed keywords

HOMOPIPERIDINE; INHIBITOR OF APOPTOSIS PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN INHIBITOR; PIPERIDINE; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER CELL; CANCER INHIBITION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; PHENOTYPE; STRUCTURE ACTIVITY RELATION;

INTRACISTERNAL A-PARTICLES;

EID: 84862828930     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.109     Document Type: Article

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