Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior

Journal of Biological Chemistry

Volumn 289, Issue 16, 2014, Pages 10975-10987

  Gee, Christine E ^a,b   Peterlik, Daniel ^c   Neuhäuser, Christoph ^c   Bouhelal, Rochdi ^a   Kaupmann, Klemens ^a   Laue, Grit ^a   Uschold Schmidt, Nicole ^c   Feuerbach, Dominik ^a   Zimmermann, Kaspar ^a   Ofner, Silvio ^a   Cryan, John F ^a,d   Van Der Putten, Herman ^a   Fendt, Markus ^a,e   Vranesic, Ivo ^a   Glatthar, Ralf ^a   Flor, Peter J ^a,c  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d UNIVERSITY COLLEGE CORK   (Ireland)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALS;

COMPUTER ASSISTED; DRUG DESIGN; EMOTION CIRCUITS; KEY REGULATORS; METABOTROPIC GLUTAMATE RECEPTORS; SYNAPTIC PLASTICITY; VENUS FLYTRAP DOMAINS;

BRAIN;

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 7 HYDROXY 3 (4 IODOPHENOXY) 4H CHROMEN 4 ONE; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CHLORDIAZEPOXIDE; DIAZEPAM; IMIPRAMINE; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR ANTAGONIST; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; XAP 044;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ANTISTRESS ACTIVITY; ANXIETY DISORDER; AREA UNDER THE CURVE; ARTICLE; BEHAVIOR DISORDER; BRAIN SLICE; CELL MEMBRANE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; EXTRACELLULAR MATRIX; FEAR; GENE SILENCING; LONG TERM POTENTIATION; MALE; MAXIMUM PLASMA CONCENTRATION; MENTAL STRESS; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RECEPTOR BLOCKING; RODENT; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANQUILIZING ACTIVITY; VENUS FLYTRAP DOMAIN;

ELEVATED PLUS-MAZE; FEAR CONDITIONING; GLUTAMATE RECEPTORS METABOTROPIC; NEUROTRANSMITTER RELEASE; PHARMACOLOGY; STRESS; SYNAPTIC PLASTICITY; XAP044;

AMYGDALA; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; CHO CELLS; CRICETINAE; CRICETULUS; L CELLS (CELL LINE); LONG-TERM POTENTIATION; MICE; MICE, MUTANT STRAINS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, METABOTROPIC GLUTAMATE; STRESS, PSYCHOLOGICAL;

EID: 84899024860     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.542654     Document Type: Article

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