MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 20, 1998, Pages 2839-2844

  Duncia, John V ^a   Santella III, Joseph B ^a   Higley, C Anne ^a   Pitts, William J ^a   Wityak, John ^a   Frietze, William E ^a   Rankin, F Wayne ^a   Sun, Jung Hui ^a   Earl, Richard A ^a   Tabaka, A Christine ^a   Teleha, Christopher A ^a   Blom, Karl F ^a   Favata, Margaret F ^a   Manos, Elizabeth J ^a   Daulerio, Andrea J ^a   Stradley, Deborah A ^a   Horiuchi, Kurumi ^a   Copeland, Robert A ^a   Scherle, Peggy A ^a   Trzaskos, James M ^a   Magolda, Ronald L ^a   Trainor, George L ^a   Wexler, Ruth R ^a   Hobbs, Frank W ^a   Olson, Richard E ^a   more..

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CYCLIZATION; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME SPECIFICITY; NONHUMAN; TRANSCRIPTION REGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOTRANSFORMATION; BUTADIENES; CYCLIZATION; ENZYME INHIBITORS; NF-KAPPA B; NITRILES; PROTEIN-SERINE-THREONINE KINASES; RATS; TRANSCRIPTION FACTOR AP-1;

EID: 0032552994     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00522-8     Document Type: Article

References (13)

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