Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation

Biochemical Journal

Volumn 441, Issue 1, 2012, Pages 77-85

  Cirit, Murat ^a   Haugh, Jason M ^a  

^a North Carolina State University   (United States)

Author keywords

Computational biology; Cross talk; Growth factor; Kinetic analysis; Mitogen activated protein kinase (MAPK); Receptor tyrosine kinase

Indexed keywords

FIBROBLAST GROWTH FACTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN TYROSINE KINASE; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL STIMULATION; CONTROLLED STUDY; FEEDBACK SYSTEM; FIBROBLAST; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

ANIMALS; COMPUTER SIMULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 2; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KINETICS; MICE; MODELS, BIOLOGICAL; NIH 3T3 CELLS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-SIS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, FIBROBLAST GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84055223930     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110833     Document Type: Article

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