Substrate-dependent control of MAPK phosphorylation in vivo

Molecular Systems Biology

Volumn 7, Issue , 2011, Pages

  Kim, Yoosik ^a   Paroush, Ze'Ev ^b   Nairz, Knud ^c   Hafen, Ernst ^c   Jiménez, Gerardo ^d   Shvartsman, Stanislav Y ^a  

^a PRINCETON UNIVERSITY   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c ETH ZURICH   (Switzerland)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

cell signaling; MAPK cascades; network biology

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CIC PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; DUAL SPECIFICITY PHOSPHATASE 6; GROUCHO PROTEIN, DROSOPHILA; HIGH MOBILITY GROUP B PROTEIN; REPRESSOR PROTEIN; PHOSPHATASE;

ARTICLE; DEPHOSPHORYLATION; DROSOPHILA; EMBRYO; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE DOSAGE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL EMBRYO; BIOLOGICAL MODEL; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SYSTEMS BIOLOGY; COVALENT BOND; ENZYME SPECIFICITY; IN VIVO STUDY; PROTEIN DEPHOSPHORYLATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DROSOPHILA; DROSOPHILA PROTEINS; DUAL SPECIFICITY PHOSPHATASE 6; EMBRYO, NONMAMMALIAN; HMGB PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PHOSPHORYLATION; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 79551577046     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2010.121     Document Type: Article

References (41)

1. Astigarraga S, Grossman R, Diaz-Delfin J, Caelles C, Paroush Z, Jimenez G (2007) A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling. EMBOJ26: 668-677
2. Bardwell AJ, Abdollahi M, Bardwell L (2003) Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity. Biochem J 370(Part 3): 1077-1085
3. Blackwell E, Kim HJ, Stone DE (2007) The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2. BMC Cell Biol 26: 44
4. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu BE, Wright A, Vanderbilt C, Cobb MH (2001) MAP kinases. Chem Rev 101: 2449-2476
5. Cinnamon E, Helman A, Ben-Haroush SR, Orian A, Jiménez G, Paroush Z (2008) Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis. Development 135:829-837
6. Cirit M, Wang CC, Haugh JM (2010) Systematic quantification of negative feedback mechanisms in the extracellular signal-regulated kinase (ERK) signaling network. J Biol Chem 285: 36736-36744
7. Coppey M, Boettiger AN, Berezhkovskii AM, Shvartsman SY (2008) Nuclear trapping shapes the terminal gradient in the Drosophila embryo. CurrBiol 18: 915-919
8. Del Vecchio D, Ninfa AJ, Sontag ED (2008) Modular cell biology: retroactivity and insulation. Mol Syst Biol 4: 161
9. Dowd S, Sneddon AA, Keyse SM (1998) Isolation of the human genes encoding the pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. J Cell Sci 11 1: 3389-3399
10. Fujioka A, Terai K, Itoh RE, Aoki K, Nakamura T, Kuroda S, Nishida E, Matsuda M (2006) Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes. J Biol Chem 281: 8917-8926
11. Furriols M, Casanova J (2003) In and out of Torso RTK signalling. EMBOJ22: 1947-1952
12. Gabay L, Scholz H, Golembo M, Klaes A, Shilo BZ, Klambt C (1996) EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Development 122: 3355-3362
13. Gabay L, Seger R, Shilo B (1997a) In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277: 1103-1106
14. Gabay L, Seger R, Shilo BZ (1997b) MAP kinase in situ activation atlas during Drosophila embryogenesis. Development 124: 3535-3541
15. Gomez AR, Lopez-Varea A, Molnar C, de la Calle-Mustienes E, Ruiz-Gomez M, Gomez-Skarmeta JL, de Celis JF (2005) Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3. Dev Dyn 232: 695-708
16. Grewal S, Molina DM, Bardwell L (2006) Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPKregulation invivo. CellSignal 18:123-134
17. Hacker U, Perrimon N (1998) DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev 12: 274-284
18. Huang C, Ferrell JJ (1996) Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc Natl Acad Sci 93: 10078-10083
19. Jimenez G, Guichet A, Ephrussi A, Casanova J (2000) Relief of gene repression by Torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning. Genes Dev 14: 224-231
20. Karlsson M, Mandl M, Keyse SM (2006) Spatio-temporal regulation of mitogen-activated protein kinase (MAPK) signalling by protein phosphatases. Biochem Soc Trans 34: 842-845
21. Kiel C, Serrano L (2009) Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling. Sci Signaling2: ra38
22. Kim M, Cha GH, Kim S, Lee JH, Park J, Koh H, Choi KY, Chung J (2004) MKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development. Mol Cell Biol 24: 573-583
23. Kim SH, Kwon HB, Kim YS, Ryu JH, Kim KS, Ahn Y Lee WJ, Choi KY (2002) Isolation and characterization of a Drosophila homologue of mitogen-activated protein kinase phosphatase-3 which has a high substrate specificity towards extracellular-signal-regulated kinase. Biochem J 361: 143-151
24. Kim Y Coppey M, Grossman R, Ajuria L, Jimenez G, Paroush Z, Shvartsman SY (2010) MAPK substrate competition integrates patterning signals in the Drosophila embryo. CurrBiol 20: 446-451
25. Kolch W (2005) Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 6: 827-837
26. Lenormand P, Brondello JM, Brunet A, Pouysségur J (1998) Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and neosynthesis of nuclear anchoring proteins. J Cell Biol 142: 625-633
27. Li WX (2005) Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development. Dev Dyn 232: 656-672
28. Liu X, Bardwell L, Nie Q (2010) A combination of multisite phosphorylation and substrate sequestration produces switchlike responses. Biophys J98: 1396-1407
29. Nakakuki T, Birtwistle MR, Saeki Y Yumoto N, Ide K, Nagashima T, Brusch L, Ogunnaike BA, Okada-Hatakeyama M, Kholodenko BN (2010) Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. Cell 141: 884-896
30. Paroush Z, Wainwright SM, IshHorowicz D (1997) Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression. Development 124: 3827-3834
31. Qiao L, Nachbar RB, Kevrekidis IG, Shvartsman SY (2007) Bistability and oscillations in the Huang-Ferrell model of MAPK signaling. PLoS ComputBiol 3: 1819-1826
32. Rebay I, Rubin GM (1995) Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81: 857-866
33. Rintelen F, Hafen E, Nairz K (2003) The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER. Development 130: 3479-3490
34. Roch F, Jiménez G, Casanova J (2002) EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins. Development 129: 993-1002
35. Ronchi E, Treisman J, Dostatni N, Struhl G, Desplan C (1993) Down-regulation of the Drosophila morphogen bicoid by the torso receptor-mediated signal transduction cascade. Cell 74: 347-355
36. Saez-Rodriguez J, Gayer S, Ginkel M, Gilles ED (2008) Automatic decomposition of kinetic models of signaling networks minimizing the retroactivity among modules. Bioinformatics 24: i213-i219
37. Shaul YD, Seger R (2007) The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta 1773: 1213-1226
38. Tanoue T, Yamamoto T, Nishida E (2002) Modular structure of a docking surface on MAPK phosphatases. J Biol Chem 277: 22942-22949
39. Ventura AC, Jiang P, Van Wassenhove L, Del Vecchio D, Merajver SD, Ninfa AJ (2010) Signaling properties of a covalent modification cycle are altered by a downstream target. Proc Natl Acad Sci 107: 10032-10037
40. Ventura AC, Sepulchre JA, Merajver SD (2008) A hidden feedback in signaling cascades is revealed. PLoS Comput Biol 4: e1000041
41. von Kriegsheim A, Baiocchi D, Birtwistle M, Sumpton D, Bienvenut W, Morrice N, Yamada K, Lamond A, Kalna G, Orton R, Gilbert D, Kolch W (2009) Cell fate decisions are specified by the dynamic ERK interactome. Nat Cell Biol 11: 1458-1464