Quantitative assessment of hypoxia subtypes in microcirculatory supply units of malignant tumors Using (immuno-)fluorescence techniques

Strahlentherapie und Onkologie

Volumn 187, Issue 4, 2011, Pages 260-266

  Maftei, Constantin Alin ^a   Bayer, Christine ^a   Shi, Kuangyu ^a   Astner, Sabrina T ^a   Vaupel, Peter ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acute hypoxia; Chronic hypoxia; Diffusion limited hypoxia; Hypoxia subtypes; Microcirculatory supply unit; Perfusion limited hypoxia; Tumor hypoxia

Indexed keywords

CD31 ANTIGEN; HOE 33342; PIMONIDAZOLE;

ANALYTIC METHOD; CANCER CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPOXEMIA; HYPOXIA; IMMUNOFLUORESCENCE; MALIGNANT NEOPLASTIC DISEASE; MICROVASCULATURE; QUANTITATIVE ANALYSIS; TUMOR BLOOD FLOW;

BENZIMIDAZOLES; CELL HYPOXIA; CELL LINE, TUMOR; DIFFUSION; HUMANS; MICROCIRCULATION; MICROSCOPY, FLUORESCENCE; MICROVESSELS; NEOPLASMS; NITROIMIDAZOLES; PERFUSION IMAGING; PROGNOSIS; RADIATION-SENSITIZING AGENTS; TUMOR CELLS, CULTURED;

EID: 79955705786     PISSN: 01797158     EISSN: 1439099X     Source Type: Journal    
DOI: 10.1007/s00066-010-2216-0     Document Type: Conference Paper

References (36)

1. G.E. Arteel R.G. Thurman J.M. Yates 1995 Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver Br J Cancer 72 889 95 7547236 10.1038/bjc.1995.429 1:CAS:528: DyaK2MXptlKjtLc%3D
2. C. Bayer C.-A. Maftei S.T. Astner 2010 Subtypes of chronic and acute hypoxia in tumors according to different causative mechanisms Strahlenther Onkol 186 Suppl1 66
3. Bayer C, Shi K, Astner ST, et al. Acute versus chronic hypoxia: why a simplified classification is simply not enough. Int J Radiat Oncol Biol Phys 2011; in press.
4. K.L. Bennewith R.E. Durand 2004 Quantifying transient hypoxia in human tumor xenografts by flow cytometry Cancer Res 64 6183 9 15342403 10.1158/0008-5472.CAN-04-0289 1:CAS:528:DC%2BD2cXntFClsbk%3D (Pubitemid 39129420)
5. C.R. Bley D. Laluhova M. Roos 2009 Correlation of pretreatment polarographically measured oxygen pressures with quantified contrast-enhanced power Doppler ultrasonography in spontaneous canine tumors and their impact on outcome after radiation therapy Strahlenther Onkol 185 756 62 10.1007/s00066-009-1988-6
6. J.M. Brown 1979 Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation Br J Radiol 52 650 6 486895 10.1259/0007-1285-52-620-650 1:STN:280:DyaL3c%2FitFOktA%3D%3D (Pubitemid 9239867)
7. D.J. Chaplin R.E. Durand P.L. Olive 1986 Acute hypoxia in tumors: implications for modifiers of radiation effects Int J Radiat Oncol Biol Phys 12 1279 82 3759546 10.1016/0360-3016(86)90153-7 1:CAS:528:DyaL28XmtVGnur0%3D (Pubitemid 16030598)
8. D.J. Chaplin P.L. Olive R.E. Durand 1987 Intermittent blood flow in a murine tumor: radiobiological effects Cancer Res 47 597 601 3791244 1:STN:280:DyaL2s%2FnvVSgug%3D%3D (Pubitemid 17009632)
9. M.W. Dewhirst H. Kimura S.W. Rehmus 1996 Microvascular studies on the origins of perfusion-limited hypoxia Br J Cancer 27 S247 51 1:STN:280: DyaK283osFajtw%3D%3D
10. A.J. Giaccia 1996 Hypoxic stress proteins: survival of the fittest Semin Radiat Oncol 6 46 58 10717161 10.1016/S1053-4296(96)80035-X (Pubitemid 26029373)
11. L. Goethals A. Debucquoy C. Perneel 2006 Hypoxia in human colorectal adenocarcinoma: comparison between extrinsic and potential intrinsic hypoxia markers Int J Radiat Oncol Biol Phys 65 246 54 16618579 10.1016/j.ijrobp.2006. 01.007 1:CAS:528:DC%2BD28Xjs1GlsLo%3D
12. K. Groebe P. Vaupel 1988 Evaluation of oxygen diffusion distances in human breast cancer xenografts using tumor-specific in vivo data: role of various mechanisms in the development of tumor hypoxia Int J Radiat Oncol Biol Phys 15 691 7 3417489 10.1016/0360-3016(88)90313-6 1:STN:280: DyaL1czjtVGiug%3D%3D
13. K. Gulliksrud I.K. Vestvik K. Galappathi 2008 Detection of different hypoxic cell subpopulations in human melanoma xenografts by pimonidazole immunohistochemistry Radiat Res 170 638 50 18959463 10.1667/RR1400.1 1:CAS:528:DC%2BD1cXhtlCnt7zF
14. M. Hoeckel P. Vaupel 2001 Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects J Natl Cancer Inst 93 266 76 10.1093/jnci/93.4.266 (Pubitemid 32219813)
15. H. Kimura R.D. Braun E.T. Ong 1996 Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma Cancer Res 56 5522 8 8968110 1:STN:280:DyaK2s7it1GitA%3D%3D (Pubitemid 27011389)
16. M. Kotas P. Schmitt P.M. Jakob 2009 Monitoring of tumor oxygenation changes in head-and-neck carcinoma patients breathing a hyperoxic hypercapnic gas mixture with a non-invasive MRI technique Strahlenther Onkol 185 19 26 19224143 10.1007/s00066-009-1870-6
17. A.S. Ljungkvist J. Bussink P.F. Rijken 2002 Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas Int J Radiat Oncol Biol Phys 54 215 28 12182995
18. C.-A. Maftei C. Bayer S.T. Astner 2010 Quantitative assessment of hypoxia subtypes in xenografted human tumors Strahlenther Onkol 186 Suppl1 69
19. I.M. Pires Z. Bencokova M. Milani 2010 Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability Cancer Res 70 925 35 20103649 10.1158/0008-5472.CAN-09-2715 1:CAS:528:DC%2BC3cXht12qsro%3D
20. E.K. Rofstad K. Galappathi B. Mathiesen 2007 Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis Clin Cancer Res 13 1971 8 17360973 10.1158/1078-0432.CCR-06-1967 1:CAS:528:DC%2BD2sXjs12rsbk%3D (Pubitemid 46649862)
21. E.K. Rofstad J.V. Gaustad T.A. Egeland 2010 Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination Int J Cancer 127 1535 46 20091868 1:CAS:528:DC%2BC3cXpvV2itb0%3D
22. E.K. Rofstad K. Maseide 1999 Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours Int J Radiat Biol 75 1377 93 10597912 10.1080/ 095530099139250 1:CAS:528:DyaK1MXns12mtrs%3D
23. R.H. Thomlinson I. Gray 1955 The histological structure of some human lung cancers and the possible implications for radiotherapy Br J Cancer 9 539 49 13304213 10.1038/bjc.1955.55 1:STN:280:DyaG28%2Fls1Gltg%3D%3D
24. I. Tufto E.K. Rofstad 1995 Transient perfusion in human melanoma xenografts Br J Cancer 71 789 93 7536022 10.1038/bjc.1995.153 1:STN:280:DyaK2M3is1aquw%3D%3D
25. P. Vaupel 2004 The role of hypoxia-induced factors in tumor progression Oncologist 9 Suppl5 10 7 15591418 10.1634/theoncologist.9-90005-10 1:CAS:528:DC%2BD2MXltVWluw%3D%3D (Pubitemid 39658341)
26. P. Vaupel 2008 Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis Oncologist 13 Suppl3 21 6 18458121 10.1634/theoncologist. 13-S3-21 1:CAS:528:DC%2BD1cXotFaisbg%3D
27. Vaupel P. Pathophysiology of tumors. In: Molls M, Vaupel P, Nieder C, et al. (eds) The impact of tumor biology on cancer treatment and multidisciplinary strategies. Berlin-Heidelberg: Springer, 2009:51-92.
28. Vaupel P. Physiological mechanisms of treatment resistance. In: Molls M, Vaupel P, Nieder C, et al. (eds) The impact of tumor biology on cancer treatment and multidisciplinary strategies. Berlin-Heidelberg: Springer, 2009:273-90.
29. P. Vaupel L. Harrison 2004 Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response Oncologist 9 Suppl5 4 9 15591417 10.1634/theoncologist.9-90005-4 (Pubitemid 39658340)
30. Vaupel P, Mayer A. Effects of anaemia and hypoxia on tumor biology. In: Bokemeyer C, Ludwig H (eds) Anaemia in cancer. European school of oncology scientific updates. 2nd edn. Edinburgh-London: Elsevier, 2005:47-66.
31. P. Vaupel A. Mayer 2007 Hypoxia in cancer: significance and impact on clinical outcome Cancer Metastasis Rev 26 225 39 17440684 10.1007/s10555-007- 9055-1 1:CAS:528:DC%2BD2sXotFWrtLo%3D (Pubitemid 47101660)
32. A. Yaromina M. Krause H. Thames 2007 Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation Radiother Oncol 83 304 10 17517444 10.1016/j.radonc.2007.04.020 1:CAS:528:DC%2BD2sXmsFKhsLY%3D (Pubitemid 46915546)
33. Yaromina A, Kroeber T, Meinzer A, et al. Exploratory study of the prognostic value of microenvironmental parameters during fractionared irradiation in human squamuous cell carcinoma xenografts. Int J Radiat Oncol Biol Phys 2011; in press.
34. A. Yaromina H. Thames X. Zhou 2010 Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation Radiother Oncol 96 116 22 20570380 10.1016/j.radonc. 2010.04.020
35. A. Yaromina D. Zips H.D. Thames 2006 Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: The need for a multivariate approach in biomarker studies Radiother Oncol 81 122 9 16956683 10.1016/j.radonc.2006.08.010 1:CAS:528:DC%2BD28Xht1Sht7fM (Pubitemid 44780780)
36. D. Zips A. Yaromina C. Schutze 2007 Experimental evaluation of functional imaging for radiotherapy Strahlenther Onkol 183 Suppl2 41 2 18167009 10.1007/s00066-007-2016-3