메뉴 건너뛰기




Volumn 31, Issue 3, 2014, Pages 367-377

The roles of HLH transcription factors in epithelial mesenchymal transition and multiple molecular mechanisms

Author keywords

E cadherin; Epithelial mesenchymal transition; Helix loop helix transcription factors; Metastasis

Indexed keywords

CADHERIN; HELIX LOOP HELIX PROTEIN; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TWIST; TWIST1 PROTEIN, HUMAN;

EID: 84897572927     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-013-9621-6     Document Type: Review
Times cited : (35)

References (111)
  • 1
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139:871-890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 2
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • De Craene B, Berx G (2013) Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer 13(2):97-110
    • (2013) Nat Rev Cancer , vol.13 , Issue.2 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 3
    • 84877928478 scopus 로고    scopus 로고
    • Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs
    • Lamouille S, Subramanyam D, Blelloch R, Derynck R (2013) Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol 25:200-207
    • (2013) Curr Opin Cell Biol , vol.25 , pp. 200-207
    • Lamouille, S.1    Subramanyam, D.2    Blelloch, R.3    Derynck, R.4
  • 4
    • 0028245813 scopus 로고
    • Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness
    • DOI 10.1016/0304-419X(94)90003-5
    • Birchmeier W, Behrens J (1994) Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1198(1): 11-26 (Pubitemid 24159061)
    • (1994) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1198 , Issue.1 , pp. 11-26
    • Birchmeier, W.1    Behrens, J.2
  • 5
    • 84897977206 scopus 로고    scopus 로고
    • Multilayer control of the EMT master regulators
    • doi:10.1038/onc.2013.128
    • Zheng H, Kang Y (2013) Multilayer control of the EMT master regulators. Oncogene. doi:10.1038/onc.2013.128
    • (2013) Oncogene
    • Zheng, H.1    Kang, Y.2
  • 6
    • 84860389952 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and cancer stem cells: A dangerously dynamic duo in breast cancer progression
    • May CD, Sphyris N, Evans KW, Werden SJ, Guo W, Mani SA (2011) Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res 13(1):202
    • (2011) Breast Cancer Res , vol.13 , Issue.1 , pp. 202
    • May, C.D.1    Sphyris, N.2    Evans, K.W.3    Werden, S.J.4    Guo, W.5    Mani, S.A.6
  • 7
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9:265-273
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 8
    • 34249289041 scopus 로고    scopus 로고
    • Snail, ZEB and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • DOI 10.1038/nrc2131, PII NRC2131
    • Peinado H, Olmeda D, Cano A (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7(6):415-428 (Pubitemid 46809165)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 11
    • 0034051923 scopus 로고    scopus 로고
    • Generation of neurons by transient expression of neural bHLH proteins in mammalian cells
    • FarahMH, Olson JM, Sucic HB, Hume RI, Tapscott SJ, Turner DL (2000) Generation of neurons by transient expression of neural bHLH proteins in mammalian cells. Development 127(4):693-702 (Pubitemid 30129016)
    • (2000) Development , vol.127 , Issue.4 , pp. 693-702
    • Farah, M.H.1    Olson, J.M.2    Sucic, H.B.3    Hume, R.I.4    Tapscott, S.J.5    Turner, D.L.6
  • 12
    • 0034471262 scopus 로고    scopus 로고
    • ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
    • Norton JD (2000) ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 113(22):3897-3905
    • (2000) J Cell Sci , vol.113 , Issue.22 , pp. 3897-3905
    • Norton, J.D.1
  • 13
    • 77956646295 scopus 로고    scopus 로고
    • The role of bHLH genes in ear development and evolution: Revisiting a 10-year-old hypothesis
    • Fritzsch B, Eberl DF, Beisel KW (2010) The role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesis. Cell Mol Life Sci 67(18):3089-3099
    • (2010) Cell Mol Life Sci , vol.67 , Issue.18 , pp. 3089-3099
    • Fritzsch, B.1    Eberl, D.F.2    Beisel, K.W.3
  • 14
    • 84877678816 scopus 로고    scopus 로고
    • SRY induced TCF21 genome-wide targets and cascade of bHLH factors during Sertoli cell differentiation and male sex determination in rats
    • Bhandari RK, Schinke EN, Haque MM, Sadler-Riggleman I, Skinner MK (2012) SRY induced TCF21 genome-wide targets and cascade of bHLH factors during Sertoli cell differentiation and male sex determination in rats. Biol Reprod 87(6):131
    • (2012) Biol Reprod , vol.87 , Issue.6 , pp. 131
    • Bhandari, R.K.1    Schinke, E.N.2    Haque, M.M.3    Sadler-Riggleman, I.4    Skinner, M.K.5
  • 15
    • 84863242877 scopus 로고    scopus 로고
    • Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice
    • Wang HC, Peng V, Zhao Y, Sun XH (2012) Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice. PLoS One 7(2):e32944
    • (2012) PLoS One , vol.7 , Issue.2
    • Wang, H.C.1    Peng, V.2    Zhao, Y.3    Sun, X.H.4
  • 16
    • 0033980393 scopus 로고    scopus 로고
    • Helix-loop-helix proteins: Regulators of transcription in eucaryotic organisms
    • DOI 10.1128/MCB.20.2.429-440.2000
    • Massari ME, Murre C (2000) Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 20(2):429-440 (Pubitemid 30023084)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.2 , pp. 429-440
    • Massari, M.E.1    Murre, C.2
  • 17
    • 4043141372 scopus 로고    scopus 로고
    • An overview of the basic helix-loop-helix proteins
    • Jones S (2004) An overview of the basic helix-loop-helix proteins. Genome Biol 5(6):226
    • (2004) Genome Biol , vol.5 , Issue.6 , pp. 226
    • Jones, S.1
  • 19
    • 54349102116 scopus 로고    scopus 로고
    • Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: Genomic approach to cellular differentiation
    • Stevens JD, Roalson EH, Skinner MK (2008) Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation. Differentiation 76:1006-1022
    • (2008) Differentiation , vol.76 , pp. 1006-1022
    • Stevens, J.D.1    Roalson, E.H.2    Skinner, M.K.3
  • 20
    • 77954144725 scopus 로고    scopus 로고
    • Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature
    • Skinner MK, Rawls A, Wilson-Rawls J, Roalson EH (2010) Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation 80(1):1-8
    • (2010) Differentiation , vol.80 , Issue.1 , pp. 1-8
    • Skinner, M.K.1    Rawls, A.2    Wilson-Rawls, J.3    Roalson, E.H.4
  • 21
    • 79960623998 scopus 로고    scopus 로고
    • The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy
    • Savino M, Annibali D, Carucci N, Favuzzi E, Cole MD, Evan GI, Soucek L, Nasi S (2011) The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy. PLoS One 6(7):e22284
    • (2011) PLoS One , vol.6 , Issue.7
    • Savino, M.1    Annibali, D.2    Carucci, N.3    Favuzzi, E.4    Cole, M.D.5    Evan, G.I.6    Soucek, L.7    Nasi, S.8
  • 22
    • 77949867499 scopus 로고    scopus 로고
    • Kinetic analysis of the interaction of b/HLH/Z transcription factors Myc, Max, and Mad with cognate DNA
    • Ecevit O, Khan MA, Goss DJ (2010) Kinetic analysis of the interaction of b/HLH/Z transcription factors Myc, Max, and Mad with cognate DNA. Biochemistry 49(12):2627-2635
    • (2010) Biochemistry , vol.49 , Issue.12 , pp. 2627-2635
    • Ecevit, O.1    Khan, M.A.2    Goss, D.J.3
  • 24
    • 34547922380 scopus 로고    scopus 로고
    • Delta-Notch-and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
    • DOI 10.1093/nar/gkm477
    • Fischer A, Gessler M (2007) Delta-Notch-and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res 35(14):4583-4596 (Pubitemid 47250333)
    • (2007) Nucleic Acids Research , vol.35 , Issue.14 , pp. 4583-4596
    • Fischer, A.1    Gessler, M.2
  • 25
    • 84873160542 scopus 로고    scopus 로고
    • Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells
    • Mimeault M, Batra SK (2013) Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells. J Cell Mol Med 17(1):30-54
    • (2013) J Cell Mol Med , vol.17 , Issue.1 , pp. 30-54
    • Mimeault, M.1    Batra, S.K.2
  • 26
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148(3):399-408
    • (2012) Cell , vol.148 , Issue.3 , pp. 399-408
    • Semenza, G.L.1
  • 27
    • 0027215177 scopus 로고
    • E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins
    • Bain G, Gruenwald S, Murre C (1993) E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins. Mol Cell Biol 13(6):3522-3529 (Pubitemid 23157290)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.6 , pp. 3522-3529
    • Bain, G.1    Gruenwald, S.2    Murre, C.3
  • 30
    • 33745861287 scopus 로고    scopus 로고
    • Overexpression of E2A proteins induces epithelial-mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis
    • DOI 10.1016/j.febslet.2006.06.039, PII S0014579306007460
    • Slattery C, McMorrow T, Ryan MP (2006) Overexpression of E2A proteins induces epithelial-mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis. FEBS Lett 580(17):4021-4030 (Pubitemid 44037564)
    • (2006) FEBS Letters , vol.580 , Issue.17 , pp. 4021-4030
    • Slattery, C.1    McMorrow, T.2    Ryan, M.P.3
  • 32
    • 33846684874 scopus 로고    scopus 로고
    • Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1
    • DOI 10.1681/ASN.2006030236
    • Li Y, Yang J, Luo JH, Dedhar S, Liu Y (2007) Tubular epithelial cell dedifferentiation is driven by the Helix-Loop-Helix transcriptional inhibitor Id1. J Am Soc Nephrol 18(2):449-460 (Pubitemid 46193311)
    • (2007) Journal of the American Society of Nephrology , vol.18 , Issue.2 , pp. 449-460
    • Li, Y.1    Yang, J.2    Luo, J.-H.3    Dedhar, S.4    Liu, Y.5
  • 33
    • 84881230851 scopus 로고    scopus 로고
    • Pitt-Hopkins Syndrome: Intellectual disability due to loss of TCF4-regulated gene transcription
    • Sweatt JD (2013) Pitt-Hopkins Syndrome: intellectual disability due to loss of TCF4-regulated gene transcription. Exp Mol Med 45:e21
    • (2013) Exp Mol Med , vol.45
    • Sweatt, J.D.1
  • 35
    • 3242885067 scopus 로고    scopus 로고
    • Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo
    • DOI 10.1242/jcs.01145
    • Peinado H, Marin F, Cubillo E, Stark HJ, Fusenig N, Nieto MA, Cano A (2004) Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo. J Cell Sci 117:2827-2839 (Pubitemid 38997264)
    • (2004) Journal of Cell Science , vol.117 , Issue.13 , pp. 2827-2839
    • Peinado, H.1    Marin, F.2    Cubillo, E.3    Stark, H.-J.4    Fusenig, N.5    Nieto, M.A.6    Cano, A.7
  • 36
    • 0035920152 scopus 로고    scopus 로고
    • A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions
    • Perez-Moreno MA, Locascio A, Rodrigo I, Dhondt G, Portillo F, Nieto MA, Cano A (2001) A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J Biol Chem 276:27424-27431
    • (2001) J Biol Chem , vol.276 , pp. 27424-27431
    • Perez-Moreno, M.A.1    Locascio, A.2    Rodrigo, I.3    Dhondt, G.4    Portillo, F.5    Nieto, M.A.6    Cano, A.7
  • 38
    • 0026503190 scopus 로고
    • Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
    • Aslakson CJ, Miller FR (1992) Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res 52:1399-1405
    • (1992) Cancer Res , vol.52 , pp. 1399-1405
    • Aslakson, C.J.1    Miller, F.R.2
  • 41
    • 39449133669 scopus 로고    scopus 로고
    • Regulation of cancer cell survival, migration, and invasion by twist: AKT2 comes to interplay
    • DOI 10.1158/0008-5472.CAN-07-5067
    • Cheng GZ, Zhang W, Wang LH (2008) Regulation of cancer cell survival, migration, and invasion by Twist: AKT2 comes to interplay. Cancer Res 68:957-960 (Pubitemid 351272210)
    • (2008) Cancer Research , vol.68 , Issue.4 , pp. 957-960
    • Cheng, G.Z.1    Zhang, W.2    Wang, L.-H.3
  • 43
    • 65249155400 scopus 로고    scopus 로고
    • Twist1-mediated adriamycin induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells
    • Li QQ, Xu JD, Wang WJ, Cao XX, Chen Q, Tang F, Chen ZQ, Liu XP, Xu ZD (2009) Twist1-mediated adriamycin induced epithelial-mesenchymal transition relates to multidrug resistance and invasive potential in breast cancer cells. Clin Cancer Res 15:2657-2665
    • (2009) Clin Cancer Res , vol.15 , pp. 2657-2665
    • Li, Q.Q.1    Xu, J.D.2    Wang, W.J.3    Cao, X.X.4    Chen, Q.5    Tang, F.6    Chen, Z.Q.7    Liu, X.P.8    Xu, Z.D.9
  • 44
    • 79651474948 scopus 로고    scopus 로고
    • The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis
    • Fu J, Qin L, He T, Qin J, Hong J, Wong J, Liao L, Xu J (2011) The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res 21:275-289
    • (2011) Cell Res , vol.21 , pp. 275-289
    • Fu, J.1    Qin, L.2    He, T.3    Qin, J.4    Hong, J.5    Wong, J.6    Liao, L.7    Xu, J.8
  • 46
    • 67649449918 scopus 로고    scopus 로고
    • Negative regulation of TIMP1 is mediated by transcription factor TWIST1
    • Okamura H, Yoshida K, Haneji T (2009) Negative regulation of TIMP1 is mediated by transcription factor TWIST1. Int J Oncol 35:181-186
    • (2009) Int J Oncol , vol.35 , pp. 181-186
    • Okamura, H.1    Yoshida, K.2    Haneji, T.3
  • 47
    • 34247245262 scopus 로고    scopus 로고
    • MicroRNAs in the search for understanding human diseases
    • DOI 10.2165/00063030-200721020-00004
    • Perera RJ, Ray A (2007) MicroRNAs in the search for understanding human diseases. BioDrugs 21(2):97-104 (Pubitemid 46624554)
    • (2007) BioDrugs , vol.21 , Issue.2 , pp. 97-104
    • Perera, R.J.1    Ray, A.2
  • 48
    • 72949111146 scopus 로고    scopus 로고
    • MicroRNA regulation of cancer stem cells and therapeutic implications
    • DeSano JT, Xu L (2009) MicroRNA regulation of cancer stem cells and therapeutic implications. AAPS J 4:682-692
    • (2009) AAPS J , vol.4 , pp. 682-692
    • DeSano, J.T.1    Xu, L.2
  • 49
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • DOI 10.1038/nature06174, PII NATURE06174
    • Mal L, Teruya-Feldstein J, Weinberg RA (2007) Tumor invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449(7163):682-688 (Pubitemid 47552092)
    • (2007) Nature , vol.449 , Issue.7163 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 50
    • 41849092209 scopus 로고    scopus 로고
    • MicroRNAs in malignant progression
    • Ma L, Weinberg RA (2008) MicroRNAs in malignant progression. Cell Cycle 7(5):570-572 (Pubitemid 351498993)
    • (2008) Cell Cycle , vol.7 , Issue.5 , pp. 570-572
    • Ma, L.1    Weinberg, R.A.2
  • 52
    • 79952228140 scopus 로고    scopus 로고
    • Basic Helix-Loop- Helix transcription factors DEC1 and DEC2 regulate the paclitaxel- induced apoptotic pathway of MCF-7 human breast cancer cells
    • Wu Y, Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Morohashi S, Kato Y, Kijima H (2011) Basic Helix-Loop- Helix transcription factors DEC1 and DEC2 regulate the paclitaxel- induced apoptotic pathway of MCF-7 human breast cancer cells. Int J Mol Med 4:491-495
    • (2011) Int J Mol Med , vol.4 , pp. 491-495
    • Wu, Y.1    Sato, F.2    Bhawal, U.K.3    Kawamoto, T.4    Fujimoto, K.5    Noshiro, M.6    Morohashi, S.7    Kato, Y.8    Kijima, H.9
  • 55
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
    • DOI 10.1016/j.devcel.2008.05.009, PII S1534580708002098
    • Yang J, Weinberg RA (2008) Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14:818-829 (Pubitemid 351757205)
    • (2008) Developmental Cell , vol.14 , Issue.6 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 56
    • 77954759731 scopus 로고    scopus 로고
    • Hey bHLH factors in cardiovascular development
    • Wiese C, Heisig J, Gessler M (2010) Hey bHLH factors in cardiovascular development. Pediatr Cardiol 31:363-370
    • (2010) Pediatr Cardiol , vol.31 , pp. 363-370
    • Wiese, C.1    Heisig, J.2    Gessler, M.3
  • 57
    • 79957487931 scopus 로고    scopus 로고
    • Notch-1 induces epithelial- mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells
    • Bao B, Wang Z, Ali S, Kong D, Li Y, Ahmad A, Banerjee S, Azmi AS, Miele L, Sarkar FH (2011) Notch-1 induces epithelial- mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. Cancer Lett 307(1):26-36
    • (2011) Cancer Lett , vol.307 , Issue.1 , pp. 26-36
    • Bao, B.1    Wang, Z.2    Ali, S.3    Kong, D.4    Li, Y.5    Ahmad, A.6    Banerjee, S.7    Azmi, A.S.8    Miele, L.9    Sarkar, F.H.10
  • 59
    • 84874704122 scopus 로고    scopus 로고
    • C-Myc suppressed E-cadherin through miR-9 at the post-transcriptional level
    • Liu M, Zhu H, Yang S, Wang Z, Bai J, Xu N (2013) C-Myc suppressed E-cadherin through miR-9 at the post-transcriptional level. Cell Biol Int 37(3):197-202
    • (2013) Cell Biol Int , vol.37 , Issue.3 , pp. 197-202
    • Liu, M.1    Zhu, H.2    Yang, S.3    Wang, Z.4    Bai, J.5    Xu, N.6
  • 60
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, Lee ES, Hu G, Kang Y (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 283(22):14910-14914
    • (2008) J Biol Chem , vol.283 , Issue.22 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 61
    • 84872744792 scopus 로고    scopus 로고
    • Tamoxifen represses miR-200 MicroRNAs and promotes epithelial- to-mesenchymal transition by up-regulating c-myc in endometrial carcinoma cell lines
    • Bai JX, Yan B, Zhao ZN, Xiao X, Qin WW, Zhang R, Jia LT, Meng YL, Jin BQ, Fan DM, Wang T, Yang AG (2013) Tamoxifen represses miR-200 MicroRNAs and promotes epithelial- to-mesenchymal transition by up-regulating c-myc in endometrial carcinoma cell lines. Endocrinology 154(2): 635-645
    • (2013) Endocrinology , vol.154 , Issue.2 , pp. 635-645
    • Bai, J.X.1    Yan, B.2    Zhao, Z.N.3    Xiao, X.4    Qin, W.W.5    Zhang, R.6    Jia, L.T.7    Meng, Y.L.8    Jin, B.Q.9    Fan, D.M.10    Wang, T.11    Yang, A.G.12
  • 62
    • 84867296323 scopus 로고    scopus 로고
    • c-myc expression and MEK1 induced Erk2 nuclear localization are required for TGFbeta induced epithelial-mesenchymal transition and invasion in prostate cancer
    • Amatangelo MD, Goodyear S, Varma D, Stearns ME (2012) c-myc expression and MEK1 induced Erk2 nuclear localization are required for TGFbeta induced epithelial-mesenchymal transition and invasion in prostate cancer. Carcinogenesis 33(10):1965-1975
    • (2012) Carcinogenesis , vol.33 , Issue.10 , pp. 1965-1975
    • Amatangelo, M.D.1    Goodyear, S.2    Varma, D.3    Stearns, M.E.4
  • 64
    • 56749184298 scopus 로고    scopus 로고
    • Reflecting on 25 years with MYC
    • Meyer N, Penn LZ (2008) Reflecting on 25 years with MYC. Nat Rev Cancer 8(12):976-990
    • (2008) Nat Rev Cancer , vol.8 , Issue.12 , pp. 976-990
    • Meyer, N.1    Penn, L.Z.2
  • 65
    • 70649105527 scopus 로고    scopus 로고
    • Myc's other life: Stem cells and beyond
    • Laurenti E, Wilson A, Trumpp A (2009) Myc's other life: stem cells and beyond. Curr Opin Cell Biol 21(6):844-854
    • (2009) Curr Opin Cell Biol , vol.21 , Issue.6 , pp. 844-854
    • Laurenti, E.1    Wilson, A.2    Trumpp, A.3
  • 66
    • 77749279644 scopus 로고    scopus 로고
    • Myc proteins as therapeutic targets
    • Gustafson WC, Weiss WA (2010) Myc proteins as therapeutic targets. Oncogene 29(9):1249-1259
    • (2010) Oncogene , vol.29 , Issue.9 , pp. 1249-1259
    • Gustafson, W.C.1    Weiss, W.A.2
  • 67
    • 75849131117 scopus 로고    scopus 로고
    • The ups and downs of Myc biology
    • Soucek L, Evan GI (2010) The ups and downs of Myc biology. Curr Opin Genet Dev 20(1):91-95
    • (2010) Curr Opin Genet Dev , vol.20 , Issue.1 , pp. 91-95
    • Soucek, L.1    Evan, G.I.2
  • 68
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV (2012) MYC on the path to cancer. Cell 149(1):22-35
    • (2012) Cell , vol.149 , Issue.1 , pp. 22-35
    • Dang, C.V.1
  • 72
    • 1642327586 scopus 로고    scopus 로고
    • Id-1 and Id-2 Proteins as Molecular Markers for Human Prostate Cancer Progression
    • DOI 10.1158/1078-0432.CCR-03-0933
    • Coppe JP, Itahana Y, Moore DH, Bennington JL, Desprez PY (2004) Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression. Clin Cancer Res 10(6):2044-2051 (Pubitemid 38375565)
    • (2004) Clinical Cancer Research , vol.10 , Issue.6 , pp. 2044-2051
    • Coppe, J.-P.1    Itahana, Y.2    Moore, D.H.3    Bennington, J.L.4    Desprez, P.-Y.5
  • 74
    • 2942536704 scopus 로고    scopus 로고
    • Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein
    • DOI 10.1128/MCB.24.10.4241-4254.2004
    • Kowanetz M, Valcourt U, Bergstrom R, Heldin CH, Moustakas A (2004) Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein. Mol Cell Biol 24(10):4241-4254 (Pubitemid 41070996)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.10 , pp. 4241-4254
    • Kowanetz, M.1    Valcourt, U.2    Bergstrom, R.3    Heldin, C.-H.4    Moustakas, A.5
  • 75
    • 33846684874 scopus 로고    scopus 로고
    • Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1
    • DOI 10.1681/ASN.2006030236
    • Li Y, Yang J, Luo JH, Dedhar S, Liu Y (2007) Tubular epithelial cell dedifferentiation is driven by the Helix-Loop-Helix transcriptional inhibitor Id1. J Am Soc Nephrol 18(2):449-460 (Pubitemid 46193311)
    • (2007) Journal of the American Society of Nephrology , vol.18 , Issue.2 , pp. 449-460
    • Li, Y.1    Yang, J.2    Luo, J.-H.3    Dedhar, S.4    Liu, Y.5
  • 76
    • 0042347689 scopus 로고    scopus 로고
    • Id proteins in development, cell cycle and cancer
    • DOI 10.1016/S0962-8924(03)00147-8
    • Ruzinova MB, Benezra R (2003) Id proteins in development, cell cycle and cancer. Trends Cell Biol 13(8):410-418 (Pubitemid 36897645)
    • (2003) Trends in Cell Biology , vol.13 , Issue.8 , pp. 410-418
    • Ruzinova, M.B.1    Benezra, R.2
  • 77
    • 77951953778 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: From molecular mechanisms, redox regulation to implications in human health and disease
    • Cannito S,Novo E, di Bonzo LV, Busletta C, Colombatto S, Parola M (2010) Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease. Antioxid Redox Signal 12(12):1383-1430
    • (2010) Antioxid Redox Signal , vol.12 , Issue.12 , pp. 1383-1430
    • Cannito, S.1    Novo, E.2    Di Bonzo, L.V.3    Busletta, C.4    Colombatto, S.5    Parola, M.6
  • 78
    • 79954582454 scopus 로고    scopus 로고
    • Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer
    • Chang Q, Jurisica I, Do T, Hedley DW (2011) Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res 71(8):3110-3120
    • (2011) Cancer Res , vol.71 , Issue.8 , pp. 3110-3120
    • Chang, Q.1    Jurisica, I.2    Do, T.3    Hedley, D.W.4
  • 79
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • DOI 10.1126/science.1066373
    • Bruick RK, McKnight SL (2001) A conserved family of prolyl- 4-hydroxylases that modify HIF. Science 294(5545):1337-1340 (Pubitemid 33063099)
    • (2001) Science , vol.294 , Issue.5545 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 80
    • 84655161946 scopus 로고    scopus 로고
    • HIF1a and HIF2a: Sibling rivalry in hypoxic tumour growth and progression
    • Keith B, Johnson RS, Simon MC (2012) HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12(1):9-22
    • (2012) Nat Rev Cancer , vol.12 , Issue.1 , pp. 9-22
    • Keith, B.1    Johnson, R.S.2    Simon, M.C.3
  • 81
    • 79954579633 scopus 로고    scopus 로고
    • EMT: A new vision of hypoxia promoting cancer progression
    • Jiang J, Tang YL, Liang XH (2011) EMT: a new vision of hypoxia promoting cancer progression. Cancer Biol Ther 11(8):714-723
    • (2011) Cancer Biol Ther , vol.11 , Issue.8 , pp. 714-723
    • Jiang, J.1    Tang, Y.L.2    Liang, X.H.3
  • 84
    • 79956020554 scopus 로고    scopus 로고
    • Hypoxia and senescence: The impact of oxygenation on tumor suppression
    • Welford SM, Giaccia AJ (2011) Hypoxia and senescence: the impact of oxygenation on tumor suppression. Mol Cancer Res 9(5):538-544
    • (2011) Mol Cancer Res , vol.9 , Issue.5 , pp. 538-544
    • Welford, S.M.1    Giaccia, A.J.2
  • 85
    • 77954372059 scopus 로고    scopus 로고
    • Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms
    • Copple BL (2010) Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int 30(5):669-682
    • (2010) Liver Int , vol.30 , Issue.5 , pp. 669-682
    • Copple, B.L.1
  • 86
    • 84875790987 scopus 로고    scopus 로고
    • Hypoxiainducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells
    • Han WQ, Zhu Q, Hu J, Li PL, Zhang F, Li N (2013) Hypoxiainducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. Biochim Biophys Acta 1833(6):1454-1462
    • (2013) Biochim Biophys Acta , vol.1833 , Issue.6 , pp. 1454-1462
    • Han, W.Q.1    Zhu, Q.2    Hu, J.3    Li, P.L.4    Zhang, F.5    Li, N.6
  • 89
    • 77449108417 scopus 로고    scopus 로고
    • VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop
    • Gonzalez-Moreno O, Lecanda J, Green JE, Segura V, Catena R, Serrano D, Calvo A (2010) VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop. Exp Cell Res 316(4): 554-567
    • (2010) Exp Cell Res , vol.316 , Issue.4 , pp. 554-567
    • Gonzalez-Moreno, O.1    Lecanda, J.2    Green, J.E.3    Segura, V.4    Catena, R.5    Serrano, D.6    Calvo, A.7
  • 90
    • 77950476293 scopus 로고    scopus 로고
    • ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: Implications for Gleason grading
    • Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti CA, Gouvin LM, Sharma VM, Mercurio AM (2010) ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell 17(4):319-332
    • (2010) Cancer Cell , vol.17 , Issue.4 , pp. 319-332
    • Mak, P.1    Leav, I.2    Pursell, B.3    Bae, D.4    Yang, X.5    Taglienti, C.A.6    Gouvin, L.M.7    Sharma, V.M.8    Mercurio, A.M.9
  • 91
    • 84857147817 scopus 로고    scopus 로고
    • Hypoxia-induced down-regulation of microRNA- 34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells
    • Du R, Sun W, Xia L, Zhao A, Yu Y, Zhao L, Wang H, Huang C, Sun S (2012) Hypoxia-induced down-regulation of microRNA- 34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One 7(2):e30771
    • (2012) PLoS One , vol.7 , Issue.2
    • Du, R.1    Sun, W.2    Xia, L.3    Zhao, A.4    Yu, Y.5    Zhao, L.6    Wang, H.7    Huang, C.8    Sun, S.9
  • 94
    • 34147096361 scopus 로고    scopus 로고
    • Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition
    • DOI 10.1161/01.RES.0000260913.95642.3b
    • Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M (2007) Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res 100:856-863 (Pubitemid 46555691)
    • (2007) Circulation Research , vol.100 , Issue.6 , pp. 856-863
    • Fischer, A.1    Steidl, C.2    Wagner, T.U.3    Lang, E.4    Jakob, P.M.5    Friedl, P.6    Knobeloch, K.-P.7    Gessler, M.8
  • 95
    • 84872899556 scopus 로고    scopus 로고
    • The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function
    • Bildsoe Heidi, Loebel David AF, Jones Vanessa J, Hor Angelyn CC, Braithwaite Antony W, Chen You-Tzung, Behringer Richard R, Tama Patrick PL (2013) The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Dev Biol 374(2):295-307
    • (2013) Dev Biol , vol.374 , Issue.2 , pp. 295-307
    • Bildsoe, H.1    Loebel, D.A.F.2    Jones, V.J.3    Hor, A.C.C.4    Braithwaite, A.W.5    Chen, Y.-T.6    Behringer, R.R.7    Tama, P.P.L.8
  • 97
    • 84864067904 scopus 로고    scopus 로고
    • Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart
    • Braitsch CM, Combs MD, Quaggin SE, Yutzey KE (2012) Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Dev Biol 368(2):345-357
    • (2012) Dev Biol , vol.368 , Issue.2 , pp. 345-357
    • Braitsch, C.M.1    Combs, M.D.2    Quaggin, S.E.3    Yutzey, K.E.4
  • 99
    • 0033393087 scopus 로고    scopus 로고
    • The basic-helix-loop-helix protein Pod1 is critically important for kidney and lung organogenesis
    • Quaggin SE, Schwartz L, Cui S, Igarashi P, Deimling J, Post M, Rossant J (1999) The basic-Helix-Loop-Helix protein Pod1 is critically important for kidney and lung organogenesis. Development 126(24):5771-5783 (Pubitemid 30035024)
    • (1999) Development , vol.126 , Issue.24 , pp. 5771-5783
    • Quaggin, S.E.1    Schwartz, L.2    Cui, S.3    Igarashi, P.4    Deimling, J.5    Post, M.6    Rossant, J.7
  • 100
    • 78650681563 scopus 로고    scopus 로고
    • Mesp1: A key regulator of cardiovascular lineage commitment
    • Bondue A, Blanpain C (2010) Mesp1: a key regulator of cardiovascular lineage commitment. Circ Res 107(12):1414-1427
    • (2010) Circ Res , vol.107 , Issue.12 , pp. 1414-1427
    • Bondue, A.1    Blanpain, C.2
  • 101
    • 33845456359 scopus 로고    scopus 로고
    • Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis
    • DOI 10.1016/j.ydbio.2006.08.043, PII S001216060601133X
    • Morimoto M, Kiso M, Sasaki N, Saga Y (2006) Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis. Dev Biol 300(2):687-698 (Pubitemid 44909103)
    • (2006) Developmental Biology , vol.300 , Issue.2 , pp. 687-698
    • Morimoto, M.1    Kiso, M.2    Sasaki, N.3    Saga, Y.4
  • 103
    • 40349091380 scopus 로고    scopus 로고
    • Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2
    • DOI 10.1128/MCB.01701-07
    • Laffin B, Wellberg E, Kwak HI, Burghardt RC, Metz RP, Gustafson T, Schedin P, Porter WW (2008) Loss of singleminded-2 s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2. Mol Cell Biol 28(6):1936-1946 (Pubitemid 351342625)
    • (2008) Molecular and Cellular Biology , vol.28 , Issue.6 , pp. 1936-1946
    • Laffin, B.1    Wellberg, E.2    Kwak, H.-I.3    Burghardt, R.C.4    Metz, R.P.5    Gustafson, T.6    Schedin, P.7    Porter, W.W.8
  • 104
    • 31144469715 scopus 로고    scopus 로고
    • Sim1 and Sim2 are required for the correct targeting of mammillary body axons
    • DOI 10.1242/dev.02142
    • Marion JF, Yang C, Caqueret A, Boucher F, Michaud JL (2005) Sim1 and Sim2 are required for the correct targeting of mammillary body axons. Development 132(24):5527-5537 (Pubitemid 43125879)
    • (2005) Development , vol.132 , Issue.24 , pp. 5527-5537
    • Marion, J.-F.1    Yang, C.2    Caqueret, A.3    Boucher, F.4    Michaud, J.L.5
  • 106
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J (2012) Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 22(6):725-736
    • (2012) Cancer Cell , vol.22 , Issue.6 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 107
    • 33845809125 scopus 로고    scopus 로고
    • Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2
    • DOI 10.1158/0008-5472.CAN-06-2044
    • Chaffer CL, Brennan JP, Slavin JL, Blick T, Thompson EW, Williams ED (2006) Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Res 66(23):11271-11278 (Pubitemid 46009956)
    • (2006) Cancer Research , vol.66 , Issue.23 , pp. 11271-11278
    • Chaffer, C.L.1    Brennan, J.P.2    Slavin, J.L.3    Blick, T.4    Thompson, E.W.5    Williams, E.D.6
  • 110
    • 79955751669 scopus 로고    scopus 로고
    • Phosphorylation of the Twist1- family basic Helix-Loop-Helix transcription factors is involved in pathological cardiac remodeling
    • Lu S, Nie J, Luan Q, Feng Q, Xiao Q, Chang Z, Shan C, Hess D, Hemmings BA, Yang Z (2011) Phosphorylation of the Twist1- family basic Helix-Loop-Helix transcription factors is involved in pathological cardiac remodeling. PLoS One 6(4):e19251
    • (2011) PLoS One , vol.6 , Issue.4
    • Lu, S.1    Nie, J.2    Luan, Q.3    Feng, Q.4    Xiao, Q.5    Chang, Z.6    Shan, C.7    Hess, D.8    Hemmings, B.A.9    Yang, Z.10
  • 111
    • 84856253468 scopus 로고    scopus 로고
    • Phosphorylation of basic helix- loop-helix transcription factor Twist in development and disease
    • Xue G, Hemmings BA (2012) Phosphorylation of basic helix- loop-helix transcription factor Twist in development and disease. Biochem Soc Trans 40(1):90-93
    • (2012) Biochem Soc Trans , vol.40 , Issue.1 , pp. 90-93
    • Xue, G.1    Hemmings, B.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.