C-Myc suppressed E-cadherin through miR-9 at the post-transcriptional level

Cell Biology International

Volumn 37, Issue 3, 2013, Pages 197-202

  Liu, Mei ^a   Zhu, Hongxia ^a   Yang, Shangbin ^a,b   Wang, Zaozao ^a   Bai, Jinfeng ^a   Xu, Ningzhi ^a  

^a CANCER HOSPITAL   (China)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

C Myc; Dox; E cadherin; EMT; Inducible; MiR 9

Indexed keywords

DOXYCYCLINE; MICRORNA 9; MYC PROTEIN; UVOMORULIN; VIMENTIN;

ARTICLE; CELL LINE; CELL STRAIN T REX 293; CONTROLLED STUDY; GENETIC TRANSFECTION; PLASMID; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; BINDING SITES; CADHERINS; HEK293 CELLS; HUMANS; MICRORNAS; PROTO-ONCOGENE PROTEINS C-MYC; RNA INTERFERENCE; RNA, MESSENGER;

EID: 84874704122     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10039     Document Type: Article

References (23)

1. Angst BD,Marcozzi C, Magee AI (2001) The cadherin superfamily. J Cell Sci 114: 625-6.
2. Beavon IR (2000) The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation. Eur J Cancer 36: 1607-20.
3. Berx G, Cleton-Jansen AM, Nollet F, de Leeuw WJ, van de Vijver M, Cornelisse C, van Roy F (1995) E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO J 14: 6107-15.
4. Birchmeier W, Behrens J, Weidner KM, Frixen UH, Schipper J (1991) Dominant and recessive genes involved in tumor cell invasion. Curr Opin Cell Biol 3: 832-40.
5. Ceteci F, Ceteci S, Karreman C, Kramer BW, Asan E, Gotz R, Rapp UR (2007) Disruption of tumor cell adhesion promotesangiogenic switch and progression to micrometastasis in RAFdriven murine lung cancer. Cancer Cell 12: 145-59.
6. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, Lao KQ, Livak KJ, Guegler KJ (2005) Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33: e179.
7. Cowling VH, Cole MD (2006) Mechanism of transcriptional activation by theMyc oncoproteins. Semin Cancer Biol 16: 242-52.
8. Dang CV, O'Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F (2006) The c-Myc target gene network. Semin Cancer Biol 16: 253-64.
9. DiFeo A, Narla G, Camacho-Vanegas O, Nishio H, Rose SL, Buller RE, Friedman SL,Walsh MJ,Martignetti JA (2006) E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor. Oncogene 25: 6026-31.
10. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Löchner D, BirchmeierW(1991) E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113: 173-85.
11. Gartel AL (2006) A new mode of transcriptional repression by c-myc: methylation. Oncogene 25: 1989-90.
12. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281: 1509-12.
13. Hennig G, Lowrick O, Birchmeier W, Behrens J (1996) Mechanisms identified in the transcriptional control of epithelial gene expression. J Biol Chem 271: 595-602.
14. Henriksson M, Luscher B (1996) Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv Cancer Res 68: 109-82.
15. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) method. Methods 25: 402-8.
16. Ma L, Teruya-Feldstein J, Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449: 682-8.
17. Ma L, Young J, Prabhala H, Pan E, Mestdagh P, Muth D, Teruya-Feldstein J, Reinhardt F, Onder TT, Valastyan S, Westermann F, Speleman F, Vandesompele J, Weinberg RA (2010) miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12: 247-56.
18. Meyer N, Penn LZ (2008) Reflecting on 25 years with MYC. Nat Rev Cancer 8: 976-90.
19. Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA (2008) Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 68: 3645-54.
20. Sole X, Hernandez P, de Heredia ML, Armengol L, Rodriguez-Santiago B, Gomez L, Maxwell CA, Aguiló F, Condom E, Abril J, Pérez-Jurado L, Estivill X, Nunes V, Capellá G, Gruber SB, Moreno V, Pujana MA (2008) Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility. BMC Genomics 9: 12.
21. Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-54.
22. van Roy F, Berx G (2008) The cell-cell adhesion molecule Ecadherin. Cell Mol Life Sci 65: 3756-88.
23. Zhou C, Liu S, Zhou X, Xue L, Quan L, Lu N, Zhang G, Bai J,Wang Y, Liu Z, Zhan Q, Zhu H, XuN(2005) Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin/TCF pathway in human esophageal squamous cell carcinoma. Int J Cancer 113: 891-8.