Mouse gridlock: No aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice

Current Biology

Volumn 12, Issue 18, 2002, Pages 1601-1604

  Gessler, Manfred ^a   Knobeloch, Klaus Peter ^b   Helisch, Armin ^c   Amann, Kerstin ^d   Schumacher, Nina ^a   Rohde, Elvira ^b   Fischer, Andreas ^a   Leimeister, Cornelia ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HEY2 PROTEIN, ZEBRAFISH; PROTEIN; TRANSCRIPTION FACTOR; ZEBRAFISH PROTEIN;

ANIMAL; AORTA COARCTATION; ARTICLE; EVOLUTION; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; GENE EXPRESSION; GENETICS; HUMAN; IN SITU HYBRIDIZATION; MOUSE; MOUSE MUTANT; MUTATION; PATHOLOGY; PHENOTYPE; PHYSIOLOGY; PRENATAL DEVELOPMENT; ZEBRA FISH;

ANIMALS; AORTIC COARCTATION; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARDIOMYOPATHY, HYPERTROPHIC, FAMILIAL; EVOLUTION; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; MUTATION; PHENOTYPE; PROTEINS; TRANSCRIPTION FACTORS; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; MAMMALIA; MURINAE;

EID: 0037125916     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01150-8     Document Type: Article

References (11)

1. Gridlock, an HLH gene required for assembly of the aorta in zebrafish
2. Gridlock, a localized heritable vascular patterning defect in the zebrafish
3. Gridlock: A model for coarctation of the aorta?
4. Gridlock signalling pathway fashions the first embryonic artery
5. Hey genes: A novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis
6. HRT1, HRT2, and HRT3: A new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments
7. Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split
8. Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system
9. Characterization of the human and mouse HEY1, HEY2, and HEYL genes: Cloning, mapping, and mutation screening of a new bHLH gene family
10. Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors
11. Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family