Trehalose suppresses antibody aggregation during the culture of Chinese hamster ovary cells

Journal of Bioscience and Bioengineering

Volumn 117, Issue 5, 2014, Pages 632-638

  Onitsuka, Masayoshi ^a   Tatsuzawa, Miki ^a   Asano, Ryutaro ^b   Kumagai, Izumi ^b   Shirai, Akihiro ^a   Maseda, Hideaki ^a   Omasa, Takeshi ^a,c  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Antibody aggregation; Antibody production; Bispecific diabody; Cell culture; Chemical chaperone; Chinese hamster ovary cell; Trehalose

Indexed keywords

AGGREGATES; CELL CULTURE;

ANTIBODY AGGREGATION; ANTIBODY PRODUCTION; BISPECIFIC DIABODY; CHEMICAL CHAPERONE; CHINESE HAMSTER OVARY CELLS; TREHALOSE;

ANTIBODIES;

BISPECIFIC ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN G; TREHALOSE;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL CULTURE; CHO CELL; DRUG EFFECT; DRUG MECHANISM; KINETICS; LYMPHOKINE ACTIVATED KILLER CELL; NONHUMAN; PROTEIN POLYMERIZATION; PROTEIN SECRETION; TOTAL QUALITY MANAGEMENT; VOLUMETRIC ANTIBODY PRODUCTION;

CRICETULUS GRISEUS;

ANTIBODY AGGREGATION; ANTIBODY PRODUCTION; BISPECIFIC DIABODY; CELL CULTURE; CHEMICAL CHAPERONE; CHINESE HAMSTER OVARY CELL; TREHALOSE;

ANIMALS; ANTIBODIES, BISPECIFIC; BIOREACTORS; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; KINETICS; PROTEIN BINDING; TREHALOSE;

EID: 84897055074     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2013.10.022     Document Type: Article

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