Changes in the quality of antibodies produced by Chinese hamster ovary cells during the death phase of cell culture

Journal of Bioscience and Bioengineering

Volumn 109, Issue 3, 2010, Pages 281-287

  Kaneko, Yoshihiro ^a,b   Sato, Ryuji ^c   Aoyagi, Hideki ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c Chugai Pharmaceutical Manufacturing Co Ltd   (Japan)

Author keywords

HM1.24 antigen; Monoclonal antibody; Recombinant CHO cell

Indexed keywords

ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITIES; BATCH CULTURE; CHINESE HAMSTER OVARY CELLS; CHO CELL; CULTURE SUPERNATANT; HM1.24 ANTIGEN; IN-CELL; ION-EXCHANGE CHROMATOGRAPHY; MAMMALIAN CELLS; RECOMBINANT CHO CELL; RECOMBINANT PROTEIN; STABLE CELL LINES;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL CULTURE; ANTIGENS; BATCH CELL CULTURE; CARBOHYDRATES; CELLS; CHROMATOGRAPHIC ANALYSIS; ION EXCHANGE; MAMMALS; MONOCLONAL ANTIBODIES; PROTEINS; QUALITY CONTROL; SURFACE PLASMON RESONANCE;

CELL CULTURE;

HM1.24 ANTIGEN; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY PRODUCTION; ARTICLE; BIOREACTOR; CARBOHYDRATE ANALYSIS; CELL CULTURE; CELL DEATH; CELL LINE; CELL VIABILITY; CHO CELL; FEMALE; GEL PERMEATION CHROMATOGRAPHY; GENETIC HETEROGENEITY; ION EXCHANGE CHROMATOGRAPHY; NONHUMAN;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; GENETIC ENHANCEMENT; PROTEIN ENGINEERING;

CRICETULUS GRISEUS; MAMMALIA;

EID: 76049113295     PISSN: 13891723     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2009.09.043     Document Type: Article

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