Biphasic addition strategy of hypoxanthine and thymidine for improving monoclonal antibody production

Journal of Bioscience and Bioengineering

Volumn 114, Issue 3, 2012, Pages 347-352

  Chen, Fei ^a   Ye, Zhaoyang ^a   Zhao, Liang ^a   Liu, Xuping ^a   Fan, Li ^a   Tan, Wen Song ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Chinese hamster ovary cells; Fed batch culture; Hypoxanthine; Monoclonal antibody production; Thymidine

Indexed keywords

CHINESE HAMSTER OVARY CELLS; FED-BATCH CULTURES; HYPOXANTHINE; MONOCLONAL ANTIBODY PRODUCTION; THYMIDINE;

BATCH CELL CULTURE; GROWTH KINETICS; MONOCLONAL ANTIBODIES;

CELL GROWTH;

HYPOXANTHINE; MONOCLONAL ANTIBODY; THYMIDINE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIBODY PRODUCTION; ARTICLE; BIOREACTOR; CELL COUNT; CELL DENSITY; CELL GROWTH; CHO CELL; CONCENTRATION PROCESS; CONCENTRATION RESPONSE; FED BATCH CULTURE; FEMALE; NONHUMAN;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY FORMATION; BATCH CELL CULTURE TECHNIQUES; BIOREACTORS; CELL COUNT; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOXANTHINE; THYMIDINE;

CRICETULUS GRISEUS;

EID: 84864601911     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2012.04.015     Document Type: Article

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