Plakophilins in desmosomal adhesion and signaling

Cell Communication and Adhesion

Volumn 21, Issue 1, 2014, Pages 25-42

  Hatzfeld, Mechthild ^a   Wolf, Annika ^a   Keil, René ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Armadillo protein; Desmosome; Phosphorylation; Plakophilin; Post translational modification; Rho signaling; Scaffold; Translation

Indexed keywords

BETA CATENIN; DESMOSOMAL CADHERIN; INSULIN; KERATIN; PLAKOGLOBIN; PLAKOPHILIN; RHO FACTOR; SOMATOMEDIN C;

ARMADILLO; CARCINOGENESIS; CELL ADHESION; CELL NUCLEUS; CELL PROLIFERATION; DESMOSOME; DNA DAMAGE; DOWN REGULATION; GAIN OF FUNCTION MUTATION; GENETIC CONSERVATION; GROWTH REGULATION; HEART DISEASE; HUMAN; INTRACELLULAR SIGNALING; LOSS OF FUNCTION MUTATION; MECHANICAL STRESS; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVIEW; RNA METABOLISM; RNA TRANSLATION; SKIN DISEASE; TRANSCRIPTION REGULATION;

ANIMALS; BETA CATENIN; CELL ADHESION; DESMOSOMES; HUMANS; NEOPLASMS; PLAKOPHILINS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84896946562     PISSN: 15419061     EISSN: 15435180     Source Type: Journal    
DOI: 10.3109/15419061.2013.876017     Document Type: Review

References (186)

1. Abba M, Laufs S, Aghajany M, Korn B, Benner A, Allgayer H (2012). Look who' s talking: deregulated signaling in colorectal cancer. Cancer Genomics Proteomics. 9 : 15-25.
2. Aigner K, Descovich L, Mikula M, Sultan A, Dampier B, Bonne S, Van Roy F, Mikulits W, Schreiber M, Brabletz T, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A (2007). The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. FEBS Lett. 581 : 1617-1624.
3. Al-Jassar C, Bikker H, Overduin M, Chidgey M (2013). Mechanistic Basis of Desmosome-Targeted Diseases. J Mol Biol. 425 : 4006-4022.
4. Anastasiadis PZ (2007). p120-ctn: A nexus for contextual signaling via Rho GTPases. Biochim Biophys Acta. 1773 : 34-46.
5. Ancona N, Maglietta R, Piepoli A, D ' addabbo A, Cotugno R, Savino M, Liuni S, Carella M, Pesole G, Perri F (2006). On the statistical assessment of classifiers using DNA microarray data. BMC Bioinformatics. 7 : 387.
6. Anisimova M, Gascuel O (2006). Approximate likelihoodratio test for branches: a fast, accurate, and powerful alternative. Syst Biol. 55 : 539-552.
7. April C, Klotzle B, Royce T, Wickham-Garcia E, Boyaniwsky T, Izzo J, Cox D, Jones W, Rubio R, Holton K, Matulonis U, Quackenbush J, Fan JB (2009). Whole-genome gene expression profiling of formalin-fixed, paraffin-embedded tissue samples. PLoS One. 4 : e8162.
8. Arencibia JM, Martin S, Perez-Rodriguez FJ, Bonnin A (2009). Gene expression profiling reveals overexpression of TSPAN13 in prostate cancer. Int J Oncol. 34 : 457-463.
9. Bass-Zubek AE, Godsel LM, Delmar M, Green KJ (2009). Plakophilins: multifunctional scaffolds for adhesion and signaling. Curr Opin Cell Biol. 21 : 708-716.
10. Bazzi H, Christiano AM (2007). Broken hearts, woolly hair, and tattered skin: when desmosomal adhesion goes awry. Curr Opin Cell Biol. 19 : 515-520.
11. Bennett EJ, Rush J, Gygi SP, Harper JW (2010). Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Cell. 143 : 951-965.
12. Bierkamp C, Schwarz H, Huber O, Kemler R (1999). Desmosomal localization of beta-catenin in the skin of plakoglobin nullmutant mice. Development. 126 : 371-381.
13. Bigler J, Rand HA, Kerkof K, Timour M, Russell CB (2013). Cross-study homogeneity of psoriasis gene expression in skin across a large expression range. PLoS One. 8 : e52242.
14. Birchmeier W, Hulsken J, Behrens J (1995). Adherens junction proteins in tumour progression. Cancer Surv. 24 : 129-140.
15. Bonne S, Gilbert B, Hatzfeld M, Chen X, Green KJ, Van Roy F (2003). Defining desmosomal plakophilin-3 interactions. J Cell Biol. 161 : 403-416.
16. Bose S, Yap LF, Fung M, Starzcynski J, Saleh A, Morgan S, Dawson C, Chukwuma MB, Maina E, Buettner M, Wei W, Arrand J, Lim PV, Young LS, Teo SH, Stankovic T, Woodman CB and Murray PG (2009). The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. J Pathol. 217 : 345-352.
17. Brooke MA, Nitoiu D, Kelsell DP (2012). Cell-cell connectivity: desmosomes and disease. J Pathol. 226 : 158-171.
18. Callari M, Dugo M, Musella V, Marchesi E, Chiorino G, Grand MM, Pierotti MA, Daidone MG, Canevari S, De Cecco L (2012). Comparison of microarray platforms for measuring differential microRNA expression in paired normal/cancer colon tissues. PLoS One. 7 : e45105.
19. Castresana J (2000). Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis. Mol Biol Evol. 17 : 540-552.
20. Chandran UR, Ma C, Dhir R, Bisceglia M, Lyons-Weiler M, Liang W, Michalopoulos G, Becich M, Monzon FA (2007). Gene expression profiles of prostate cancer reveal involvement of multiple molecular pathways in the metastatic process. BMC Cancer. 7 : 64.
21. Chen C, Mendez E, Houck J, Fan W, Lohavanichbutr P, Doody D, Yueh B, Futran ND, Upton M, Farwell DG, Schwartz SM, Zhao LP (2008). Gene expression profiling identifies genes predictive of oral squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 17 : 2152-2162.
22. Chen DT, Nasir A, Culhane A, Venkataramu C, Fulp W, Rubio R, Wang T, Agrawal D, Mccarthy SM, Gruidl M, Bloom G, Anderson T, White J, Quackenbush J, Yeatman T (2010). Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Breast Cancer Res Treat. 119 : 335-346.
23. Chen X, Bonne S, Hatzfeld M, Van Roy F, Green KJ (2002). Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta-catenin signaling. J Biol Chem. 277 : 10512-10522.
24. Chen X, Leung SY, Yuen ST, Chu KM, Ji J, Li R, Chan AS, Law S, Troyanskaya OG, Wong J, So S, Botstein D, Brown PO (2003). Variation in gene expression patterns in human gastric cancers. Mol Biol Cell. 14 : 3208-3215.
25. Cheng AS, Culhane AC, Chan MW, Venkataramu CR, Ehrich M, Nasir A, Rodriguez BA, Liu J, Yan PS, Quackenbush J, Nephew KP, Yeatman TJ, Huang TH (2008). Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome. Cancer Res. 68 : 1786-1796.
26. Cheung IY, Feng Y, Danis K, Shukla N, Meyers P, Ladanyi M, Cheung NK (2007). Novel markers of subclinical disease for Ewing family tumors from gene expression profiling. Clin Cancer Res. 13 : 6978-6983.
27. Chevenet F, Brun C, Banuls AL, Jacq B, Christen R (2006). TreeDyn: towards dynamic graphics and annotations for analyses of trees. BMC Bioinformatics. 7 : 439.
28. Cho JY, Lim JY, Cheong JH, Park YY, Yoon SL, Kim SM, Kim SB, Kim H, Hong SW, Park YN, Noh SH, Park ES, Chu IS, Hong WK, Ajani JA, Lee JS (2011). Gene expression signature-based prognostic risk score in gastric cancer. Clin Cancer Res. 17 : 1850-1857.
29. Choi HJ, Weis WI (2005). Structure of the armadillo repeat domain of plakophilin 1. J Mol Biol. 346 : 367-376.
30. Cohen MM Jr. (2013). The AKT genes and their roles in various disorders. Am J Med Genet A. 161 : 2931-2937.
31. Conacci-Sorrell M, Zhurinsky J, Ben-Ze ' ev A (2002). The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest. 109 : 987-991.
32. Cromer A, Carles A, Millon R, Ganguli G, Chalmel F, Lemaire F, Young J, Dembele D, Thibault C, Muller D, Poch O, Abecassis J, Wasylyk B (2004). Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis. Oncogene. 23 : 2484-2498.
33. D ' Errico M, De Rinaldis E, Blasi MF, Viti V, Falchetti M, Calcagnile A, Sera F, Saieva C, Ottini L, Palli D, Palombo F, Giuliani A, Dogliotti E (2009). Genome-wide expression profile of sporadic gastric cancers with microsatellite instability. Eur J Cancer. 45 : 461-469.
34. Darnell JC, Van Driesche SJ, Zhang C, Hung KY, Mele A, Fraser CE, Stone EF, Chen C, Fak JJ, Chi SW, Licatalosi DD, Richter JD, Darnell RB (2011). FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell. 146 : 247-261.
35. Dehan E, Ben-Dor A, Liao W, Lipson D, Frimer H, Rienstein S, Simansky D, Krupsky M, Yaron P, Friedman E, Rechavi G, Perlman M, Aviram-Goldring A, Izraeli S, Bittner M, Yakhini Z, Kaminski N (2007). Chromosomal aberrations and gene expression profiles in non-small cell lung cancer. Lung Cancer. 56 : 175-184.
36. Demirag GG, Sullu Y, Gurgenyatagi D, Okumus NO, Yucel I (2011). Expression of plakophilins (PKP1, PKP2, and PKP3) in gastric cancers. Diagn Pathol. 6 : 1.
37. Demirag GG, Sullu Y, Yucel I (2012). Expression of Plakophilins (PKP1, PKP2, and PKP3) in breast cancers. Med Oncol. 29 : 1518-1522.
38. Dereeper A, Audic S, Claverie JM, Blanc G (2010). BLASTEXPLORER helps you building datasets for phylogenetic analysis. BMC Evol Biol. 10 : 8.
39. Dereeper A, Guignon V, Blanc G, Audic S, Buffet S, Chevenet F, Dufayard JF, Guindon S, Lefort V, Lescot M, Claverie JM, Gascuel O (2008). Phylogeny.fr: robust phylogenetic analysis for the non-specialist. Nucleic Acids Res. 36 : W465-469.
40. Dodd LE, Sengupta S, Chen IH, Den Boon JA, Cheng YJ, Westra W, Newton MA, Mittl BF, Mcshane L, Chen CJ, Ahlquist P, Hildesheim A (2006). Genes involved in DNA repair and nitrosamine metabolism and those located on chromosome 14q32 are dysregulated in nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 15 : 2216-2225.
41. Dohn MR, Brown MV, Reynolds AB (2009). An essential role for p120-catenin in Src- and Rac1-mediated anchorageindependent cell growth. J Cell Biol. 184 : 437-450.
42. Dubash AD, Green KJ (2011). Desmosomes. Curr Biol. 21 : R529-531.
43. Dusek RL, Attardi LD (2011). Desmosomes: new perpetrators in tumour suppression. Nat Rev Cancer. 11 : 317-323.
44. Dyrskjot L, Kruhoffer M, Thykjaer T, Marcussen N, Jensen JL, Moller K, Orntoft TF (2004). Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res. 64 : 4040-4048.
45. Edgar RC (2004). MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32 : 1792-1797.
46. Emery LA, Tripathi A, King C, Kavanah M, Mendez J, Stone MD, De Las Morenas A, Sebastiani P, Rosenberg CL (2009). Early dysregulation of cell adhesion and extracellular matrix pathways in breast cancer progression. Am J Pathol. 175 : 1292-1302.
47. Estilo CL, O-Charoenrat P, Talbot S, Socci ND, Carlson DL, Ghossein R, Williams T, Yonekawa Y, Ramanathan Y, Boyle JO, Kraus DH, Patel S, Shaha AR, Wong RJ, Huryn JM, Shah JP, Singh B (2009). Oral tongue cancer gene expression profiling: identification of novel potential prognosticators by oligonucleotide microarray analysis. BMC Cancer. 9 : 11.
48. Furukawa C, Daigo Y, Ishikawa N, Kato T, Ito T, Tsuchiya E, Sone S, Nakamura Y (2005). Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. Cancer Res. 65 : 7102-7110.
49. Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, Gehoff A, Sax U, Schirmer M, Becker H, Beissbarth T, Ried T, Ghadimi BM (2010). Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas. Genes Chromosomes Cancer. 49 : 1024-1034.
50. Galamb O, Sipos F, Solymosi N, Spisak S, Krenacs T, Toth K, Tulassay Z, Molnar B (2008). Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results. Cancer Epidemiol Biomarkers Prev. 17 : 2835-2845.
51. Galamb O, Spisak S, Sipos F, Toth K, Solymosi N, Wichmann B, Krenacs T, Valcz G, Tulassay Z, Molnar B (2010). Reversal of gene expression changes in the colorectal normaladenoma pathway by NS398 selective COX2 inhibitor. Br J Cancer. 102 : 765-773.
52. Gallicano GI, Kouklis P, Bauer C, Yin M, Vasioukhin V, Degenstein L, Fuchs E (1998). Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol. 143 : 2009-2022.
53. Gloushankova NA (2008). Changes in regulation of cell-cell adhesion during tumor transformation. Biochemistry (Mosc). 73 : 742-750.
54. Godsel LM, Dubash AD, Bass-Zubek AE, Amargo EV, Klessner JL, Hobbs RP, Chen X, Green KJ (2010). Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA. Mol Biol Cell. 21 : 2844-2859.
55. Gomez-Morales M, Camara-Pulido M, Miranda-Leon MT, Sanchez-Palencia A, Boyero L, Gomez-Capilla JA, Farez-Vidal ME (2013). Differential immunohistochemical localization of desmosomal plaque-related proteins in nonsmall- cell lung cancer. Histopathology. 63 : 103-113.
56. Gosavi P, Kundu ST, Khapare N, Sehgal L, Karkhanis MS, Dalal SN (2011). E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly. Cell Mol Life Sci. 68 : 1439-1454.
57. Grossmann KS, Grund C, Huelsken J, Behrend M, Erdmann B, Franke WW, Birchmeier W (2004). Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol. 167 : 149-160.
58. Grotenhuis BA, Van Lanschot JJ, Dinjens WN, Wijnhoven BP (2010). The pathogenesis of Barrett's metaplasia and the progression to esophageal adenocarcinoma. Recent Results Cancer Res. 182 : 39-63.
59. Guindon S, Gascuel O (2003). A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol. 52 : 696-704.
60. Hao Y, Triadafilopoulos G, Sahbaie P, Young HS, Omary MB, Lowe AW (2006). Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma. Gastroenterology. 131 : 925-933.
61. Harvell DM, Kim J, O'brien J, Tan AC, Borges VF, Schedin P, Jacobsen BM, Horwitz KB (2013). Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone. Horm Cancer. 4 : 140-153.
62. Hatzfeld M (2007). Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion? Biochim Biophys Acta. 1773 : 69-77.
63. Hatzfeld M (2010). A nuclear function for plakophilin-1 in the DNA damage response? J Invest Dermatol. 130 : 2538-2540.
64. Hatzfeld M, Green KJ, Sauter H (2003). Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. J Cell Sci. 116 : 1219-1233.
65. Hatzfeld M, Haffner C, Schulze K, Vinzens U (2000). The function of plakophilin 1 in desmosome assembly and actin filament organization. J Cell Biol. 149 : 209-222.
66. Hatzfeld M, Kristjansson GI, Plessmann U, Weber K (1994). Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family. J Cell Sci. 107 : 2259-2270.
67. Hawthorn L, Luce J, Stein L, Rothschild J (2010). Integration of transcript expression, copy number and LOH analysis of infiltrating ductal carcinoma of the breast. BMC Cancer. 10 : 460.
68. Heid HW, Schmidt A, Zimbelmann R, Schafer S, Winter-Simanowski S, Stumpp S, Keith M, Figge U, Schnolzer M, Franke WW (1994). Cell type-specific desmosomal plaque proteins of the plakoglobin family: plakophilin 1 (band 6 protein). Differentiation. 58 : 113-131.
69. Hinoue T, Weisenberger DJ, Lange CP, Shen H, Byun HM, Van Den Berg D, Malik S, Pan F, Noushmehr H, Van Dijk CM, Tollenaar RA, Laird PW (2012). Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res. 22 : 271-282.
70. Hofmann I, Casella M, Schnolzer M, Schlechter T, Spring H, Franke WW (2006). Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. Mol Biol Cell. 17 : 1388-1398.
71. Hong Y, Ho KS, Eu KW, Cheah PY (2007). A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis. Clin Cancer Res. 13 : 1107-1114.
72. Hou J, Aerts J, Den Hamer B, Van Ijcken W, Den Bakker M, Riegman P, Van Der Leest C, Van Der Spek P, Foekens JA, Hoogsteden HC, Grosveld F, Philipsen S (2010). Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One. 5 : e10312.
73. Hu Z, Fan C, Livasy C, He X, Oh DS, Ewend MG, Carey LA, Subramanian S, West R, Ikpatt F, Olopade OI, Van De Rijn M, Perou CM (2009). A compact VEGF signature associated with distant metastases and poor outcomes. BMC Med. 7 : 9
74. Huber AH, Nelson WJ, Weis WI (1997). Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell. 92 : 871-882.
75. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP (2010). A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 143 : 1174-1189.
76. Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, Ji H, Potash JB, Sabunciyan S, Feinberg AP (2009). The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 41 : 178-186.
77. Johnson-Huang LM, Pensabene CA, Shah KR, Pierson KC, Kikuchi T, Lentini T, Gilleaudeau P, Sullivan-Whalen M, Cueto I, Khatcherian A, Hyder LA, Suarez-Farinas M, Krueger JG, Lowes MA (2012). Post-therapeutic relapse of psoriasis after CD11a blockade is associated with T cells and inflammatory myeloid DCs. PLoS One. 7 : e30308.
78. Jones MH, Virtanen C, Honjoh D, Miyoshi T, Satoh Y, Okumura S, Nakagawa K, Nomura H, Ishikawa Y (2004). Two prognostically significant subtypes of high-grade lung neuroendocrine tumours independent of small-cell and large-cell neuroendocrine carcinomas identified by gene expression profiles. Lancet. 363 : 775-781.
79. Kanno M, Aoyama Y, Isa Y, Yamamoto Y, Kitajima Y (2008a). P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2 + medium but not when disassembled in low-Ca2 + medium in DJM-1 cells. J Dermatol. 35 : 317-324.
80. Kanno M, Isa Y, Aoyama Y, Yamamoto Y, Nagai M, Ozawa M, Kitajima Y (2008b). P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3. Exp Cell Res. 314 : 1683-1692.
81. Kapprell HP, Owaribe K, Franke WW (1988). Identification of a basic protein of Mr 75,000 as an accessory desmosomal plaque protein in stratified and complex epithelia. J Cell Biol. 106 : 1679-1691.
82. Kaz AM, Luo Y, Dzieciatkowski S, Chak A, Willis JE, Upton MP, Leidner RS, Grady WM (2012). Aberrantly methylated PKP1 in the progression of Barrett ' s esophagus to esophageal adenocarcinoma. Genes Chromosomes Cancer. 51 : 384-393.
83. Keil R, Wolf A, Huttelmaier S, Hatzfeld M (2007). Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. Cell Cycle. 6 : 122-127.
84. Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A (2013a). Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun. 4 : 1701.
85. Kim M, Ceman S (2012). Fragile X mental retardation protein: past, present and future. Curr Protein Pept Sci. 13 : 358-371.
86. Kim SM, Park YY, Park ES, Cho JY, Izzo JG, Zhang D, Kim SB, Lee JH, Bhutani MS, Swisher SG, Wu X, Coombes KR, Maru D, Wang KK, Buttar NS, Ajani JA, Lee JS (2010). Prognostic biomarkers for esophageal adenocarcinoma identified by analysis of tumor transcriptome. PLoS One. 5 : e15074.
87. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP (2011). Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell. 44 : 325-340.
88. Kim YJ, Yoon HY, Kim JS, Kang HW, Min BD, Kim SK, Ha YS, Kim IY, Ryu KH, Lee SC, Kim WJ (2013b). HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: arraybased DNA methylation and expression profiling. Int J Cancer. 133 : 1135-1142.
89. Kimchi ET, Posner MC, Park JO, Darga TE, Kocherginsky M, Karrison T, Hart J, Smith KD, Mezhir JJ, Weichselbaum RR, Khodarev NN (2005). Progression of Barrett ' s metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation. Cancer Res. 65 : 3146-3154.
90. Koetsier JL, Amargo EV, Todorovic V, Green KJ, Godsel LM (2013). Plakophilin 2 affects cell migration by modulating focal adhesion dynamics and integrin protein expression. J Invest Dermatol. [Epub] Advance online publication, doi:10.1038/jid.2013.266.
91. Kowalczyk AP, Hatzfeld M, Bornslaeger EA, Kopp DS, Borgwardt JE, Corcoran CM, Settler A, Green KJ (1999). The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease. J Biol Chem. 274 : 18145-18148.
92. Kulski JK, Kenworthy W, Bellgard M, Taplin R, Okamoto K, Oka A, Mabuchi T, Ozawa A, Tamiya G, Inoko H (2005). Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals. J Mol Med (Berl). 83 : 964-975.
93. Kundu ST, Gosavi P, Khapare N, Patel R, Hosing AS, Maru GB, Ingle A, Decaprio JA, Dalal SN (2008). Plakophilin3 downregulation leads to a decrease in cell adhesion and promotes metastasis. Int J Cancer. 123 : 2303-2314.
94. Kuner R, Falth M, Pressinotti NC, Brase JC, Puig SB, Metzger J, Gade S, Schafer G, Bartsch G, Steiner E, Klocker H, Sultmann H (2013). The maternal embryonic leucine zipper kinase (MELK) is upregulated in high-grade prostate cancer. J Mol Med (Berl). 91 : 237-248.
95. Kupershmidt I, Su QJ, Grewal A, Sundaresh S, Halperin I, Flynn J, Shekar M, Wang H, Park J, Cui W, Wall GD, Wisotzkey R, Alag S, Akhtari S, Ronaghi M (2010). Ontologybased meta-analysis of global collections of high-throughput public data. PLoS One. 5 : e 10.1371
96. Kurzen H, Munzing I, Hartschuh W (2003). Expression of desmosomal proteins in squamous cell carcinomas of the skin. J Cutan Pathol. 30 : 621-630.
97. Lai-Cheong JE, Arita K, McGrath JA (2007). Genetic diseases of junctions. J Invest Dermatol. 127 : 2713-2725.
98. Lapointe J, Li C, Higgins JP, Van De Rijn M, Bair E, Montgomery K, Ferrari M, Egevad L, Rayford W, Bergerheim U, Ekman P, Demarzo AM, Tibshirani R, Botstein D, Brown PO, Brooks JD, Pollack J.R. (2004). Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proc Natl Acad Sci U S A. 101 : 811-816.
99. Latulippe E, Satagopan J, Smith A, Scher H, Scardino P, Reuter V, Gerald WL (2002). Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res. 62 : 4499-4506.
100. Leitner L, Shaposhnikov D, Mengel A, Descot A, Julien S, Hoffmann R, Posern G (2011). MAL/MRTF-A controls migration of non-invasive cells by upregulation of cytoskeleton-associated proteins. J Cell Sci. 124: 4318-4331.
101. Leja J, Essaghir A, Essand M, Wester K, Oberg K, Totterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V (2009). Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas. Mod Pathol. 22 : 261-272.
102. Lin G, He X, Ji H, Shi L, Davis RW, Zhong S (2006). Reproducibility Probability Score-incorporating measurement variability across laboratories for gene selection. Nat Biotechnol. 24 : 1476-1477.
103. Lohavanichbutr P, Mendez E, Holsinger FC, Rue TC, Zhang Y, Houck J, Upton MP, Futran N, Schwartz SM, Wang P, Chen C (2013). A 13-gene signature prognostic of HPV-negative OSCC: discovery and external validation. Clin Cancer Res. 19 : 1197-1203.
104. Lu TP, Tsai MH, Lee JM, Hsu CP, Chen PC, Lin CW, Shih JY, Yang PC, Hsiao CK, Lai LC, Chuang EY (2010). Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. Cancer Epidemiol Biomarkers Prev. 19 : 2590-2597.
105. Maynadier M, Chambon M, Basile I, Gleizes M, Nirde P, Gary-Bobo M, Garcia M (2012). Estrogens promote cell-cell adhesion of normal and malignant mammary cells through increased desmosome formation. Mol Cell Endocrinol. 364 : 126-133.
106. McGrath JA, Mcmillan J.R., Shemanko CS, Runswick SK, Leigh IM, Lane EB, Garrod DR, Eady RA (1997). Mutations in the plakophilin 1 gene result in ectodermal dysplasia/ skin fragility syndrome. Nat Genet. 17 : 240-244.
107. McGrath JA, Mellerio JE (2010). Ectodermal dysplasiaskin fragility syndrome. Dermatol Clin. 28 : 125-129.
108. Mengual L, Burset M, Ars E, Lozano JJ, Villavicencio H, Ribal MJ, Alcaraz A (2009). DNA microarray expression profiling of bladder cancer allows identification of noninvasive diagnostic markers. J Urol. 182 : 741-748.
109. Mertens C, Hofmann I, Wang Z, Teichmann M, Sepehri Chong S, Schnolzer M, Franke WW (2001). Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2. Proc Natl Acad Sci U S A. 98 : 7795-7800.
110. Mitsui H, Suarez-Farinas M, Belkin DA, Levenkova N, Fuentes-Duculan J, Coats I, Fujita H, Krueger JG (2012). Combined use of laser capture microdissection and cDNA microarray analysis identifies locally expressed diseaserelated genes in focal regions of psoriasis vulgaris skin lesions. J Invest Dermatol. 132 : 1615-1626.
111. Moriya Y, Iyoda A, Kasai Y, Sugimoto T, Hashida J, Nimura Y, Kato M, Takiguchi M, Fujisawa T, Seki N, Yoshino I (2009). Prediction of lymph node metastasis by gene expression profiling in patients with primary resected lung cancer. Lung Cancer. 64 : 86-91.
112. Muhmer M, Ditthardt D, Jakel J, Wischmann V, Moll R, Schmidt A (2013). An alternative promoter of the human plakophilin-3 gene controls the expression of the new isoform PKP3b. Cell Tissue Res. [Epub] Advance online publication, doi:10.1007/s00441-013-1736-1.
113. Muller J, Ritt DA, Copeland TD, Morrison DK (2003). Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. EMBO J. 22 : 4431-4442.
114. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR (2009). Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet. 41 : 199-204.
115. Narayana N, Gist J, Smith T, Tylka D, Trogdon G, Wahl JK (2010). Desmosomal component expression in normal, dysplastic, and oral squamous cell carcinoma. Dermatol Res Pract. 2010 : 649731. doi:10.1155/2010/649731. Epub 2010 Mar 18.
116. Nindl I, Dang C, Forschner T, Kuban RJ, Meyer T, Sterry W, Stockfleth E (2006). Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microarray expression profiling. Mol Cancer. 5 : 30.
117. North AJ, Bardsley WG, Hyam J, Bornslaeger EA, Cordingley HC, Trinnaman B, Hatzfeld M, Green KJ, Magee AI, Garrod DR (1999). Molecular map of the desmosomal plaque. J Cell Sci. 112 : 4325-4336.
118. Novak P, Jensen T, Oshiro MM, Wozniak RJ, Nouzova M, Watts GS, Klimecki WT, Kim C, Futscher BW (2006). Epigenetic inactivation of the HOXA gene cluster in breast cancer. Cancer Res. 66 : 10664-10670.
119. Okayama H, Kohno T, Ishii Y, Shimada Y, Shiraishi K, Iwakawa R, Furuta K, Tsuta K, Shibata T, Yamamoto S, Watanabe S, Sakamoto H, Kumamoto K, Takenoshita S, Gotoh N, Mizuno H, Sarai A, Kawano S, Yamaguchi R, Miyano S, Yokota J (2012). Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas. Cancer Res. 72 : 100-111.
120. Olsson M, Broberg A, Jernas M, Carlsson L, Rudemo M, Suurkula M, Svensson PA, Benson M (2006). Increased expression of aquaporin 3 in atopic eczema. Allergy. 61 : 1132-1137.
121. Pascal LE, Goo YA, Vencio RZ, Page LS, Chambers AA, Liebeskind ES, Takayama TK, True LD, Liu AY (2009). Gene expression down-regulation in CD90 + prostate tumor-associated stromal cells involves potential organspecific genes. BMC Cancer. 9 : 317.
122. Pedraza V, Gomez-Capilla JA, Escaramis G, Gomez C, Torne P, Rivera JM, Gil A, Araque P, Olea N, Estivill X, Farez-Vidal ME (2010). Gene expression signatures in breast cancer distinguish phenotype characteristics, histologic subtypes, and tumor invasiveness. Cancer. 116 : 486-496.
123. Peng Z, Wei D, Wang L, Tang H, Zhang J, Le X, Jia Z, Li Q, Xie K (2006). RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. Clin Cancer Res. 12 : 6386-6394.
124. Pieperhoff S, Schumacher H, Franke WW (2008). The area composita of adhering junctions connecting heart muscle cells of vertebrates. V. The importance of plakophilin-2 demonstrated by small interference RNA-mediated knockdown in cultured rat cardiomyocytes. Eur J Cell Biol. 87, 399-411.
125. Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, Ladd C, Reich M, Latulippe E, Mesirov JP, Poggio T, Gerald W, Loda M, Lander ES, Golub TR (2001). Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A. 98 : 15149-15154.
126. Reischl J, Schwenke S, Beekman JM, Mrowietz U, Sturzebecher S, Heubach JF (2007). Increased expression of Wnt5a in psoriatic plaques. J Invest Dermatol. 127 : 163-169.
127. Rentoft M, Coates PJ, Laurell G, Nylander K (2012). Transcriptional profiling of formalin fixed paraffin embedded tissue: pitfalls and recommendations for identifying biologically relevant changes. PLoS One. 7 : e35276.
128. Richardson AL, Wang ZC, De Nicolo A, Lu X, Brown M, Miron A, Liao X, Iglehart JD, Livingston DM, Ganesan S (2006). X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell. 9 : 121-132.
129. Riker AI, Enkemann SA, Fodstad O, Liu S, Ren S, Morris C, Xi Y, Howell P, Metge B, Samant RS, Shevde LA, Li W, Eschrich S, Daud A, Ju J, Matta J (2008). The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis. BMC Med Genomics. 1 : 13.
130. Roberts BJ, Reddy R, Wahl JK III (2013). Stratifin (14-3-3 sigma) Limits plakophilin-3 exchange with the desmosomal plaque. PLoS One. 8 : e77012.
131. Rousseaux S, Debernardi A, Jacquiau B, Vitte AL, Vesin A, Nagy-Mignotte H, Moro-Sibilot D, Brichon PY, Lantuejoul S, Hainaut P, Laffaire J, De Reynies A, Beer DG, Timsit JF, Brambilla C, Brambilla E, Khochbin S (2013). Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers. Sci Transl Med. 5 : 186ra66.
132. Ruiz P, Birchmeier W (1998). The plakoglobin knock-out mouse: a paradigm for the molecular analysis of cardiac cell junction formation. Trends Cardiovasc Med. 8 : 97-101.
133. Ruiz P, Brinkmann V, Ledermann B, Behrend M, Grund C, Thalhammer C, Vogel F, Birchmeier C, Gunthert U, Franke WW, Birchmeier W (1996). Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol. 135 : 215-225.
134. Sabatier R, Finetti P, Cervera N, Lambaudie E, Esterni B, Mamessier E, Tallet A, Chabannon C, Extra JM, Jacquemier J, Viens P, Birnbaum D, Bertucci F (2011). A gene expression signature identifies two prognostic subgroups of basal breast cancer. Breast Cancer Res Treat. 126 : 407-420.
135. Sanchez-Palencia A, Gomez-Morales M, Gomez-Capilla JA, Pedraza V, Boyero L, Rosell R, Farez-Vidal ME (2011). Gene expression profiling reveals novel biomarkers in nonsmall cell lung cancer. Int J Cancer. 129 : 355-364.
136. Schackmann RC, Tenhagen M, Van De Ven RA, Derksen PW (2013). p120-catenin in cancer - mechanisms, models and opportunities for intervention. J Cell Sci. 126 : 3515-3525.
137. Schmidt A, Jager S (2005). Plakophilins-hard work in the desmosome, recreation in the nucleus? Eur J Cell Biol. 84 : 189-204.
138. Schmidt A, Langbein L, Rode M, Pratzel S, Zimbelmann R, Franke WW (1997). Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. Cell Tissue Res. 290 : 481-499.
139. Sengupta S, Den Boon JA, Chen IH, Newton MA, Dahl DB, Chen M, Cheng YJ, Westra WH, Chen CJ, Hildesheim A, Sugden B, Ahlquist P (2006). Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma. Cancer Res. 66 : 7999-8006.
140. Sheffer M, Bacolod MD, Zuk O, Giardina SF, Pincas H, Barany F, Paty PB, Gerald WL, Notterman DA, Domany E (2009). Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci U S A. 106: 7131-7136.
141. Sircoulomb F, Bekhouche I, Finetti P, Adelaide J, Ben Hamida A, Bonansea J, Raynaud S, Innocenti C, Charafe-Jauffret E, Tarpin C, Ben Ayed F, Viens P, Jacquemier J, Bertucci F, Birnbaum D, Chaffanet M (2010). Genome profiling of ERBB2-amplified breast cancers. BMC Cancer. 10 : 539.
142. Sklyarova T, Bonne S, D'hooge P, Denecker G, Goossens S, De Rycke R, Borgonie G, Bosl M, Van Roy F, Van Hengel J (2008). Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. J Invest Dermatol. 128 : 1375-1385.
143. Skrzypczak M, Goryca K, Rubel T, Paziewska A, Mikula M, Jarosz D, Pachlewski J, Oledzki J, Ostrowski J (2010). Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS One. 5.
144. Smith EA, Fuchs E (1998). Defining the interactions between intermediate filaments and desmosomes. J Cell Biol. 141 : 1229-1241.
145. Sobolik-Delmaire T, Katafiasz D, Keim SA, Mahoney MG, Wahl JK III (2007). Decreased plakophilin-1 expression promotes increased motility in head and neck squamous cell carcinoma cells. Cell Commun Adhes. 14 : 99-109.
146. Sobolik-Delmaire T, Reddy R, Pashaj A, Roberts BJ, Wahl JK III (2010). Plakophilin-1 localizes to the nucleus and interacts with single-stranded DNA. J Invest Dermatol. 130 : 2638-2646.
147. South AP (2004). Plakophilin 1: an important stabilizer of desmosomes. Clin Exp Dermatol. 29 : 161-167.
148. South AP, Wan H, Stone MG, Dopping-Hepenstal PJ, Purkis PE, Marshall JF, Leigh IM, Eady RA, Hart IR, McGrath JA (2003). Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability. J Cell Sci. 116 : 3303-3314.
149. Stearman RS, Dwyer-Nield L, Zerbe L, Blaine SA, Chan Z, Bunn PA, Jr ., Johnson GL, Hirsch FR, Merrick DT, Franklin WA, Baron AE, Keith RL, Nemenoff RA, Malkinson AM, Geraci MW (2005). Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcino gen-induced murine model. Am J Pathol. 167 : 1763-1775.
150. Su H, Hu N, Yang HH, Wang C, Takikita M, Wang QH, Giffen C, Clifford R, Hewitt SM, Shou JZ, Goldstein AM, Lee MP, Taylor PR (2011). Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes. Clin Cancer Res. 17 : 2955-2966.
151. Su LJ, Chang CW, Wu YC, Chen KC, Lin CJ, Liang SC, Lin CH, Whang-Peng J, Hsu SL, Chen CH, Huang CY (2007). Selection of DDX5 as a novel internal control for Q-RT-PCR from microarray data using a block bootstrap re-sampling scheme. BMC Genomics. 8 : 140.
152. Suarez-Farinas M, Li K, Fuentes-Duculan J, Hayden K, Brodmerkel C, Krueger JG (2012). Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis. J Invest Dermatol. 132 : 2552-2564.
153. Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT, Wang XJ, Sano S, Prens EP, Digiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE (2011). Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis. PLoS One. 6 : e18266.
154. Takahashi H, Nakatsuji H, Takahashi M, Avirmed S, Fukawa T, Takemura M, Fukumori T, Kanayama H (2012). Up-regulation of plakophilin-2 and Down-regulation of plakophilin-3 are correlated with invasiveness in bladder cancer. Urology. 79 : 240.e1-8.
155. Tewari R, Bailes E, Bunting KA, Coates JC (2010). Armadillorepeat protein functions: questions for little creatures. Trends Cell Biol. 20 : 470-481.
156. Thelemann A, Petti F, Griffin G, Iwata K, Hunt T, Settinari T, Fenyo D, Gibson N, Haley JD (2005). Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells. Mol Cell Proteomics. 4 : 356-376.
157. Thomason HA, Scothern A, Mcharg S, Garrod DR (2010). Desmosomes: adhesive strength and signalling in health and disease. Biochem J. 429 : 419-433.
158. Toruner GA, Ulger C, Alkan M, Galante AT, Rinaggio J, Wilk R, Tian B, Soteropoulos P, Hameed MR, Schwalb MN, Dermody JJ (2004). Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. Cancer Genet Cytogenet. 154 : 27-35.
159. Tu CL, You M (2013). Obligatory roles of filamin A in E-cadherin-mediated cell-cell adhesion in epidermal keratinocytes. J Dermatol Sci. [Epub] Advance online publication, doi:10.1016/j.jdermsci.2013.09.007.
160. Tucker DK, Stahley SN, Kowalczyk AP (2013). Plakophilin-1 protects keratinocytes from pemphigus vulgaris IgG by forming calcium-independent desmosomes. J Invest Dermatol. [Epub] Advance online publication, doi:10.1038/ jid.2013.401.
161. Uddin S, Ahmed M, Hussain A, Abubaker J, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Jehan Z, Bavi P, Siraj AK, Al-Kuraya KS (2011). Genomewide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy. Am J Pathol. 178 : 537-547.
162. Uhart M, Bustos DM (2013). Human 14-3-3 paralogs differences uncovered by cross-talk of phosphorylation and lysine acetylation. PLoS One. 8 : e55703.
163. Vasioukhin V, Bauer C, Yin M, Fuchs E (2000). Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell. 100 : 209-219.
164. Vasudevan S, Steitz JA (2007). AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell. 128 : 1105-1118.
165. Wachi S, Yoneda K, Wu R (2005). Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics. 21 : 4205-4208.
166. Wagner SA, Beli P, Weinert BT, Scholz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C (2012). Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Mol Cell Proteomics. 11 : 1578-1585.
167. Waschke J, Spindler V, Bruggeman P, Zillikens D, Schmidt G, Drenckhahn D (2006). Inhibition of Rho A activity causes pemphigus skin blistering. J Cell Biol. 175 : 721-727.
168. Wei TY, Juan CC, Hisa JY, Su LJ, Lee YC, Chou HY, Chen JM, Wu YC, Chiu SC, Hsu CP, Liu KL, Yu CT (2012). Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer Sci. 103 : 1640-1650.
169. Whitman SA, Cover C, Yu L, Nelson DL, Zarnescu DC, Gregorio CC (2011). Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle. Circ Res. 109 : 262-271.
170. Wolf A, Hatzfeld M (2010). A role of plakophilins in the regulation of translation. Cell Cycle. 9 : 2973-2978.
171. Wolf A, Keil R, Gotzl O, Mun A, Schwarze K, Lederer M, Huttelmaier S, Hatzfeld M (2006). The armadillo protein p0071 regulates Rho signalling during cytokinesis. Nat Cell Biol. 8 : 1432-1440.
172. Wolf A, Krause-Gruszczynska M, Birkenmeier O, Ostareck- Lederer A, Huttelmaier S, Hatzfeld M (2010). Plakophilin 1 stimulates translation by promoting eIF4A1 activity. J Cell Biol. 188 : 463-471.
173. Wolf A, Rietscher K, Glass M, Huttelmaier S, Schutkowski M, Ihling C, Sinz A, Wingenfeld A, Mun A, Hatzfeld M (2013). Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation. J Cell Sci. 126 : 1832-1844.
174. Wrage M, Ruosaari S, Eijk PP, Kaifi JT, Hollmen J, Yekebas EF, Izbicki J.R., Brakenhoff RH, Streichert T, Riethdorf S, Glatzel M, Ylstra B, Pantel K, Wikman H (2009). Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletion. Clin Cancer Res. 15 : 1566-1574.
175. Wu Y, Grabsch H, Ivanova T, Tan IB, Murray J, Ooi CH, Wright AI, West NP, Hutchins GG, Wu J, Lee M, Lee J, Koo JH, Yeoh KG, Van Grieken N, Ylstra B, Rha SY, Ajani JA, Cheong JH, Noh SH, Lim KH, Boussioutas A, Lee JS, Tan P (2013). Comprehensive genomic metaanalysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer. Gut. 62 : 1100-1111.
176. Yan W, Shih JH, Rodriguez-Canales J, Tangrea MA, Ylaya K, Hipp J, Player A, Hu N, Goldstein AM, Taylor PR, Emmert-Buck MR, Erickson HS (2012). Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma. BMC Res Notes. 5 : 73.
177. Yao Y, Richman L, Morehouse C, De Los Reyes M, Higgs BW, Boutrin A, White B, Coyle A, Krueger J, Kiener PA, Jallal B (2008). Type I interferon: potential therapeutic target for psoriasis? PLoS One. 3 : e2737.
178. Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, Li H, Leung CH, Zhu Y, Wei CL, Hooi SC, Miller L, Tan P (2008). A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers. PLoS Genet. 4 : e1000129.
179. Yu YP, Landsittel D, Jing L, Nelson J, Ren B, Liu L, Mcdonald C, Thomas R, Dhir R, Finkelstein S, Michalopoulos G, Becich M, Luo JH (2004). Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol. 22 : 2790-2799.
180. Zanivan S, Gnad F, Wickstrom SA, Geiger T, Macek B, Cox J, Fassler R, Mann M (2008). Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res. 7 : 5314-5326.
181. Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, Van Ree JH, Van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickstrom SA, Fassler R, Mann M (2013). In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Rep. 3 : 552-566.
182. Zarnescu DC, Gregorio CC (2013). Fragile hearts: New insights into translational control in cardiac muscle. Trends Cardiovasc Med. 23 : 275-281.
183. Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, Bhakoo KK, Jayapal S.R., Nichane M, Yu Q, Ahmed DA, Tan C, Sing WP, Tam J, Thirugananam A, Noghabi MS, Pang YH, Ang HS, Mitchell W, Robson P, Kaldis P, Soo RA, Swarup S, Lim EH, Lim B (2012). Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell. 148 : 259-272.
184. Zhao H, Langerod A, Ji Y, Nowels KW, Nesland JM, Tibshirani R, Bukholm IK, Karesen R, Botstein D, Borresen-Dale AL, Jeffrey SS (2004). Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Mol Biol Cell. 15 : 2523-2536.
185. Zhou N, Singh K, Mir MC, Parker Y, Lindner D, Dreicer R, Ecsedy JA, Zhang Z, Teh BT, Almasan A, Hansel DE (2013). The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo. Clin Cancer Res. 19 : 1717-1728.
186. Zhuang Z, Jewett AI, Kuttimalai S, Bellesia G, Gnanakaran S, Shea JE (2011). Assisted peptide folding by surface pattern recognition. Biophys J. 100 : 1306-1315.