Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Swindell, William R ^a   Johnston, Andrew ^b   Carbajal, Steve ^c   Han, Gangwen ^d   Wohn, Christian ^e   Lu, Jun ^f   Xing, Xianying ^b   Nair, Rajan P ^b   Voorhees, John J ^b   Elder, James T ^b,g   Wang, Xiao Jing ^d   Sano, Shigetoshi ^h   Prens, Errol P ^e   DiGiovanni, John ⁱ   Pittelkow, Mark R ^f   Ward, Nicole L ^j   Gudjonsson, Johann E ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f MAYO CLINIC   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

^h KOCHI MEDICAL SCHOOL   (Japan)

ⁱ UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^j CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; AMINOQUINOLINE DERIVATIVE; CYTOKINE; IMIQUIMOD; PROTEIN TYROSINE KINASE; TEK PROTEIN, MOUSE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPIDERMIS; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HUMAN; IMMUNE SYSTEM; INFLAMMATION; KERATINIZATION; MAJOR CLINICAL STUDY; MITOSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PSORIASIS; ADOLESCENT; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; GENETICS; GENOMICS; IMMUNOLOGY; KERATINOCYTE; LEUKOCYTE; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOLOGY;

ADOLESCENT; ADULT; AGED; AMINOQUINOLINES; ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; EPIDERMIS; GENE EXPRESSION PROFILING; GENOMICS; HUMANS; KERATINOCYTES; LEUKOCYTES; MICE; MIDDLE AGED; MITOSIS; PHENOTYPE; PSORIASIS; RECEPTOR PROTEIN-TYROSINE KINASES; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 79953721663     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018266     Document Type: Article

References (60)

1. Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, et al. (2007) Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med 13: 836-842.
2. Nickoloff BJ, Wrone-Smith T, (1999) Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis. Am J Pathol 155: 145-158.
3. Boehncke WH, Schön MP, (2007) Animal models of psoriasis. Clin Dermatol 25: 596-605.
4. Gudjonsson JE, Johnston A, Dyson M, Valdimarsson H, Elder JT, (2007) Mouse models of psoriasis. J Invest Dermatol 127: 1292-1308.
5. Nestle FO, Nickoloff BJ, (2006) Animal models of psoriasis: a brief update. J Eur Acad Dermatol Venereol 20: 24-27.
6. Lowe NJ, Breeding J, Kean C, Cohn ML, (1981) Psoriasiform dermatosis in a rhesus monkey. J Invest Dermatol 76: 141-143.
7. Zanolli MD, Jayo MJ, Jayo JM, Blaine D, Hall J, et al. (1989) Evaluation of psoriatic plaques that spontaneously developed in a cynomolgus monkey (Macaca fascicularis). Acta Derm Venereol Suppl (Stockh) 146: 58.
8. Berking C, Takemoto R, Binder RL, Hartman SM, Ruiter DJ, et al. (2002) Photocarcinogenesis in human adult skin grafts. Carcinogenesis 23: 181-187.
9. Khavari PA, (2006) Modelling cancer in human skin tissue. Nat Rev Cancer 6: 270-280.
10. Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ, Baxter AG, (2000) NKT cells: facts, functions and fallacies. Immunol Today 21: 573-583.
11. Ardavín C, (2003) Origin, precursors and differentiation of mouse dendritic cells. Nat Rev Immunol 3: 582-590.
12. Wolfram JA, Diaconu D, Hatala DA, Rastegar J, Knutsen DA, et al. (2009) Keratinocyte but not endothelial cell-specific overexpression of Tie2 leads to the development of psoriasis. Am J Pathol 174: 1443-1458.
13. van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, et al. (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol 182: 5836-45.
14. Cook PW, Piepkorn M, Clegg CH, Plowman GD, DeMay JM, et al. (1997) Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest 100: 2286-94.
15. Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, et al. (2005) Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 11: 43-9.
16. Li AG, Wang D, Feng XH, Wang XJ, (2004) Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J 23: 1770-81.
17. Gilliet M, Conrad C, Geiges M, Cozzio A, Thürlimann W, et al. (2004) Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch Dermatol 140: 1490-5.
18. Wu JK, Siller G, Strutton G, (2004) Psoriasis induced by topical imiquimod. Australas J Dermatol 45: 47-50.
19. Rajan N, Langtry JA, (2006) Generalized exacerbation of psoriasis associated with imiquimod cream treatment of superficial basal cell carcinomas. Clin Exp Dermatol 31: 140-1.
20. Fanti PA, Dika E, Vaccari S, Miscial C, Varotti C, (2006) Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod. Int J Dermatol 45: 1464-5.
21. Bowcock AM, Shannon W, Du F, Duncan J, Cao K, et al. (2001) Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet 10: 1793-1805.
22. Zhou X, Krueger JG, Kao MC, Lee E, Du F, et al. (2003) Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. Physiol Genomics 13: 69-78.
23. Kulski JK, Kenworthy W, Bellgard M, Taplin R, Okamoto K, et al. (2005) Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals. J Mol Med 83: 964-975.
24. Romanowska M, al Yacoub N, Seidel H, Donandt S, Gerken H, et al. (2008) PPARdelta enhances keratinocyte proliferation in psoriasis and induces heparin-binding EGF-like growth factor. J Invest Dermatol 128: 110-124.
25. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, et al. (2009) Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 41: 199-204.
26. Strange A, Capon F, Spencer CC, Knight J, et al. Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 (2010) A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet 42: 985-90.
27. Stuart PE, Nair RP, Ellinghaus E, Ding J, Tejasvi T, et al. (2010) Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat Genet 42: 1000-4.
28. Sun LD, Cheng H, Wang ZX, Zhang AP, Wang PG, et al. (2010) Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet 42: 1005-9.
29. Hüffmeier U, Uebe S, Ekici AB, Bowes J, Giardina E, et al. (2010) Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat Genet 42: 996-9.
30. Zhang XJ, Huang W, Yang S, Sun LD, Zhang FY, et al. (2009) Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 41: 205-10.
31. Swindell WR, Johnston A, Gudjonsson JE, (2010) Transcriptional profiles of leukocyte populations provide a tool for interpreting gene expression patterns associated with high fat diet in mice. PLoS One 5: e11861.
32. Lottaz C, Yang X, Scheid S, Spang R, (2006) OrderedList-a bioconductor package for detecting similarity in ordered gene lists. Bioinformatics 22: 2315-2316.
33. Swindell WR, (2009) Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse. BMC Genomics 10: 585.
34. Philippakis AA, Busser BW, Gisselbrecht SS, He FS, Estrada B, et al. (2006) Expression-guided in silico evaluation of candidate cis regulatory codes for Drosophila muscle founder cells. PLoS Comput Biol 2: e53.
35. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102: 15545-50.
36. Zenaro E, Donini M, Dusi S, (2009) Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN. J Leukoc Biol 86: 1393-401.
37. Haider AS, Lowes MA, Suàrez-Fariñas M, Zaba LC, Cardinale I, et al. (2008) Cellular genomic maps help dissect pathology in human skin disease. J Invest Dermatol 128: 606-15.
38. Nestle FO, Kaplan DH, Barker J, (2009) Psoriasis. N Engl J Med 361: 496-509.
39. Gürtl B, Kratky D, Guelly C, Zhang L, Gorkiewicz G, et al. (2009) Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy. Int J Exp Pathol 90: 338-346.
40. Janus C, Westaway D, (2001) Transgenic mouse models of Alzheimer's disease. Physiol Behav 73: 873-886.
41. Allen TJ, Cooper ME, Lan HY, (2004) Use of genetic mouse models in the study of diabetic nephropathy. Curr Diab Rep 4: 435-440.
42. Kim S, (2009) Animal models of cancer in the head and neck region. Clin Exp Otorhinolaryngol 2: 55-60.
43. Seredkina N, Zykova SN, Rekvig OP, (2009) Progression of murine lupus nephritis is linked to acquired renal Dnase1 deficiency and not to up-regulated apoptosis. Am J Pathol 175: 97-106.
44. Asquith DL, Miller AM, McInnes IB, Liew FY, (2009) Animal models of rheumatoid arthritis. Eur J Immunol 39: 2040-2044.
45. Elder JT, Bruce AT, Gudjonsson JE, Johnston A, Stuart PE, et al. (2010) Molecular dissection of psoriasis: integrating genetics and biology. J Invest Dermatol 130: 1213-26.
46. Van Joost T, Bos JD, Heule F, Meinardi MM, (1988) Low-dose cyclosporin A in severe psoriasis. A double-blind study. Br J Dermatol 118: 183-90.
47. Eedy DJ, Burrows D, Bridges JM, Jones FG, (1990) Clearance of severe psoriasis after allogenic bone marrow transplantation. BMJ 300: 908.
48. Ward NL, Loyd CM, Wolfram JA, Diaconu D, Michaels CM, et al. (2010) Depletion of antigen presenting cells by clodronate liposomes reverses the psoriatic skin phenotype in KC-Tie2 mice. Br J Dermatol In Press.
49. Kircik LH, Del Rosso JQ, (2009) Anti-TNF agents for the treatment of psoriasis. J Drugs Dermatol 8: 546-59.
50. Haider AS, Cohen J, Fei J, Zaba LC, Cardinale I, et al. (2008) Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome. J Invest Dermatol 128: 655-66.
51. Gudjonsson JE, Ding J, Li X, Nair RP, Tejasvi T, et al. (2009) Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin. J Invest Dermatol 129: 2795-804.
52. Diamond I, Owolabi T, Marco M, Lam C, Glick A, (2000) Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. J Invest Dermatol 115: 788-794.
53. Jones N, Voskas D, Master Z, Sarao R, Jones J, et al. (2001) Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function. EMBO Rep 2: 438-445.
54. Coulombe PA, Kopan R, Fuchs E, (1989) Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. J Cell Biol 109: 2295-312.
55. Liu G, Loraine AE, Shigeta R, Cline M, Cheng J, et al. (2003) NetAffx: Affymetrix probesets and annotations. Nucleic Acids Res 31: 82-86.
56. Sayers EW, Barrett T, Benson DA, Bryant SH, Canese K, et al. (2009) Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 37: D5-D15.
57. Smyth GK, (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: 3.
58. Benjamini Y, Hochberg Y, (1995) Controlling the false discovery rate: a powerful and practical approach to multiple testing. J Roy Stat Soc B 57: 289-300.
59. Falcon S, Gentleman R, (2007) Using GOstats to test gene lists for GO term association. Bioinformatics 23: 257-258.
60. Reimers M, Carey VJ, (2006) Bioconductor: an open source framework for bioinformatics and computational biology. Methods Enzymol 411: 119-134.