Increased expression of Wnt5a in psoriatic plaques

Journal of Investigative Dermatology

Volumn 127, Issue 1, 2007, Pages 163-169

  Reischl, Joachim ^a   Schwenke, Susanne ^a   Beekman, Johanna M ^a   Mrowietz, Ulrich ^b   Stürzebecher, Steffen ^a   Heubach, Jürgen F ^a  

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN D1; DICKKOPF HOMOLOG 2; FRIZZLED RELATED PROTEIN; MESSENGER RNA; PROTEIN; RNA; UNCLASSIFIED DRUG; WNT 16 PROTEIN; WNT 7B PROTEIN; WNT4 PROTEIN; WNT5A PROTEIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE IDENTIFICATION; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; MALE; MICROARRAY ANALYSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS VULGARIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN DEFECT;

BETA CATENIN; BIOPSY; CALCIUM; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; LDL-RECEPTOR RELATED PROTEIN 1; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS; PSORIASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN; WNT PROTEINS;

EID: 33845783691     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5700488     Document Type: Article

References (38)

1. Bikle DD, Ng D, Tu CL, Oda Y, Xie Z (2001) Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol 177:161-71
2. Bittner M, Meltzer P, Chen Y, Jiang Y, Seftor E, Hendrix M et al. (2000) Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406:536-40
3. Bhanot P, Brink M, Samos CH, Hsieh JC, Wang Y, Macke JP et al. (1996) A new member of the frizzled family from Drosophila functions as a wingless receptor. Nature 382:225-30
4. Bowcock AM, Shannon W, Du F, Duncan J, Cao K, Aftergut K et al. (2001) Insights into psoriasis and other inflammatory diseases from large-scale gene expression studies. Hum Mol Genet 10:1793-805
5. Crabtree GR, Olson EN (2002) NFAT signaling: choreographing the social lives of cells. Cell 109:S67-79
6. Danielson KG, Pillarisetti J, Cohen IR, Sholehvar B, Huebner K, Ng LJ et al. (1995) Characterization of the complete genomic structure of the human WNT-5A gene, functional analysis of its promoter, chromosomal mapping, and expression in early human embryogenesis. J Biol Chem 270:31225-34
7. Hoang B, Moos M Jr, Vukicevic S, Luyten FP (1996) Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis. J Biol Chem 271:26131-7
8. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W (2001) Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105:533-45
9. Iizuka H, Takahashi H, Honma M, Ishida-Yamamoto A (2004) Unique keratinization process in psoriasis: late differentiation markers are abolished because of the premature cell death. J Dermatol 31:271-6
10. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L et al. (1999) Functional and structural diversity of the human Dickkopf gene family. Gene 238:301-13
11. Kuhnert F, Davis CR, Wang HT, Chu P, Lee M, Yuan J et al. (2004) Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of dickkopf-1. Proc Natl Acad Sci USA 101:266-71
12. Liang H, Chen Q, Coles AH, Anderson SJ, Pihan G, Bradley A et al. (2003) Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell 4:349-60
13. Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807-15
14. Liu WM, Mei R, Di X, Ryder TB, Hubbell E, Dee S et al. (2002) Analysis of high density expression microarrays with signed-rank call algorithms. Bioinformatics 18:1593-9
15. -ddCT method. Methods 25:402-8
16. Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781-810
17. Merrill BJ, Gat U, DasGupta R, Fuchs E (2001) Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev 15:1688-705
18. Milisavljevic V, Freedberg IM, Blumenberg M (1996) Characterization of nuclear protein binding sites in the promoter of keratin K17 gene. DNA Cell Biol 15:65-74
19. Miyasaka H, Choudhury BK, Hou EW, Li SS (1993) Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. Eur J Biochem 216:343-52
20. Miyazaki T, Kanou Y, Murata Y, Ohmori S, Niwa T, Maeda K et al. (1996) Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. J Biol Chem 271:14567-71
21. Motokura T, Bloom T, Kim HG, Juppner H, Rudermann JV, Kronenberg HM et al. (1991) A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350:512-5
22. Oestreicher JL, Walters IB, Kikuchi T, Gilleaudeau P, Surette J, Schwertschlag U et al. (2001) Molecular classification of psoriasis disease-associated genes through pharmacogenomic expression profiling. Pharmacogenomics 1:272-87
23. Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature 407:535-8
24. Quekenborn-Trinquet V, Fogel P, Aldana-Jammayrac O, Ancian P, Demarchez M, Rossio P et al. (2005) Gene expression profiles in psoriasis: analysis of impact of body site location and clinical severity. Br J Dermatol 152:489-504
25. Roman-Roman S, Shi DL, Stiot V, Hay E, Vayssiere B, Garcia T et al. (2004) Murine frizzled-1 behaves as an antagonist of the canonical Wnt/β-catenin signaling. J Biol Chem 279:5725-33
26. Saldanha G, Ghura V, Potter L, Fletcher A (2004) Nuclear β-catenin in basal cell carcinoma correlates with increased proliferation. Br J Dermatol 151:157-64
27. Schön MP, Boehncke WH (2005) Psoriasis. N Engl J Med 352:1899-912
28. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M, Carson DA (2000) Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci USA 97:2791-6
29. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y et al. (2000) Inhibition of Wnt signaling by ICAT, a novel β-catenin-interacting protein. Genes Dev 14:1741-9
30. Taki M, Kamata N, Yokohama K, Fujimoto R, Tsutsumi S, Nagayama M (2003) Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci 94:593-7
31. Topol L, Jiang X, Choi H, Garrett-Beal L, Carolan PJ, Yang Y (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent β-catenin degradation. J Cell Biol 162:899-908
32. Torres MA, Yang-Snyder JA, Purcell SM, DeMarais AA, McGrew LL, Moon RT (1996) Activities of the Wnt-1 class of secreted signalling factors are antagonized by the Wnt-5A class and by dominant negative cadherin in early Xenopus development. J Cell Biol 133:1123-37
33. Veeman MT, Axelrod JD, Moon RT (2003) A second canon: functions and mechanisms of β-catenin-independent Wnt signaling. Dev Cell 5:367-77
34. Wang S, Krinks M, Moos M Jr (1997) Frzb-1, an antagonist of Wnt-1 and Wnt-8, does not block signaling by Wnts-3A, -5A, or -11. Biochem Biophys Res Commun 236:502-4
35. Wang YN, Chang WC (2003) Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun. J Biol Chem 278:45848-57
36. Wei Y, Renard CA, Labalette C, Wu Y, Levy L, Neuveut C et al. (2003) Identification of the LIM protein FHL2 as a coactivator of β-catenin. J Biol Chem 278:5188-94
37. Yamazaki F, Aragane Y, Kawada A, Tezuka T (2001) Immunohistochemical detection for nuclear β-catenin in sporadic basal cell carcinoma. Br J Dermatol 145:771-7
38. Zhou X, Krueger JG, Kao MJ, Lee E, Du F, Menter A, Wong WH et al. (2003) Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucteotide array. Physiol Genomics 13:69-78