Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation

Journal of Investigative Dermatology

Volumn 128, Issue 6, 2008, Pages 1375-1385

  Sklyarova, Tatyana ^a,b   Bonné, Stefan ^a,b,d   D'hooge, Petra ^a,b   Denecker, Geertrui ^a,b   Goossens, Steven ^a,b   De Rycke, Riet ^a,b   Borgonie, Gaetan ^b   Bösl, Michael ^c   Van Roy, Frans ^a,b   Van Hengel, Jolanda ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^d DIABETES RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PLAKOPHILIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CELL DENSITY; CELL JUNCTION; CONTROLLED STUDY; DESMOSOME; EPIDERMIS; EPITHELIUM CELL; FEMALE; HAIR; HAIR DISEASE; HAIR FOLLICLE; HAIR ROOT; MALE; MORPHOGENESIS; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SKIN INFLAMMATION; STRESS;

EID: 43749116674     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701189     Document Type: Article

References (42)

1. P.Z. Anastasiadis p120-ctn: a nexus for contextual signaling via Rho GTPases Biochim Biophys Acta—Mol Cell Res 1773 2007 34 46
2. S.A. Beausoleil M. Jedrychowski D. Schwartz J.E. Elias J. Villen J. Li Large-scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci USA 101 2004 12130 12135
3. U.A.K. Betz C.A.J. Vosshenrich K. Rajewsky W. Muller Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination Curr Biol 6 1996 1307 1316
4. S. Bonné B. Gilbert M. Hatzfeld X. Chen K.J. Green F. van Roy Defining desmosomal plakophilin-3 interactions J Cell Biol 161 2003 403 416
5. S. Bonné J. van Hengel F. Nollet P. Kools F. van Roy Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells J Cell Sci 112 1999 2265 2276
6. X. Chen S. Bonné M. Hatzfeld F. van Roy K.J. Green Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and β-catenin signaling J Biol Chem 277 2002 10512 10522
7. H. Clevers Wnt/beta-catenin signaling in development and disease Cell 127 2006 469 480
8. R.L. Dusek L.M. Godsel K.J. Green Discriminating roles of desmosomal cadherins: beyond desmosomal adhesion J Dermatol Sci 45 2007 7 21
9. T. Ellis L. Gambardella M. Horcher S. Tschanz J. Capol P. Bertram The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle Genes Dev 15 2001 2307 2319
10. M. Gabor The mouse ear as a model for cutaneous irritation J Toxicol—Cut Ocular Toxicol 21 2002 191 202
11. B. Gerull A. Heuser T. Wichter M. Paul C.T. Basson D.A. McDermott Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy Nat Genet 36 2004 1162 1164
12. S. Goossens B. Janssens G. Vanpoucke R. De Rycke J. van Hengel F. van Roy Truncated isoform of mouse alpha-T-catenin is testis-restricted in expression and function FASEB J 21 2007 647 655
13. K.J. Green C.A. Gaudry Are desmosomes more than tethers for intermediate filaments? Nat Rev Mol Cell Biol 1 2000 208 216
14. K.J. Green A.P. Kowalczyk E.A. Bornslaeger H.L. Palka S.M. Norvell Desmosomes: integrators of mechanical integrity in tissues Biol Bull 194 1998 374 376
15. K.S. Grossmann C. Grund J. Huelsken M. Behrend B. Erdmann W.W. Franke Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation J Cell Biol 167 2004 149 160
16. L. Guo L. Degenstein E. Fuchs Keratinocyte growth factor is required for hair development but not for wound healing Genes Dev 10 1996 165 175
17. M. Hatzfeld Plakophilins: multifunctional proteins or just regulators of desmosomal adhesion? Biochim Biophys Acta—Mol Cell Res 1773 2007 69 77
18. M. Hatzfeld K.J. Green H. Sauter Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains J Cell Sci 116 2003 1219 1233
19. I. Hofmann M. Casella M. Schnolzer T. Schlechter H. Spring W.W. Franke Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules Mol Biol Cell 17 2006 1388 1398
20. C.K. Kaufman P. Zhou H.A. Pasolli M. Rendl D. Bolotin K.C. Lim GATA-3: an unexpected regulator of cell lineage determination in skin Genes Dev 17 2003 2108 2122
21. A. Kljuic H. Bazzi J.P. Sundberg A. MartinezMir R. O'Shaughnessy M.G. Mahoney Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris Cell 113 2003 249 260
22. E. Legue J.F. Nicolas Hair follicle renewal: organization of stem cells in the matrix and the role of stereotyped lineages and behaviors Development 132 2005 4143 4154
23. J.E. Lewis J.K. Wahl K.M. Sass P.J. Jensen K.R. Johnson M.J. Wheelock Cross-talk between adherens junctions and desmosomes depends on plakoglobin J Cell Biol 136 1997 919 934
24. K.K. Lin D. Chudova G.W. Hatfield P. Smyth B. Andersen Identification of hair cycle-associated genes from time- course gene expression profile data by using replicate variance Proc Natl Acad Sci USA 101 2004 15955 15960
25. J.A. McGrath J.R. McMillan C.S. Shemanko S.K. Runswick I.M. Leigh E.B. Lane Mutations in the plakophilin 1 gene result in ectodermal dysplasia skin fragility syndrome Nat Genet 17 1997 240 244
26. A.J. North W.G. Bardsley J. Hyam E.A. Bornslaeger H.C. Cordingley B. Trinnaman Molecular map of the desmosomal plaque J Cell Sci 112 1999 4325 4336
27. M. Perez-Moreno M.A. Davis E. Wong H.A. Pasolli A.B. Reynolds E. Fuchs p120-Catenin mediates inflammatory responses in the skin Cell 124 2006 631 644
28. M. Perez-Moreno E. Fuchs Catenins: keeping cells from getting their signals crossed Dev Cell 11 2006 601 612
29. M. Perez-Moreno C. Jamora E. Fuchs Sticky business: orchestrating cellular signals at adherens junctions Cell 112 2003 535 548
30. A.B. Reynolds R.H. Carnahan Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer Semin Cell Dev Biol 15 2004 657 663
31. E. Robanus-Maandag M. Dekker M. van der Valk M.L. Carrozza J.C. Jeanny J.H. Dannenberg p107 is a suppressor of retinoblastoma development in pRb-deficient mice Genes Dev 12 1998 1599 1609
32. C.I. Rodriguez F. Buchholz J. Galloway R. Sequerra J. Kasper R. Ayala High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP Nat Genet 25 2000 139 140
33. D.J. Rossi A. Londesborough N. Korsisaari A. Pihlak E. Lehtonen M. Henkemeyer Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1 EMBO J 20 2001 2844 2856
34. D. Russell P.D. Andrews J. James E.B. Lane Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes J Cell Sci 117 2004 5233 5243
35. T. Schlake FGF signals specifically regulate the structure of hair shaft medulla via IGF-binding protein 5 Development 132 2005 2981 2990
36. T. Schlake Determination of hair structure and shape Semin Cell Dev Biol 18 2007 267 273
37. A. Schmidt L. Langbein S. Pratzel M. Rode H.R. Rackwitz W.W. Franke Plakophilin 3—a novel cell-type-specific desmosomal plaque protein Differentiation 64 1999 291 306
38. D.J. Tobin K. Foitzik T. Reinheckel L. Mecklenburg V.A. Botchkarev C. Peters The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling Am J Pathol 160 2002 1807 1821
39. J.P. van Tintelen M.M. Entius Z.A. Bhuiyan R. Jongbloed A.C.P. Wiesfeld A.A.M. Wilde Plakophilin-2 mutations are the major determinant of familial arrhythmogenic right ventricular dysplasia/cardiomyopathy Circulation 113 2006 1650 1658
40. V. Vasioukhin E. Bowers C. Bauer L. Degenstein E. Fuchs Desmoplakin is essential in epidermal sheet formation Nat Cell Biol 3 2001 1076 1085
41. A. Wolf R. Keil O. Gotzl A. Mun K. Schwarze M. Lederer The armadillo protein p0071 regulates Rho signalling during cytokinesis Nat Cell Biol 8 2006 1432 1440
42. T.F. Yin K.J. Green Regulation of desmosome assembly and adhesion Semin Cell Dev Biol 15 2004 665 677