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Volumn 161, Issue 12, 2013, Pages 2931-2937

The AKT genes and their roles in various disorders

Author keywords

AKT1; AKT2; AKT3; Cellular functions of AKT effectors; G protein coupled receptor; MTORC2; Phosphatydlinositol 3 kinase and 3 kinase gamma; Phosphatydlinositol 4,5 bisphosphate and 3,4,5 trisphosphate; PTEN; RAS; Receptor tyrosine kinase

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR; LIGAND; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN AKT1; PROTEIN AKT3; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

EID: 84888029492     PISSN: 15524825     EISSN: 15524833     Source Type: Journal    
DOI: 10.1002/ajmg.a.36101     Document Type: Article
Times cited : (81)

References (40)
  • 3
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK, Testa JR. 1996. Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA Proc Natl Acad Sci 93:3636-3642.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 3636-3642
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3    Sonoda, G.4    Altomare, D.A.5    Watson, D.K.6    Testa, J.R.7
  • 5
    • 0033212348 scopus 로고    scopus 로고
    • Etiology of fibrous dysplasia and McCune-Albright syndrome
    • Cohen MM Jr Howell RE. 1999. Etiology of fibrous dysplasia and McCune-Albright syndrome. Int J Oral Maxillofac Surg 28:366-371.
    • (1999) Int J Oral Maxillofac Surg , vol.28 , pp. 366-371
    • Cohen Jr., M.M.1    Howell, R.E.2
  • 8
    • 0036683691 scopus 로고    scopus 로고
    • Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide-3-kinases
    • Djordjevic S, Driscoll PC. 2002. Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide-3-kinases. Trends Biochem Sci 27:426-432.
    • (2002) Trends Biochem Sci , vol.27 , pp. 426-432
    • Djordjevic, S.1    Driscoll, P.C.2
  • 9
    • 84859348838 scopus 로고    scopus 로고
    • AKT/GSK3 signaling pathway and schizophrenia
    • Article 33.
    • Emamian ES. 2012. AKT/GSK3 signaling pathway and schizophrenia. Front Mol Neurosci 5:1-12. Article 33.
    • (2012) Front Mol Neurosci , vol.5 , pp. 1-12
    • Emamian, E.S.1
  • 10
  • 11
    • 1842483950 scopus 로고    scopus 로고
    • Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent
    • Esfandiarei M, Luo H, Yanagawa B, Suarez A, Dabiri E, Si X, Rahmani M, McManus BM. 2004. Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent. J Virol 78:4289-4298.
    • (2004) J Virol , vol.78 , pp. 4289-4298
    • Esfandiarei, M.1    Luo, H.2    Yanagawa, B.3    Suarez, A.4    Dabiri, E.5    Si, X.6    Rahmani, M.7    McManus, B.M.8
  • 12
    • 33747387246 scopus 로고    scopus 로고
    • Novel role for integrin-linked kinase in modulation of coxsackievirus B3 replication and virus-induced cardiomyocyte injury
    • Esfandiarei M, Suarez A, Amaral A, Si X, Rahmani M, Dedhar S, McManus BM. 2006. Novel role for integrin-linked kinase in modulation of coxsackievirus B3 replication and virus-induced cardiomyocyte injury. Circ Res 99:354-361.
    • (2006) Circ Res , vol.99 , pp. 354-361
    • Esfandiarei, M.1    Suarez, A.2    Amaral, A.3    Si, X.4    Rahmani, M.5    Dedhar, S.6    McManus, B.M.7
  • 13
    • 34548442100 scopus 로고    scopus 로고
    • Coxsackievirus B3 activates nuclear kappa B transcription factor via a phosphatydlinositol-3 kinase/protein kinase B-dependent pathway to improve host cell viability
    • Esfandiarei M, Boroomand S, Suarez A, Si X, Rahmani M, McManus BM. 2007. Coxsackievirus B3 activates nuclear kappa B transcription factor via a phosphatydlinositol-3 kinase/protein kinase B-dependent pathway to improve host cell viability. Cell Microbiol 9:2358-2371.
    • (2007) Cell Microbiol , vol.9 , pp. 2358-2371
    • Esfandiarei, M.1    Boroomand, S.2    Suarez, A.3    Si, X.4    Rahmani, M.5    McManus, B.M.6
  • 16
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • Hers I, Vicent EE, Tavare JM. 2011. Akt signalling in health and disease. Cell Signal 23:1515-1527.
    • (2011) Cell Signal , vol.23 , pp. 1515-1527
    • Hers, I.1    Vicent, E.E.2    Tavare, J.M.3
  • 18
    • 79751535258 scopus 로고    scopus 로고
    • Inositol pentakis phosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions
    • Jackson SG, Al-Saigh S, Schultz C, Junop MS. 2011. Inositol pentakis phosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions. BMC Struct Biol 11:11.
    • (2011) BMC Struct Biol , vol.11 , pp. 11
    • Jackson, S.G.1    Al-Saigh, S.2    Schultz, C.3    Junop, M.S.4
  • 19
    • 0029908016 scopus 로고    scopus 로고
    • Expression of a constitutionally active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
    • Kohn AD, Summers SA, Birnbaum MJ, Roth RA. 1996. Expression of a constitutionally active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378.
    • (1996) J Biol Chem , vol.271 , pp. 31372-31378
    • Kohn, A.D.1    Summers, S.A.2    Birnbaum, M.J.3    Roth, R.A.4
  • 23
    • 11144253483 scopus 로고    scopus 로고
    • Convergent signal transduction pathways controlling cardiomyocyte survival and function: The role of PI3-kinase and Akt
    • Matsui T, Rosenzweig A. 2005. Convergent signal transduction pathways controlling cardiomyocyte survival and function: The role of PI3-kinase and Akt. J Mol Cell Cardiol 38:63-71.
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 63-71
    • Matsui, T.1    Rosenzweig, A.2
  • 25
    • 0042750799 scopus 로고    scopus 로고
    • Akt and PI3-kinase signaling in cardiomyoctye hypertrophy and survival
    • Matsui T, Nagoshi T, Rosenzweig A. 2003. Akt and PI3-kinase signaling in cardiomyoctye hypertrophy and survival. Cell Cycle 2:220-223.
    • (2003) Cell Cycle , vol.2 , pp. 220-223
    • Matsui, T.1    Nagoshi, T.2    Rosenzweig, A.3
  • 26
    • 84856219440 scopus 로고    scopus 로고
    • Megalencephaly-capillary malformation [MCAP] and megalencephaly-polydactyly-polymicrogyria-hydrocephalus [MPPH] syndromes: Two closely related disorders of brain overgrowth and abnormal brain and body morphogenesis
    • Mizaa GM, Conway RL, Gripp KW, Lerman-Sagle T, Siegel DH, deVries LS, Lev D, Kramer N, Hopkins E, Graham JM Jr Dobyns WB. 2012. Megalencephaly-capillary malformation [MCAP] and megalencephaly-polydactyly-polymicrogyria-hydrocephalus [MPPH] syndromes: Two closely related disorders of brain overgrowth and abnormal brain and body morphogenesis. Am J Med Genet Part A 158A:269-291.
    • (2012) Am J Med Genet Part A , vol.158 A , pp. 269-291
    • Mizaa, G.M.1    Conway, R.L.2    Gripp, K.W.3    Lerman-Sagle, T.4    Siegel, D.H.5    deVries, L.S.6    Lev, D.7    Kramer, N.8    Hopkins, E.9    Graham Jr., J.M.10    Dobyns, W.B.11
  • 27
    • 0033591008 scopus 로고    scopus 로고
    • Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site
    • Nakatani K, Sakaue H, Thompson DA, Weigel RJ, Roth RA. 1999. Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site. Biochem Biophys Res Comm 257:906-910.
    • (1999) Biochem Biophys Res Comm , vol.257 , pp. 906-910
    • Nakatani, K.1    Sakaue, H.2    Thompson, D.A.3    Weigel, R.J.4    Roth, R.A.5
  • 28
    • 84888039395 scopus 로고    scopus 로고
    • OMIM 164730 (AKT1), 164731 (AKT2), 611223 (AKT3), 610643 (PP2A), 609396 (PHLPP1), 601231 (mTOR), 612465 (TBC1D4), 116899 (CDKN1A), 600778 (CDKN1B), 603167 (BAD), 602233 (APAF1), 602448 (MAP3K5), 136533 (FOXO1), 123810 (CREB1), 606608 (YAP1), 164785 (MDM2), 609850 (TBC1D1), 163729 (NOS3).
    • OMIM 164730 (AKT1), 164731 (AKT2), 611223 (AKT3), 610643 (PP2A), 609396 (PHLPP1), 601231 (mTOR), 612465 (TBC1D4), 116899 (CDKN1A), 600778 (CDKN1B), 603167 (BAD), 602233 (APAF1), 602448 (MAP3K5), 136533 (FOXO1), 123810 (CREB1), 606608 (YAP1), 164785 (MDM2), 609850 (TBC1D1), 163729 (NOS3).
  • 29
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: Its functions and alterations in human cancer
    • Osaki M, Oshimura M, Ito H. 2004. PI3K-Akt pathway: Its functions and alterations in human cancer. Apoptosis 9:667-676.
    • (2004) Apoptosis , vol.9 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 33
    • 77950819588 scopus 로고    scopus 로고
    • The role of insulin resistance in the pathogenesis of atherosclerotic cardiovascular disease: An updated review
    • Reddy KJ, Singh M, Bangit JR, Batsell RR. 2010. The role of insulin resistance in the pathogenesis of atherosclerotic cardiovascular disease: An updated review. J Cardiovasc Med 11:633-647.
    • (2010) J Cardiovasc Med , vol.11 , pp. 633-647
    • Reddy, K.J.1    Singh, M.2    Bangit, J.R.3    Batsell, R.R.4
  • 36
    • 33845711358 scopus 로고    scopus 로고
    • Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
    • Shiojima I, Walsh K. 2006. Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Genes Dev 20:3347-3365.
    • (2006) Genes Dev , vol.20 , pp. 3347-3365
    • Shiojima, I.1    Walsh, K.2
  • 37
    • 0001582482 scopus 로고
    • Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary gastric adenocarcinoma
    • Staal SP. 1987. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary gastric adenocarcinoma. Proc Natl Acad Sci USA 84:5034-5037.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 5034-5037
    • Staal, S.P.1
  • 38
  • 39
    • 33847410199 scopus 로고    scopus 로고
    • Analysis of genetic variation in Akt2/PKB-β in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes
    • Tan K, Kimber WA, Luan J, Soos MA, Semple RK, Wareham NJ, O'Rahilly S, Barroso I. 2007. Analysis of genetic variation in Akt2/PKB-β in severe insulin resistance, lipodystrophy, type 2 diabetes, and related metabolic phenotypes. Diabetes 56:714-719.
    • (2007) Diabetes , vol.56 , pp. 714-719
    • Tan, K.1    Kimber, W.A.2    Luan, J.3    Soos, M.A.4    Semple, R.K.5    Wareham, N.J.6    O'Rahilly, S.7    Barroso, I.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.