Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate

EMBO Journal

Volumn 22, Issue 17, 2003, Pages 4431-4442

  Müller, Jürgen ^a   Ritt, Daniel A ^a   Copeland, Terry D ^a   Morrison, Deborah K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

14 3 3; C TAK1; Phosphorylation motif; Protein kinase; Subcellular protein localization

Indexed keywords

CDC25C ASSOCIATED PROTEIN KINASE 1; CDC25C PHOSPHATASE; KSR1 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PLAKOPHILIN 2; PROTEIN; PROTEIN 14 3 3; RAS PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CELL CYCLE; CELL MEMBRANE; CONTROLLED STUDY; INTERPHASE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

14-3-3 PROTEINS; 3T3 CELLS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; COS CELLS; FEMALE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PHOSPHORYLATION; PLAKOPHILINS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION; TYROSINE 3-MONOOXYGENASE; XENOPUS;

ANIMALIA;

EID: 0042738101     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg426     Document Type: Article

References (36)

1. Brunet, A. et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96, 857-868.
2. Cacace, A.M., Michaud, N.R., Therrien, M., Mathes, K., Copeland, T., Rubin, G.M. and Morrison, D.K. (1999) Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding and KSR overexpression. Mol. Cell. Biol., 19, 229-240.
3. Chen, X., Bonne, S., Hatzfeld, M., van Roy, F. and Green, K.J. (2002) Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and β-catenin signaling. J. Biol. Chem., 277, 10512-10522.
4. Dale, S., Wilson, W.A., Edelman, A.M. and Hardie, D.G. (1995) Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1 and mammalian calmodulin-dependent protein kinase I. FEBS Lett., 361, 191-195.
5. Graves, P.R., Lovly, C.M., Uy, G.L. and Piwnica-Worms, H. (2001) Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Oncogene, 20, 1839-1851.
6. Grozinger, C.M. and Schreiber, S.L. (2000) Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc. Natl Acad. Sci. USA, 97, 7835-7840.
7. Hutchins, J.R., Hughes, M. and Clarke, P.R. (2000) Substrate specificity determinants of the checkpoint protein kinase Chk1. FEBS Lett., 466, 91-95.
8. Jaumot, M. and Hancock, J.F. (2001) Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene, 20, 3949-3958.
9. Kao, H.Y., Verdel, A., Tsai, C.C., Simon, C., Juguilon, H. and Khochbin, S. (2001) Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7. J. Biol. Chem., 276, 47496-47507.
10. Klymkowsky, M.W. (1999) Plakophilin, armadillo repeats and nuclear localization. Microsc. Res. Tech., 45, 43-54.
11. Kubicek, M., Pacher, M., Abraham, D., Podar, K., Eulitz, M. and Baccarini, M. (2002) Dephosphorylation of Ser-259 regulates Raf-1 membrane association. J. Biol. Chem., 277, 7913-7919.
12. Kumagai, A. and Dunphy, W.G. (1999) Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25. Genes Dev., 13, 1067-1072.
13. Light, Y., Paterson, H. and Marais, R. (2002) 14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity. Mol. Cell. Biol., 22, 4984-4996.
14. Marshall, C.J. (1996) Ras effectors. Curr. Opin. Cell Biol., 2, 197-204.
15. Mertens, C., Kuhn, C. and Franke, W.W. (1996) Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque. J. Cell Biol., 135, 1009-1025.
16. Morrison, D.K. (2001) KSR: a MAPK scaffold of the Ras pathway? J. Cell Sci., 114, 1609-1612.
17. Morrison, D.K., Heidecker, G., Rapp, U.R. and Copeland, T.D. (1993) Identification of the major phosphorylation sites of the Raf-1 kinase. J. Biol. Chem., 268, 17309-17316.
18. Müller, J., Ory, S., Copeland, T., Piwnica-Worms, H. and Morrison, D.K. (2001) C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol. Cell, 8, 983-993.
19. Muslin, A.J. and Xing, H. (2000) 14-3-3 proteins: regulation of subcellular localization by molecular interference. Cell Signal., 12, 703-709.
20. Muslin, A.J., Tanner, J.W., Allen, P.M. and Shaw, A.S. (1996) Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell, 84, 889-897.
21. Ogg, S., Gabrielli, B. and Piwnica-Worms, H. (1994) Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216. J. Biol. Chem., 269, 30461-30469.
22. O'Neill, T. et al. (2002) Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J. Biol. Chem., 277, 16102-16115.
23. Pearson, R.B. and Kemp, B.E. (1991) Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations. Methods Enzymol., 200, 62-81.
24. 2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25c on serine 216. Science, 277, 1501-1505.
25. Peng, C.Y., Graves, P.R., Ogg, S., Thoma, R.S., Byrnes, M.J., Wu, Z., Stephenson, M.T. and Piwnica-Worms, H. (1998) C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ., 9, 197-208.
26. Sanchez, Y., Wong, C., Thoma, R., Richman, R., Wu, Z., Piwnica-Worms, H. and Elledge, S. (1997) Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regultion through Cdc25. Science, 277, 1497-1501.
27. Schmidt, A., Langbein, L., Rode, M., Pratzel, S., Zimbelmann, R. and Franke, W.W. (1997) Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components. Cell Tissue Res., 290, 481-499.
28. Songyang, Z. et al. (1996) A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5 and Erk1. Mol. Cell. Biol., 16, 6486-6493.
29. Sun, T.Q., Lu, B., Feng, J.J., Reinhard, C., Jan, Y.N., Fantl, W.J. and Williams, L.T. (2001) PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling. Nat. Cell Biol., 3, 628-636.
30. Therrien, M., Michaud, N.R., Rubin, G.M. and Morrison, D.K. (1996) KSR modulates signal propagation within the MAPK cascade. Genes Dev., 10, 2684-2695.
31. Yaffe, M.B. (2002a) How do 14-3-3 proteins work? - Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett., 513, 53-57.
32. Yaffe, M.B. (2002b) Phosphotyrosine-binding domains in signal transduction. Nat. Rev. Mol. Cell. Biol., 3, 177-186.
33. Yaffe, M.B., Rittinger, K., Volinia, S., Caron, P.R., Aitken, A., Leffers, H., Gamblin, S.J., Smerdon, S.J. and Cantley, L.C. (1997) The structural basis for 14-3-3:phosphopeptide binding specificity. Cell, 91, 961-971.
34. 2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. EMBO J., 18, 2174-2183.
35. Zhang, S.H., Kobayashi, R., Graves, P.R., Piwnica-Worms, H. and Tonks, N.K. (1997) Serine phosphorylation-dependent association of the band 4. 1-related protein-tyrosine phosphatase PTPH1 with 14-3-3β protein. J. Biol. Chem., 272, 27281-27287.
36. Zhou, M., Horita, D.A., Waugh, D.S., Byrd, R.A. and Morrison, D.K. (2002) Solution structure and functional analysis of the cystein-rich C1 domain of kinase suppressor of ras (KSR). J. Mol. Biol., 315, 435-446.