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Volumn 431, Issue , 2014, Pages 211-220

KRAS mutations: Analytical considerations

Author keywords

Colorectal cancer; KRAS gene; Method and mutation analysis; Mutation

Indexed keywords

RAS PROTEIN; VASCULOTROPIN RECEPTOR; ANTINEOPLASTIC AGENT; KRAS PROTEIN, HUMAN; ONCOPROTEIN;

EID: 84896819420     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2014.01.049     Document Type: Review
Times cited : (30)

References (118)
  • 1
    • 84863707351 scopus 로고    scopus 로고
    • Cancer treatment and survivorship statistics, 2012
    • Siegel R., DeSantis C., Virgo K., et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin 2012, 62:220-241.
    • (2012) CA Cancer J Clin , vol.62 , pp. 220-241
    • Siegel, R.1    DeSantis, C.2    Virgo, K.3
  • 3
    • 61549138171 scopus 로고    scopus 로고
    • Targeting colorectal cancer with anti-epidermal growth factor receptor antibodies: focus on panitumumab
    • Hoda D., Simon G.R., Garrett C.R. Targeting colorectal cancer with anti-epidermal growth factor receptor antibodies: focus on panitumumab. Ther Clin Risk Manag 2008, 4:1221-1227.
    • (2008) Ther Clin Risk Manag , vol.4 , pp. 1221-1227
    • Hoda, D.1    Simon, G.R.2    Garrett, C.R.3
  • 5
    • 14644445166 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling in colorectal cancer: preclinical data and therapeutic perspectives
    • Spano J.P., Fagard R., Soria J.C., Rixe O., Khayat D., Milano G. Epidermal growth factor receptor signaling in colorectal cancer: preclinical data and therapeutic perspectives. Ann Oncol 2005, 16:189-194.
    • (2005) Ann Oncol , vol.16 , pp. 189-194
    • Spano, J.P.1    Fagard, R.2    Soria, J.C.3    Rixe, O.4    Khayat, D.5    Milano, G.6
  • 6
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado R.G., Wolf M., Peeters M., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26:1626-1634.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 7
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis C.S., Khambata-Ford S., Jonker D.J., et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008, 359:1757-1765.
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 8
    • 79951578834 scopus 로고    scopus 로고
    • KRAS, BRAF, EGFR and HER2 gene status in a Spanish population of colorectal cancer
    • Herreros-Villanueva M., Rodrigo M., Claver M., et al. KRAS, BRAF, EGFR and HER2 gene status in a Spanish population of colorectal cancer. Mol Biol Rep 2011, 38:1315-1320.
    • (2011) Mol Biol Rep , vol.38 , pp. 1315-1320
    • Herreros-Villanueva, M.1    Rodrigo, M.2    Claver, M.3
  • 9
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E., Kohne C.H., Hitre E., et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009, 360:1408-1417.
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 10
    • 40149088765 scopus 로고    scopus 로고
    • KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
    • De Roock W., Piessevaux H., De Schutter J., et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol 2008, 19:508-515.
    • (2008) Ann Oncol , vol.19 , pp. 508-515
    • De Roock, W.1    Piessevaux, H.2    De Schutter, J.3
  • 11
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
    • Di Fiore F., Blanchard F., Charbonnier F., et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br J Cancer 2007, 96:1166-1169.
    • (2007) Br J Cancer , vol.96 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3
  • 12
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre A., Bachet J.B., Boige V., et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008, 26:374-379.
    • (2008) J Clin Oncol , vol.26 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3
  • 13
    • 61449154484 scopus 로고    scopus 로고
    • KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection
    • Jimeno A., Messersmith W.A., Hirsch F.R., Franklin W.A., Eckhardt S.G. KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection. J Clin Oncol 2009, 27:1130-1136.
    • (2009) J Clin Oncol , vol.27 , pp. 1130-1136
    • Jimeno, A.1    Messersmith, W.A.2    Hirsch, F.R.3    Franklin, W.A.4    Eckhardt, S.G.5
  • 14
    • 67651154618 scopus 로고    scopus 로고
    • Individualized therapies in colorectal cancer: KRAS as a marker for response to EGFR-targeted therapy
    • Chang D.Z., Kumar V., Ma Y., Li K., Kopetz S. Individualized therapies in colorectal cancer: KRAS as a marker for response to EGFR-targeted therapy. J Hematol Oncol 2009, 2:18.
    • (2009) J Hematol Oncol , vol.2 , pp. 18
    • Chang, D.Z.1    Kumar, V.2    Ma, Y.3    Li, K.4    Kopetz, S.5
  • 15
    • 79551580551 scopus 로고    scopus 로고
    • Systematic review: anti-epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectal cancer
    • Dahabreh I.J., Terasawa T., Castaldi P.J., Trikalinos T.A. Systematic review: anti-epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectal cancer. Ann Intern Med 2011, 154:37-49.
    • (2011) Ann Intern Med , vol.154 , pp. 37-49
    • Dahabreh, I.J.1    Terasawa, T.2    Castaldi, P.J.3    Trikalinos, T.A.4
  • 16
    • 77349091545 scopus 로고    scopus 로고
    • Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation
    • Suda K., Tomizawa K., Mitsudomi T. Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation. Cancer Metastasis Rev 2010, 29:49-60.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 49-60
    • Suda, K.1    Tomizawa, K.2    Mitsudomi, T.3
  • 17
    • 78649487698 scopus 로고    scopus 로고
    • Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
    • Vigil D., Cherfils J., Rossman K.L., Der C.J. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?. Nat Rev Cancer 2010, 10:842-857.
    • (2010) Nat Rev Cancer , vol.10 , pp. 842-857
    • Vigil, D.1    Cherfils, J.2    Rossman, K.L.3    Der, C.J.4
  • 19
    • 0032490124 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study
    • Andreyev H.J., Norman A.R., Cunningham D., Oates J.R., Clarke P.A. Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study. J Natl Cancer Inst 1998, 90:675-684.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 675-684
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3    Oates, J.R.4    Clarke, P.A.5
  • 20
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: the first 30years
    • Malumbres M., Barbacid M. RAS oncogenes: the first 30years. Nat Rev Cancer 2003, 3:459-465.
    • (2003) Nat Rev Cancer , vol.3 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 21
    • 84874248179 scopus 로고    scopus 로고
    • Computational analysis of KRAS mutations: implications for different effects on the KRAS p.G12D and p.G13D mutations
    • Chen C.C., Er T.K., Liu Y.Y., et al. Computational analysis of KRAS mutations: implications for different effects on the KRAS p.G12D and p.G13D mutations. PLoS One 2013, 8:e55793.
    • (2013) PLoS One , vol.8
    • Chen, C.C.1    Er, T.K.2    Liu, Y.Y.3
  • 23
    • 68749119351 scopus 로고    scopus 로고
    • KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
    • Loupakis F., Ruzzo A., Cremolini C., et al. KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer. Br J Cancer 2009, 101:715-721.
    • (2009) Br J Cancer , vol.101 , pp. 715-721
    • Loupakis, F.1    Ruzzo, A.2    Cremolini, C.3
  • 24
    • 75549090214 scopus 로고    scopus 로고
    • Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
    • Neumann J., Zeindl-Eberhart E., Kirchner T., Jung A. Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. Pathol Res Pract 2009, 205:858-862.
    • (2009) Pathol Res Pract , vol.205 , pp. 858-862
    • Neumann, J.1    Zeindl-Eberhart, E.2    Kirchner, T.3    Jung, A.4
  • 25
    • 84881391898 scopus 로고    scopus 로고
    • 454 next generation-sequencing outperforms allele-specific PCR, Sanger sequencing, and pyrosequencing for routine KRAS mutation analysis of formalin-fixed, paraffin-embedded samples
    • Altimari A., de Biase D., De Maglio G., et al. 454 next generation-sequencing outperforms allele-specific PCR, Sanger sequencing, and pyrosequencing for routine KRAS mutation analysis of formalin-fixed, paraffin-embedded samples. OncoTargets Ther 2013, 6:1057-1064.
    • (2013) OncoTargets Ther , vol.6 , pp. 1057-1064
    • Altimari, A.1    de Biase, D.2    De Maglio, G.3
  • 26
    • 0024346181 scopus 로고
    • Direct sequencing analysis of exon 1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas
    • Gonzalez-Cadavid N.F., Zhou D., Battifora H., Bar-Eli M., Cline M.J. Direct sequencing analysis of exon 1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas. Oncogene 1989, 4:1137-1140.
    • (1989) Oncogene , vol.4 , pp. 1137-1140
    • Gonzalez-Cadavid, N.F.1    Zhou, D.2    Battifora, H.3    Bar-Eli, M.4    Cline, M.J.5
  • 27
    • 84880531371 scopus 로고    scopus 로고
    • Direct sequencing is a reliable assay with good clinical applicability for KRAS mutation testing in colorectal cancer
    • Wang J., Yang H., Shen Y., et al. Direct sequencing is a reliable assay with good clinical applicability for KRAS mutation testing in colorectal cancer. Cancer Biomark 2013, 13:89-97.
    • (2013) Cancer Biomark , vol.13 , pp. 89-97
    • Wang, J.1    Yang, H.2    Shen, Y.3
  • 28
    • 77953302185 scopus 로고    scopus 로고
    • Comparison of two different screening methods for the KRAS mutation in colorectal cancer
    • Er T.K., Chang Y.S., Yeh K.T., Chang T.J., Chang J.G. Comparison of two different screening methods for the KRAS mutation in colorectal cancer. Clin Lab 2010, 56:175-186.
    • (2010) Clin Lab , vol.56 , pp. 175-186
    • Er, T.K.1    Chang, Y.S.2    Yeh, K.T.3    Chang, T.J.4    Chang, J.G.5
  • 29
    • 84878560045 scopus 로고    scopus 로고
    • Study of KRAS new predictive marker in a clinical laboratory
    • Bando I., Cillero L., Sanz-Ortega J., et al. Study of KRAS new predictive marker in a clinical laboratory. Clin Transl Oncol 2012, 14:937-942.
    • (2012) Clin Transl Oncol , vol.14 , pp. 937-942
    • Bando, I.1    Cillero, L.2    Sanz-Ortega, J.3
  • 30
    • 84869816018 scopus 로고    scopus 로고
    • KRAS mutation testing in colorectal cancer as an example of the pathologist's role in personalized targeted therapy: a practical approach
    • Domagala P., Hybiak J., Sulzyc-Bielicka V., Cybulski C., Rys J., Domagala W. KRAS mutation testing in colorectal cancer as an example of the pathologist's role in personalized targeted therapy: a practical approach. Pol J Pathol 2012, 63:145-164.
    • (2012) Pol J Pathol , vol.63 , pp. 145-164
    • Domagala, P.1    Hybiak, J.2    Sulzyc-Bielicka, V.3    Cybulski, C.4    Rys, J.5    Domagala, W.6
  • 31
    • 84880544985 scopus 로고    scopus 로고
    • Evaluation of Genomic Applications in P, Prevention Working G. Recommendations from the EGAPP Working Group: can testing of tumor tissue for mutations in EGFR pathway downstream effector genes in patients with metastatic colorectal cancer improve health outcomes by guiding decisions regarding anti-EGFR therapy?
    • Evaluation of Genomic Applications in P, Prevention Working G. Recommendations from the EGAPP Working Group: can testing of tumor tissue for mutations in EGFR pathway downstream effector genes in patients with metastatic colorectal cancer improve health outcomes by guiding decisions regarding anti-EGFR therapy?. Genet Med 2013, 15:517-527.
    • (2013) Genet Med , vol.15 , pp. 517-527
  • 32
    • 79960238239 scopus 로고    scopus 로고
    • Laboratory methods for KRAS mutation analysis
    • Anderson S.M. Laboratory methods for KRAS mutation analysis. Expert Rev Mol Diagn 2011, 11:635-642.
    • (2011) Expert Rev Mol Diagn , vol.11 , pp. 635-642
    • Anderson, S.M.1
  • 33
    • 84878581633 scopus 로고    scopus 로고
    • KRAS and BRAF mutation analysis in colorectal adenocarcinoma specimens with a low percentage of tumor cells
    • Lewandowska M.A., Jozwicki W., Zurawski B. KRAS and BRAF mutation analysis in colorectal adenocarcinoma specimens with a low percentage of tumor cells. Mol Diagn Ther 2013, 17:193-203.
    • (2013) Mol Diagn Ther , vol.17 , pp. 193-203
    • Lewandowska, M.A.1    Jozwicki, W.2    Zurawski, B.3
  • 34
    • 0033638755 scopus 로고    scopus 로고
    • K-ras point mutation detection in lung cancer: comparison of two approaches to somatic mutation detection using ARMS allele-specific amplification
    • Clayton S.J., Scott F.M., Walker J., et al. K-ras point mutation detection in lung cancer: comparison of two approaches to somatic mutation detection using ARMS allele-specific amplification. Clin Chem 2000, 46:1929-1938.
    • (2000) Clin Chem , vol.46 , pp. 1929-1938
    • Clayton, S.J.1    Scott, F.M.2    Walker, J.3
  • 35
    • 0034307747 scopus 로고    scopus 로고
    • Mode of action and application of Scorpion primers to mutation detection
    • Thelwell N., Millington S., Solinas A., Booth J., Brown T. Mode of action and application of Scorpion primers to mutation detection. Nucleic Acids Res 2000, 28:3752-3761.
    • (2000) Nucleic Acids Res , vol.28 , pp. 3752-3761
    • Thelwell, N.1    Millington, S.2    Solinas, A.3    Booth, J.4    Brown, T.5
  • 36
    • 77951725120 scopus 로고    scopus 로고
    • A commercial real-time PCR kit provides greater sensitivity than direct sequencing to detect KRAS mutations: a morphology-based approach in colorectal carcinoma
    • Angulo B., Garcia-Garcia E., Martinez R., et al. A commercial real-time PCR kit provides greater sensitivity than direct sequencing to detect KRAS mutations: a morphology-based approach in colorectal carcinoma. J Mol Diagn 2010, 12:292-299.
    • (2010) J Mol Diagn , vol.12 , pp. 292-299
    • Angulo, B.1    Garcia-Garcia, E.2    Martinez, R.3
  • 37
    • 84876334891 scopus 로고    scopus 로고
    • Mutation analysis of KRAS in primary colorectal cancer and matched metastases by means of highly sensitivity molecular assay
    • Miglio U., Mezzapelle R., Paganotti A., et al. Mutation analysis of KRAS in primary colorectal cancer and matched metastases by means of highly sensitivity molecular assay. Pathol Res Pract 2013, 209:233-236.
    • (2013) Pathol Res Pract , vol.209 , pp. 233-236
    • Miglio, U.1    Mezzapelle, R.2    Paganotti, A.3
  • 38
    • 84863723714 scopus 로고    scopus 로고
    • A comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens
    • Gonzalez de Castro D., Angulo B., Gomez B., et al. A comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens. Br J Cancer 2012, 107:345-351.
    • (2012) Br J Cancer , vol.107 , pp. 345-351
    • Gonzalez de Castro, D.1    Angulo, B.2    Gomez, B.3
  • 39
    • 84876088853 scopus 로고    scopus 로고
    • Comparison of COBAS 4800 KRAS, TaqMan PCR and high resolution melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas
    • Harle A., Busser B., Rouyer M., et al. Comparison of COBAS 4800 KRAS, TaqMan PCR and high resolution melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas. Virchows Arch 2013, 462:329-335.
    • (2013) Virchows Arch , vol.462 , pp. 329-335
    • Harle, A.1    Busser, B.2    Rouyer, M.3
  • 40
    • 70449377167 scopus 로고    scopus 로고
    • Targeted KRAS mutation assessment on patient tumor histologic material in real time diagnostics
    • Kotoula V., Charalambous E., Biesmans B., et al. Targeted KRAS mutation assessment on patient tumor histologic material in real time diagnostics. PLoS One 2009, 4:e7746.
    • (2009) PLoS One , vol.4
    • Kotoula, V.1    Charalambous, E.2    Biesmans, B.3
  • 41
    • 84857233589 scopus 로고    scopus 로고
    • Comparison of a PNA clamp PCR and an ARMS/Scorpion PCR assay for the detection of K-ras mutations
    • Nordgard O., Oltedal S., Janssen E.A., et al. Comparison of a PNA clamp PCR and an ARMS/Scorpion PCR assay for the detection of K-ras mutations. Diagn Mol Pathol 2012, 21:9-13.
    • (2012) Diagn Mol Pathol , vol.21 , pp. 9-13
    • Nordgard, O.1    Oltedal, S.2    Janssen, E.A.3
  • 42
    • 81755172150 scopus 로고    scopus 로고
    • Comparison of KRAS mutation tests in colorectal cancer patients
    • Hancer V.S., Buyukdogan M., Turkmen I., et al. Comparison of KRAS mutation tests in colorectal cancer patients. Genet Test Mol Biomarkers 2011, 15:831-834.
    • (2011) Genet Test Mol Biomarkers , vol.15 , pp. 831-834
    • Hancer, V.S.1    Buyukdogan, M.2    Turkmen, I.3
  • 43
    • 70350462904 scopus 로고    scopus 로고
    • A multicenter blinded study to evaluate KRAS mutation testing methodologies in the clinical setting
    • Whitehall V., Tran K., Umapathy A., et al. A multicenter blinded study to evaluate KRAS mutation testing methodologies in the clinical setting. J Mol Diagn 2009, 11:543-552.
    • (2009) J Mol Diagn , vol.11 , pp. 543-552
    • Whitehall, V.1    Tran, K.2    Umapathy, A.3
  • 44
    • 78650781323 scopus 로고    scopus 로고
    • Feasibility and robustness of amplification refractory mutation system (ARMS)-based KRAS testing using clinically available formalin-fixed, paraffin-embedded samples of colorectal cancers
    • Ogasawara N., Bando H., Kawamoto Y., et al. Feasibility and robustness of amplification refractory mutation system (ARMS)-based KRAS testing using clinically available formalin-fixed, paraffin-embedded samples of colorectal cancers. Jpn J Clin Oncol 2011, 41:52-56.
    • (2011) Jpn J Clin Oncol , vol.41 , pp. 52-56
    • Ogasawara, N.1    Bando, H.2    Kawamoto, Y.3
  • 45
    • 0036177726 scopus 로고    scopus 로고
    • Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool
    • Prix L., Uciechowski P., Bockmann B., Giesing M., Schuetz A.J. Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool. Clin Chem 2002, 48:428-435.
    • (2002) Clin Chem , vol.48 , pp. 428-435
    • Prix, L.1    Uciechowski, P.2    Bockmann, B.3    Giesing, M.4    Schuetz, A.J.5
  • 46
    • 0029865354 scopus 로고    scopus 로고
    • Simple and sensitive detection of mutations in the ras proto-oncogenes using PNA-mediated PCR clamping
    • Thiede C., Bayerdorffer E., Blasczyk R., Wittig B., Neubauer A. Simple and sensitive detection of mutations in the ras proto-oncogenes using PNA-mediated PCR clamping. Nucleic Acids Res 1996, 24:983-984.
    • (1996) Nucleic Acids Res , vol.24 , pp. 983-984
    • Thiede, C.1    Bayerdorffer, E.2    Blasczyk, R.3    Wittig, B.4    Neubauer, A.5
  • 47
    • 70350445909 scopus 로고    scopus 로고
    • Sensitive detection of KRAS mutations in archived formalin-fixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization
    • Ausch C., Buxhofer-Ausch V., Oberkanins C., et al. Sensitive detection of KRAS mutations in archived formalin-fixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization. J Mol Diagn 2009, 11:508-513.
    • (2009) J Mol Diagn , vol.11 , pp. 508-513
    • Ausch, C.1    Buxhofer-Ausch, V.2    Oberkanins, C.3
  • 48
    • 79952257109 scopus 로고    scopus 로고
    • SNaPshot and StripAssay as valuable alternatives to direct sequencing for KRAS mutation detection in colon cancer routine diagnostics
    • Farina Sarasqueta A., Moerland E., de Bruyne H., et al. SNaPshot and StripAssay as valuable alternatives to direct sequencing for KRAS mutation detection in colon cancer routine diagnostics. J Mol Diagn 2011, 13:199-205.
    • (2011) J Mol Diagn , vol.13 , pp. 199-205
    • Farina Sarasqueta, A.1    Moerland, E.2    de Bruyne, H.3
  • 49
    • 78751564399 scopus 로고    scopus 로고
    • KRAS genotyping as biomarker in colorectal cancer: a comparison of three commercial kits on histologic material
    • Cavallini A., Valentini A.M., Lippolis C., Campanella D., Guerra V., Caruso M.L. KRAS genotyping as biomarker in colorectal cancer: a comparison of three commercial kits on histologic material. Anticancer Res 2010, 30:5251-5256.
    • (2010) Anticancer Res , vol.30 , pp. 5251-5256
    • Cavallini, A.1    Valentini, A.M.2    Lippolis, C.3    Campanella, D.4    Guerra, V.5    Caruso, M.L.6
  • 50
    • 84863844267 scopus 로고    scopus 로고
    • KRAS assay selection: sensitivity and accuracy in clinical application
    • Herreros-Villanueva M., Aggarwal G. KRAS assay selection: sensitivity and accuracy in clinical application. Mol Biol Rep 2012, 39:2467-2470.
    • (2012) Mol Biol Rep , vol.39 , pp. 2467-2470
    • Herreros-Villanueva, M.1    Aggarwal, G.2
  • 51
    • 23044509486 scopus 로고    scopus 로고
    • Distinguishing different DNA heterozygotes by high-resolution melting
    • Graham R., Liew M., Meadows C., Lyon E., Wittwer C.T. Distinguishing different DNA heterozygotes by high-resolution melting. Clin Chem 2005, 51:1295-1298.
    • (2005) Clin Chem , vol.51 , pp. 1295-1298
    • Graham, R.1    Liew, M.2    Meadows, C.3    Lyon, E.4    Wittwer, C.T.5
  • 52
    • 40749117206 scopus 로고    scopus 로고
    • Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis
    • Takano E.A., Mitchell G., Fox S.B., Dobrovic A. Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis. BMC Cancer 2008, 8:59.
    • (2008) BMC Cancer , vol.8 , pp. 59
    • Takano, E.A.1    Mitchell, G.2    Fox, S.B.3    Dobrovic, A.4
  • 53
    • 48649092117 scopus 로고    scopus 로고
    • High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer
    • Simi L., Pratesi N., Vignoli M., et al. High-resolution melting analysis for rapid detection of KRAS, BRAF, and PIK3CA gene mutations in colorectal cancer. Am J Clin Pathol 2008, 130:247-253.
    • (2008) Am J Clin Pathol , vol.130 , pp. 247-253
    • Simi, L.1    Pratesi, N.2    Vignoli, M.3
  • 54
    • 33846641709 scopus 로고    scopus 로고
    • High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer
    • Krypuy M., Newnham G.M., Thomas D.M., Conron M., Dobrovic A. High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer. BMC Cancer 2006, 6:295.
    • (2006) BMC Cancer , vol.6 , pp. 295
    • Krypuy, M.1    Newnham, G.M.2    Thomas, D.M.3    Conron, M.4    Dobrovic, A.5
  • 55
    • 84864886864 scopus 로고    scopus 로고
    • KRAS mutation detection by high-resolution melting analysis significantly predicts clinical benefit of cetuximab in metastatic colorectal cancer
    • Malapelle U., Carlomagno C., Salatiello M., et al. KRAS mutation detection by high-resolution melting analysis significantly predicts clinical benefit of cetuximab in metastatic colorectal cancer. Br J Cancer 2012, 107:626-631.
    • (2012) Br J Cancer , vol.107 , pp. 626-631
    • Malapelle, U.1    Carlomagno, C.2    Salatiello, M.3
  • 56
    • 84878173533 scopus 로고    scopus 로고
    • KRAS mutations in patients with colorectal cancer as detected by high-resolution melting analysis and direct sequencing
    • Akiyoshi K., Yamada Y., Honma Y., et al. KRAS mutations in patients with colorectal cancer as detected by high-resolution melting analysis and direct sequencing. Anticancer Res 2013, 33:2129-2134.
    • (2013) Anticancer Res , vol.33 , pp. 2129-2134
    • Akiyoshi, K.1    Yamada, Y.2    Honma, Y.3
  • 57
    • 78149468081 scopus 로고    scopus 로고
    • KRAS mutation detection and prognostic potential in sporadic colorectal cancer using high-resolution melting analysis
    • Deschoolmeester V., Boeckx C., Baay M., et al. KRAS mutation detection and prognostic potential in sporadic colorectal cancer using high-resolution melting analysis. Br J Cancer 2010, 103:1627-1636.
    • (2010) Br J Cancer , vol.103 , pp. 1627-1636
    • Deschoolmeester, V.1    Boeckx, C.2    Baay, M.3
  • 58
    • 84866522096 scopus 로고    scopus 로고
    • High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS, BRAF, PIK3CA, and AKT1 mutations in formalin-fixed, paraffin-embedded tissues
    • Ney J.T., Froehner S., Roesler A., Buettner R., Merkelbach-Bruse S. High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS, BRAF, PIK3CA, and AKT1 mutations in formalin-fixed, paraffin-embedded tissues. Arch Pathol Lab Med 2012, 136:983-992.
    • (2012) Arch Pathol Lab Med , vol.136 , pp. 983-992
    • Ney, J.T.1    Froehner, S.2    Roesler, A.3    Buettner, R.4    Merkelbach-Bruse, S.5
  • 59
    • 70349653814 scopus 로고    scopus 로고
    • Detection of KRAS mutations in colorectal cancer by high-resolution melting analysis
    • Ma E.S., Wong C.L., Law F.B., Chan W.K., Siu D. Detection of KRAS mutations in colorectal cancer by high-resolution melting analysis. J Clin Pathol 2009, 62:886-891.
    • (2009) J Clin Pathol , vol.62 , pp. 886-891
    • Ma, E.S.1    Wong, C.L.2    Law, F.B.3    Chan, W.K.4    Siu, D.5
  • 60
    • 84868377537 scopus 로고    scopus 로고
    • High-resolution melting assay (HRMA) is a simple and sensitive stool-based DNA Test for the detection of mutations in colorectal neoplasms
    • Li B.S., Wang X.Y., Xu A.G., et al. High-resolution melting assay (HRMA) is a simple and sensitive stool-based DNA Test for the detection of mutations in colorectal neoplasms. Clin Colorectal Cancer 2012, 11:280-290.
    • (2012) Clin Colorectal Cancer , vol.11 , pp. 280-290
    • Li, B.S.1    Wang, X.Y.2    Xu, A.G.3
  • 61
    • 84870393673 scopus 로고    scopus 로고
    • The utility of diagnostic biopsy specimens for predictive molecular testing in colorectal cancer
    • Fadhil W., Ibrahem S., Seth R., et al. The utility of diagnostic biopsy specimens for predictive molecular testing in colorectal cancer. Histopathology 2012, 61:1117-1124.
    • (2012) Histopathology , vol.61 , pp. 1117-1124
    • Fadhil, W.1    Ibrahem, S.2    Seth, R.3
  • 62
    • 78649516331 scopus 로고    scopus 로고
    • Comparative analysis of pyrosequencing and QMC-PCR in conjunction with high resolution melting for KRAS/BRAF mutation detection
    • Ibrahem S., Seth R., O'Sullivan B., Fadhil W., Taniere P., Ilyas M. Comparative analysis of pyrosequencing and QMC-PCR in conjunction with high resolution melting for KRAS/BRAF mutation detection. Int J Exp Pathol 2010, 91:500-505.
    • (2010) Int J Exp Pathol , vol.91 , pp. 500-505
    • Ibrahem, S.1    Seth, R.2    O'Sullivan, B.3    Fadhil, W.4    Taniere, P.5    Ilyas, M.6
  • 63
    • 84882944057 scopus 로고    scopus 로고
    • Highly sensitive and noninvasive detection of epidermal growth factor receptor T790M mutation in non-small cell lung cancer
    • He C., Zheng L., Xu Y., Liu M., Li Y., Xu J. Highly sensitive and noninvasive detection of epidermal growth factor receptor T790M mutation in non-small cell lung cancer. Clin Chim Acta 2013, 425:119-124.
    • (2013) Clin Chim Acta , vol.425 , pp. 119-124
    • He, C.1    Zheng, L.2    Xu, Y.3    Liu, M.4    Li, Y.5    Xu, J.6
  • 64
    • 0036898622 scopus 로고    scopus 로고
    • P16(INK4A) Hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer
    • Bearzatto A., Conte D., Frattini M., et al. p16(INK4A) Hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer. Clin Cancer Res 2002, 8:3782-3787.
    • (2002) Clin Cancer Res , vol.8 , pp. 3782-3787
    • Bearzatto, A.1    Conte, D.2    Frattini, M.3
  • 65
    • 31544459265 scopus 로고    scopus 로고
    • Detection of EGFR gene mutation in lung cancer by mutant-enriched polymerase chain reaction assay
    • Asano H., Toyooka S., Tokumo M., et al. Detection of EGFR gene mutation in lung cancer by mutant-enriched polymerase chain reaction assay. Clin Cancer Res 2006, 12:43-48.
    • (2006) Clin Cancer Res , vol.12 , pp. 43-48
    • Asano, H.1    Toyooka, S.2    Tokumo, M.3
  • 66
    • 79960435101 scopus 로고    scopus 로고
    • Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer
    • Molinari F., Felicioni L., Buscarino M., et al. Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer. Clin Cancer Res 2011, 17:4901-4914.
    • (2011) Clin Cancer Res , vol.17 , pp. 4901-4914
    • Molinari, F.1    Felicioni, L.2    Buscarino, M.3
  • 67
    • 79952940017 scopus 로고    scopus 로고
    • COLD-PCR: improving the sensitivity of molecular diagnostics assays
    • Milbury C.A., Li J., Liu P., Makrigiorgos G.M. COLD-PCR: improving the sensitivity of molecular diagnostics assays. Expert Rev Mol Diagn 2011, 11:159-169.
    • (2011) Expert Rev Mol Diagn , vol.11 , pp. 159-169
    • Milbury, C.A.1    Li, J.2    Liu, P.3    Makrigiorgos, G.M.4
  • 68
    • 79958062775 scopus 로고    scopus 로고
    • Rapid and sensitive detection of KRAS mutation after fast-COLD-PCR enrichment and high-resolution melting analysis
    • Song C., Milbury C.A., Li J., Liu P., Zhao M., Makrigiorgos G.M. Rapid and sensitive detection of KRAS mutation after fast-COLD-PCR enrichment and high-resolution melting analysis. Diagn Mol Pathol 2011, 20:81-89.
    • (2011) Diagn Mol Pathol , vol.20 , pp. 81-89
    • Song, C.1    Milbury, C.A.2    Li, J.3    Liu, P.4    Zhao, M.5    Makrigiorgos, G.M.6
  • 69
    • 84857816896 scopus 로고    scopus 로고
    • COLD-PCR enrichment of rare cancer mutations prior to targeted amplicon resequencing
    • Milbury C.A., Correll M., Quackenbush J., Rubio R., Makrigiorgos G.M. COLD-PCR enrichment of rare cancer mutations prior to targeted amplicon resequencing. Clin Chem 2012, 58:580-589.
    • (2012) Clin Chem , vol.58 , pp. 580-589
    • Milbury, C.A.1    Correll, M.2    Quackenbush, J.3    Rubio, R.4    Makrigiorgos, G.M.5
  • 70
    • 64149087406 scopus 로고    scopus 로고
    • Coamplification at lower denaturation temperature-PCR increases mutation-detection selectivity of TaqMan-based real-time PCR
    • Li J., Wang L., Janne P.A., Makrigiorgos G.M. Coamplification at lower denaturation temperature-PCR increases mutation-detection selectivity of TaqMan-based real-time PCR. Clin Chem 2009, 55:748-756.
    • (2009) Clin Chem , vol.55 , pp. 748-756
    • Li, J.1    Wang, L.2    Janne, P.A.3    Makrigiorgos, G.M.4
  • 71
    • 64149103904 scopus 로고    scopus 로고
    • PCR-based methods for the enrichment of minority alleles and mutations
    • Milbury C.A., Li J., Makrigiorgos G.M. PCR-based methods for the enrichment of minority alleles and mutations. Clin Chem 2009, 55:632-640.
    • (2009) Clin Chem , vol.55 , pp. 632-640
    • Milbury, C.A.1    Li, J.2    Makrigiorgos, G.M.3
  • 72
    • 78649538649 scopus 로고    scopus 로고
    • Increased sensitivity of KRAS mutation detection by high-resolution melting analysis of COLD-PCR products
    • Kristensen L.S., Daugaard I.L., Christensen M., Hamilton-Dutoit S., Hager H., Hansen L.L. Increased sensitivity of KRAS mutation detection by high-resolution melting analysis of COLD-PCR products. Hum Mutat 2010, 31:1366-1373.
    • (2010) Hum Mutat , vol.31 , pp. 1366-1373
    • Kristensen, L.S.1    Daugaard, I.L.2    Christensen, M.3    Hamilton-Dutoit, S.4    Hager, H.5    Hansen, L.L.6
  • 73
    • 84885428325 scopus 로고    scopus 로고
    • Sensitive detection of KRAS mutations using enhanced-ice-COLD-PCR mutation enrichment and direct sequence identification
    • How Kit A., Mazaleyrat N., Daunay A., Nielsen H.M., Terris B., Tost J. Sensitive detection of KRAS mutations using enhanced-ice-COLD-PCR mutation enrichment and direct sequence identification. Hum Mutat 2013, 34:1568-1580.
    • (2013) Hum Mutat , vol.34 , pp. 1568-1580
    • How Kit, A.1    Mazaleyrat, N.2    Daunay, A.3    Nielsen, H.M.4    Terris, B.5    Tost, J.6
  • 75
    • 32644435012 scopus 로고    scopus 로고
    • Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe
    • Luo J.D., Chan E.C., Shih C.L., et al. Detection of rare mutant K-ras DNA in a single-tube reaction using peptide nucleic acid as both PCR clamp and sensor probe. Nucleic Acids Res 2006, 34:e12.
    • (2006) Nucleic Acids Res , vol.34
    • Luo, J.D.1    Chan, E.C.2    Shih, C.L.3
  • 76
    • 33746334153 scopus 로고    scopus 로고
    • Promising nucleic acid analogs and mimics: characteristic features and applications of PNA, LNA, and morpholino
    • Karkare S., Bhatnagar D. Promising nucleic acid analogs and mimics: characteristic features and applications of PNA, LNA, and morpholino. Appl Microbiol Biotechnol 2006, 71:575-586.
    • (2006) Appl Microbiol Biotechnol , vol.71 , pp. 575-586
    • Karkare, S.1    Bhatnagar, D.2
  • 77
    • 77954350475 scopus 로고    scopus 로고
    • Detection of low-level KRAS mutations using PNA-mediated asymmetric PCR clamping and melting curve analysis with unlabeled probes
    • Oh J.E., Lim H.S., An C.H., et al. Detection of low-level KRAS mutations using PNA-mediated asymmetric PCR clamping and melting curve analysis with unlabeled probes. J Mol Diagn 2010, 12:418-424.
    • (2010) J Mol Diagn , vol.12 , pp. 418-424
    • Oh, J.E.1    Lim, H.S.2    An, C.H.3
  • 78
    • 84879903169 scopus 로고    scopus 로고
    • Colorectal cancer patients with low abundance of KRAS mutation may benefit from EGFR antibody therapy
    • Yu S., Xiao X., Lu J., Qian X., Liu B., Feng J. Colorectal cancer patients with low abundance of KRAS mutation may benefit from EGFR antibody therapy. PLoS One 2013, 8:e68022.
    • (2013) PLoS One , vol.8
    • Yu, S.1    Xiao, X.2    Lu, J.3    Qian, X.4    Liu, B.5    Feng, J.6
  • 79
    • 84863272505 scopus 로고    scopus 로고
    • Modified PNA-PCR method: a convenient and accurate method to screen plasma KRAS mutations of cancer patients
    • Yu S., Wu J., Xu S., Tan G., Liu B., Feng J. Modified PNA-PCR method: a convenient and accurate method to screen plasma KRAS mutations of cancer patients. Cancer Biol Ther 2012, 13:314-320.
    • (2012) Cancer Biol Ther , vol.13 , pp. 314-320
    • Yu, S.1    Wu, J.2    Xu, S.3    Tan, G.4    Liu, B.5    Feng, J.6
  • 80
    • 77951892843 scopus 로고    scopus 로고
    • The frequency of KRAS mutation detection in human colon carcinoma is influenced by the sensitivity of assay methodology: a comparison between direct sequencing and real-time PCR
    • Kobunai T., Watanabe T., Yamamoto Y., Eshima K. The frequency of KRAS mutation detection in human colon carcinoma is influenced by the sensitivity of assay methodology: a comparison between direct sequencing and real-time PCR. Biochem Biophys Res Commun 2010, 395:158-162.
    • (2010) Biochem Biophys Res Commun , vol.395 , pp. 158-162
    • Kobunai, T.1    Watanabe, T.2    Yamamoto, Y.3    Eshima, K.4
  • 81
    • 82655177985 scopus 로고    scopus 로고
    • Frequency of KRAS, BRAF, and PIK3CA mutations in advanced colorectal cancers: comparison of peptide nucleic acid-mediated PCR clamping and direct sequencing in formalin-fixed, paraffin-embedded tissue
    • Kwon M.J., Lee S.E., Kang S.Y., Choi Y.L. Frequency of KRAS, BRAF, and PIK3CA mutations in advanced colorectal cancers: comparison of peptide nucleic acid-mediated PCR clamping and direct sequencing in formalin-fixed, paraffin-embedded tissue. Pathol Res Pract 2011, 207:762-768.
    • (2011) Pathol Res Pract , vol.207 , pp. 762-768
    • Kwon, M.J.1    Lee, S.E.2    Kang, S.Y.3    Choi, Y.L.4
  • 82
    • 0036011282 scopus 로고    scopus 로고
    • Pyrosequencing: an accurate detection platform for single nucleotide polymorphisms
    • Fakhrai-Rad H., Pourmand N., Ronaghi M. Pyrosequencing: an accurate detection platform for single nucleotide polymorphisms. Hum Mutat 2002, 19:479-485.
    • (2002) Hum Mutat , vol.19 , pp. 479-485
    • Fakhrai-Rad, H.1    Pourmand, N.2    Ronaghi, M.3
  • 84
    • 14644422591 scopus 로고    scopus 로고
    • Use of pyrosequencing of 16S rRNA fragments to differentiate between bacteria responsible for neonatal sepsis
    • Jordan J.A., Butchko A.R., Durso M.B. Use of pyrosequencing of 16S rRNA fragments to differentiate between bacteria responsible for neonatal sepsis. J Mol Diagn 2005, 7:105-110.
    • (2005) J Mol Diagn , vol.7 , pp. 105-110
    • Jordan, J.A.1    Butchko, A.R.2    Durso, M.B.3
  • 85
    • 23844497341 scopus 로고    scopus 로고
    • Sensitive sequencing method for KRAS mutation detection by Pyrosequencing
    • Ogino S., Kawasaki T., Brahmandam M., et al. Sensitive sequencing method for KRAS mutation detection by Pyrosequencing. J Mol Diagn 2005, 7:413-421.
    • (2005) J Mol Diagn , vol.7 , pp. 413-421
    • Ogino, S.1    Kawasaki, T.2    Brahmandam, M.3
  • 86
    • 78649522401 scopus 로고    scopus 로고
    • KRAS analysis in colorectal carcinoma: analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice
    • Sundstrom M., Edlund K., Lindell M., et al. KRAS analysis in colorectal carcinoma: analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice. BMC Cancer 2010, 10:660.
    • (2010) BMC Cancer , vol.10 , pp. 660
    • Sundstrom, M.1    Edlund, K.2    Lindell, M.3
  • 88
    • 67449158731 scopus 로고    scopus 로고
    • Pyrosequencing method to detect KRAS mutation in formalin-fixed and paraffin-embedded tumor tissues
    • Dufort S., Richard M.J., de Fraipont F. Pyrosequencing method to detect KRAS mutation in formalin-fixed and paraffin-embedded tumor tissues. Anal Biochem 2009, 391:166-168.
    • (2009) Anal Biochem , vol.391 , pp. 166-168
    • Dufort, S.1    Richard, M.J.2    de Fraipont, F.3
  • 89
    • 84861433613 scopus 로고    scopus 로고
    • Pyrosequencing data analysis software: a useful tool for EGFR, KRAS, and BRAF mutation analysis
    • Shen S., Qin D. Pyrosequencing data analysis software: a useful tool for EGFR, KRAS, and BRAF mutation analysis. Diagn Pathol 2012, 7:56.
    • (2012) Diagn Pathol , vol.7 , pp. 56
    • Shen, S.1    Qin, D.2
  • 91
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F., Martini M., Molinari F., et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008, 26:5705-5712.
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 92
    • 84873817509 scopus 로고    scopus 로고
    • Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study
    • Andre T., Blons H., Mabro M., et al. Panitumumab combined with irinotecan for patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy: a GERCOR efficacy, tolerance, and translational molecular study. Ann Oncol 2013, 24:412-419.
    • (2013) Ann Oncol , vol.24 , pp. 412-419
    • Andre, T.1    Blons, H.2    Mabro, M.3
  • 93
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    • De Roock W., Claes B., Bernasconi D., et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010, 11:753-762.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 94
    • 78649744892 scopus 로고    scopus 로고
    • Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?
    • Rizzo S., Bronte G., Fanale D., et al. Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?. Cancer Treat Rev 2010, 36(Suppl. 3):S56-S61.
    • (2010) Cancer Treat Rev , vol.36 , Issue.SUPPL. 3
    • Rizzo, S.1    Bronte, G.2    Fanale, D.3
  • 95
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • Bardelli A., Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol 2010, 28:1254-1261.
    • (2010) J Clin Oncol , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 96
  • 97
    • 77955604846 scopus 로고    scopus 로고
    • Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal cancer
    • Perkins G., Lievre A., Ramacci C., et al. Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal cancer. Int J Cancer 2010, 127:1321-1331.
    • (2010) Int J Cancer , vol.127 , pp. 1321-1331
    • Perkins, G.1    Lievre, A.2    Ramacci, C.3
  • 98
    • 84860702958 scopus 로고    scopus 로고
    • PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer
    • Sood A., McClain D., Maitra R., et al. PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer. Clin Colorectal Cancer 2012, 11:143-150.
    • (2012) Clin Colorectal Cancer , vol.11 , pp. 143-150
    • Sood, A.1    McClain, D.2    Maitra, R.3
  • 99
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E., Kohne C.H., Lang I., et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 2011, 29:2011-2019.
    • (2011) J Clin Oncol , vol.29 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3
  • 100
    • 78649473910 scopus 로고    scopus 로고
    • The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients
    • Farina-Sarasqueta A., van Lijnschoten G., Moerland E., et al. The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients. Ann Oncol 2010, 21:2396-2402.
    • (2010) Ann Oncol , vol.21 , pp. 2396-2402
    • Farina-Sarasqueta, A.1    van Lijnschoten, G.2    Moerland, E.3
  • 101
    • 79952282994 scopus 로고    scopus 로고
    • BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer
    • Yokota T., Ura T., Shibata N., et al. BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer. Br J Cancer 2011, 104:856-862.
    • (2011) Br J Cancer , vol.104 , pp. 856-862
    • Yokota, T.1    Ura, T.2    Shibata, N.3
  • 102
    • 84902189509 scopus 로고    scopus 로고
    • Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology
    • [Epub ahead of print]
    • Ogino S., Lochhead P., Giovannucci E., Meyerhardt J.A., Fuchs C.S., Chan A.T. Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology. Oncogene 2013 Jun 24, [Epub ahead of print]. 10.1038/onc.2013.244.
    • (2013) Oncogene
    • Ogino, S.1    Lochhead, P.2    Giovannucci, E.3    Meyerhardt, J.A.4    Fuchs, C.S.5    Chan, A.T.6
  • 103
    • 84883680951 scopus 로고    scopus 로고
    • Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
    • Douillard J.Y., Oliner K.S., Siena S., et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 2013, 369:1023-1034.
    • (2013) N Engl J Med , vol.369 , pp. 1023-1034
    • Douillard, J.Y.1    Oliner, K.S.2    Siena, S.3
  • 104
    • 84877087305 scopus 로고    scopus 로고
    • Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer
    • Peeters M., Oliner K.S., Parker A., et al. Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase III study of metastatic colorectal cancer. Clin Cancer Res 2013, 19:1902-1912.
    • (2013) Clin Cancer Res , vol.19 , pp. 1902-1912
    • Peeters, M.1    Oliner, K.S.2    Parker, A.3
  • 105
    • 84877952198 scopus 로고    scopus 로고
    • Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing
    • Han S.W., Kim H.P., Shin J.Y., et al. Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing. PLoS One 2013, 8:e64271.
    • (2013) PLoS One , vol.8
    • Han, S.W.1    Kim, H.P.2    Shin, J.Y.3
  • 106
    • 53649088131 scopus 로고    scopus 로고
    • Applications of next-generation sequencing technologies in functional genomics
    • Morozova O., Marra M.A. Applications of next-generation sequencing technologies in functional genomics. Genomics 2008, 92:255-264.
    • (2008) Genomics , vol.92 , pp. 255-264
    • Morozova, O.1    Marra, M.A.2
  • 107
    • 84862605504 scopus 로고    scopus 로고
    • Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease
    • Bras J., Guerreiro R., Hardy J. Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease. Nat Rev Neurosci 2012, 13:453-464.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 453-464
    • Bras, J.1    Guerreiro, R.2    Hardy, J.3
  • 108
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies-the next generation
    • Metzker M.L. Sequencing technologies-the next generation. Nat Rev Genet 2010, 11:31-46.
    • (2010) Nat Rev Genet , vol.11 , pp. 31-46
    • Metzker, M.L.1
  • 109
    • 84868329014 scopus 로고    scopus 로고
    • Clinical implementation of KRAS testing in metastatic colorectal carcinoma: the pathologist's perspective
    • Ross J.S. Clinical implementation of KRAS testing in metastatic colorectal carcinoma: the pathologist's perspective. Arch Pathol Lab Med 2012, 136:1298-1307.
    • (2012) Arch Pathol Lab Med , vol.136 , pp. 1298-1307
    • Ross, J.S.1
  • 110
    • 84859934922 scopus 로고    scopus 로고
    • Nucleic acids from long-term preserved FFPE tissues are suitable for downstream analyses
    • Ludyga N., Grunwald B., Azimzadeh O., et al. Nucleic acids from long-term preserved FFPE tissues are suitable for downstream analyses. Virchows Arch 2012, 460:131-140.
    • (2012) Virchows Arch , vol.460 , pp. 131-140
    • Ludyga, N.1    Grunwald, B.2    Azimzadeh, O.3
  • 111
    • 77649185945 scopus 로고    scopus 로고
    • Comparison of methods in the recovery of nucleic acids from archival formalin-fixed paraffin-embedded autopsy tissues
    • Okello J.B., Zurek J., Devault A.M., et al. Comparison of methods in the recovery of nucleic acids from archival formalin-fixed paraffin-embedded autopsy tissues. Anal Biochem 2010, 400:110-117.
    • (2010) Anal Biochem , vol.400 , pp. 110-117
    • Okello, J.B.1    Zurek, J.2    Devault, A.M.3
  • 112
    • 80155187105 scopus 로고    scopus 로고
    • Nucleic acid quantity and quality from paraffin blocks: defining optimal fixation, processing and DNA/RNA extraction techniques
    • Turashvili G., Yang W., McKinney S., et al. Nucleic acid quantity and quality from paraffin blocks: defining optimal fixation, processing and DNA/RNA extraction techniques. Exp Mol Pathol 2012, 92:33-43.
    • (2012) Exp Mol Pathol , vol.92 , pp. 33-43
    • Turashvili, G.1    Yang, W.2    McKinney, S.3
  • 113
    • 77956910135 scopus 로고    scopus 로고
    • Multicentre validation study of nucleic acids extraction from FFPE tissues
    • Bonin S., Hlubek F., Benhattar J., et al. Multicentre validation study of nucleic acids extraction from FFPE tissues. Virchows Arch 2010, 457:309-317.
    • (2010) Virchows Arch , vol.457 , pp. 309-317
    • Bonin, S.1    Hlubek, F.2    Benhattar, J.3
  • 114
    • 65649113589 scopus 로고    scopus 로고
    • College of American Pathologists Molecular Pathology Resource C. Recommended principles and practices for validating clinical molecular pathology tests
    • Jennings L., Van Deerlin V.M., Gulley M.L. College of American Pathologists Molecular Pathology Resource C. Recommended principles and practices for validating clinical molecular pathology tests. Arch Pathol Lab Med 2009, 133:743-755.
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 743-755
    • Jennings, L.1    Van Deerlin, V.M.2    Gulley, M.L.3
  • 115
    • 66449099765 scopus 로고    scopus 로고
    • Checklist for optimization and validation of real-time PCR assays
    • Raymaekers M., Smets R., Maes B., Cartuyvels R. Checklist for optimization and validation of real-time PCR assays. J Clin Lab Anal 2009, 23:145-151.
    • (2009) J Clin Lab Anal , vol.23 , pp. 145-151
    • Raymaekers, M.1    Smets, R.2    Maes, B.3    Cartuyvels, R.4
  • 116
    • 78549273639 scopus 로고    scopus 로고
    • A standardized framework for the validation and verification of clinical molecular genetic tests
    • Mattocks C.J., Morris M.A., Matthijs G., et al. A standardized framework for the validation and verification of clinical molecular genetic tests. Eur J Hum Genet 2010, 18:1276-1288.
    • (2010) Eur J Hum Genet , vol.18 , pp. 1276-1288
    • Mattocks, C.J.1    Morris, M.A.2    Matthijs, G.3
  • 117
    • 77954605045 scopus 로고    scopus 로고
    • Validation of laboratory-developed molecular assays for infectious diseases
    • Burd E.M. Validation of laboratory-developed molecular assays for infectious diseases. Clin Microbiol Rev 2010, 23:550-576.
    • (2010) Clin Microbiol Rev , vol.23 , pp. 550-576
    • Burd, E.M.1


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