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Volumn 154, Issue 1, 2011, Pages 37-49

Systematic review: Anti-epidermal growth factor receptor treatment effect modification by KRAS mutations in advanced colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; K RAS PROTEIN;

EID: 79551580551     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-154-1-201101040-00006     Document Type: Review
Times cited : (156)

References (93)
  • 2
    • 55049134360 scopus 로고    scopus 로고
    • Chemotherapy for colorectal cancer liver metasta-ses
    • [PMID: 18838438]
    • Alberts SR, Wagman LD. Chemotherapy for colorectal cancer liver metasta-ses. Oncologist. 2008;13:1063-73. [PMID: 18838438]
    • (2008) Oncologist , vol.13 , pp. 1063-1073
    • Alberts, S.R.1    Wagman, L.D.2
  • 4
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes-the Achilles heal of cancer
    • [PMID: 12098689]
    • Weinstein IB. Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science. 2002;297:63-4. [PMID: 12098689]
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 5
    • 77956103532 scopus 로고    scopus 로고
    • A review of the most promising biomarkers in colorectal cancer: One step closer to targeted therapy
    • [PMID: 20584808]
    • Deschoolmeester V, Baay M, Specenier P, Lardon F, Vermorken JB. A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy. Oncologist. 2010;15:699-731. [PMID: 20584808]
    • (2010) Oncologist , vol.15 , pp. 699-731
    • Deschoolmeester, V.1    Baay, M.2    Specenier, P.3    Lardon, F.4    Vermorken, J.B.5
  • 6
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? The rationale for cancer therapy
    • [PMID: 12202782]
    • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist. 2002;7 Suppl 4:2-8. [PMID: 12202782]
    • (2002) Oncologist , vol.7 , Issue.4 SUPPL , pp. 2-8
    • Baselga, J.1
  • 7
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: Targets for cancer therapy
    • [PMID: 15122207]
    • Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer. 2004;4:361-70. [PMID: 15122207]
    • (2004) Nat Rev Cancer , vol.4 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 8
    • 19944426509 scopus 로고    scopus 로고
    • Impact of EGFR expression on colorectal cancer patient prognosis and survival
    • [PMID: 15598946]
    • Spano JP, Lagorce C, Atlan D, Milano G, Domont J, Benamouzig R, et al. Impact of EGFR expression on colorectal cancer patient prognosis and survival. Ann Oncol. 2005;16:102-8. [PMID: 15598946]
    • (2005) Ann Oncol , vol.16 , pp. 102-108
    • Spano, J.P.1    Lagorce, C.2    Atlan, D.3    Milano, G.4    Domont, J.5    Benamouzig, R.6
  • 9
    • 77649179941 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases
    • [PMID: 19701635]
    • Kuramochi H, Hayashi K, Nakajima G, Kamikozuru H, Yamamoto M, Danenberg KD, et al. Epidermal growth factor receptor (EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases. Cancer Chemother Pharmacol. 2010;65:825-31. [PMID: 19701635]
    • (2010) Cancer Chemother Pharmacol , vol.65 , pp. 825-831
    • Kuramochi, H.1    Hayashi, K.2    Nakajima, G.3    Kamikozuru, H.4    Yamamoto, M.5    Danenberg, K.D.6
  • 11
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory meta-static colorectal cancer
    • [PMID: 17470858]
    • Van Cutsem E, Peeters M, Siena S, Humblet Y, Hendlisz A, Neyns B, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory meta-static colorectal cancer. J Clin Oncol. 2007;25:1658-64. [PMID: 17470858]
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4    Hendlisz, A.5    Neyns, B.6
  • 12
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • [PMID: 2547513]
    • Bos JL. Ras oncogenes in human cancer: a review. Cancer Res. 1989;49: 4682-9. [PMID: 2547513]
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 13
    • 70349939382 scopus 로고    scopus 로고
    • Bi-omarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
    • [PMID: 19738166]
    • Siena S, Sartore-Bianchi A, Di Nicolantonio F, Balfour J, Bardelli A. Bi-omarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J Natl Cancer Inst. 2009;101: 1308-24. [PMID: 19738166]
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1308-1324
    • Siena, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Balfour, J.4    Bardelli, A.5
  • 14
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with met-astatic colorectal cancer
    • [PMID: 18316791]
    • Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, et al. Wild-type KRAS is required for panitumumab efficacy in patients with met-astatic colorectal cancer. J Clin Oncol. 2008;26:1626-34. [PMID: 18316791]
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3    van Cutsem, E.4    Siena, S.5    Freeman, D.J.6
  • 16
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colo-rectal cancer
    • [PMID: 19339720]
    • Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. Cetuximab and chemotherapy as initial treatment for metastatic colo-rectal cancer. N Engl J Med. 2009;360:1408-17. [PMID: 19339720]
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • van Cutsem, E.1    Köhne, C.H.2    Hitre, E.3    Zaluski, J.4    Chien, C.R.C.5    Makhson, A.6
  • 17
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetux-imab in the first-line treatment of metastatic colorectal cancer
    • [PMID: 19114683]
    • Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetux-imab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2009;27:663-71. [PMID: 19114683]
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3    Hartmann, J.T.4    Aparicio, J.5    de Braud, F.6
  • 18
    • 70449420123 scopus 로고    scopus 로고
    • Use of archived specimens in evaluation of prognostic and predictive biomarkers
    • [PMID: 19815849]
    • Simon RM, Paik S, Hayes DF. Use of archived specimens in evaluation of prognostic and predictive biomarkers. J Natl Cancer Inst. 2009;101:1446-52. [PMID: 19815849]
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1446-1452
    • Simon, R.M.1    Paik, S.2    Hayes, D.F.3
  • 19
    • 33745427131 scopus 로고    scopus 로고
    • Tracking the epidemiology of human genes in the literature: The HuGE Published Literature database
    • [PMID: 16641305]
    • Lin BK, Clyne M, Walsh M, Gomez O, Yu W, Gwinn M, et al. Tracking the epidemiology of human genes in the literature: the HuGE Published Literature database. Am J Epidemiol. 2006;164:1-4. [PMID: 16641305]
    • (2006) Am J Epidemiol , vol.164 , pp. 1-4
    • Lin, B.K.1    Clyne, M.2    Walsh, M.3    Gomez, O.4    Yu, W.5    Gwinn, M.6
  • 20
    • 77955084711 scopus 로고    scopus 로고
    • dbCPCO: A database of genetic markers tested for their predictive and prognostic value in colorectal cancer
    • [PMID: 20506273]
    • Savas S, Younghusband HB. dbCPCO: a database of genetic markers tested for their predictive and prognostic value in colorectal cancer. Hum Mutat. 2010; 31:901-7. [PMID: 20506273]
    • (2010) Hum Mutat , vol.31 , pp. 901-907
    • Savas, S.1    Younghusband, H.B.2
  • 21
    • 34548503420 scopus 로고    scopus 로고
    • End points in advanced colon cancer clinical trials: A review and proposal
    • [PMID: 17704403]
    • Allegra C, Blanke C, Buyse M, Goldberg R, Grothey A, Meropol NJ, et al. End points in advanced colon cancer clinical trials: a review and proposal. J Clin Oncol. 2007;25:3572-5. [PMID: 17704403]
    • (2007) J Clin Oncol , vol.25 , pp. 3572-3575
    • Allegra, C.1    Blanke, C.2    Buyse, M.3    Goldberg, R.4    Grothey, A.5    Meropol, N.J.6
  • 22
    • 59749089432 scopus 로고    scopus 로고
    • Targeted therapy for advanced colorectal cancer-more is not always better [Editorial]
    • [PMID: 19196680]
    • Mayer RJ. Targeted therapy for advanced colorectal cancer-more is not always better [Editorial]. N Engl J Med. 2009;360:623-5. [PMID: 19196680]
    • (2009) N Engl J Med , vol.360 , pp. 623-625
    • Mayer, R.J.1
  • 23
    • 62249094521 scopus 로고    scopus 로고
    • Overstating the evidence: Double counting in meta-analysis and related problems
    • [PMID: 19216779]
    • Senn SJ. Overstating the evidence: double counting in meta-analysis and related problems. BMC Med Res Methodol. 2009;9:10. [PMID: 19216779]
    • (2009) BMC Med Res Methodol , vol.9 , pp. 10
    • Senn, S.J.1
  • 24
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • [PMID: 9921604]
    • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 1998; 17:2815-34. [PMID: 9921604]
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 25
    • 13644267742 scopus 로고    scopus 로고
    • Meta-analysis when only the median survival times are known: A comparison with individual patient data results
    • [PMID: 15736523]
    • Michiels S, Piedbois P, Burdett S, Syz N, Stewart L, Pignon JP. Meta-analysis when only the median survival times are known: a comparison with individual patient data results. Int J Technol Assess Health Care. 2005;21:119-25. [PMID: 15736523]
    • (2005) Int J Technol Assess Health Care , vol.21 , pp. 119-125
    • Michiels, S.1    Piedbois, P.2    Burdett, S.3    Syz, N.4    Stewart, L.5    Pignon, J.P.6
  • 26
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • [PMID: 17555582]
    • Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007;8: 16. [PMID: 17555582]
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3    Burdett, S.4    Sydes, M.R.5
  • 28
    • 23844534811 scopus 로고    scopus 로고
    • Reporting recommendations for tumor marker prognostic studies (REMARK)
    • [PMID: 16106022], Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics
    • McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM; Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics. Reporting recommendations for tumor marker prognostic studies (REMARK). J Natl Cancer Inst. 2005;97:1180-4. [PMID: 16106022]
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1180-1184
    • McShane, L.M.1    Altman, D.G.2    Sauerbrei, W.3    Taube, S.E.4    Gion, M.5    Clark, G.M.6
  • 29
    • 84921702413 scopus 로고    scopus 로고
    • Interaction revisited: The difference between two estimates
    • [PMID: 12543843]
    • Altman DG, Bland JM. Interaction revisited: the difference between two estimates. BMJ. 2003;326:219. [PMID: 12543843]
    • (2003) BMJ , pp. 326
    • Altman, D.G.1    Bland, J.M.2
  • 31
    • 58049206683 scopus 로고    scopus 로고
    • Cochrane Diagnostic Test Accuracy Working Group. Systematic reviews of diagnostic test accuracy
    • [PMID: 19075208]
    • Leeflang MM, Deeks JJ, Gatsonis C, Bossuyt PM; Cochrane Diagnostic Test Accuracy Working Group. Systematic reviews of diagnostic test accuracy. Ann Intern Med. 2008;149:889-97. [PMID: 19075208]
    • (2008) Ann Intern Med , vol.149 , pp. 889-897
    • Leeflang, M.M.1    Deeks, J.J.2    Gatsonis, C.3    Bossuyt, P.M.4
  • 32
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • [PMID: 18804418]
    • Linardou H, Dahabreh IJ, Kanaloupiti D, Siannis F, Bafaloukos D, Kos-midis P, et al. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol. 2008;9:962-72. [PMID: 18804418]
    • (2008) Lancet Oncol , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3    Siannis, F.4    Bafaloukos, D.5    Kos-Midis, P.6
  • 33
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • [PMID: 3802833]
    • DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-88. [PMID: 3802833]
    • (1986) Control Clin Trials , vol.7 , pp. 177-188
    • Dersimonian, R.1    Laird, N.2
  • 34
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • [PMID: 12958120]
    • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-60. [PMID: 12958120]
    • (2003) BMJ , vol.327 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3    Altman, D.G.4
  • 35
    • 0028659004 scopus 로고
    • Operating characteristics of a rank correlation test for publication bias
    • [PMID: 7786990]
    • Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088-101. [PMID: 7786990]
    • (1994) Biometrics , vol.50 , pp. 1088-1101
    • Begg, C.B.1    Mazumdar, M.2
  • 36
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • [PMID: 9310563]
    • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-34. [PMID: 9310563]
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Smith, G.D.2    Schneider, M.3    Minder, C.4
  • 37
    • 23644457189 scopus 로고    scopus 로고
    • In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias
    • [PMID: 16085192]
    • Terrin N, Schmid CH, Lau J. In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias. J Clin Epidemiol. 2005; 58:894-901. [PMID: 16085192]
    • (2005) J Clin Epidemiol , vol.58 , pp. 894-901
    • Terrin, N.1    Schmid, C.H.2    Lau, J.3
  • 38
    • 33748935095 scopus 로고    scopus 로고
    • The case of the misleading funnel plot
    • [PMID: 16974018]
    • Lau J, Ioannidis JP, Terrin N, Schmid CH, Olkin I. The case of the misleading funnel plot. BMJ. 2006;333:597-600. [PMID: 16974018]
    • (2006) BMJ , vol.333 , pp. 597-600
    • Lau, J.1    Ioannidis, J.P.2    Terrin, N.3    Schmid, C.H.4    Olkin, I.5
  • 39
    • 24944498883 scopus 로고    scopus 로고
    • Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews
    • [PMID: 16168343]
    • Reitsma JB, Glas AS, Rutjes AW, Scholten RJ, Bossuyt PM, Zwinderman AH. Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews. J Clin Epidemiol. 2005;58:982-90. [PMID: 16168343]
    • (2005) J Clin Epidemiol , vol.58 , pp. 982-990
    • Reitsma, J.B.1    Glas, A.S.2    Rutjes, A.W.3    Scholten, R.J.4    Bossuyt, P.M.5    Zwinderman, A.H.6
  • 40
    • 33750696367 scopus 로고    scopus 로고
    • Bivariate meta-analysis of sensitivity and specificity with sparse data: A generalized linear mixed model approach [Letter]
    • author reply 1332-3. [PMID: 17098577]
    • Chu H, Cole SR. Bivariate meta-analysis of sensitivity and specificity with sparse data: a generalized linear mixed model approach [Letter]. J Clin Epidemiol. 2006;59:1331-2; author reply 1332-3. [PMID: 17098577]
    • (2006) J Clin Epidemiol , vol.59 , pp. 1331-1332
    • Chu, H.1    Cole, S.R.2
  • 41
    • 68949144867 scopus 로고    scopus 로고
    • Meta-analysis of diagnostic accuracy using hierarchical logistic regression
    • Harbord RM, Whiting P. metandi: Meta-analysis of diagnostic accuracy using hierarchical logistic regression. Stata Journal. 2009;9:211-29.
    • (2009) Stata Journal , vol.9 , pp. 211-229
    • Harbord, R.M.1    Whiting, P.2    Metandi3
  • 42
    • 0042926567 scopus 로고    scopus 로고
    • Improved tests for a random effects meta-regression with a single covariate
    • [PMID: 12939780]
    • Knapp G, Hartung J. Improved tests for a random effects meta-regression with a single covariate. Stat Med. 2003;22:2693-710. [PMID: 12939780]
    • (2003) Stat Med , vol.22 , pp. 2693-2710
    • Knapp, G.1    Hartung, J.2
  • 43
    • 0037098178 scopus 로고    scopus 로고
    • How should meta-regression analyses be undertaken and interpreted?
    • [PMID: 12111920]
    • Thompson SG, Higgins JP. How should meta-regression analyses be undertaken and interpreted? Stat Med. 2002;21:1559-73. [PMID: 12111920]
    • (2002) Stat Med , vol.21 , pp. 1559-1573
    • Thompson, S.G.1    Higgins, J.P.2
  • 44
    • 0037186429 scopus 로고    scopus 로고
    • Advanced methods in meta-analysis: Multivariate approach and meta-regression
    • [PMID: 11836738]
    • van Houwelingen HC, Arends LR, Stijnen T. Advanced methods in meta-analysis: multivariate approach and meta-regression. Stat Med. 2002;21:589-624. [PMID: 11836738]
    • (2002) Stat Med , vol.21 , pp. 589-624
    • van Houwelingen, H.C.1    Arends, L.R.2    Stijnen, T.3
  • 45
    • 73649108585 scopus 로고    scopus 로고
    • Meta-Analyst: Software for meta-analysis of binary, continuous and diagnostic data
    • [PMID: 19961608]
    • Wallace BC, Schmid CH, Lau J, Trikalinos TA. Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data. BMC Med Res Meth-odol. 2009;9:80. [PMID: 19961608]
    • (2009) BMC Med Res Meth-odol , vol.9 , pp. 80
    • Wallace, B.C.1    Schmid, C.H.2    Lau, J.3    Trikalinos, T.A.4
  • 46
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • [PMID: 19114685]
    • Hecht JR, Mitchell E, Chidiac T, Scroggin C, Hagenstad C, Spigel D, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27:672-80. [PMID: 19114685]
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3    Scroggin, C.4    Hagenstad, C.5    Spigel, D.6
  • 47
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • [PMID: 19196673]
    • Tol J, Koopman M, Cats A, Rodenburg CJ, Creemers GJ, Schrama JG, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009;360:563-72. [PMID: 19196673]
    • (2009) N Engl J Med , vol.360 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3    Rodenburg, C.J.4    Creemers, G.J.5    Schrama, J.G.6
  • 48
    • 73249130298 scopus 로고    scopus 로고
    • Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: The CELIM randomized phase 2 trial
    • [PMID: 19942479]
    • Folprecht G, Gruenberger T, Bechstein WO, Raab HR, Lordick F, Hart-mann JT, et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomized phase 2 trial. Lancet Oncol. 2010;11:38-47. [PMID: 19942479]
    • (2010) Lancet Oncol , vol.11 , pp. 38-47
    • Folprecht, G.1    Gruenberger, T.2    Bechstein, W.O.3    Raab, H.R.4    Lordick, F.5    Hart-Mann, J.T.6
  • 49
    • 67650366758 scopus 로고    scopus 로고
    • Detection of KRAS oncogene in peripheral blood as a predictor of the response to cetuximab plus chemotherapy in patients with metastatic colorectal cancer
    • [PMID: 19549774]
    • Yen LC, Yeh YS, Chen CW, Wang HM, Tsai HL, Lu CY, et al. Detection of KRAS oncogene in peripheral blood as a predictor of the response to cetuximab plus chemotherapy in patients with metastatic colorectal cancer. Clin Cancer Res. 2009;15:4508-13. [PMID: 19549774]
    • (2009) Clin Cancer Res , vol.15 , pp. 4508-4513
    • Yen, L.C.1    Yeh, Y.S.2    Chen, C.W.3    Wang, H.M.4    Tsai, H.L.5    Lu, C.Y.6
  • 50
    • 77954306356 scopus 로고    scopus 로고
    • Cetuximab administered once every second week to patients with metastatic colorectal cancer: A two-part pharmacokinetic/pharmacodynamic phase I dose-escalation study
    • [PMID: 19940007]
    • Tabernero J, Ciardiello F, Rivera F, Rodriguez-Braun E, Ramos FJ, Mar-tinelli E, et al. Cetuximab administered once every second week to patients with metastatic colorectal cancer: a two-part pharmacokinetic/pharmacodynamic phase I dose-escalation study. Ann Oncol. 2010;21:1537-45. [PMID: 19940007]
    • (2010) Ann Oncol , vol.21 , pp. 1537-1545
    • Tabernero, J.1    Ciardiello, F.2    Rivera, F.3    Rodriguez-Braun, E.4    Ramos, F.J.5    Mar-Tinelli, E.6
  • 51
    • 77449101632 scopus 로고    scopus 로고
    • Activating KRAS mutations and overexpression of epidermal growth factor receptor as independent predictors in metastatic colorectal cancer patients treated with cetuximab
    • [PMID: 20010090]
    • Yen LC, Uen YH, Wu DC, Lu CY, Yu FJ, Wu IC, et al. Activating KRAS mutations and overexpression of epidermal growth factor receptor as independent predictors in metastatic colorectal cancer patients treated with cetuximab. Ann Surg. 2010;251:254-60. [PMID: 20010090]
    • (2010) Ann Surg , vol.251 , pp. 254-260
    • Yen, L.C.1    Uen, Y.H.2    Wu, D.C.3    Lu, C.Y.4    Yu, F.J.5    Wu, I.C.6
  • 52
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: A cohort study
    • [PMID: 15863375]
    • Moroni M, Veronese S, Benvenuti S, Marrapese G, Sartore-Bianchi A, Di Nicolantonio F, et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol. 2005;6:279-86. [PMID: 15863375]
    • (2005) Lancet Oncol , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3    Marrapese, G.4    Sartore-Bianchi, A.5    Di Nicolantonio, F.6
  • 53
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • [PMID: 16618717]
    • Lievre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006;66:3992-5. [PMID: 16618717]
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    le Corre, D.3    Boige, V.4    Landi, B.5    Emile, J.F.6
  • 54
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • [PMID: 17363584]
    • Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, Veronese S, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 2007;67:2643-8. [PMID: 17363584]
    • (2007) Cancer Res , vol.67 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Zanon, C.4    Moroni, M.5    Veronese, S.6
  • 55
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
    • [PMID: 17375050]
    • Di Fiore F, Blanchard F, Charbonnier F, Le Pessot F, Lamy A, Galais MP, et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br J Cancer. 2007;96:1166-9. [PMID: 17375050]
    • (2007) Br J Cancer , vol.96 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3    le Pessot, F.4    Lamy, A.5    Galais, M.P.6
  • 56
    • 35348908314 scopus 로고    scopus 로고
    • PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
    • [PMID: 17940504]
    • Frattini M, Saletti P, Romagnani E, Martin V, Molinari F, Ghisletta M, et al. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer. 2007;97:1139-45. [PMID: 17940504]
    • (2007) Br J Cancer , vol.97 , pp. 1139-1145
    • Frattini, M.1    Saletti, P.2    Romagnani, E.3    Martin, V.4    Molinari, F.5    Ghisletta, M.6
  • 57
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • [PMID: 17664471]
    • Khambata-Ford S, Garrett CR, Meropol NJ, Basik M, Harbison CT, Wu S, et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol. 2007;25:3230-7. [PMID: 17664471]
    • (2007) J Clin Oncol , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3    Basik, M.4    Harbison, C.T.5    Wu, S.6
  • 58
    • 46349092797 scopus 로고    scopus 로고
    • Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients
    • [PMID: 18577988]
    • Cappuzzo F, Varella-Garcia M, Finocchiaro G, Skokan M, Gajapathy S, Carnaghi C, et al. Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. Br J Cancer. 2008;99:83-9. [PMID: 18577988]
    • (2008) Br J Cancer , vol.99 , pp. 83-89
    • Cappuzzo, F.1    Varella-Garcia, M.2    Finocchiaro, G.3    Skokan, M.4    Gajapathy, S.5    Carnaghi, C.6
  • 59
    • 40149088765 scopus 로고    scopus 로고
    • KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
    • [PMID: 17998284]
    • De Roock W, Piessevaux H, De Schutter J, Janssens M, De Hertogh G, Personeni N, et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol. 2008;19:508-15. [PMID: 17998284]
    • (2008) Ann Oncol , vol.19 , pp. 508-515
    • de Roock, W.1    Piessevaux, H.2    de Schutter, J.3    Janssens, M.4    de Hertogh, G.5    Personeni, N.6
  • 60
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • [PMID: 19001320]
    • Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol. 2008;26:5705-12. [PMID: 19001320]
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3    Sartore-Bianchi, A.4    Arena, S.5    Saletti, P.6
  • 61
    • 44449090596 scopus 로고    scopus 로고
    • Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone
    • [PMID: 18621636]
    • Freeman DJ, Juan T, Reiner M, Hecht JR, Meropol NJ, Berlin J, et al. Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone. Clin Colorectal Cancer. 2008;7:184-90. [PMID: 18621636]
    • (2008) Clin Colorectal Cancer , vol.7 , pp. 184-190
    • Freeman, D.J.1    Juan, T.2    Reiner, M.3    Hecht, J.R.4    Meropol, N.J.5    Berlin, J.6
  • 62
    • 45949083997 scopus 로고    scopus 로고
    • A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based treatment
    • [PMID: 18544172]
    • Goncalves A, Esteyries S, Taylor-Smedra B, Lagarde A, Ayadi M, Monges G, et al. A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based treatment. BMC Cancer. 2008;8:169. [PMID: 18544172]
    • (2008) BMC Cancer , vol.8 , pp. 169
    • Goncalves, A.1    Esteyries, S.2    Taylor-Smedra, B.3    Lagarde, A.4    Ayadi, M.5    Monges, G.6
  • 63
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • [PMID: 18202412]
    • Lievre A, Bachet JB, Boige V, Cayre A, Le Corre D, Buc E, et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol. 2008;26:374-9. [PMID: 18202412]
    • (2008) J Clin Oncol , vol.26 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3    Cayre, A.4    le Corre, D.5    Buc, E.6
  • 64
    • 59449091688 scopus 로고    scopus 로고
    • Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab
    • [PMID: 19047118]
    • Lurje G, Nagashima F, Zhang W, Yang D, Chang HM, Gordon MA, et al. Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. Clin Cancer Res. 2008; 14:7884-95. [PMID: 19047118]
    • (2008) Clin Cancer Res , vol.14 , pp. 7884-7895
    • Lurje, G.1    Nagashima, F.2    Zhang, W.3    Yang, D.4    Chang, H.M.5    Gordon, M.A.6
  • 65
    • 53249123419 scopus 로고    scopus 로고
    • Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: A fluorescent in situ hybridization study
    • [PMID: 18794099]
    • Personeni N, Fieuws S, Piessevaux H, De Hertogh G, De Schutter J, Biesmans B, et al. Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study. Clin Cancer Res. 2008;14:5869-76. [PMID: 18794099]
    • (2008) Clin Cancer Res , vol.14 , pp. 5869-5876
    • Personeni, N.1    Fieuws, S.2    Piessevaux, H.3    de Hertogh, G.4    de Schutter, J.5    Biesmans, B.6
  • 66
    • 61449239114 scopus 로고    scopus 로고
    • Impact of FcyRIIa-FcyRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
    • [PMID: 19164213]
    • Bibeau F, Lopez-Crapez E, Di Fiore F, Thezenas S, Ychou M, Blanchard F, et al. Impact of FcyRIIa-FcyRIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J Clin Oncol. 2009;27:1122-9. [PMID: 19164213]
    • (2009) J Clin Oncol , vol.27 , pp. 1122-1129
    • Bibeau, F.1    Lopez-Crapez, E.2    Di Fiore, F.3    Thezenas, S.4    Ychou, M.5    Blanchard, F.6
  • 67
    • 65549143792 scopus 로고    scopus 로고
    • The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer
    • [PMID: 19179548]
    • Garm Spindler KL, Pallisgaard N, Rasmussen AA, Lindebjerg J, Andersen RF, Cruger D, et al. The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer. Ann Oncol. 2009;20:879-84. [PMID: 19179548]
    • (2009) Ann Oncol , vol.20 , pp. 879-884
    • Garm Spindler, K.L.1    Pallisgaard, N.2    Rasmussen, A.A.3    Lindebjerg, J.4    Andersen, R.F.5    Cruger, D.6
  • 68
    • 73349098041 scopus 로고    scopus 로고
    • Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab
    • [PMID: 19738126]
    • Jacobs B, De Roock W, Piessevaux H, Van Oirbeek R, Biesmans B, De Schutter J, et al. Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab. J Clin Oncol. 2009;27:5068-74. [PMID: 19738126]
    • (2009) J Clin Oncol , vol.27 , pp. 5068-5074
    • Jacobs, B.1    de Roock, W.2    Piessevaux, H.3    van Oirbeek, R.4    Biesmans, B.5    de Schutter, J.6
  • 69
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • [PMID: 19884556]
    • Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, et al. Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol. 2009;27: 5924-30. [PMID: 19884556]
    • (2009) J Clin Oncol , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3    Buc, E.4    Bachet, J.B.5    Lecomte, T.6
  • 70
    • 66849140563 scopus 로고    scopus 로고
    • PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
    • [PMID: 19398573]
    • Loupakis F, Pollina L, Stasi I, Ruzzo A, Scartozzi M, Santini D, et al. PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J Clin Oncol. 2009;27:2622-9. [PMID: 19398573]
    • (2009) J Clin Oncol , vol.27 , pp. 2622-2629
    • Loupakis, F.1    Pollina, L.2    Stasi, I.3    Ruzzo, A.4    Scartozzi, M.5    Santini, D.6
  • 71
    • 68749119351 scopus 로고    scopus 로고
    • KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
    • [PMID: 19603018]
    • Loupakis F, Ruzzo A, Cremolini C, Vincenzi B, Salvatore L, Santini D, et al. KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer. Br J Cancer. 2009;101:715-21. [PMID: 19603018]
    • (2009) Br J Cancer , vol.101 , pp. 715-721
    • Loupakis, F.1    Ruzzo, A.2    Cremolini, C.3    Vincenzi, B.4    Salvatore, L.5    Santini, D.6
  • 72
    • 63949084084 scopus 로고    scopus 로고
    • Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant
    • [PMID: 19293803]
    • Molinari F, Martin V, Saletti P, De Dosso S, Spitale A, Camponovo A, et al. Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant. Br J Cancer. 2009;100:1087-94. [PMID: 19293803]
    • (2009) Br J Cancer , vol.100 , pp. 1087-1094
    • Molinari, F.1    Martin, V.2    Saletti, P.3    de Dosso, S.4    Spitale, A.5    Camponovo, A.6
  • 73
    • 65549128100 scopus 로고    scopus 로고
    • A phase 2 clinical trial of panitumumab monotherapy in Japanese patients with metastatic colorectal cancer
    • [PMID: 19287023]
    • Muro K, Yoshino T, Doi T, Shirao K, Takiuchi H, Hamamoto Y, et al. A phase 2 clinical trial of panitumumab monotherapy in Japanese patients with metastatic colorectal cancer. Jpn J Clin Oncol. 2009;39:321-6. [PMID: 19287023]
    • (2009) Jpn J Clin Oncol , vol.39 , pp. 321-326
    • Muro, K.1    Yoshino, T.2    Doi, T.3    Shirao, K.4    Takiuchi, H.5    Hamamoto, Y.6
  • 74
    • 65349149003 scopus 로고    scopus 로고
    • TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy
    • [PMID: 19367287]
    • Oden-Gangloff A, Di Fiore F, Bibeau F, Lamy A, Bougeard G, Charbonnier F, et al. TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy. Br J Cancer. 2009;100: 1330-5. [PMID: 19367287]
    • (2009) Br J Cancer , vol.100 , pp. 1330-1335
    • Oden-Gangloff, A.1    Di Fiore, F.2    Bibeau, F.3    Lamy, A.4    Bougeard, G.5    Charbonnier, F.6
  • 75
    • 59049089201 scopus 로고    scopus 로고
    • PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
    • [PMID: 18669866]
    • Perrone F, Lampis A, Orsenigo M, Di Bartolomeo M, Gevorgyan A, Losa M, et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol. 2009;20:84-90. [PMID: 18669866]
    • (2009) Ann Oncol , vol.20 , pp. 84-90
    • Perrone, F.1    Lampis, A.2    Orsenigo, M.3    Di Bartolomeo, M.4    Gevorgyan, A.5    Losa, M.6
  • 76
    • 65649086786 scopus 로고    scopus 로고
    • PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer
    • [PMID: 19366826]
    • Prenen H, De Schutter J, Jacobs B, De Roock W, Biesmans B, Claes B, et al. PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. Clin Cancer Res. 2009;15:3184-8. [PMID: 19366826]
    • (2009) Clin Cancer Res , vol.15 , pp. 3184-3188
    • Prenen, H.1    de Schutter, J.2    Jacobs, B.3    de Roock, W.4    Biesmans, B.5    Claes, B.6
  • 77
    • 79951772042 scopus 로고    scopus 로고
    • MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer
    • [PMID: 19862647]
    • Paule B, Castagne V, Picard V, Saffroy R, Adam R, Guettier C, et al. MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer. Med Oncol. 2009. [PMID: 19862647]
    • (2009) Med Oncol
    • Paule, B.1    Castagne, V.2    Picard, V.3    Saffroy, R.4    Adam, R.5    Guettier, C.6
  • 78
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • [PMID: 19223544]
    • Sartore-Bianchi A, Martini M, Molinari F, Veronese S, Nichelatti M, Artale S, et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res. 2009;69:1851-7. [PMID: 19223544]
    • (2009) Cancer Res , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3    Veronese, S.4    Nichelatti, M.5    Artale, S.6
  • 79
    • 70350028742 scopus 로고    scopus 로고
    • Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer
    • [PMID: 19806185]
    • Sartore-Bianchi A, Di Nicolantonio F, Nichelatti M, Molinari F, De Dosso S, Saletti P, et al. Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer. PLoS One. 2009;4:e7287. [PMID: 19806185]
    • (2009) PLoS One , vol.4
    • Sartore-Bianchi, A.1    Di Nicolantonio, F.2    Nichelatti, M.3    Molinari, F.4    de Dosso, S.5    Saletti, P.6
  • 80
    • 69749104382 scopus 로고    scopus 로고
    • The role of KRAS mutations in predicting the efficacy of cetuximab-plus-irinotecan therapy in irinotecan-refractory Korean metastatic colorectal cancer patients
    • [PMID: 19738388]
    • Sohn BS, Kim TW, Lee JL, Ryu MH, Chang HM, Kang YK, et al. The role of KRAS mutations in predicting the efficacy of cetuximab-plus-irinotecan therapy in irinotecan-refractory Korean metastatic colorectal cancer patients. Oncology. 2009;77:224-30. [PMID: 19738388]
    • (2009) Oncology , vol.77 , pp. 224-230
    • Sohn, B.S.1    Kim, T.W.2    Lee, J.L.3    Ryu, M.H.4    Chang, H.M.5    Kang, Y.K.6
  • 81
    • 68149165771 scopus 로고    scopus 로고
    • Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
    • [PMID: 19603024]
    • Souglakos J, Philips J, Wang R, Marwah S, Silver M, Tzardi M, et al. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer. 2009;101:465-72. [PMID: 19603024]
    • (2009) Br J Cancer , vol.101 , pp. 465-472
    • Souglakos, J.1    Philips, J.2    Wang, R.3    Marwah, S.4    Silver, M.5    Tzardi, M.6
  • 82
    • 76149106147 scopus 로고    scopus 로고
    • Detection of tumor epidermal growth factor receptor pathway dependence by serum mass spectrometry in cancer patients
    • [PMID: 20086114]
    • Chung CH, Seeley EH, Roder H, Grigorieva J, Tsypin M, Roder J, et al. Detection of tumor epidermal growth factor receptor pathway dependence by serum mass spectrometry in cancer patients. Cancer Epidemiol Biomarkers Prev. 2010;19:358-65. [PMID: 20086114]
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 358-365
    • Chung, C.H.1    Seeley, E.H.2    Roder, H.3    Grigorieva, J.4    Tsypin, M.5    Roder, J.6
  • 83
    • 77957145245 scopus 로고    scopus 로고
    • Genetic modulation of the Let-7 microRNA binding to KRAS 3'-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab-irinotecan
    • [PMID: 20177422]
    • Graziano F, Canestrari E, Loupakis F, Ruzzo A, Galluccio N, Santini D, et al. Genetic modulation of the Let-7 microRNA binding to KRAS 3'-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab-irinotecan. Pharmacogenomics J. 2010;10:458-64. [PMID: 20177422]
    • (2010) Pharmacogenomics J , vol.10 , pp. 458-464
    • Graziano, F.1    Canestrari, E.2    Loupakis, F.3    Ruzzo, A.4    Galluccio, N.5    Santini, D.6
  • 84
    • 77950368212 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase-1 (MKP-1) impairs the response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab in metastatic colorectal cancer patients
    • [PMID: 20234366]
    • Montagut C, Iglesias M, Arumi M, Bellosillo B, Gallen M, Martinez-Fernandez A, et al. Mitogen-activated protein kinase phosphatase-1 (MKP-1) impairs the response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab in metastatic colorectal cancer patients. Br J Cancer. 2010;102:1137-44. [PMID: 20234366]
    • (2010) Br J Cancer , vol.102 , pp. 1137-1144
    • Montagut, C.1    Iglesias, M.2    Arumi, M.3    Bellosillo, B.4    Gallen, M.5    Martinez-Fernandez, A.6
  • 85
    • 77955604846 scopus 로고    scopus 로고
    • Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal cancer
    • [PMID: 20049837]
    • Perkins G, Lievre A, Ramacci C, Méatchi T, de Reynies A, Emile JF, et al. Additional value of EGFR downstream signaling phosphoprotein expression to KRAS status for response to anti-EGFR antibodies in colorectal cancer. Int J Cancer. 2010;127:1321-31. [PMID: 20049837]
    • (2010) Int J Cancer , vol.127 , pp. 1321-1331
    • Perkins, G.1    Lievre, A.2    Ramacci, C.3    Méatchi, T.4    Reynies, A.5    Emile, J.F.6
  • 86
    • 77956996167 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan
    • [PMID: 20099280]
    • Scartozzi M, Mandolesi A, Giampieri R, Pierantoni C, Loupakis F, Zani-boni A, et al. Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan. Int J Cancer. 2010;127:1941-7. [PMID: 20099280]
    • (2010) Int J Cancer , vol.127 , pp. 1941-1947
    • Scartozzi, M.1    Mandolesi, A.2    Giampieri, R.3    Pierantoni, C.4    Loupakis, F.5    Zani-Boni, A.6
  • 87
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • [PMID: 19188670]
    • Allegra CJ, Jessup JM, Somerfield MR, Hamilton SR, Hammond EH, Hayes DF, et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol. 2009;27:2091-6. [PMID: 19188670]
    • (2009) J Clin Oncol , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3    Hamilton, S.R.4    Hammond, E.H.5    Hayes, D.F.6
  • 88
    • 78649965504 scopus 로고    scopus 로고
    • Clinical trials for predictive medicine: New challenges and paradigms
    • [PMID: 20338899]
    • Simon R. Clinical trials for predictive medicine: new challenges and paradigms. Clin Trials. 2010;7:516-24. [PMID: 20338899]
    • (2010) Clin Trials , vol.7 , pp. 516-524
    • Simon, R.1
  • 89
    • 73149107502 scopus 로고    scopus 로고
    • KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803
    • [PMID: 19934290], Cancer and Leukemia Group B
    • Ogino S, Meyerhardt JA, Irahara N, Niedzwiecki D, Hollis D, Saltz LB, et al; Cancer and Leukemia Group B. KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803. Clin Cancer Res. 2009;15:7322-9. [PMID: 19934290]
    • (2009) Clin Cancer Res , vol.15 , pp. 7322-7329
    • Ogino, S.1    Meyerhardt, J.A.2    Irahara, N.3    Niedzwiecki, D.4    Hollis, D.5    Saltz, L.B.6
  • 90
    • 9144231228 scopus 로고    scopus 로고
    • Molecular lesions in colorectal cancer: Impact on prognosis? Original data and review of the literature
    • [PMID: 12827409]
    • Klump B, Nehls O, Okech T, Hsieh CJ, Gaco V, Gittinger FS, et al. Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature. Int J Colorectal Dis. 2004;19:23-42. [PMID: 12827409]
    • (2004) Int J Colorectal Dis , vol.19 , pp. 23-42
    • Klump, B.1    Nehls, O.2    Okech, T.3    Hsieh, C.J.4    Gaco, V.5    Gittinger, F.S.6
  • 91
    • 84922359109 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration, 22 September 2010
    • U.S. Food and Drug Administration. Panitumumab: highlights of prescribing information. 2009. Accessed at www.accessdata.fda.gov/drugsatfda_docs/label/2009/125147s080lbl.pdf on 22 September 2010.
    • (2009) Panitumumab: Highlights of Prescribing Information
  • 92
    • 76949095166 scopus 로고    scopus 로고
    • KRAS mutational status assessment in patients with metastatic colorectal cancer: Are the clinical implications so clear?
    • [PMID: 19702696]
    • Hebbar M, Fournier P, Romano O. KRAS mutational status assessment in patients with metastatic colorectal cancer: are the clinical implications so clear? Eur J Cancer Care (Engl). 2010;19:167-71. [PMID: 19702696]
    • (2010) Eur J Cancer Care (Engl) , vol.19 , pp. 167-171
    • Hebbar, M.1    Fournier, P.2    Romano, O.3
  • 93
    • 69849108427 scopus 로고    scopus 로고
    • Clinical trial designs for predictive biomarker validation: Theoretical considerations and practical challenges
    • [PMID: 19597023]
    • Mandrekar SJ, Sargent DJ. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J Clin Oncol. 2009;27:4027-34. [PMID: 19597023]
    • (2009) J Clin Oncol , vol.27 , pp. 4027-4034
    • Mandrekar, S.J.1    Sargent, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.