-
1
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan- refractory metastatic colorectal cancer
-
DOI 10.1056/NEJMoa033025
-
Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-345. (Pubitemid 38944402)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
Bets, D.7
Mueser, M.8
Harstrick, A.9
Verslype, C.10
Chau, I.11
Van Cutsem, E.12
-
2
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lièvre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006; 66: 3992-3995.
-
(2006)
Cancer Res
, vol.66
, pp. 3992-3995
-
-
Lièvre, A.1
Bachet, J.B.2
Le Corre, D.3
Boige, V.4
Landi, B.5
Emile, J.F.6
-
3
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ, O'Callaghan CJ, Tu D, Tebbutt NC, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008; 359: 1757-1765.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
O'Callaghan, C.J.4
Tu, D.5
Tebbutt, N.C.6
-
4
-
-
42649145667
-
Wild type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, et al. Wild type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26: 1626-1634.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
Van Cutsem, E.4
Siena, S.5
Freeman, D.J.6
-
5
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009; 27: 663-671.
-
(2009)
J Clin Oncol
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
Hartmann, J.T.4
Aparicio, J.5
De Braud, F.6
-
6
-
-
78149250536
-
Randomized, phase III trial of panitu-mumab with infusional fluorouracil, leucovorin, and oxali-platin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorec-tal cancer: The PRIME study
-
Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, et al. Randomized, phase III trial of panitu-mumab with infusional fluorouracil, leucovorin, and oxali-platin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorec-tal cancer: the PRIME study. J Clin Oncol 2010; 28: 4697-4705.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4697-4705
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
Tabernero, J.4
Burkes, R.5
Barugel, M.6
-
7
-
-
65349189958
-
American society of clinical oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
-
Allegra CJ, Jessup JM, Somerfield MR, Hamilton SR, Hammond EH, Hayes DF, et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J Clin Oncol 2009; 27: 2091-2096.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2091-2096
-
-
Allegra, C.J.1
Jessup, J.M.2
Somerfield, M.R.3
Hamilton, S.R.4
Hammond, E.H.5
Hayes, D.F.6
-
8
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009; 360: 1408-1417.
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Köhne, C.H.2
Hitre, E.3
Zaluski, J.4
Chang Chien, C.R.5
Makhson, A.6
-
9
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetux-imab in metastatic colorectal cancer
-
Tol J, Koopman M, Cats A, Rodenburg CJ, Creemers GJ, Schrama JG, et al. Chemotherapy, bevacizumab, and cetux-imab in metastatic colorectal cancer. N Engl J Med 2009; 360: 563-572.
-
(2009)
N Engl J Med
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
Rodenburg, C.J.4
Creemers, G.J.5
Schrama, J.G.6
-
10
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorec-tal cancer: A retrospective consortium analysis
-
De Roock W, Claes B, Bernasconi D, De Schutter J, Bies-mans B, Fountzilas G, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorec-tal cancer: A retrospective consortium analysis. Lancet Oncol 2010; 11: 753-762.
-
(2010)
Lancet Oncol
, vol.11
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
De Schutter, J.4
Bies-Mans, B.5
Fountzilas, G.6
-
11
-
-
33947594129
-
Hyperactive Ras in developmental disorders and cancer
-
DOI 10.1038/nrc2109, PII NRC2109
-
Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 2007; 7: 295-308. (Pubitemid 46480970)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.4
, pp. 295-308
-
-
Schubbert, S.1
Shannon, K.2
Bollag, G.3
-
12
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
DOI 10.1158/0008-5472.CAN-06-4158
-
Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, Veronese S, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 2007; 67: 2643-2648. (Pubitemid 46548951)
-
(2007)
Cancer Research
, vol.67
, Issue.6
, pp. 2643-2648
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Zanon, C.4
Moroni, M.5
Veronese, S.6
Siena, S.7
Bardelli, A.8
-
13
-
-
43949125179
-
EGFR/KRAS mutations and gefitinib therapy in Chinese NSCLC patients
-
DOI 10.1159/000116736
-
Wang Z, Wu YL, Zhang GC, Zhou Q, Xu CR, Guo AL. EGFR/KRAS mutations and gefitinib therapy in Chinese NSCLC patients. Onkologie 2008; 31: 174-178. (Pubitemid 351700540)
-
(2008)
Onkologie
, vol.31
, Issue.4
, pp. 174-178
-
-
Wang, Z.1
Wu, Y.L.2
Zhang, G.C.3
Zhou, Q.4
Xu, C.R.5
Guo, A.L.6
-
14
-
-
70350462904
-
A multicenter blinded study to evaluate KRAS mutation testing methodologies in the clinical setting
-
Whitehall V, Tran K, Umapathy A, Grieu F, Hewitt C, Evans TJ, et al. A multicenter blinded study to evaluate KRAS mutation testing methodologies in the clinical setting. J Mol Diagn 2009; 11: 543-552.
-
(2009)
J Mol Diagn
, vol.11
, pp. 543-552
-
-
Whitehall, V.1
Tran, K.2
Umapathy, A.3
Grieu, F.4
Hewitt, C.5
Evans, T.J.6
-
15
-
-
77349103908
-
KRAS mutation: Comparison of testing methods and tissue sampling techniques in colon cancer
-
Franklin WA, Haney J, Sugita M, Bemis L, Jimeno A, Messersmith WA. KRAS mutation: comparison of testing methods and tissue sampling techniques in colon cancer. J Mol Diagn 2010; 12: 43-50.
-
(2010)
J Mol Diagn
, vol.12
, pp. 43-50
-
-
Franklin, W.A.1
Haney, J.2
Sugita, M.3
Bemis, L.4
Jimeno, A.5
Messersmith, W.A.6
-
16
-
-
84858699677
-
Comparative screening of K-ras mutations in colorectal cancer and lung cancer patients using a novel real-time PCR with ADx-K-ras kit and sanger DNA sequencing
-
Zhang H, Zheng X, Ji T, Fu L, Bai D, Liao Y, et al. Comparative screening of K-ras mutations in colorectal cancer and lung cancer patients using a novel real-time PCR with ADx-K-ras kit and Sanger DNA sequencing. Cell Biochem Biophys 2012; 62: 415-420.
-
(2012)
Cell Biochem Biophys
, vol.62
, pp. 415-420
-
-
Zhang, H.1
Zheng, X.2
Ji, T.3
Fu, L.4
Bai, D.5
Liao, Y.6
-
17
-
-
77149176249
-
KRAS mutation screening in colorectal cancer: From paper to practice
-
Fakih MM. KRAS mutation screening in colorectal cancer: From paper to practice. Clin Colorectal Cancer 2010; 9: 22-30.
-
(2010)
Clin Colorectal Cancer
, vol.9
, pp. 22-30
-
-
Fakih, M.M.1
-
18
-
-
70350028742
-
Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer
-
Sartore-Bianchi A, Di Nicolantonio F, Nichelatti M, Molinari F, De Dosso S, Saletti P, et al. Multi-determinants analysis of molecular alterations for predicting clinical benefit to EGFR-targeted monoclonal antibodies in colorectal cancer. PLoS One 2009; 4: e7287.
-
(2009)
PLoS One
, vol.4
-
-
Sartore-Bianchi, A.1
Di Nicolantonio, F.2
Nichelatti, M.3
Molinari, F.4
De Dosso, S.5
Saletti, P.6
-
19
-
-
67650082332
-
Fast simultaneous detection of K-RAS mutations in colorectal cancer
-
Chang YS, Yeh KT, Chang TJ, Chai C, Lu HC, Hsu NC, et al. Fast simultaneous detection of K-RAS mutations in colorectal cancer. BMC Cancer 2009; 9: 179.
-
(2009)
BMC Cancer
, vol.9
, pp. 179
-
-
Chang, Y.S.1
Yeh, K.T.2
Chang, T.J.3
Chai, C.4
Lu, H.C.5
Hsu, N.C.6
-
20
-
-
77956610320
-
Gene mutations in epidermal growth factor receptor signaling network and their association with survival in Chinese patients with metastatic colorectal cancers
-
Liao W, Liao Y, Zhou JX, Xie J, Chen J, Huang W, et al. Gene mutations in epidermal growth factor receptor signaling network and their association with survival in Chinese patients with metastatic colorectal cancers. Anat Rec (Hoboken) 2010; 293: 1506-1511.
-
(2010)
Anat Rec (Hoboken)
, vol.293
, pp. 1506-1511
-
-
Liao, W.1
Liao, Y.2
Zhou, J.X.3
Xie, J.4
Chen, J.5
Huang, W.6
-
21
-
-
79955928991
-
Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients
-
Shen H, Yuan Y, Hu HG, Zhong X, Ye XX, Li MD, et al. Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients. World J Gastroenterol 2011; 17: 809-816.
-
(2011)
World J Gastroenterol
, vol.17
, pp. 809-816
-
-
Shen, H.1
Yuan, Y.2
Hu, H.G.3
Zhong, X.4
Ye, X.X.5
Li, M.D.6
-
22
-
-
80755132294
-
Mutations in BRAF correlate with poor survival of colorectal cancers in Chinese population
-
Liou JM, Wu MS, Shun CT, Chiu HM, Chen MJ, Chen CC, et al. Mutations in BRAF correlate with poor survival of colorectal cancers in Chinese population. Int J Colorectal Dis 2011; 6: 1387-1395.
-
(2011)
Int J Colorectal Dis
, vol.6
, pp. 1387-1395
-
-
Liou, J.M.1
Wu, M.S.2
Shun, C.T.3
Chiu, H.M.4
Chen, M.J.5
Chen, C.C.6
-
23
-
-
79954490871
-
KRAS, BRAF and PIK3CA mutations in human colorectal cancer: Relationship with metastatic colorectal cancer
-
Li HT, Lu YY, An YX, Wang X, Zhao QC. KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer. Oncol Rep 2011; 25: 1691-1697.
-
(2011)
Oncol Rep
, vol.25
, pp. 1691-1697
-
-
Li, H.T.1
Lu, Y.Y.2
An, Y.X.3
Wang, X.4
Zhao, Q.C.5
-
24
-
-
84864390143
-
Characteristics and prevalence of KRAS, BRAF, and PIK3CA mutations in colorectal cancer by high-resolution melting analysis in taiwanese population
-
[Epub ahead of print]
-
Hsieh LL, Er TK, Chen CC, Hsieh JS, Chang JG, Liu TC. Characteristics and prevalence of KRAS, BRAF, and PIK3CA mutations in colorectal cancer by high-resolution melting analysis in Taiwanese population. Clin Chim Acta 2012, [Epub ahead of print].
-
(2012)
Clin Chim Acta
-
-
Hsieh, L.L.1
Er, T.K.2
Chen, C.C.3
Hsieh, J.S.4
Chang, J.G.5
Liu, T.C.6
-
25
-
-
84860617477
-
KRAS, BRAF and PIK3CA mutations and the loss of PTEN expression in Chinese patients with colorectal cancer
-
Mao C, Zhou J, Yang Z, Huang Y, Wu X, Shen H, et al. KRAS, BRAF and PIK3CA Mutations and the Loss of PTEN Expression in Chinese Patients with Colorectal Cancer. PLoS One 2012; 7: e36653.
-
(2012)
PLoS One
, vol.7
-
-
Mao, C.1
Zhou, J.2
Yang, Z.3
Huang, Y.4
Wu, X.5
Shen, H.6
-
26
-
-
75549090214
-
Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer
-
Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A. Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer. Pathol Res Pract 2009; 205: 858-862.
-
(2009)
Pathol Res Pract
, vol.205
, pp. 858-862
-
-
Neumann, J.1
Zeindl-Eberhart, E.2
Kirchner, T.3
Jung, A.4
-
27
-
-
62449302407
-
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
-
Sartore-Bianchi A, Martini M, Molinari F, Veronese S, Nichelatti M, Artale S, et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 2009; 69: 1851-1857.
-
(2009)
Cancer Res
, vol.69
, pp. 1851-1857
-
-
Sartore-Bianchi, A.1
Martini, M.2
Molinari, F.3
Veronese, S.4
Nichelatti, M.5
Artale, S.6
-
28
-
-
68749119351
-
KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
-
Loupakis F, Ruzzo A, Cremolini C, Vincenzi B, Salvatore L, Santini D, et al. KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer. Br J Cancer 2009; 101: 715-721. Chinese Academy of Medical Sciences
-
(2009)
Br J Cancer
, vol.101
, pp. 715-721
-
-
Loupakis, F.1
Ruzzo, A.2
Cremolini, C.3
Vincenzi, B.4
Salvatore, L.5
Santini, D.6
|