Kirsten ras mutations in patients with colorectal cancer: The multicenter 'RASCAL' study

Journal of the National Cancer Institute

Volumn 90, Issue 9, 1998, Pages 675-684

  Andreyev, H Jervoise N ^a,b   Norman, Andrew R ^c   Cunningham, David ^a,c   Oates, Jacqueline R ^c   Clarke, Paul A ^b  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c Royal Marsden Hospital

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; GLYCINE; GUANINE; THYMINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER MORTALITY; CANCER RECURRENCE; CODON; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; MAJOR CLINICAL STUDY; MALE; ONCOGENE K RAS; TUMOR DIFFERENTIATION;

EID: 0032490124     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/90.9.675     Document Type: Article

References (35)

1. Oudejans JJ, Slebos RJ, Zoetmulder FA, Mooi WJ, Rodenhuis S. Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver. Int J Cancer 1991;49:875-9.
2. Suchy B, Zietz C, Rabes HM. K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis. Int J Cancer 1992;52: 30-3.
3. Benhattar J, Losi L, Chaubert P, Givel JC, Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993;104: 1044-8.
4. Moerkerk P, Arends JW, van Driel M, de Bruine A, de Goeij A, ten Kate J. Type and number of Ki-ras point mutations relate to stage of human colorectal cancer. Cancer Res 1994;54:3376-8.
5. Tanaka M, Omura K, Watanabe Y, Oda Y, Nakanishi I. Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity. J Surg Oncol 1994;57:57-64.
6. Elnatan J, Goh HS, Smith DR. C-KI-RAS activation and the biological behaviour of proximal and distal colonic adenocarcinomas. Eur J Cancer 1996;32A:491-7.
7. Pricolo VE, Finkelstein SD, Wu TT, Keller G, Bakker A, Swalsky PA, et al. Prognostic value of TP53 and K-ras-2 mutational analysis in stage III carcinoma of the colon. Am J Surg 1996;171:41-6.
8. Lee J, Wang S, Lai M, Yang H. K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers. Anticancer Res 1996;16: 3839-44.
9. Troungos C, Valavanis C, Kapranos N, Kittas C. K-ras mutation in Greek patients with poorly and moderately differentiated tumors of the lower intestinal tract. Anticancer Res 1997;17:1399-404.
10. Kern SE, Fearon ER, Tersmette KW, Enterline JP, Leppert M, Nakamura Y, et al. Clinical and pathological associations with allelic loss in colorectal carcinoma [corrected] [published erratum appears in JAMA 1989;262: 1952]. JAMA 1989;261:3099-103.
11. Sun XF, Hatschek T, Wingren S, Stal O, Carstensen JM, Zhang H, et al. Ras p21 expression in relation to histopathological variables and prognosis in colorectal adenocarcinoma. Acta Oncol 1991;30:933-9.
12. Halter SA, Webb L, Rose J. Lack of ras mutations and prediction of long-term survival in carcinoma of the colon. Mod Pathol 1992;5:131-4.
13. Laurent-Puig P, Olschwang S, Delattre O, Remvikos Y, Asselain B, Melot T, et al. Survival and acquired genetic alterations in colorectal cancer. Gastroenterology 1992;102:1136-41.
14. Rochlitz CF, Heide I, de Kant E, Bohmer R, Peter FJ, Neuhaus P, et al. Position specificity of Ki-ras oncogene mutations during the progression of colorectal carcinoma. Oncology 1993;50:70-6.
15. Bell SM, Scott N, Cross D, Sagar P, Lewis FA, Blair GE, et al. Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterology 1993;104:57-64.
16. Dix BR, Robbins P, Soong R, Jenner D, House AK, Iacopetta BJ. The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival. Int J Cancer 1994;59:747-51.
17. Morrin M, Kelly M, Barren N, Delaney P. Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance. Gut 1994;35: 1627-31.
18. Bennett MA, Kay EW, Mulcahy H, O'Flaherty L, O'Donoghue DP, Leader M, et al. Ras and p53 in the prediction of survival in Dukes' stage B colorectal carcinoma. J Clin Path Clin Mol Pathol 1995;48:M310-M315.
19. Kastrinakis WV, Ramchurren N, Maggard M, Steele G Jr, Summerhayes IC. K-ras status does not predict successful hepatic resection of colorectal cancer metastasis. Arch Surg 1995;130:9-14.
20. Markowitz S, Hines J, Lutterbaugh J, Myeroff L, Mackay W, Gordon N, et al. Mutant K-ras oncogenes in colon cancers do not predict patient's chemotherapy response or survival. Clin Cancer Res 1995;1:441-5.
21. Kato M, Ito Y, Kobayashi S, Isono K. Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence. Cancer 1996;77(8 Suppl):1729-35.
22. Andersen SN, Lovig T, Breivik J, Lund E, Gaudernack G, Meling GI, et al. K-ras mutations and prognosis in large-bowel carcinomas. Scand J Gastroenterol 1997;32:62-9.
23. Andreyev H, Tilsed JV, Cunningham D, Norman AR, Sampson SA, Schneider HJ, et al. Kirsten ras mutations in patients with early colorectal cancers. Gut 1997;41:323-9.
24. Finkelstein SD, Sayegh R, Christensen S, Swalsky PA. Genotypic classification of colorectal adenocarcinoma. Biologic behavior correlates with K-ras-2 mutation type. Cancer 1993;71:3827-38.
25. Breivik J, Meling GI, Spurkland A, Rognum TO, Gaudernack G. K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location. Br J Cancer 1994;69:367-71.
26. Hayakumo T, Cho E, Nakajima M, Kato G, Kawai K, Azuma T. Point mutations in the c-K-ras 2 gene in multiple colorectal carcinomas. J Gastroenterol Hepatol 1995;10:70-5.
27. Urosevic N, Krtolica K, Skaro Milic A, Knezevic-Usaj S, Dujic A. Prevalence of G-to-T transversions among K-ras oncogene mutations in human colorectal tumors in Yugoslavia. Int J Cancer 1993;54:249-54.
28. Minamoto T, Sawaguchi K, Mai M, Yamashita N, Sugimura T, Esumi H. Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas. Cancer Res 1994;54:2841-4.
29. Burmer GC, Levine DS, Kulander BG, Haggitt RC, Rubin CE, Rabinovitch PS. c-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma. Gastroenterology 1990;99:416-20.
30. Bell SM, Kelly SA, Hoyle JA, Lewis FA, Taylor GR, Thompson H, et al. c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis. Br J Cancer 1991;64:174-8.
31. Chaubert P, Benhattar J, Saraga E, Costa J. K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis. Am J Pathol 1994;144:767-75.
32. Konishi M, Kikuchi-Yanoshita R, Tanaka K, Muraoka M, Onda A, Okumura Y, et al. Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 1996;111:307-17.
33. Giaretti W, Monaco R, Pujic N, Rapallo A, Nigro S, Geido E. Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy. Am J Pathol 1996;149:237-45.
34. American Joint Committee on Cancer. In: Beahrs OH, Hensen DE, Hutter RV, Kennedy BJ, editors. Manual for staging cancer. Philadelphia: JB Lippincott, 1992.
35. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.