KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer

British Journal of Cancer

Volumn 101, Issue 4, 2009, Pages 715-721

  Loupakis, F ^a   Ruzzo, A ^b   Cremolini, C ^a   Vincenzi, B ^c   Salvatore, L ^a   Santini, D ^c   Masi, G ^a   Stasi, I ^a   Canestrari, E ^b   Rulli, E ^d   Floriani, I ^d   Bencardino, K ^e   Galluccio, N ^b   Catalano, V ^f   Tonini, G ^c   Magnani, M ^b   Fontanini, G ^a   Basolo, F ^a   Falcone, A ^a   Graziano, F ^f  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF URBINO   (Italy)

^c UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e SAN RAFFAELE HOSPITAL   (Italy)

^f SAN SALVATORE HOSPITAL   (Italy)

Author keywords

BRAF; Cetuximab; Colorectal cancer; KRAS

Indexed keywords

CETUXIMAB; IRINOTECAN;

ADULT; AGED; ARTICLE; CODON; COLORECTAL CANCER; DRUG RESPONSE; FEMALE; GENE MUTATION; HUMAN; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTIDRUG RESISTANCE; ONCOGENE; ONCOGENE B RAF; ONCOGENE K RAS; PREDICTION; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL;

ADENOCARCINOMA; ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; CODON; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; DNA MUTATIONAL ANALYSIS; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; RAS PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TUMOR MARKERS, BIOLOGICAL;

EID: 68749119351     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605177     Document Type: Article

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