-
1
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with colorectal cancer
-
Amado RG, Wolf M, Peeters M, et al. 2008. Wild-type KRAS is required for panitumumab efficacy in patients with colorectal cancer. J Clin Oncol, 26:1626-34.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
2
-
-
42149083899
-
Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
-
Barault L, Veyrie N, Jooste V, et al. 2008. Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. Int J Cancer, 122:2255-9.
-
(2008)
Int J Cancer
, vol.122
, pp. 2255-2259
-
-
Barault, L.1
Veyrie, N.2
Jooste, V.3
-
4
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by inummohistochemistry
-
Chung KY, Shia J, Kemeny N, et al. 2005. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by inummohistochemistry. J Clin Oncol, 23:1803-10.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.3
-
5
-
-
0028237038
-
A kinase-negative epidermal growth factorreceptor that retains the capcity to stimulate DNA synthesis
-
Cocker KJ, Staros JV, Guyer CA, et al. 1994. A kinase-negative epidermal growth factorreceptor that retains the capcity to stimulate DNA synthesis. Proc Natl Acad Sci U S A, 91:6967-71.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 6967-6971
-
-
Cocker, K.J.1
Staros, J.V.2
Guyer, C.A.3
-
6
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblett Y, Siena S, et al. 2004. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Eng J Med, 351:337-45.
-
(2004)
N Eng J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblett, Y.2
Siena, S.3
-
7
-
-
61549134940
-
-
European Medicines Evaluation Agency European Public Assesment Report October, online, URL
-
[EMEA] European Medicines Evaluation Agency European Public Assesment Report October. 2007. [online]. URL: http://www.emea.europa.eu/humandocs/ PDFs/EPAR/vectibix/H-741-en1.pdf
-
(2007)
-
-
-
8
-
-
0037440471
-
Ligand-and kinase activity independentcell survival mediated by the epidermal growth factor receptor expressed in 32D cells
-
Ewald JA, Wilkinson JC, Guyer CA, et al. 2003. Ligand-and kinase activity independentcell survival mediated by the epidermal growth factor receptor expressed in 32D cells. Exp Cell Res, 282:121-31.
-
(2003)
Exp Cell Res
, vol.282
, pp. 121-131
-
-
Ewald, J.A.1
Wilkinson, J.C.2
Guyer, C.A.3
-
10
-
-
33749015571
-
Pathology and management of dermatologic toxicities associated with anti-EGFR therapy
-
Fox LP. 2006. Pathology and management of dermatologic toxicities associated with anti-EGFR therapy. Oncology (Williston Park), 20:26-34.
-
(2006)
Oncology (Williston Park)
, vol.20
, pp. 26-34
-
-
Fox, L.P.1
-
11
-
-
0003514452
-
-
Guidelines on the Use of International Nonproprietary Names (INNs) for Pharmaceutical Substances, URL
-
Guidelines on the Use of International Nonproprietary Names (INNs) for Pharmaceutical Substances. 1997. World Health Organization [online]. pp. 27-28. URL: http://whqlibdoc.who.int/hq/1997/WHO_PHARM_S_NOM_1570.pdf
-
(1997)
World Health Organization [online]
, pp. 27-28
-
-
-
12
-
-
34548147248
-
Panitumumab montherapy in patients with previously treated metastatic colorectal cancer
-
Hecht JR, Patnaik A, Berlin J, et al. 2007. Panitumumab montherapy in patients with previously treated metastatic colorectal cancer. Cancer, 110:980-7.
-
(2007)
Cancer
, vol.110
, pp. 980-987
-
-
Hecht, J.R.1
Patnaik, A.2
Berlin, J.3
-
13
-
-
33847694798
-
Panitumumab in combination with 5-fluorouracil, leucovorin, and Irinotecan or FOLFIRI for the first-line treatment of metastatic colorectal cancer
-
abstract 237
-
Hecht J, Posey J, Tchekmedyian E, et al. 2006. Panitumumab in combination with 5-fluorouracil, leucovorin, and Irinotecan or FOLFIRI for the first-line treatment of metastatic colorectal cancer. Gastrointestinal Cancer Symposium (abstract 237).
-
(2006)
Gastrointestinal Cancer Symposium
-
-
Hecht, J.1
Posey, J.2
Tchekmedyian, E.3
-
14
-
-
34547778520
-
An interim analysis of efficacy and safety from a randomized controlled trial of panitumumab with chemotherapy plus bevacizumab in metastatic colorectal cancer
-
abstract 9
-
Hecht J, Chidiac T, Mitchell E, et al. 2007. An interim analysis of efficacy and safety from a randomized controlled trial of panitumumab with chemotherapy plus bevacizumab in metastatic colorectal cancer. Ninth World Congress on Gastrointestinal Cancer (abstract 9).
-
(2007)
Ninth World Congress on Gastrointestinal Cancer
-
-
Hecht, J.1
Chidiac, T.2
Mitchell, E.3
-
15
-
-
42049092269
-
Interim results from PACCE: Irinotecan/bevacizumab ± panitumumab as first-line treatment for metastatic colorectal cancer
-
abstract 279
-
Hecht JR, Mitchell E, Chidiac T, et al. 2008. Interim results from PACCE: irinotecan/bevacizumab ± panitumumab as first-line treatment for metastatic colorectal cancer. Gastrointestinal Cancer Symposium (abstract 279).
-
(2008)
Gastrointestinal Cancer Symposium
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
16
-
-
0010233988
-
Growth stimulation of A431 cells by epidermal growth factor: Identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody
-
Kawamoto TK, Sato JD, Le A, et al. 1983 Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody. Proc Natl Acad Sci U S A, 80:1337-41.
-
(1983)
Proc Natl Acad Sci U S A
, vol.80
, pp. 1337-1341
-
-
Kawamoto, T.K.1
Sato2
JD, L.A.3
-
18
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lievre A, Bachet JB, Le Corre D, et al. 2006. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res, 66:3992-5
-
(2006)
Cancer Res
, vol.66
, pp. 3992-3995
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
-
19
-
-
13844250537
-
The epidermal growth factor as a receptor target for colorectal cancer therapy
-
Lockhart AC, Berlin JD. 2005. The epidermal growth factor as a receptor target for colorectal cancer therapy. Semin Oncol, 32:52-60.
-
(2005)
Semin Oncol
, vol.32
, pp. 52-60
-
-
Lockhart, A.C.1
Berlin, J.D.2
-
20
-
-
0037106273
-
Targeting the epidermal growth factor receptor for cancer therapy
-
s
-
Mendelsohn J. 2002, Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol, 20:1-13s.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1-13
-
-
Mendelsohn, J.1
-
22
-
-
64649098897
-
A phase II, open-label, randomized clinical trial of skin toxicity evaluation (STEPP) in metastatic colorectal cancer patients receiving second-line FOLFIRI or irinotecan-only chemotherapy with panitumumab: Early analysis
-
abstract 462
-
Mitchell EP, LaCouture M, Shearer H, et al. 2008. A phase II, open-label, randomized clinical trial of skin toxicity evaluation (STEPP) in metastatic colorectal cancer patients receiving second-line FOLFIRI or irinotecan-only chemotherapy with panitumumab: early analysis. Proceedings ASCO Gastrointestinal Cancer Symposium (abstract 462).
-
(2008)
Proceedings ASCO Gastrointestinal Cancer Symposium
-
-
Mitchell, E.P.1
LaCouture, M.2
Shearer, H.3
-
23
-
-
17844362179
-
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to anti-EGFR treatment in colorectal cancer: A cohort study
-
Moroni M, Veronese S, Benvenuti S, et al. 2005. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to anti-EGFR treatment in colorectal cancer: a cohort study. Lancet Oncol, 6:257-8.
-
(2005)
Lancet Oncol
, vol.6
, pp. 257-258
-
-
Moroni, M.1
Veronese, S.2
Benvenuti, S.3
-
24
-
-
0034235955
-
Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice
-
Overholser JP, Prewett MC, Hooper AT, et al. 2000 Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer, 89:74-82.
-
(2000)
Cancer
, vol.89
, pp. 74-82
-
-
Overholser, J.P.1
Prewett, M.C.2
Hooper, A.T.3
-
25
-
-
0036094194
-
Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
-
Prewett M, Hooper A, Bassi R, et al. 2002. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin Cancer Res, 8:994-1003.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 994-1003
-
-
Prewett, M.1
Hooper, A.2
Bassi, R.3
-
26
-
-
37549007196
-
Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab
-
Prewett M, Deevi DS, Bassi R, et al. 2007. Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab. Clin Cancer Res, 13:7432-40.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7432-7440
-
-
Prewett, M.1
Deevi, D.S.2
Bassi, R.3
-
27
-
-
33644822287
-
Randomized phase II trial of the clinical and biological effects of two doses levels of gefitinib in patients with recurrent colorectal cancer
-
Rothenberg ML, LaFleur B, Levy DE, et al. 2005. Randomized phase II trial of the clinical and biological effects of two doses levels of gefitinib in patients with recurrent colorectal cancer. J Clin Oncol, 23:9265-74.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9265-9274
-
-
Rothenberg, M.L.1
LaFleur, B.2
Levy, D.E.3
-
28
-
-
0033779765
-
Single-molecule imaging of EGFR signaling on the surface of living cells
-
Sako Y, Minoghchi S, Yanagida T, 2000. Single-molecule imaging of EGFR signaling on the surface of living cells. Nat Cell Biol, 2:168-172.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 168-172
-
-
Sako, Y.1
Minoghchi, S.2
Yanagida, T.3
-
29
-
-
0344773402
-
The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies
-
abstract 817
-
Saltz L, Keis M, Abbruzzese JL, et al. 2003. The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Proc Am Soc Clin Oncol, 22(abstract 817).
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Saltz, L.1
Keis, M.2
Abbruzzese, J.L.3
-
30
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that express the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer PJ Sr, et al. 2004. Phase II trial of cetuximab in patients with refractory colorectal cancer that express the epidermal growth factor receptor. J Clin Oncol, 22:1201-8.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer Sr, P.J.3
-
31
-
-
57149101253
-
Phase III study (PRIME/ 20050203) of panitumumab with FOLFOX compared with FOLFOX alone in patients with previously untreated metastatic colorectal cancer: Pooled safety data
-
abstract 4034
-
Siena S, Tabernero J, Buttes RL, et al. 2008. Phase III study (PRIME/ 20050203) of panitumumab with FOLFOX compared with FOLFOX alone in patients with previously untreated metastatic colorectal cancer: pooled safety data. Proc Am Soc Clin Oncol, 25(abstract 4034).
-
(2008)
Proc Am Soc Clin Oncol
, vol.25
-
-
Siena, S.1
Tabernero, J.2
Buttes, R.L.3
-
32
-
-
34548258303
-
Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
-
Sartore-Bianchi A, Moroni M, Veronese S, et al. 2007. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J Clin Oncol, 25:3238-45.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3238-3245
-
-
Sartore-Bianchi, A.1
Moroni, M.2
Veronese, S.3
-
33
-
-
0020933452
-
Biologic effects in vitro of monoclonal antibodies to human epidermal growth factor receptors
-
Sato JD, Kawamoto, Le AD, et al. 1983. Biologic effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol Biol Med, 1:511-29.
-
(1983)
Mol Biol Med
, vol.1
, pp. 511-529
-
-
Sato, J.D.1
Kawamoto, L.A.2
-
34
-
-
36949037220
-
Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): Pharmacokinetic, pharmacodynamic and efficacy data
-
abstract 4037
-
Tejpar S, Peeters M, Humblet Y et al. 2007. Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): pharmacokinetic, pharmacodynamic and efficacy data. Proc Am Soc Clin Oncol, 25(abstract 4037).
-
(2007)
Proc Am Soc Clin Oncol
, vol.25
-
-
Tejpar, S.1
Peeters, M.2
Humblet, Y.3
-
35
-
-
22044446497
-
Responsiveness to cetuximab without mutations in EGFR
-
Tsuchihashi Z, Khambata-Ford S, Hanna N, et al. 2005. Responsiveness to cetuximab without mutations in EGFR. N Engl J Med, 353:208-9.
-
(2005)
N Engl J Med
, vol.353
, pp. 208-209
-
-
Tsuchihashi, Z.1
Khambata-Ford, S.2
Hanna, N.3
-
36
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem E, Peeters M, Siena S, et al. 2007. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol, 25:1658-64.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
38
-
-
42949176742
-
-
Survival of cancer cells is maintained by \EGFR independent of its kinase activity
-
Weihua Z, Tsan R, Huang WC, et al. 2008. Survival of cancer cells is maintained by \EGFR independent of its kinase activity. Cancer Cell, 13:385-93.
-
(2008)
Cancer Cell
, vol.13
, pp. 385-393
-
-
Weihua, Z.1
Tsan, R.2
Huang, W.C.3
-
39
-
-
38949178132
-
Dose and schedule study of panitumumab monotherapy in patients with advanced solid malignancies
-
Weiner LM, Belldegrun AS, Crawford J, et al. 2008. Dose and schedule study of panitumumab monotherapy in patients with advanced solid malignancies. Clin Cancer Res, 14:502-8.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 502-508
-
-
Weiner, L.M.1
Belldegrun, A.S.2
Crawford, J.3
-
40
-
-
0035117355
-
Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
-
Yang XD, Jia XC, Corvalan JR, et al. 2001. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol, 38:17-23.
-
(2001)
Crit Rev Oncol Hematol
, vol.38
, pp. 17-23
-
-
Yang, X.D.1
Jia, X.C.2
Corvalan, J.R.3
|