-
1
-
-
50149120366
-
Cellular mechanisms of tumour suppression by the retinoblastoma gene
-
Burkhart, D. L. & Sage, J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev. Cancer 8, 671-682 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 671-682
-
-
Burkhart, D.L.1
Sage, J.2
-
2
-
-
79551490353
-
RB1, development, and cancer
-
Chinnam, M. & Goodrich, D. W. RB1, development, and cancer. Curr. Top. Dev. Biol. 94, 129-169 (2011).
-
(2011)
Curr. Top. Dev. Biol
, vol.94
, pp. 129-169
-
-
Chinnam, M.1
Goodrich, D.W.2
-
3
-
-
0031897273
-
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/- ) mice
-
DOI 10.1038/ng0498-360
-
Yamasaki, L. et al. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat. Genet. 18, 360-364 (1998). (Pubitemid 28158165)
-
(1998)
Nature Genetics
, vol.18
, Issue.4
, pp. 360-364
-
-
Yamasaki, L.1
Bronson, R.2
Williams, B.O.3
Dyson, N.J.4
Harlow, E.5
Jacks, T.6
-
4
-
-
0042190650
-
E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas
-
DOI 10.1128/MCB.23.18.6542-6552.2003
-
Ziebold, U., Lee, E. Y., Bronson, R. T. & Lees, J. A. E2F3 loss has opposing effects on different pRB-deficient tumors, resulting in suppression of pituitary tumors but metastasis of medullary thyroid carcinomas. Mol. Cell Biol. 23, 6542-6552 (2003). (Pubitemid 37075765)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.18
, pp. 6542-6552
-
-
Ziebold, U.1
Lee, E.Y.2
Bronson, R.T.3
Lees, J.A.4
-
5
-
-
0001445037
-
E2F4 loss suppresses tumorigenesis in Rb mutant mice
-
DOI 10.1016/S1535-6108(02)00207-6
-
Lee, E. Y. et al. E2F4 loss suppresses tumorigenesis in Rb mutant mice. Cancer Cell 2, 463-472 (2002). (Pubitemid 41043951)
-
(2002)
Cancer Cell
, vol.2
, Issue.6
, pp. 463-472
-
-
Lee, E.Y.1
Cam, H.2
Ziebold, U.3
Rayman, J.B.4
Lees, J.A.5
Dynlacht, B.D.6
-
6
-
-
0028980273
-
P19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase
-
Zhang, H., Kobayashi, R., Galaktionov, K. & Beach, D. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell 82, 915-925 (1995).
-
(1995)
Cell
, vol.82
, pp. 915-925
-
-
Zhang, H.1
Kobayashi, R.2
Galaktionov, K.3
Beach, D.4
-
7
-
-
0030602813
-
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
-
Bai, C. et al. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86, 263-274 (1996).
-
(1996)
Cell
, vol.86
, pp. 263-274
-
-
Bai, C.1
-
8
-
-
44349122993
-
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: Tipping the scales of cancer
-
DOI 10.1038/nrc2396, PII NRC2396
-
Frescas, D. & Pagano, M. Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat. Rev. Cancer 8, 438-449 (2008). (Pubitemid 351744963)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.6
, pp. 438-449
-
-
Frescas, D.1
Pagano, M.2
-
9
-
-
33646356739
-
F-box protein Skp2: A novel transcriptional target of E2F
-
Zhang, L. & Wang, C. F-box protein Skp2: a novel transcriptional target of E2F. Oncogene 25, 2615-2627 (2005).
-
(2005)
Oncogene
, vol.25
, pp. 2615-2627
-
-
Zhang, L.1
Wang, C.2
-
10
-
-
34548356374
-
A Skp2 autoinduction loop and restriction point control
-
DOI 10.1083/jcb.200703034
-
Yung, Y., Walker, J. L., Roberts, J. M. & Assoian, R. K. A Skp2 autoinduction loop and restriction point control. J. Cell Biol. 178, 741-747 (2007). (Pubitemid 47347359)
-
(2007)
Journal of Cell Biology
, vol.178
, Issue.5
, pp. 741-747
-
-
Yung, Y.1
Walker, J.L.2
Roberts, J.M.3
Assoian, R.K.4
-
11
-
-
33947246502
-
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit
-
DOI 10.1038/ncb1532, PII NCB1532
-
Binne, U. K. et al. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat. Cell Biol. 9, 225-232 (2007). (Pubitemid 46420866)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.2
, pp. 225-232
-
-
Binne, U.K.1
Classon, M.K.2
Dick, F.A.3
Wei, W.4
Rape, M.5
Kaelin, W.G.6
Naar, A.M.7
Dyson, N.J.8
-
12
-
-
4944252223
-
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant
-
DOI 10.1016/j.molcel.2004.09.029, PII S1097276504005726
-
Ji, P. et al. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Mol. Cell 16, 47-58 (2004). (Pubitemid 39330151)
-
(2004)
Molecular Cell
, vol.16
, Issue.1
, pp. 47-58
-
-
Ji, P.1
Jiang, H.2
Rekhtman, K.3
Bloom, J.4
Ichetovkin, M.5
Pagano, M.6
Zhu, L.7
-
13
-
-
73349139851
-
Skp2 is required for survival of aberrantly proliferating Rb1- deficient cells and for tumorigenesis in Rb1+/- mice
-
Wang, H. et al. Skp2 is required for survival of aberrantly proliferating Rb1- deficient cells and for tumorigenesis in Rb1+/- mice. Nat. Genet. 42, 83-88 (2010).
-
(2010)
Nat. Genet
, vol.42
, pp. 83-88
-
-
Wang, H.1
-
14
-
-
57049123764
-
A vanishing act, explained
-
Korenjak, M. & Dyson, N. A vanishing act, explained. Dev. Cell 15, 793-794 (2008).
-
(2008)
Dev. Cell
, vol.15
, pp. 793-794
-
-
Korenjak, M.1
Dyson, N.2
-
15
-
-
0028362359
-
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
-
DOI 10.1016/0092-8674(94)90582-7
-
Krek, W. et al. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78, 161-172 (1994). (Pubitemid 24228310)
-
(1994)
Cell
, vol.78
, Issue.1
, pp. 161-172
-
-
Krek, W.1
Ewen, M.E.2
Shirodkar, S.3
Arany, Z.4
Kaelin Jr., W.G.5
Livingston, D.M.6
-
16
-
-
0029559027
-
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
-
DOI 10.1016/0092-8674(95)90141-8
-
Krek, W., Xu, G. & Livingston, D. M. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 83, 1149-1158 (1995). (Pubitemid 26007806)
-
(1995)
Cell
, vol.83
, Issue.7
, pp. 1149-1158
-
-
Krek, W.1
Xu, G.2
Livingston, D.M.3
-
17
-
-
0027936686
-
Differential regulation of E2F transactivation by cyclin/cdk2 complexes
-
Dynlacht, B. D., Flores, O., Lees, J. A. & Harlow, E. Differential regulation of E2F trans-activation by cyclin-cdk2 complexes. Genes Dev. 8, 1772-1786 (1994). (Pubitemid 24265784)
-
(1994)
Genes and Development
, vol.8
, Issue.15
, pp. 1772-1786
-
-
Dynlacht, B.D.1
Flores, O.2
Lees, J.A.3
Harlow, E.4
-
18
-
-
0028019279
-
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation
-
Xu, M., Sheppard, K. A., Peng, C. Y., Yee, A. S. & Piwnica-Worms, H. Cyclin A/ CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/ DP-1 by phosphorylation. Mol. Cell Biol. 14, 8420-8431 (1994). (Pubitemid 24373591)
-
(1994)
Molecular and Cellular Biology
, vol.14
, Issue.12
, pp. 8420-8431
-
-
Xu, M.1
Sheppard, K.-A.2
Peng, C.-Y.3
Yee, A.S.4
Piwnica-Worms, H.5
-
19
-
-
0033130137
-
SKP2 and E2F-1 underlies the regulation of E2F-1 degradation
-
Marti, A., Wirbelauer, C., Scheffner, M. & Krek, W. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat. Cell Biol. 1, 14-19 (1999). (Pubitemid 129495004)
-
(1999)
Nature Cell Biology
, vol.1
, Issue.1
, pp. 14-19
-
-
Marti, A.1
Wirbelauer, C.2
Scheffner, M.3
Krek, W.4
-
20
-
-
2442677837
-
Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila
-
Heriche, J. K., Ang, D., Bier, E. & O'Farrell, P. H. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 4, 9 (2003).
-
(2003)
BMC Genet
, vol.4
, pp. 9
-
-
Heriche, J.K.1
Ang, D.2
Bier, E.3
O'Farrell, P.H.4
-
21
-
-
57049097607
-
Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase
-
Shibutani, S. T. et al. Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev. Cell 15, 890-900 (2008).
-
(2008)
Dev. Cell
, vol.15
, pp. 890-900
-
-
Shibutani, S.T.1
-
22
-
-
0034595292
-
Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication
-
Nakayama, K. et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069-2081 (2000). (Pubitemid 30237582)
-
(2000)
EMBO Journal
, vol.19
, Issue.9
, pp. 2069-2081
-
-
Nakayama, K.1
Nagahama, H.2
Minamishima, Y.A.3
Matsumoto, M.4
Nakamichi, I.5
Kitagawa, K.6
Shirane, M.7
Tsunematsu, R.8
Tsukiyama, T.9
Ishida, N.10
Kitagawa, M.11
Nakayama, K.-I.12
Hatakeyama, S.13
-
23
-
-
0038342441
-
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
-
DOI 10.1038/nature01764
-
Sage, J., Miller, A. L., Perez-Mancera, P. A., Wysocki, J. M. & Jacks, T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 424, 223-228 (2003). (Pubitemid 36858693)
-
(2003)
Nature
, vol.424
, Issue.6945
, pp. 223-228
-
-
Sage, J.1
Miller, A.L.2
Perez-Mancera, P.A.3
Wysocki, J.M.4
Jacks, T.5
-
24
-
-
0036884829
-
The retinoblastoma tumour suppressor in development and cancer
-
DOI 10.1038/nrc950
-
Classon, M. & Harlow, E. The retinoblastoma tumour suppressor in development and cancer. Nat. Rev. Cancer 2, 910-917 (2002). (Pubitemid 37328892)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.12
, pp. 910-917
-
-
Classon, M.1
Harlow, E.2
-
25
-
-
0037075898
-
Activation of the p53 tumor suppressor protein
-
DOI 10.1016/S0304-419X(02)00035-5, PII S0304419X02000355
-
Vousden, K. H. Activation of the p53 tumor suppressor protein. Biochim Biophys. Acta 1602, 47-59 2002. (Pubitemid 34311899)
-
(2002)
Biochimica et Biophysica Acta - Reviews on Cancer
, vol.1602
, Issue.1
, pp. 47-59
-
-
Vousden, K.H.1
-
26
-
-
0034609798
-
Role for the p53 homologue p73 in E2F-1-induced apoptosis
-
Irwin, M. et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 407, 645-648 (2000).
-
(2000)
Nature
, vol.407
, pp. 645-648
-
-
Irwin, M.1
-
27
-
-
0033666776
-
Role of the p53-homologue p73 in E2F1-induced apoptosis
-
Stiewe, T. & Putzer, B. M. Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat. Genet. 26, 464-469 (2000).
-
(2000)
Nat. Genet
, vol.26
, pp. 464-469
-
-
Stiewe, T.1
Putzer, B.M.2
-
28
-
-
0030738479
-
Distinct roles for E2F proteins in cell growth control and apoptosis
-
DOI 10.1073/pnas.94.14.7245
-
DeGregori, J., Leone, G., Miron, A., Jakoi, L. & Nevins, J. R. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl Acad. Sci. USA 94, 7245-7250 (1997). (Pubitemid 27345300)
-
(1997)
Proceedings of the National Academy of Sciences of the United States of America
, vol.94
, Issue.14
, pp. 7245-7250
-
-
Degregori, J.1
Leone, G.2
Miron, A.3
Jakoi, L.4
Nevins, J.R.5
-
29
-
-
23744507860
-
E2F1 is crucial for E2F-dependent apoptosis
-
Lazzerini Denchi, E. & Helin, K. E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep. 6, 661-668 (2005).
-
(2005)
EMBO Rep
, vol.6
, pp. 661-668
-
-
Lazzerini Denchi, E.1
Helin, K.2
-
30
-
-
0035118893
-
E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos
-
DOI 10.1101/gad.858801
-
Ziebold, U., Reza, T., Caron, A. & Lees, J. A. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos. Genes Dev. 15, 386-391 (2001). (Pubitemid 32186999)
-
(2001)
Genes and Development
, vol.15
, Issue.4
, pp. 386-391
-
-
Ziebold, U.1
Reza, T.2
Caron, A.3
Lees, J.A.4
-
32
-
-
84880274644
-
E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3
-
Chen, D., Chen, Y., Forrest, D. & Bremner, R. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3. Cell Death Differ. 20, 931-940 (2013).
-
(2013)
Cell Death Differ
, vol.20
, pp. 931-940
-
-
Chen, D.1
Chen, Y.2
Forrest, D.3
Bremner, R.4
-
33
-
-
0034816580
-
The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin e and regulates ubiquitin-dependent degradation of cyclin e
-
Yeh, K. H. et al. The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin E and regulates ubiquitin-dependent degradation of cyclin E. Biochem. Biophys. Res. Commun. 281, 884-890 (2001).
-
(2001)
Biochem. Biophys. Res. Commun
, vol.281
, pp. 884-890
-
-
Yeh, K.H.1
-
34
-
-
15444367709
-
The ubiquitin-protein ligase Itch regulates p73 stability
-
DOI 10.1038/sj.emboj.7600444
-
Rossi, M. et al. The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J. 24, 836-848 (2005). (Pubitemid 40396112)
-
(2005)
EMBO Journal
, vol.24
, Issue.4
, pp. 836-848
-
-
Rossi, M.1
De Laurenzi, V.2
Munarriz, E.3
Green, D.R.4
Liu, Y.-C.5
Vousden, K.H.6
Cesareni, G.7
Melino, G.8
-
35
-
-
2542540517
-
A link between p73 transcriptional activity and p73 degradation
-
DOI 10.1038/sj.onc.1207538
-
Wu, L., Zhu, H., Nie, L. & Maki, C. G. A link between p73 transcriptional activity and p73 degradation. Oncogene 23, 4032-4036 (2004). (Pubitemid 38747932)
-
(2004)
Oncogene
, vol.23
, Issue.22
, pp. 4032-4036
-
-
Wu, L.1
Zhu, H.2
Nie, L.3
Maki, C.G.4
-
36
-
-
84887560579
-
Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors
-
Zhao, H. et al. Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors. Cancer Cell 24, 645-659 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 645-659
-
-
Zhao, H.1
-
37
-
-
0034175616
-
Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
-
Takahashi, Y., Rayman, J. B. & Dynlacht, B. D. Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev. 14, 804-816 (2000). (Pubitemid 30215000)
-
(2000)
Genes and Development
, vol.14
, Issue.7
, pp. 804-816
-
-
Takahashi, Y.1
Rayman, J.B.2
Dynlacht, B.D.3
-
38
-
-
0033857983
-
Target gene specificity of E2F and pocket protein family members in living cells
-
DOI 10.1128/MCB.20.16.5797-5807.2000
-
Wells, J., Boyd, K. E., Fry, C. J., Bartley, S. M. & Farnham, P. J. Target gene specificity of E2F and pocket protein family members in living cells. Mol. Cell Biol. 20, 5797-5807 (2000). (Pubitemid 30613029)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.16
, pp. 5797-5807
-
-
Wells, J.1
Boyd, K.E.2
Fry, C.J.3
Bartley, S.M.4
Farnham, P.J.5
-
39
-
-
0028983384
-
P107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F
-
Zhu, L., Harlow, E. & Dynlacht, B. D. p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9, 1740-1752 (1995).
-
(1995)
Genes Dev
, vol.9
, pp. 1740-1752
-
-
Zhu, L.1
Harlow, E.2
Dynlacht, B.D.3
-
40
-
-
0029973557
-
Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors
-
Adams, P. D. et al. Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol. Cell Biol. 16, 6623-6633 (1996). (Pubitemid 26389720)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.12
, pp. 6623-6633
-
-
Adams, P.D.1
Sellers, W.R.2
Sharma, S.K.3
Wu, A.D.4
Nalin, C.M.5
Kaelin Jr., W.G.6
-
41
-
-
34447544650
-
Kip1 that causes stem cell expansion and a multiple tumor phenotype
-
DOI 10.1101/gad.1556607
-
Besson, A. et al. Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev. 21, 1731-1746 (2007). (Pubitemid 47076473)
-
(2007)
Genes and Development
, vol.21
, Issue.14
, pp. 1731-1746
-
-
Besson, A.1
Hwang, H.C.2
Cicero, S.3
Donovan, S.L.4
Gurian-West, M.5
Johnson, D.6
Clurman, B.E.7
Dyer, M.A.8
Roberts, J.M.9
-
42
-
-
33747670837
-
Kip1
-
DOI 10.1074/jbc.M603105200
-
Ji, P. et al. Skp2 contains a novel cyclin A binding domain that directly protects cyclin A from inhibition by p27Kip1. J. Biol. Chem. 281, 24058-24069 (2006). (Pubitemid 44274179)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.33
, pp. 24058-24069
-
-
Ji, P.1
Goldin, L.2
Ren, H.3
Sun, D.4
Guardavaccaro, D.5
Pagano, M.6
Zhu, L.7
-
43
-
-
1642399624
-
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
-
DOI 10.1038/nature02381
-
Wei, W. et al. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428, 194-198 (2004). (Pubitemid 38374317)
-
(2004)
Nature
, vol.428
, Issue.6979
, pp. 194-198
-
-
Wei, W.1
Ayad, N.G.2
Wan, Y.3
Zhang, G.-J.4
Kirschner, M.W.5
Kaelin Jr., W.G.6
-
44
-
-
1642378661
-
Cdh1 ubiquitin ligase
-
DOI 10.1038/nature02330
-
Bashir, T., Dorrello, N. V., Amador, V., Guardavaccaro, D. & Pagano, M. Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase. Nature 428, 190-193 (2004). (Pubitemid 38374316)
-
(2004)
Nature
, vol.428
, Issue.6979
, pp. 190-193
-
-
Bashir, T.1
Dorello, H.V.2
Amador, V.3
Guardavaccaro, D.4
Pagano, M.5
-
45
-
-
64049086572
-
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
-
Gao, D. et al. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat. Cell Biol. 11, 397-408 (2009).
-
(2009)
Nat. Cell Biol
, vol.11
, pp. 397-408
-
-
Gao, D.1
-
46
-
-
0034964014
-
Retinoblastoma protein partners
-
DOI 10.1016/S0065-230X(01)82001-7
-
Morris, E. J. & Dyson, N. J. Retinoblastoma protein partners. Adv. Cancer Res. 82, 1-54 (2001). (Pubitemid 32613381)
-
(2001)
Advances in Cancer Research
, vol.82
, pp. 1-54
-
-
Morris, E.J.1
Dyson, N.J.2
-
47
-
-
84873039208
-
Loss of RBF1 changes glutamine catabolism
-
Nicolay, B. N. et al. Loss of RBF1 changes glutamine catabolism. Genes Dev. 27, 182-196 (2013).
-
(2013)
Genes Dev
, vol.27
, pp. 182-196
-
-
Nicolay, B.N.1
-
48
-
-
17644387182
-
Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice
-
DOI 10.1128/MCB.25.9.3563-3574.2005
-
Lasorella, A., Rothschild, G., Yokota, Y., Russell, R. G. & Iavarone, A. Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice. Mol. Cell Biol. 25, 3563-3574 (2005). (Pubitemid 40559563)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.9
, pp. 3563-3574
-
-
Lasorella, A.1
Rothschild, G.2
Yokota, Y.3
Russell, R.G.4
Iavarone, A.5
-
49
-
-
8644240914
-
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression
-
DOI 10.1128/MCB.24.23.10406-10415.2004
-
Takahashi, C., Contreras, B., Bronson, R. T., Loda, M. & Ewen, M. E. Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression. Mol. Cell Biol. 24, 10406-10415 (2004). (Pubitemid 39507877)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.23
, pp. 10406-10415
-
-
Takahashi, C.1
Contreras, B.2
Bronson, R.T.3
Loda, M.4
Ewen, M.E.5
-
50
-
-
29444432928
-
Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor
-
DOI 10.1038/ng1703
-
Takahashi, C. et al. Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor. Nat. Genet. 38, 118-123 (2006). (Pubitemid 43011892)
-
(2006)
Nature Genetics
, vol.38
, Issue.1
, pp. 118-123
-
-
Takahashi, C.1
Contreras, B.2
Iwanaga, T.3
Takegami, Y.4
Bakker, A.5
Bronson, R.T.6
Noda, M.7
Loda, M.8
Hunt, J.L.9
Ewen, M.E.10
-
51
-
-
80051998696
-
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1
-
Lin, W. et al. Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc. Natl Acad. Sci. USA 108, 13379-13386 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 13379-13386
-
-
Lin, W.1
-
52
-
-
9244224723
-
Intrinsic tumour suppression
-
DOI 10.1038/nature03098
-
Lowe, S. W., Cepero, E. & Evan, G. Intrinsic tumour suppression. Nature 432, 307-315 (2004). (Pubitemid 39551658)
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
53
-
-
37349070024
-
An E2F1-Dependent Gene Expression Program that Determines the Balance between Proliferation and Cell Death
-
DOI 10.1016/j.ccr.2007.11.031, PII S1535610807003704
-
Hallstrom, T. C., Mori, S. & Nevins, J. R. An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell 13, 11-22 (2008). (Pubitemid 350309738)
-
(2008)
Cancer Cell
, vol.13
, Issue.1
, pp. 11-22
-
-
Hallstrom, T.C.1
Mori, S.2
Nevins, J.R.3
-
55
-
-
84861552793
-
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis
-
Chan, C. H. et al. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell 149, 1098-1111 (2012).
-
(2012)
Cell
, vol.149
, pp. 1098-1111
-
-
Chan, C.H.1
-
56
-
-
84875450168
-
PRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location
-
Lu, Z. et al. pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location. EMBO J. 32, 844-857 (2013).
-
(2013)
EMBO J
, vol.32
, pp. 844-857
-
-
Lu, Z.1
-
57
-
-
38649108164
-
Skp2 Suppresses p53-Dependent Apoptosis by Inhibiting p300
-
DOI 10.1016/j.molcel.2007.11.036, PII S1097276508000087
-
Kitagawa, M., Lee, S. H. & McCormick, F. Skp2 suppresses p53-dependent apoptosis by inhibiting p300. Mol. Cell 29, 217-231 (2008). (Pubitemid 351172826)
-
(2008)
Molecular Cell
, vol.29
, Issue.2
, pp. 217-231
-
-
Kitagawa, M.1
Lee, S.H.2
McCormick, F.3
-
58
-
-
2942733252
-
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
-
Balthasar, N. et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42, 983-891 (2004).
-
(2004)
Neuron
, vol.42
, pp. 983-891
-
-
Balthasar, N.1
-
59
-
-
0035921821
-
Kip1 in G1 and S phase
-
DOI 10.1038/35095083
-
Malek, N. P. et al. A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 413, 323-327 (2001). (Pubitemid 32905854)
-
(2001)
Nature
, vol.413
, Issue.6853
, pp. 323-327
-
-
Malek, N.P.1
Sundberg, H.2
McGrew, S.3
Nakayama, K.4
Kyriakidis, T.R.5
Roberts, J.M.6
-
60
-
-
0029888359
-
Tumor induction and tissue atrophy in mice lacking E2F-1
-
DOI 10.1016/S0092-8674(00)81254-4
-
Yamasaki, L. et al. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell 85, 537-548 (1996). (Pubitemid 26157192)
-
(1996)
Cell
, vol.85
, Issue.4
, pp. 537-548
-
-
Yamasaki, L.1
Jacks, T.2
Bronson, R.3
Goillot, E.4
Harlow, E.5
Dyson, N.J.6
-
61
-
-
42449086489
-
Analysis of growth properties and cell cycle regulation using mouse embryonic fibroblast cells
-
Sun, H., Gulbagci, N. T. & Taneja, R. Analysis of growth properties and cell cycle regulation using mouse embryonic fibroblast cells. Methods Mol. Biol. 383, 311-319 (2007).
-
(2007)
Methods Mol. Biol
, vol.383
, pp. 311-319
-
-
Sun, H.1
Gulbagci, N.T.2
Taneja, R.3
-
62
-
-
33747603277
-
Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown
-
DOI 10.2144/000112203
-
Sun, D., Melegari, M., Sridhar, S., Rogler, C. E. & Zhu, L. A multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown. Biotechniques 41, 59-63 (2006). (Pubitemid 46534903)
-
(2006)
BioTechniques
, vol.41
, Issue.1
, pp. 59-63
-
-
Sun, D.1
Melegari, M.2
Sridhar, S.3
Rogler, C.E.4
Zhu, L.5
|