-
1
-
-
0032549811
-
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
DOI 10.1016/S0092-8674(00)81410-5
-
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998;92(6):829-39. (Pubitemid 28155321)
-
(1998)
Cell
, vol.92
, Issue.6
, pp. 829-839
-
-
Puigserver, P.1
Wu, Z.2
Park, C.W.3
Graves, R.4
Wright, M.5
Spiegelman, B.M.6
-
2
-
-
0035016566
-
PGC-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells
-
DOI 10.1128/MCB.21.11.3738-3749.2001
-
Andersson U, Scarpulla RC. Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. Mol Cell Biol. 2001;21(11):3738-49. (Pubitemid 32466987)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.11
, pp. 3738-3749
-
-
Andersson, U.1
Scarpulla, R.C.2
-
3
-
-
0037127204
-
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor
-
DOI 10.1074/jbc.C100631200
-
Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem. 2002;277(3):1645-8. (Pubitemid 34968733)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.3
, pp. 1645-1648
-
-
Lin, J.1
Puigserver, P.2
Donovan, J.3
Tarr, P.4
Spiegelman, B.M.5
-
4
-
-
24144463983
-
Metabolic control through the PGC-1 family of transcription coactivators
-
DOI 10.1016/j.cmet.2005.05.004, PII S1550413105001427
-
Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005;1(6): 361-70. doi:10.1016/j.cmet.2005.05.004. (Pubitemid 43960626)
-
(2005)
Cell Metabolism
, vol.1
, Issue.6
, pp. 361-370
-
-
Lin, J.1
Handschin, C.2
Spiegelman, B.M.3
-
5
-
-
33644660537
-
PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
-
DOI 10.1172/JCI27794
-
Finck BN, Kelly DP. PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease. J Clin Investig. 2006;116(3):615-22. (Pubitemid 43326866)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.3
, pp. 615-622
-
-
Finck, B.N.1
Kelly, D.P.2
-
6
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coaotivator PGC-1
-
DOI 10.1038/35093050
-
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, et al. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001;413(6852):131-8. (Pubitemid 32867868)
-
(2001)
Nature
, vol.413
, Issue.6852
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
Donovan, J.4
Wu, Z.5
Rhee, J.6
Adelmant, G.7
Stafford, J.8
Kahn, C.R.9
Granner, D.K.10
Newgard, C.B.11
Spiegelman, B.M.12
-
7
-
-
0035855905
-
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
-
DOI 10.1038/35093131
-
Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001;413(6852):179-83. (Pubitemid 32867880)
-
(2001)
Nature
, vol.413
, Issue.6852
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
Hedrick, S.4
Quinn, R.5
Bauer, A.6
Rudolph, D.7
Schutz, G.8
Yoon, C.9
Puigserver, P.10
Spiegelman, B.11
Montminy, M.12
-
8
-
-
0033803048
-
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
-
Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Investig. 2000;106(7):847-56.
-
(2000)
J Clin Investig
, vol.106
, Issue.7
, pp. 847-856
-
-
Lehman, J.J.1
Barger, P.M.2
Kovacs, A.3
Saffitz, J.E.4
Medeiros, D.M.5
Kelly, D.P.6
-
9
-
-
62049085382
-
Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation
-
doi: 10.1038/nm.1910
-
Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, et al. Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med. 2009;15(3):259-66. doi: 10.1038/nm.1910.
-
(2009)
Nat Med
, vol.15
, Issue.3
, pp. 259-266
-
-
Ishii, K.A.1
Fumoto, T.2
Iwai, K.3
Takeshita, S.4
Ito, M.5
Shimohata, N.6
-
10
-
-
77956408841
-
PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss
-
doi:10.1016/j.cmet.2010.04.015
-
Wei W, Wang X, Yang M, Smith LC, Dechow PC, Wan Y. PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss. Cell Metab. 2010;11(6):503-16. doi:10.1016/j.cmet.2010.04.015.
-
(2010)
Cell Metab
, vol.11
, Issue.6
, pp. 503-516
-
-
Wei, W.1
Wang, X.2
Yang, M.3
Smith, L.C.4
Dechow, P.C.5
Wan, Y.6
-
11
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
DOI 10.1016/S0092-8674(00)80611-X
-
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999;98(1):115-24. (Pubitemid 29331201)
-
(1999)
Cell
, vol.98
, Issue.1
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
Zhang, C.4
Adelmant, G.5
Mootha, V.6
Troy, A.7
Cinti, S.8
Lowell, B.9
Scarpulla, R.C.10
Spiegelman, B.M.11
-
12
-
-
2342477730
-
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
-
DOI 10.1073/pnas.0401401101
-
Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, et al. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A. 2004;101(17):6570-5. (Pubitemid 38586015)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.17
, pp. 6570-6575
-
-
Mootha, V.K.1
Handschin, C.2
Arlow, D.3
Xie, X.4
St., P.J.5
Sihag, S.6
Yang, W.7
Altshuler, D.8
Puigserver, P.9
Patterson, N.10
Willy, P.J.11
Schulman, I.G.12
Heyman, R.A.13
Lander, E.S.14
Spiegelman, B.M.15
-
13
-
-
28544438180
-
PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: A mechanism for transcriptional control of muscle glucose metabolism
-
DOI 10.1128/MCB.25.24.10684-10694.2005
-
Wende AR, Huss JM, Schaeffer PJ, Giguere V, Kelly DP. PGC- 1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: A mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol. 2005;25(24):10684-94. doi: 10.1128/MCB.25.24.10684-10694.2005. (Pubitemid 41747115)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.24
, pp. 10684-10694
-
-
Wende, A.R.1
Huss, J.M.2
Schaeffer, P.J.3
Giguere, V.4
Kelly, D.P.5
-
14
-
-
13444306450
-
Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators
-
DOI 10.1128/MCB.25.4.1354-1366.2005
-
Gleyzer N, Vercauteren K, Scarpulla RC. Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. [Research Support, U.S. Gov't, P.H.S.]. Mol Cell Biol. 2005;25(4):1354-66. doi:10.1128/MCB.25.4.1354- 1366.2005. (Pubitemid 40204913)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.4
, pp. 1354-1366
-
-
Gleyzer, N.1
Vercauteren, K.2
Scarpulla, R.C.3
-
15
-
-
0033977890
-
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
-
DOI 10.1128/MCB.20.5.1868-1876.2000
-
Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol. 2000;20(5):1868-76. (Pubitemid 30100203)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.5
, pp. 1868-1876
-
-
Vega, R.B.1
Huss, J.M.2
Kelly, D.P.3
-
16
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
-
DOI 10.1038/nature01667
-
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003;423(6939):550-5. (Pubitemid 36648580)
-
(2003)
Nature
, vol.423
, Issue.6939
, pp. 550-555
-
-
Puigserver, P.1
Rhee, J.2
Donovan, J.3
Walkey, C.J.4
Yoon, J.C.5
Oriente, F.6
Kitamura, Y.7
Altomonte, J.8
Dong, H.9
Accili, D.10
Spiegelman, B.M.11
-
17
-
-
0042232315
-
PGC-1beta in the regulation of hepatic glucose and energy metabolism
-
DOI 10.1074/jbc.M303643200
-
Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, et al. PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem. 2003;278(33):30843-8. (Pubitemid 36994593)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.33
, pp. 30843-30848
-
-
Lin, J.1
Tarr, P.T.2
Yang, R.3
Rhee, J.4
Puigserver, P.5
Newgard, C.B.6
Spiegelman, B.M.7
-
18
-
-
0035676129
-
Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus
-
DOI 10.1007/s001250100032
-
Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch- Johnsen K, et al. Mutation analysis of peroxisome proliferatoractivated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. [Research Support, Non-U.S. Gov't]. Diabetologia. 2001;44(12): 2220-6. doi:10.1007/s001250100032. (Pubitemid 34015475)
-
(2001)
Diabetologia
, vol.44
, Issue.12
, pp. 2220-2226
-
-
Ek, J.1
Andersen, G.2
Urhammer, S.A.3
Gaede, P.H.4
Drivsholm, T.5
Borch-Johnsen, K.6
Hansen, T.7
Pedersen, O.8
-
19
-
-
0035985096
-
A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes
-
DOI 10.1007/s00125-002-0803-z
-
Hara K, Tobe K, Okada T, Kadowaki H, Akanuma Y, Ito C, et al. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. [Comparative Study Research Support, Non-U.S. Gov't]. Diabetologia. 2002;45(5):740-3. doi:10.1007/s00125-002-0803-z. (Pubitemid 34810700)
-
(2002)
Diabetologia
, vol.45
, Issue.5
, pp. 740-743
-
-
Hara, K.1
Tobe, K.2
Okada, T.3
Kadowaki, H.4
Akanuma, Y.5
Ito, C.6
Kimura, S.7
Kadowaki, T.8
-
20
-
-
2342625303
-
Complex Haplotypes of the PGC-1alpha Gene Are Associated with Carbohydrate Metabolism and Type 2 Diabetes
-
DOI 10.2337/diabetes.53.5.1385
-
Oberkofler H, Linnemayr V, Weitgasser R, Klein K, Xie M, Iglseder B, et al. Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes. [Research Support, Non-U.S. Gov't]. Diabetes. 2004;53(5):1385-93. (Pubitemid 38569027)
-
(2004)
Diabetes
, vol.53
, Issue.5
, pp. 1385-1393
-
-
Oberkofler, H.1
Linnemayr, V.2
Weitgasser, R.3
Klein, K.4
Xie, M.5
Iglseder, B.6
Krempler, F.7
Paulweber, B.8
Patsch, W.9
-
21
-
-
0038054341
-
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
DOI 10.1038/ng1180
-
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34(3):267-73. (Pubitemid 36792858)
-
(2003)
Nature Genetics
, vol.34
, Issue.3
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.-F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
Puigserver, P.7
Carlsson, E.8
Ridderstrale, M.9
Laurila, E.10
Houstis, N.11
Daly, M.J.12
Patterson, N.13
Mesirov, J.P.14
Golub, T.R.15
Tamayo, P.16
Spiegelman, B.17
Lander, E.S.18
Hirschhorn, J.N.19
Altshuler, D.20
Groop, L.C.21
more..
-
22
-
-
5344252327
-
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
-
DOI 10.1016/j.cell.2004.09.013, PII S0092867404008864
-
Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004;119(1):121-35. (Pubitemid 39349325)
-
(2004)
Cell
, vol.119
, Issue.1
, pp. 121-135
-
-
Lin, J.1
Wu, P.-H.2
Tarr, P.T.3
Lindenberg, K.S.4
St-Pierre, J.5
Zhang, C.-Y.6
Mootha, V.K.7
Jager, S.8
Vianna, C.R.9
Reznick, R.M.10
Cui, L.11
Manieri, M.12
Donovan, M.X.13
Wu, Z.14
Cooper, M.P.15
Fan, M.C.16
Rohas, L.M.17
Zavacki, A.M.18
Cinti, S.19
Shulman, G.I.20
Lowell, B.B.21
Krainc, D.22
Spiegelman, B.M.23
more..
-
23
-
-
34247590356
-
PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis
-
DOI 10.1073/pnas.0611623104
-
Sonoda J, Mehl IR, Chong LW, Nofsinger RR, Evans RM. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc Natl Acad Sci U S A. 2007;104(12):5223-8. (Pubitemid 47186203)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.12
, pp. 5223-5228
-
-
Sonoda, J.1
Mehl, I.R.2
Chong, L.-W.3
Nofsinger, R.R.4
Evans, R.M.5
-
24
-
-
21144446106
-
PGC-1alpha deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis
-
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005;3(4):e101.
-
(2005)
PLoS Biol
, vol.3
, Issue.4
-
-
Leone, T.C.1
Lehman, J.J.2
Finck, B.N.3
Schaeffer, P.J.4
Wende, A.R.5
Boudina, S.6
-
25
-
-
33751400561
-
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance
-
DOI 10.1016/j.cmet.2006.11.003, PII S1550413106003652
-
Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, et al. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006;4(6):453-64. (Pubitemid 44817352)
-
(2006)
Cell Metabolism
, vol.4
, Issue.6
, pp. 453-464
-
-
Vianna, C.R.1
Huntgeburth, M.2
Coppari, R.3
Choi, C.S.4
Lin, J.5
Krauss, S.6
Barbatelli, G.7
Tzameli, I.8
Kim, Y.-B.9
Cinti, S.10
Shulman, G.I.11
Spiegelman, B.M.12
Lowell, B.B.13
-
26
-
-
65649148341
-
Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity
-
Liang H, Balas B, Tantiwong P, Dube J, Goodpaster BH, O'Doherty RM, et al. Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity. Am J Physiol Endocrinol Metab. 2009;296(4):E945-54.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.296
, Issue.4
-
-
Liang, H.1
Balas, B.2
Tantiwong, P.3
Dube, J.4
Goodpaster, B.H.5
O'Doherty, R.M.6
-
27
-
-
84859756230
-
Peri-implantation lethality in mice lacking the PGC-1-related coactivator protein
-
Research Support, Non-U.S. Gov't doi:10.1002/dvdy.23769
-
He X, Sun C, Wang F, Shan A, Guo T, Gu W, et al. Peri-implantation lethality in mice lacking the PGC-1-related coactivator protein. [Research Support, Non-U.S. Gov't]. Dev Dyn. 2012;241(5):975-83. doi:10.1002/dvdy.23769.
-
(2012)
Dev Dyn
, vol.241
, Issue.5
, pp. 975-983
-
-
He, X.1
Sun, C.2
Wang, F.3
Shan, A.4
Guo, T.5
Gu, W.6
-
28
-
-
47549114849
-
Transcriptional coactivators PGC-lalpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart
-
DOI 10.1101/gad.1661708
-
Lai L, Leone TC, Zechner C, Schaeffer PJ, Kelly SM, Flanagan DP, et al. Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Gene Dev. 2008;22(14):1948-61. (Pubitemid 352008642)
-
(2008)
Genes and Development
, vol.22
, Issue.14
, pp. 1948-1961
-
-
Lai, L.1
Leone, T.C.2
Zechner, C.3
Schaeffer, P.J.4
Kelly, S.M.5
Flanagan, D.P.6
Medeiros, D.M.7
Kovacs, A.8
Kelly, D.P.9
-
29
-
-
58149401189
-
Paradoxical effects of increased expression of PGC-1alpha on musclemitochondrial function and insulin-stimulatedmuscle glucose metabolism
-
doi:10.1073/pnas.0810339105
-
Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, et al. Paradoxical effects of increased expression of PGC-1alpha on musclemitochondrial function and insulin-stimulatedmuscle glucose metabolism. Proc Natl Acad Sci U S A. 2008;105(50):19926-31. doi:10.1073/pnas.0810339105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.50
, pp. 19926-19931
-
-
Choi, C.S.1
Befroy, D.E.2
Codella, R.3
Kim, S.4
Reznick, R.M.5
Hwang, Y.J.6
-
30
-
-
84872050740
-
PGC-1alpha improves glucose homeostasis in skeletal muscle in an activity-dependent manner
-
[Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. doi:10.2337/db12-0291
-
Summermatter S, Shui G, Maag D, Santos G, Wenk MR, Handschin C. PGC-1alpha improves glucose homeostasis in skeletal muscle in an activity-dependent manner. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. Diabetes. 2013;62(1): 85-95. doi:10.2337/db12-0291.
-
(2013)
Diabetes
, vol.62
, Issue.1
, pp. 85-95
-
-
Summermatter, S.1
Shui, G.2
Maag, D.3
Santos, G.4
Wenk, M.R.5
Handschin, C.6
-
31
-
-
84870921992
-
A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. doi:10.1016/j.cell.2012.10.050
-
Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, et al. A PGC-1alpha isoform induced by resistance training regulates skeletal muscle hypertrophy. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Cell. 2012;151(6):1319-31. doi:10.1016/j.cell.2012.10.050.
-
(2012)
Cell
, vol.151
, Issue.6
, pp. 1319-1331
-
-
Ruas, J.L.1
White, J.P.2
Rao, R.R.3
Kleiner, S.4
Brannan, K.T.5
Harrison, B.C.6
-
32
-
-
33845674997
-
The Transcriptional Coactivator PGC-1beta Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle
-
DOI 10.1016/j.cmet.2006.12.003, PII S1550413106004001
-
Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, et al. The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metab. 2007;5(1):35-46. doi:10.1016/j.cmet. 2006.12.003. (Pubitemid 44939399)
-
(2007)
Cell Metabolism
, vol.5
, Issue.1
, pp. 35-46
-
-
Arany, Z.1
Lebrasseur, N.2
Morris, C.3
Smith, E.4
Yang, W.5
Ma, Y.6
Chin, S.7
Spiegelman, B.M.8
-
33
-
-
82955187865
-
Skeletal muscle-specific expression of PGC-1alpha-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake
-
[Research Support, Non-U.S. Gov't]. doi:10.1371/journal.pone.0028290
-
Tadaishi M, Miura S, Kai Y, Kano Y, Oishi Y, Ezaki O. Skeletal muscle-specific expression of PGC-1alpha-b, an exercise-responsive isoform, increases exercise capacity and peak oxygen uptake. [Research Support, Non-U.S. Gov't]. PloS one. 2011;6(12):e28290. doi:10.1371/journal.pone.0028290.
-
(2011)
PloS One
, vol.6
, Issue.12
-
-
Tadaishi, M.1
Miura, S.2
Kai, Y.3
Kano, Y.4
Oishi, Y.5
Ezaki, O.6
-
34
-
-
36048931015
-
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk
-
DOI 10.1172/JCI31785
-
Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, et al. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Investig. 2007;117(11):3463-74. doi:10.1172/JCI31785. (Pubitemid 350097002)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.11
, pp. 3463-3474
-
-
Handschin, C.1
Cheol, S.C.2
Chin, S.3
Kim, S.4
Kawamori, D.5
Kurpad, A.J.6
Neubauer, N.7
Hu, J.8
Mootha, V.K.9
Kim, Y.-B.10
Kulkarni, R.N.11
Shulman, G.I.12
Spiegelman, B.M.13
-
35
-
-
78649508058
-
Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity
-
doi:10.1016/j.cmet.2010.11.008
-
Zechner C, Lai L, Zechner JF, Geng T, Yan Z, Rumsey JW, et al. Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab. 2010;12(6):633-42. doi:10.1016/j.cmet.2010.11.008.
-
(2010)
Cell Metab
, vol.12
, Issue.6
, pp. 633-642
-
-
Zechner, C.1
Lai, L.2
Zechner, J.F.3
Geng, T.4
Yan, Z.5
Rumsey, J.W.6
-
36
-
-
84878565172
-
Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle
-
doi:10.1016/j.celrep.2013.04.023
-
Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, et al. Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Rep. 2013;3(5):1449-56. doi:10.1016/j.celrep.2013.04.023.
-
(2013)
Cell Rep
, vol.3
, Issue.5
, pp. 1449-1456
-
-
Rowe, G.C.1
Patten, I.S.2
Zsengeller, Z.K.3
El-Khoury, R.4
Okutsu, M.5
Bampoh, S.6
-
37
-
-
84876155050
-
Hepatic-specific activation of peroxisome proliferator-activated receptor gamma coactivator-1beta protects against steatohepatitis
-
[Research Support, Non-U.S. Gov't]. doi:10.1002/hep.26222
-
Bellafante E, Murzilli S, Salvatore L, Latorre D, Villani G, Moschetta A. Hepatic-specific activation of peroxisome proliferator-activated receptor gamma coactivator-1beta protects against steatohepatitis. [Research Support, Non-U.S. Gov't]. Hepatology. 2013;57(4):1343-56. doi:10.1002/hep.26222.
-
(2013)
Hepatology
, vol.57
, Issue.4
, pp. 1343-1356
-
-
Bellafante, E.1
Murzilli, S.2
Salvatore, L.3
Latorre, D.4
Villani, G.5
Moschetta, A.6
-
38
-
-
76049093949
-
PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. doi:10.1073/pnas.0912533106
-
Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, et al. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Proc Natl Acad Sci U S A. 2009;106(52):22510 - 5. doi:10.1073/pnas.0912533106.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.52
, pp. 22510-22515
-
-
Estall, J.L.1
Ruas, J.L.2
Choi, C.S.3
Laznik, D.4
Badman, M.5
Maratos-Flier, E.6
-
39
-
-
84871675625
-
Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. doi:10.1371/journal.pone.0052645
-
Chambers KT, Chen Z, Crawford PA, Fu X, Burgess SC, Lai L, et al. Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. PloS one. 2012;7(12):e52645. doi:10.1371/journal.pone.0052645.
-
(2012)
PloS One
, vol.7
, Issue.12
-
-
Chambers, K.T.1
Chen, Z.2
Crawford, P.A.3
Fu, X.4
Burgess, S.C.5
Lai, L.6
-
40
-
-
84862162100
-
Development of insulin resistance in mice lacking PGC-1alpha in adipose tissues
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. doi:10.1073/pnas.1207287109
-
Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, et al. Development of insulin resistance in mice lacking PGC-1alpha in adipose tissues. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Proc Natl Acad Sci U S A. 2012;109(24):9635-40. doi:10.1073/pnas.1207287109.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.24
, pp. 9635-9640
-
-
Kleiner, S.1
Mepani, R.J.2
Laznik, D.3
Ye, L.4
Jurczak, M.J.5
Jornayvaz, F.R.6
-
41
-
-
84859159081
-
Transgenic expression and activation of PGC-1alpha protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease
-
[Research Support, Non-U.S. Gov't]. doi:10.1007/s00018-011-0850-z
-
Mudo G, Makela J, Di Liberto V, Tselykh TV, Olivieri M, Piepponen P, et al. Transgenic expression and activation of PGC-1alpha protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease. [Research Support, Non-U.S. Gov't]. Cell Mol Life Sci. 2012;69(7):1153-65. doi:10.1007/s00018-011- 0850-z.
-
(2012)
Cell Mol Life Sci
, vol.69
, Issue.7
, pp. 1153-1165
-
-
Mudo, G.1
Makela, J.2
Di Liberto, V.3
Tselykh, T.V.4
Olivieri, M.5
Piepponen, P.6
-
42
-
-
78649819597
-
Neuronal inactivation of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) protects mice from diet-induced obesity and leads to degenerative lesions
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. doi:10.1074/jbc.M110.151688
-
Ma D, Li S, Lucas EK, Cowell RM, Lin JD. Neuronal inactivation of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) protects mice from diet-induced obesity and leads to degenerative lesions. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. J Biol Chem. 2010;285(50):39087-95. doi:10.1074/jbc.M110.151688.
-
(2010)
J Biol Chem
, vol.285
, Issue.50
, pp. 39087-39095
-
-
Ma, D.1
Li, S.2
Lucas, E.K.3
Cowell, R.M.4
Lin, J.D.5
-
43
-
-
84875444428
-
Fetal PGC-1alpha overexpression programs adult pancreatic beta-cell dysfunction
-
[Research Support, Non-U.S. Gov't]. doi:10.2337/db12-0314
-
Valtat B, Riveline JP, Zhang P, Singh-Estivalet A, Armanet M, Venteclef N, et al. Fetal PGC-1alpha overexpression programs adult pancreatic beta-cell dysfunction. [Research Support, Non-U.S. Gov't]. Diabetes. 2013;62(4):1206-16. doi:10.2337/db12-0314.
-
(2013)
Diabetes
, vol.62
, Issue.4
, pp. 1206-1216
-
-
Valtat, B.1
Riveline, J.P.2
Zhang, P.3
Singh-Estivalet, A.4
Armanet, M.5
Venteclef, N.6
-
44
-
-
0842347859
-
Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: Restoration by troglitazone
-
DOI 10.1194/jlr.M300208-JLR200
-
Jove M, Salla J, Planavila A, Cabrero A, Michalik L, Wahli W, et al. Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: Restoration by troglitazone. J Lipid Res. 2004;45(1):113-23. (Pubitemid 38176621)
-
(2004)
Journal of Lipid Research
, vol.45
, Issue.1
, pp. 113-123
-
-
Jove, M.1
Salla, J.2
Planavila, A.3
Cabrero, A.4
Michalik, L.5
Wahli, W.6
Laguna, J.C.7
Vazquez-Carrera, M.8
-
45
-
-
34547468943
-
Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1alpha and PPARbeta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus
-
DOI 10.1038/sj.ijo.0803567, PII 0803567
-
Mensink M, Hesselink MK, Russell AP, Schaart G, Sels JP, Schrauwen P. Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus. [Controlled Clinical Trial Research Support, Non-U.S. Gov't]. Int J Obes. 2007;31(8):1302-10. doi:10.1038/sj.ijo. 0803567. (Pubitemid 47172612)
-
(2007)
International Journal of Obesity
, vol.31
, Issue.8
, pp. 1302-1310
-
-
Mensink, M.1
Hesselink, M.K.C.2
Russell, A.P.3
Schaart, G.4
Sels, J.-P.5
Schrauwen, P.6
-
46
-
-
0035957375
-
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1
-
[Research Support, U.S. Gov't, P.H.S.]. doi:10.1073/pnas.061035098
-
Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, et al. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. [Research Support, U.S. Gov't, P.H.S.]. Proc Natl Acad Sci U S A. 2001;98(7):3820 -5. doi:10.1073/pnas.061035098.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.7
, pp. 3820-3825
-
-
Michael, L.F.1
Wu, Z.2
Cheatham, R.B.3
Puigserver, P.4
Adelmant, G.5
Lehman, J.J.6
-
47
-
-
79953734462
-
PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination
-
[Comment Letter]. doi:10.1016/j.cmet.2011.03.008. author reply 352
-
Handschin C, Spiegelman BM. PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. [Comment Letter]. Cell Metabol. 2011;13(4):351. doi:10.1016/j.cmet.2011.03.008. author reply 352.
-
(2011)
Cell Metabol
, vol.13
, Issue.4
, pp. 351
-
-
Handschin, C.1
Spiegelman, B.M.2
-
48
-
-
79953737918
-
Response to Handschin and Spiegelman
-
Response
-
Zechner C, Leone TC, Kelly DP. Response to Handschin and Spiegelman. [Response]. Cell Metabol. 2011;13(4):352.
-
(2011)
Cell Metabol
, vol.13
, Issue.4
, pp. 352
-
-
Zechner, C.1
Leone, T.C.2
Kelly, D.P.3
-
49
-
-
0037102256
-
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
-
doi:10.1038/nature00904
-
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 2002;418(6899):797-801. doi:10.1038/nature00904.
-
(2002)
Nature
, vol.418
, Issue.6899
, pp. 797-801
-
-
Lin, J.1
Wu, H.2
Tarr, P.T.3
Zhang, C.Y.4
Wu, Z.5
Boss, O.6
-
50
-
-
45149108625
-
Muscle-specific expression of PPAR{gamma} coactivator-1{alpha} improves exercise performance and increases peak oxygen uptake
-
Calvo JA, Daniels TG, Wang X, Paul A, Lin J, Spiegelman BM, et al. Muscle-specific expression of PPAR{gamma} coactivator-1{alpha} improves exercise performance and increases peak oxygen uptake. J Appl Physiol. 2008;104(5):1304-12.
-
(2008)
J Appl Physiol
, vol.104
, Issue.5
, pp. 1304-1312
-
-
Calvo, J.A.1
Daniels, T.G.2
Wang, X.3
Paul, A.4
Lin, J.5
Spiegelman, B.M.6
-
51
-
-
3042734802
-
Improvements in insulin resistance with aerobic exercise training: A lipocentric approach
-
Bruce CR, Hawley JA. Improvements in insulin resistance with aerobic exercise training: A lipocentric approach. [Research Support, Non-U.S. Gov't Review]. Med Sci Sports Exerc. 2004;36(7):1196-201. (Pubitemid 38878995)
-
(2004)
Medicine and Science in Sports and Exercise
, vol.36
, Issue.7
, pp. 1196-1201
-
-
Cruce, C.R.1
Hawley, J.A.2
-
52
-
-
84862554858
-
Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients
-
[Randomized Controlled Trial Research Support, Non-U.S. Gov't]. doi:10.1007/s00125-011-2380-5
-
van Dijk JW, Manders RJ, Tummers K, Bonomi AG, Stehouwer CD, Hartgens F, et al. Both resistance- and endurance-type exercise reduce the prevalence of hyperglycaemia in individuals with impaired glucose tolerance and in insulin-treated and non-insulin-treated type 2 diabetic patients. [Randomized Controlled Trial Research Support, Non-U.S. Gov't]. Diabetologia. 2012;55(5):1273-82. doi:10.1007/s00125-011-2380-5.
-
(2012)
Diabetologia
, vol.55
, Issue.5
, pp. 1273-1282
-
-
Van Dijk, J.W.1
Manders, R.J.2
Tummers, K.3
Bonomi, A.G.4
Stehouwer, C.D.5
Hartgens, F.6
-
53
-
-
73949099327
-
Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
-
doi:10.1073/pnas.0911570106
-
Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A. 2009;106(48):20405-10. doi:10.1073/pnas. 0911570106.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.48
, pp. 20405-20410
-
-
Wenz, T.1
Rossi, S.G.2
Rotundo, R.L.3
Spiegelman, B.M.4
Moraes, C.T.5
-
54
-
-
75849155745
-
The transcriptional coactivator PGC-1{alpha} mediates exercise-induced angiogenesis in skeletal muscle
-
doi:10.1073/pnas.0909131106
-
Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe GC, et al. The transcriptional coactivator PGC-1{alpha} mediates exercise-induced angiogenesis in skeletal muscle. Proc Natl Acad Sci U S A. 2009;106(50):21401-6. doi:10.1073/pnas.0909131106.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.50
, pp. 21401-21406
-
-
Chinsomboon, J.1
Ruas, J.2
Gupta, R.K.3
Thom, R.4
Shoag, J.5
Rowe, G.C.6
-
55
-
-
62649165344
-
Identification and characterization of an alternative promoter of the human PGC-1alpha gene
-
[Research Support, Non-U.S. Gov't]. doi:10.1016/j.bbrc.2009.02.077
-
Yoshioka T, Inagaki K, Noguchi T, Sakai M, Ogawa W, Hosooka T, et al. Identification and characterization of an alternative promoter of the human PGC-1alpha gene. [Research Support, Non-U.S. Gov't]. Biochem Biophys Res Commun. 2009;381(4):537-43. doi:10.1016/j.bbrc.2009.02.077.
-
(2009)
Biochem Biophys Res Commun
, vol.381
, Issue.4
, pp. 537-543
-
-
Yoshioka, T.1
Inagaki, K.2
Noguchi, T.3
Sakai, M.4
Ogawa, W.5
Hosooka, T.6
-
56
-
-
84863119126
-
Skeletal muscle transcriptional coactivator PGC-1alpha mediates mitochondrial, but not metabolic, changes during calorie restriction
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. doi:10.1073/pnas.1115813109
-
Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, et al. Skeletal muscle transcriptional coactivator PGC-1alpha mediates mitochondrial, but not metabolic, changes during calorie restriction. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. Proc Natl Acad Sci U S A. 2012;109(8):2931 - 6. doi:10.1073/pnas.1115813109.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.8
, pp. 2931-2936
-
-
Finley, L.W.1
Lee, J.2
Souza, A.3
Desquiret-Dumas, V.4
Bullock, K.5
Rowe, G.C.6
-
57
-
-
2442701392
-
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
-
DOI 10.1038/nm1044
-
Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, et al. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Nat Med. 2004;10(5):530-4. doi:10.1038/nm1044. (Pubitemid 38667913)
-
(2004)
Nature Medicine
, vol.10
, Issue.5
, pp. 530-534
-
-
Koo, S.-H.1
Satoh, H.2
Herzig, S.3
Lee, C.-H.4
Hedrick, S.5
Kulkarni, R.6
Evans, R.M.7
Olefsky, J.8
Montminy, M.9
-
58
-
-
38649110496
-
Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis
-
DOI 10.1016/j.cmet.2007.11.013, PII S1550413107003683
-
Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Aleman JO, Suzuki R, et al. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. Cell Metab. 2008;7(2):125-34. doi:10.1016/j.cmet.2007.11.013. (Pubitemid 351168555)
-
(2008)
Cell Metabolism
, vol.7
, Issue.2
, pp. 125-134
-
-
Biddinger, S.B.1
Hernandez-Ono, A.2
Rask-Madsen, C.3
Haas, J.T.4
Aleman, J.O.5
Suzuki, R.6
Scapa, E.F.7
Agarwal, C.8
Carey, M.C.9
Stephanopoulos, G.10
Cohen, D.E.11
King, G.L.12
Ginsberg, H.N.13
Kahn, C.R.14
-
59
-
-
34250740323
-
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator
-
DOI 10.1038/nature05861, PII NATURE05861
-
Li X, Monks B, Ge Q, Birnbaum MJ. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. [Research Support, N.I.H., Extramural]. Nature. 2007;447(7147):1012-6. doi:10.1038/nature05861. (Pubitemid 46975750)
-
(2007)
Nature
, vol.447
, Issue.7147
, pp. 1012-1016
-
-
Li, X.1
Monks, B.2
Ge, Q.3
Birnbaum, M.J.4
-
60
-
-
79959635928
-
Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov ' t]. doi:10.1101/gad.2054711
-
Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, et al. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov ' t]. Gene Dev. 2011;25(12):1232-44. doi:10.1101/gad.2054711.
-
(2011)
Gene Dev
, vol.25
, Issue.12
, pp. 1232-1244
-
-
Lustig, Y.1
Ruas, J.L.2
Estall, J.L.3
Lo, J.C.4
Devarakonda, S.5
Laznik, D.6
-
61
-
-
84871676013
-
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. doi:10.1016/j.molcel.2012.09.030
-
Dominy Jr JE, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, et al. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't].Mol Cell. 2012;48(6):900-13. doi:10.1016/j.molcel.2012.09.030.
-
(2012)
Mol Cell
, vol.48
, Issue.6
, pp. 900-913
-
-
Dominy Jr., J.E.1
Lee, Y.2
Jedrychowski, M.P.3
Chim, H.4
Jurczak, M.J.5
Camporez, J.P.6
-
62
-
-
67650242167
-
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov ' t]. doi:10.2337/db08-1571
-
Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, et al. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov ' t]. Diabetes. 2009;58(7):1499-508. doi:10.2337/db08-1571.
-
(2009)
Diabetes
, vol.58
, Issue.7
, pp. 1499-1508
-
-
Estall, J.L.1
Kahn, M.2
Cooper, M.P.3
Fisher, F.M.4
Wu, M.K.5
Laznik, D.6
-
63
-
-
20444435873
-
FGF-21 as a novel metabolic regulator
-
DOI 10.1172/JCI23606
-
Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, et al. FGF-21 as a novel metabolic regulator. J Clin Investig. 2005;115(6):1627-35. doi:10.1172/JCI23606. (Pubitemid 40814671)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.6
, pp. 1627-1635
-
-
Kharitonenkov, A.1
Shiyanova, T.L.2
Koester, A.3
Ford, A.M.4
Micanovic, R.5
Galbreath, E.J.6
Sandusky, G.E.7
Hammond, L.J.8
Moyers, J.S.9
Owens, R.A.10
Gromada, J.11
Brozinick, J.T.12
Hawkins, E.D.13
Wroblewski, V.J.14
Li, D.-S.15
Mehrbod, F.16
Jaskunas, S.R.17
Shanafelt, A.B.18
-
64
-
-
79960726293
-
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. doi:10.1210/en.2011-0281
-
Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, et al. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo . [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Endocrinology. 2011;152(8):2996-3004. doi:10.1210/en.2011-0281.
-
(2011)
Endocrinology
, vol.152
, Issue.8
, pp. 2996-3004
-
-
Fisher, F.M.1
Estall, J.L.2
Adams, A.C.3
Antonellis, P.J.4
Bina, H.A.5
Flier, J.S.6
-
65
-
-
72449191699
-
Adipose tissue as an endocrine organ
-
[Review]. doi:10.1016/j.mce.2009.08.018
-
Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. [Review]. Mol Cell Endocrinol. 2010;316(2):129-39. doi:10.1016/j.mce.2009.08. 018.
-
(2010)
Mol Cell Endocrinol
, vol.316
, Issue.2
, pp. 129-139
-
-
Galic, S.1
Oakhill, J.S.2
Steinberg, G.R.3
-
66
-
-
42449097289
-
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
-
DOI 10.1038/nrm2391, PII NRM2391
-
Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. [Research Support, N.I.H., Extramural Review]. Nat Rev Mol Cell Biol. 2008;9(5):367-77. doi:10.1038/nrm2391. (Pubitemid 351574198)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.5
, pp. 367-377
-
-
Guilherme, A.1
Virbasius, J.V.2
Puri, V.3
Czech, M.P.4
-
67
-
-
0942279549
-
Expression of the thermogenic nuclear hormone receptor coactivator PGC-1alpha is reduced in the adipose tissue of morbidly obese subjects
-
DOI 10.1038/sj.ijo.0802482
-
Semple RK, Crowley VC, Sewter CP, Laudes M, Christodoulides C, Considine RV, et al. Expression of the thermogenic nuclear hormone receptor coactivator PGC-1alpha is reduced in the adipose tissue of morbidly obese subjects. Int J Obes Relat Metab Disord J Int Assoc Study Obes. 2004;28(1):176-9. doi:10.1038/sj.ijo.0802482. (Pubitemid 38142007)
-
(2004)
International Journal of Obesity
, vol.28
, Issue.1
, pp. 176-179
-
-
Semple, R.K.1
Crowley, V.C.2
Sewter, C.P.3
Laudes, M.4
Christodoulides, C.5
Considine, R.V.6
Vidal-Puig, A.7
O'Rahilly, S.8
-
68
-
-
62449166389
-
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. doi:10.1001/archneurol.2008.588
-
Qin W, Haroutunian V, Katsel P, Cardozo CP, Ho L, Buxbaum JD, et al. PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.]. Arch Neurol. 2009;66(3):352-61. doi:10.1001/archneurol.2008.588.
-
(2009)
Arch Neurol
, vol.66
, Issue.3
, pp. 352-361
-
-
Qin, W.1
Haroutunian, V.2
Katsel, P.3
Cardozo, C.P.4
Ho, L.5
Buxbaum, J.D.6
-
69
-
-
77958072667
-
PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease
-
[Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. doi:10.1126/scitranslmed.3001059
-
Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, et al. PGC-1alpha, a potential therapeutic target for early intervention in Parkinson's disease. [Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Sci Transl Med. 2010;2(52):52ra73. doi:10.1126/scitranslmed. 3001059.
-
(2010)
Sci Transl Med
, vol.2
, Issue.52
-
-
Zheng, B.1
Liao, Z.2
Locascio, J.J.3
Lesniak, K.A.4
Roderick, S.S.5
Watt, M.L.6
-
70
-
-
0015521813
-
Increased frequency of diabetes mellitus in patients with Huntington's chorea
-
Podolsky S, Leopold NA, Sax DS. Increased frequency of diabetes mellitus in patients with Huntington's chorea. Lancet. 1972;1(7765): 1356-8.
-
(1972)
Lancet
, vol.1
, Issue.7765
, pp. 1356-1358
-
-
Podolsky, S.1
Leopold, N.A.2
Sax, D.S.3
-
71
-
-
44449119315
-
Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease
-
[Research Support, Non-U.S. Gov't]. doi:10.1007/s00415-008-0774-1
-
Helisalmi S, Vepsalainen S, Hiltunen M, Koivisto AM, Salminen A, Laakso M, et al. Genetic study between SIRT1, PPARD, PGC-1alpha genes and Alzheimer's disease. [Research Support, Non-U.S. Gov't]. J Neurol. 2008;255(5):668-73. doi:10.1007/s00415-008-0774-1.
-
(2008)
J Neurol
, vol.255
, Issue.5
, pp. 668-673
-
-
Helisalmi, S.1
Vepsalainen, S.2
Hiltunen, M.3
Koivisto, A.M.4
Salminen, A.5
Laakso, M.6
-
72
-
-
0037473947
-
Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain
-
DOI 10.1016/S0006-8993(02)03961-6, PII S0006899302039616
-
Tritos NA, Mastaitis JW, Kokkotou EG, Puigserver P, Spiegelman BM, Maratos-Flier E. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Brain Res. 2003;961(2):255-60. (Pubitemid 36071586)
-
(2003)
Brain Research
, vol.961
, Issue.2
, pp. 255-260
-
-
Tritos, N.A.1
Mastaitis, J.W.2
Kokkotou, E.G.3
Puigserver, P.4
Spiegelman, B.M.5
Maratos-Flier, E.6
-
73
-
-
33749999530
-
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
-
DOI 10.1016/j.cell.2006.09.024, PII S0092867406012281
-
St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006;127(2):397-408. (Pubitemid 44572377)
-
(2006)
Cell
, vol.127
, Issue.2
, pp. 397-408
-
-
St-Pierre, J.1
Drori, S.2
Uldry, M.3
Silvaggi, J.M.4
Rhee, J.5
Jager, S.6
Handschin, C.7
Zheng, K.8
Lin, J.9
Yang, W.10
Simon, D.K.11
Bachoo, R.12
Spiegelman, B.M.13
-
74
-
-
34249275727
-
Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism
-
DOI 10.1038/nature05767, PII NATURE05767
-
Liu C, Li S, Liu T, Borjigin J, Lin JD. Transcriptional coactivator PGC-1alpha integrates themammalian clock and energymetabolism. Nature. 2007;447(7143):477-81. (Pubitemid 46816732)
-
(2007)
Nature
, vol.447
, Issue.7143
, pp. 477-481
-
-
Liu, C.1
Li, S.2
Liu, T.3
Borjigin, J.4
Lin, J.D.5
-
75
-
-
84872276087
-
PGC-1 coactivators regulate MITF and the tanning response
-
[Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. doi:10.1016/j.molcel.2012.10.027
-
Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, et al. PGC-1 coactivators regulate MITF and the tanning response. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. Mol Cell. 2013;49(1):145-57. doi:10.1016/j.molcel.2012.10.027.
-
(2013)
Mol Cell
, vol.49
, Issue.1
, pp. 145-157
-
-
Shoag, J.1
Haq, R.2
Zhang, M.3
Liu, L.4
Rowe, G.C.5
Jiang, A.6
-
76
-
-
0038686576
-
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha
-
DOI 10.1016/S1534-5807(03)00170-9, PII S1534580703001709
-
Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, et al. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. [Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. Dev Cell. 2003;5(1):73-83. (Pubitemid 36827343)
-
(2003)
Developmental Cell
, vol.5
, Issue.1
, pp. 73-83
-
-
Yoon, J.C.1
Xu, G.2
Deeney, J.T.3
Yang, S.-N.4
Rhee, J.5
Puigserver, P.6
Levens, A.R.7
Yang, R.8
Zhang, C.-Y.9
Lowell, B.B.10
Berggren, P.-O.11
Newgard, C.B.12
Bonner-Weir, S.13
Weir, G.14
Spiegelman, B.M.15
-
77
-
-
60549086405
-
Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells
-
[Research Support, Non-U.S. Gov't]. doi: 10.1007/s00109-008-0425-0
-
Oberkofler H, Hafner M, Felder T, Krempler F, Patsch W. Transcriptional co-activator peroxisome proliferator-activated receptor (PPAR)gamma co-activator-1beta is involved in the regulation of glucose-stimulated insulin secretion in INS-1E cells. [Research Support, Non-U.S. Gov't]. J Mol Med. 2009;87(3):299-306. doi: 10.1007/s00109-008-0425-0.
-
(2009)
J Mol Med
, vol.87
, Issue.3
, pp. 299-306
-
-
Oberkofler, H.1
Hafner, M.2
Felder, T.3
Krempler, F.4
Patsch, W.5
-
78
-
-
42449092519
-
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation
-
DOI 10.1073/pnas.0800979105
-
Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, Spiegelman BM. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. [Research Support, N.I.H., Extramural]. Proc Natl Acad Sci U S A. 2008;105(12):4721-6. doi:10.1073/pnas. 0800979105. (Pubitemid 351753813)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.12
, pp. 4721-4726
-
-
Arany, Z.1
Wagner, B.K.2
Ma, Y.3
Chinsomboon, J.4
Laznik, D.5
Spiegelman, B.M.6
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